DE3587214T2 - - Google Patents
Info
- Publication number
- DE3587214T2 DE3587214T2 DE85901936T DE3587214T DE3587214T2 DE 3587214 T2 DE3587214 T2 DE 3587214T2 DE 85901936 T DE85901936 T DE 85901936T DE 3587214 T DE3587214 T DE 3587214T DE 3587214 T2 DE3587214 T2 DE 3587214T2
- Authority
- DE
- Germany
- Prior art keywords
- amino acid
- acid sequence
- rotavirus
- major outer
- outer envelope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000623 proteins and genes Proteins 0.000 claims description 34
- 241000702670 Rotavirus Species 0.000 claims description 31
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 21
- 241000617996 Human rotavirus Species 0.000 claims description 18
- 101710121417 Envelope glycoprotein Proteins 0.000 claims description 14
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 150000001413 amino acids Chemical class 0.000 claims description 11
- 239000002773 nucleotide Substances 0.000 claims description 10
- 125000003729 nucleotide group Chemical group 0.000 claims description 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 10
- 229960005486 vaccine Drugs 0.000 claims description 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 7
- 239000012634 fragment Substances 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 4
- 239000013598 vector Substances 0.000 claims description 4
- 239000003153 chemical reaction reagent Substances 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims 9
- 102100021696 Syncytin-1 Human genes 0.000 claims 7
- 241001245603 Rotavirus G2 Species 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 241000700605 Viruses Species 0.000 description 20
- 108090000288 Glycoproteins Proteins 0.000 description 18
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 17
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 13
- 102000003886 Glycoproteins Human genes 0.000 description 9
- 235000018102 proteins Nutrition 0.000 description 9
- 108020004414 DNA Proteins 0.000 description 7
- 102100034349 Integrase Human genes 0.000 description 7
- 235000001014 amino acid Nutrition 0.000 description 7
- 229940024606 amino acid Drugs 0.000 description 7
- 239000000499 gel Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 6
- 230000000890 antigenic effect Effects 0.000 description 5
- 244000309466 calf Species 0.000 description 5
- 101150103591 Segment-8 gene Proteins 0.000 description 4
- 239000002299 complementary DNA Substances 0.000 description 4
- 238000006386 neutralization reaction Methods 0.000 description 4
- WRRQKFXVKRQPDB-UHFFFAOYSA-N 2-(2-aminophenyl)sulfanylaniline Chemical compound NC1=CC=CC=C1SC1=CC=CC=C1N WRRQKFXVKRQPDB-UHFFFAOYSA-N 0.000 description 3
- 239000003298 DNA probe Substances 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 238000000636 Northern blotting Methods 0.000 description 3
- 108010076504 Protein Sorting Signals Proteins 0.000 description 3
- 108091081021 Sense strand Proteins 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229920002401 polyacrylamide Polymers 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 241000282693 Cercopithecidae Species 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 238000010367 cloning Methods 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 230000013595 glycosylation Effects 0.000 description 2
- 238000006206 glycosylation reaction Methods 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 239000013612 plasmid Substances 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 108020003215 DNA Probes Proteins 0.000 description 1
- 238000001712 DNA sequencing Methods 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- 125000002842 L-seryl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])O[H] 0.000 description 1
- 241000829100 Macaca mulatta polyomavirus 1 Species 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 108700026244 Open Reading Frames Proteins 0.000 description 1
- 241000702244 Orthoreovirus Species 0.000 description 1
- 101710116435 Outer membrane protein Proteins 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 241000702263 Reovirus sp. Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 241000607760 Shigella sonnei Species 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 241000702677 Simian rotavirus Species 0.000 description 1
- 108020005038 Terminator Codon Proteins 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 238000000246 agarose gel electrophoresis Methods 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940031416 bivalent vaccine Drugs 0.000 description 1
- UDSAIICHUKSCKT-UHFFFAOYSA-N bromophenol blue Chemical compound C1=C(Br)C(O)=C(Br)C=C1C1(C=2C=C(Br)C(O)=C(Br)C=2)C2=CC=CC=C2S(=O)(=O)O1 UDSAIICHUKSCKT-UHFFFAOYSA-N 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- 108010052305 exodeoxyribonuclease III Proteins 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 229940094991 herring sperm dna Drugs 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000037797 influenza A Diseases 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 150000002482 oligosaccharides Polymers 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 230000027419 protein insertion into membrane Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000012723 sample buffer Substances 0.000 description 1
- 238000011451 sequencing strategy Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229940115939 shigella sonnei Drugs 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPG473384 | 1984-04-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3587214D1 DE3587214D1 (en) | 1993-04-29 |
| DE3587214T2 true DE3587214T2 (https=) | 1993-07-01 |
Family
ID=3770594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8585901936T Expired - Lifetime DE3587214D1 (en) | 1984-04-27 | 1985-04-29 | Rotavirus. |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US5395759A (https=) |
| EP (1) | EP0180603B1 (https=) |
| JP (1) | JPS61501958A (https=) |
| AU (1) | AU591058B2 (https=) |
| CA (1) | CA1339735C (https=) |
| DE (1) | DE3587214D1 (https=) |
| WO (1) | WO1985005122A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1339735C (en) * | 1984-04-27 | 1998-03-17 | The University Of Melbourne | Cloning and sequencing of the major outer capsid gylcoprotein gene of a human rotavirus |
| DE3505148A1 (de) * | 1985-02-15 | 1986-10-30 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Polypeptide des rhinovirusstammes hrv2 sowie die hierfuer codierenden dna-molekuele |
| US5068192A (en) * | 1986-01-27 | 1991-11-26 | Prutech Research And Development Partnership | Attenuated pseudorabies virus which includes foreign DNA encoding an amino acid sequence |
| US5763269A (en) * | 1985-09-06 | 1998-06-09 | Syntro Corporation | Recombinant infectious bovine rhinotrocheitis virus |
| CA1327096C (en) * | 1985-12-26 | 1994-02-15 | Marta I. Sabara | Peptides corresponding to antigenic and immunogenic determinants of major neutralizing proteins of rotaviruses |
| US6086880A (en) * | 1985-12-26 | 2000-07-11 | The University Of Saskatchewan | Rotavirus peptide compositions and methods of use |
| US5593873A (en) * | 1986-01-27 | 1997-01-14 | Syntro Corporation | Recombinant infectious bovine rhinotracheitis virus |
| EP0256092B1 (en) * | 1986-01-27 | 1998-04-08 | Syntro Corporation | Attenuated herpesviruses, herpesviruses which include foreign dna encoding an amino acid sequence and vaccine containing same |
| CA1331355C (en) * | 1986-04-21 | 1994-08-09 | Bioenterprises Pty. Ltd | Immunopotentation |
| EP0251467A3 (en) * | 1986-06-20 | 1988-07-20 | Abbott Laboratories | Compositions and methods of use for a major outer capsid protein (vp7) of rotavirus sa-11 |
| US5374426A (en) * | 1986-09-03 | 1994-12-20 | University Of Saskatchewan | Rotavirus nucleocapsid protein VP6 in vaccine compositions |
| US5186933A (en) * | 1986-12-30 | 1993-02-16 | Baylor College Of Medicine | Synthesis and immunogenicity of rotavirus genes using a baculovirus expression system |
| EP0402354A4 (en) * | 1987-08-10 | 1991-03-20 | The University Of Melbourne | Molecular cloning of human rotavirus serotype 4 gene 9 encoding vp7, the major outer capsid neutralisation specific glycoprotein and expression of vp7 and fragments thereof for use in a vaccine |
| WO1989006971A1 (en) * | 1988-02-01 | 1989-08-10 | The Board Of Trustees Of The Leland Stanford Junio | Conserved rotavirus gene segments and use in immunization and neutralization |
| AU672583B2 (en) * | 1991-07-18 | 1996-10-10 | Prutech Research And Development Partnership | Recombinant infectious bovine rhinotracheitis virus |
| JP4776832B2 (ja) * | 2000-10-19 | 2011-09-21 | キヤノン株式会社 | 座標入力装置、および、画像入力装置の座標板 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1678783A (en) * | 1982-07-20 | 1984-01-26 | Molecular Genetics, Inc. | Production of herpes simplex viral proteins |
| EP0133063B1 (en) * | 1983-06-23 | 1987-01-07 | Stanley Dr. Person | Immunologically reactive non-glycosylated amino acid chains of glycoprotein b of herpes virus types 1 and 2 |
| US4571385A (en) * | 1983-06-27 | 1986-02-18 | The United States Of America As Represented By The Department Of Health And Human Services | Genetic reassortment of rotaviruses for production of vaccines and vaccine precursors |
| AU585494B2 (en) * | 1984-02-09 | 1989-06-22 | Royal Children's Hospital Research Foundation | Live attenuated human rotavirus vaccine and preparation thereof |
| CA1339735C (en) * | 1984-04-27 | 1998-03-17 | The University Of Melbourne | Cloning and sequencing of the major outer capsid gylcoprotein gene of a human rotavirus |
| AU5736286A (en) * | 1985-05-14 | 1986-11-20 | Commonwealth Scientific And Industrial Research Organisation | Rotavirus antigens |
| EP1336063B1 (en) * | 2000-11-10 | 2010-05-26 | CUNNINGHAM, John | Universal support and vibration isolator |
-
1985
- 1985-04-26 CA CA000480251A patent/CA1339735C/en not_active Expired - Fee Related
- 1985-04-29 JP JP60502036A patent/JPS61501958A/ja active Pending
- 1985-04-29 EP EP85901936A patent/EP0180603B1/en not_active Expired - Lifetime
- 1985-04-29 WO PCT/AU1985/000096 patent/WO1985005122A1/en not_active Ceased
- 1985-04-29 AU AU42970/85A patent/AU591058B2/en not_active Expired
- 1985-04-29 DE DE8585901936T patent/DE3587214D1/de not_active Expired - Lifetime
- 1985-04-29 US US07/474,642 patent/US5395759A/en not_active Expired - Lifetime
-
1994
- 1994-02-28 US US08/202,380 patent/US5741698A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5741698A (en) | 1998-04-21 |
| JPS61501958A (ja) | 1986-09-11 |
| DE3587214D1 (en) | 1993-04-29 |
| CA1339735C (en) | 1998-03-17 |
| US5395759A (en) | 1995-03-07 |
| EP0180603A4 (en) | 1988-03-22 |
| WO1985005122A1 (en) | 1985-11-21 |
| AU4297085A (en) | 1985-11-28 |
| EP0180603B1 (en) | 1993-03-24 |
| EP0180603A1 (en) | 1986-05-14 |
| AU591058B2 (en) | 1989-11-30 |
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| DE3587214T2 (https=) | ||
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |