GB2171103B - Novel peptides and peptide derivatives, their preparation and use and pharmaceutical compositions containing them - Google Patents

Novel peptides and peptide derivatives, their preparation and use and pharmaceutical compositions containing them

Info

Publication number
GB2171103B
GB2171103B GB08603835A GB8603835A GB2171103B GB 2171103 B GB2171103 B GB 2171103B GB 08603835 A GB08603835 A GB 08603835A GB 8603835 A GB8603835 A GB 8603835A GB 2171103 B GB2171103 B GB 2171103B
Authority
GB
United Kingdom
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
peptide derivatives
novel peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08603835A
Other languages
English (en)
Other versions
GB8603835D0 (en
GB2171103A (en
Inventor
Robert H Abeles
Michael H Gelb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB8603835D0 publication Critical patent/GB8603835D0/en
Publication of GB2171103A publication Critical patent/GB2171103A/en
Application granted granted Critical
Publication of GB2171103B publication Critical patent/GB2171103B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
GB08603835A 1985-02-19 1986-02-17 Novel peptides and peptide derivatives, their preparation and use and pharmaceutical compositions containing them Expired GB2171103B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70265185A 1985-02-19 1985-02-19

Publications (3)

Publication Number Publication Date
GB8603835D0 GB8603835D0 (en) 1986-03-26
GB2171103A GB2171103A (en) 1986-08-20
GB2171103B true GB2171103B (en) 1989-01-25

Family

ID=24822094

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08603835A Expired GB2171103B (en) 1985-02-19 1986-02-17 Novel peptides and peptide derivatives, their preparation and use and pharmaceutical compositions containing them

Country Status (7)

Country Link
JP (1) JPS61194097A ( )
BE (1) BE904233A ( )
CH (1) CH672792A5 ( )
DE (1) DE3604510A1 ( )
FR (1) FR2577557B1 ( )
GB (1) GB2171103B ( )
IT (1) IT1203743B ( )

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194588A (en) * 1985-01-22 1993-03-16 Ici Americas Inc. Aminoalcohol intermediates for peptide derivatives
US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
US5496927A (en) * 1985-02-04 1996-03-05 Merrell Pharmaceuticals Inc. Peptidase inhibitors
US4882420A (en) * 1985-04-19 1989-11-21 The Upjohn Company Dihalo-statine substituted renin inhibitors
GB8613704D0 (en) * 1986-06-05 1986-07-09 Ici America Inc Difluoro keto compounds
GB8613703D0 (en) * 1986-06-05 1986-07-09 Ici America Inc Difluoro peptide compounds
GB8619182D0 (en) * 1986-08-06 1986-09-17 Sandoz Ltd Peptides & derivatives
NZ223148A (en) * 1987-01-16 1989-10-27 Merrell Dow Pharma Peptide derivatives having peptidase inhibition activity
US4855303A (en) * 1987-07-01 1989-08-08 Pfizer Inc. Fluorine containing renin inhibitors
US5071837A (en) * 1990-11-28 1991-12-10 Warner-Lambert Company Novel renin inhibiting peptides
CA2098020C (en) * 1991-01-02 2003-10-21 Daniel Schirlin Anti-viral compounds
KR100220876B1 (ko) * 1991-01-02 1999-10-01 슈테펜엘.네스비트 항 바이러스 화합물
IL108031A0 (en) * 1992-12-22 1994-04-12 Procter & Gamble Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
AU667995B2 (en) * 1993-02-15 1996-04-18 Bayer Aktiengesellschaft New pseudopeptides having an antiviral action
DE69425971T2 (de) * 1993-07-08 2001-05-23 Merrell Dow Pharma Analoge von difluoro-staton
KR100308839B1 (ko) * 1993-09-09 2002-10-04 메렐 파마슈티칼스 인크. 디플루오로 스타톤 항바이러스성 유사체
JP3574455B2 (ja) * 1994-02-04 2004-10-06 メレルファーマスーティカルズ インコーポレイテッド 抗ウイルス剤として有用なマクロ環式ジフルオロスタトン誘導体類
GB9502152D0 (en) * 1995-02-03 1995-03-29 Zeneca Ltd Proline derivatives
US6114380A (en) * 1995-12-18 2000-09-05 Merrell Pharmaceuticals Inc. Difluoro statone analogs
US8324347B2 (en) * 2009-02-24 2012-12-04 Institute For Systems Biology Methods of using halogenated peptides as internal standards for liquid chromatography-mass spectrometry

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2424253A1 (fr) * 1978-04-27 1979-11-23 Brun Lab Sa Le Nouveaux derives de peptides analogues des enkephalines, leur procede de preparation et leur application therapeutique
GR75019B ( ) * 1980-09-17 1984-07-12 Univ Miami
WO1986006379A1 (en) * 1985-04-19 1986-11-06 The Upjohn Company Dihalo-statine substituted renin inhibitors

Also Published As

Publication number Publication date
IT8647666A0 (it) 1986-02-18
FR2577557B1 (fr) 1990-05-11
GB8603835D0 (en) 1986-03-26
BE904233A (fr) 1986-08-18
JPS61194097A (ja) 1986-08-28
FR2577557A1 (fr) 1986-08-22
GB2171103A (en) 1986-08-20
DE3604510A1 (de) 1986-08-21
IT1203743B (it) 1989-02-23
CH672792A5 ( ) 1989-12-29

Similar Documents

Publication Publication Date Title
IL85136A0 (en) Peptide derivatives,their preparation and pharmaceutical compositions containing them
IL78219A0 (en) N,n'-dialkylguanidino dipeptide derivatives,their preparation and pharmaceutical compositions containing them
IL79235A0 (en) Pharmaceutical compositions containing solubilized proteins and their preparation
GB2171103B (en) Novel peptides and peptide derivatives, their preparation and use and pharmaceutical compositions containing them
IL79323A0 (en) Phenylethanolaminotetralines,their preparation and pharmaceutical compositions containing them
IL80296A (en) Phenylpyridone derivatives,their preparation and pharmaceutical compositions containing them
IL93845A0 (en) Amino acid derivatives,their preparation and pharmaceutical compositions containing them
IL72572A0 (en) Peptides,their preparation and pharmaceutical compositions containing them
IL89881A0 (en) Peptide derivatives,their production and pharmaceutical compositions containing them
IL80846A0 (en) Calcitonin derivatives,their preparation and pharmaceutical compositions containing them
IL77294A (en) 2-piperazino-4,7-di(cyclo)amino piperidine derivatives,their preparation and pharmaceutical compositions containing them
IL92054A0 (en) Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof,their preparation and pharmaceutical compositions containing them
IL91166A0 (en) Somatostatin analogs,their preparation and pharmaceutical compositions containing them
IL84268A (en) Amino-cyclohexyl-hydroxyalkanoic acid peptide derivatives and pharmaceutical compositions containing them
IL81833A (en) Renin inhibitory peptides,their preparation and pharmaceutical compositions containing them
IL86876A0 (en) Polypeptides,their preparation and pharmaceutical composition containing them
IL85885A0 (en) Cyclic peptides,their preparation and pharmaceutical compositions containing them
IL79402A0 (en) Poly-4-aminopyrrole-2-carboxamido derivatives,their preparation and pharmaceutical compositions containing them
IL79792A (en) Amino acid derivatives,their preparation and pharmaceutical compositions containing them
IL79039A0 (en) 4-oxoquinolinesulfonamides,their preparation and pharmaceutical compositions containing them
IL93955A0 (en) Amino acid derivatives,their preparation and pharmaceutical compositions containing them
IL79858A0 (en) Peptide antibiotics,their preparation and compositions containing them
IL88934A0 (en) Recombinant human interleukin-1alpha polypeptides,their preparation and pharmaceutical compositions containing them
IL78432A (en) Dichloroaniline derivatives,their preparation and pharmaceutical compositions containing them
GB8529880D0 (en) Polypeptide & pharmaceutical composition

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930217