IT1203743B - Peptidi e derivati peptidici,loro preparazione e loro impiego come medicamenti - Google Patents

Peptidi e derivati peptidici,loro preparazione e loro impiego come medicamenti

Info

Publication number
IT1203743B
IT1203743B IT47666/86A IT4766686A IT1203743B IT 1203743 B IT1203743 B IT 1203743B IT 47666/86 A IT47666/86 A IT 47666/86A IT 4766686 A IT4766686 A IT 4766686A IT 1203743 B IT1203743 B IT 1203743B
Authority
IT
Italy
Prior art keywords
peptidal
medications
peptides
derivatives
preparation
Prior art date
Application number
IT47666/86A
Other languages
English (en)
Other versions
IT8647666A0 (it
Inventor
Robert H Abeles
Michael H Gelb
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IT8647666A0 publication Critical patent/IT8647666A0/it
Application granted granted Critical
Publication of IT1203743B publication Critical patent/IT1203743B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IT47666/86A 1985-02-19 1986-02-18 Peptidi e derivati peptidici,loro preparazione e loro impiego come medicamenti IT1203743B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70265185A 1985-02-19 1985-02-19

Publications (2)

Publication Number Publication Date
IT8647666A0 IT8647666A0 (it) 1986-02-18
IT1203743B true IT1203743B (it) 1989-02-23

Family

ID=24822094

Family Applications (1)

Application Number Title Priority Date Filing Date
IT47666/86A IT1203743B (it) 1985-02-19 1986-02-18 Peptidi e derivati peptidici,loro preparazione e loro impiego come medicamenti

Country Status (7)

Country Link
JP (1) JPS61194097A (it)
BE (1) BE904233A (it)
CH (1) CH672792A5 (it)
DE (1) DE3604510A1 (it)
FR (1) FR2577557B1 (it)
GB (1) GB2171103B (it)
IT (1) IT1203743B (it)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
US5194588A (en) * 1985-01-22 1993-03-16 Ici Americas Inc. Aminoalcohol intermediates for peptide derivatives
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
US5496927A (en) * 1985-02-04 1996-03-05 Merrell Pharmaceuticals Inc. Peptidase inhibitors
US4882420A (en) * 1985-04-19 1989-11-21 The Upjohn Company Dihalo-statine substituted renin inhibitors
GB8613704D0 (en) * 1986-06-05 1986-07-09 Ici America Inc Difluoro keto compounds
GB8613703D0 (en) * 1986-06-05 1986-07-09 Ici America Inc Difluoro peptide compounds
GB8619182D0 (en) * 1986-08-06 1986-09-17 Sandoz Ltd Peptides & derivatives
NZ223148A (en) * 1987-01-16 1989-10-27 Merrell Dow Pharma Peptide derivatives having peptidase inhibition activity
US4855303A (en) * 1987-07-01 1989-08-08 Pfizer Inc. Fluorine containing renin inhibitors
US5071837A (en) * 1990-11-28 1991-12-10 Warner-Lambert Company Novel renin inhibiting peptides
ATE143025T1 (de) * 1991-01-02 1996-10-15 Merrell Pharma Inc Antivirale verbindungen
KR100220876B1 (ko) * 1991-01-02 1999-10-01 슈테펜엘.네스비트 항 바이러스 화합물
IL108031A0 (en) * 1992-12-22 1994-04-12 Procter & Gamble Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
AU667995B2 (en) * 1993-02-15 1996-04-18 Bayer Aktiengesellschaft New pseudopeptides having an antiviral action
EP0707564B1 (en) * 1993-07-08 2000-09-20 Merrell Pharmaceuticals Inc. Difluoro statone analogs
KR100308839B1 (ko) * 1993-09-09 2002-10-04 메렐 파마슈티칼스 인크. 디플루오로 스타톤 항바이러스성 유사체
EP0742791B1 (en) * 1994-02-04 2001-01-10 Merrell Pharmaceuticals Inc. Macrocyclic difluorostatone derivatives useful as antiviral agents
GB9502152D0 (en) * 1995-02-03 1995-03-29 Zeneca Ltd Proline derivatives
US6114380A (en) * 1995-12-18 2000-09-05 Merrell Pharmaceuticals Inc. Difluoro statone analogs
US8324347B2 (en) 2009-02-24 2012-12-04 Institute For Systems Biology Methods of using halogenated peptides as internal standards for liquid chromatography-mass spectrometry

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2424253A1 (fr) * 1978-04-27 1979-11-23 Brun Lab Sa Le Nouveaux derives de peptides analogues des enkephalines, leur procede de preparation et leur application therapeutique
GR75019B (it) * 1980-09-17 1984-07-12 Univ Miami
WO1986006379A1 (en) * 1985-04-19 1986-11-06 The Upjohn Company Dihalo-statine substituted renin inhibitors

Also Published As

Publication number Publication date
DE3604510A1 (de) 1986-08-21
GB8603835D0 (en) 1986-03-26
FR2577557A1 (fr) 1986-08-22
CH672792A5 (it) 1989-12-29
GB2171103B (en) 1989-01-25
FR2577557B1 (fr) 1990-05-11
BE904233A (fr) 1986-08-18
GB2171103A (en) 1986-08-20
JPS61194097A (ja) 1986-08-28
IT8647666A0 (it) 1986-02-18

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