DE3586987D1 - Methode zur foerderung einer disulfidverbindung in rekombinanten proteinen und formulationen, welche diese produkte enthalten. - Google Patents
Methode zur foerderung einer disulfidverbindung in rekombinanten proteinen und formulationen, welche diese produkte enthalten.Info
- Publication number
- DE3586987D1 DE3586987D1 DE8585308265T DE3586987T DE3586987D1 DE 3586987 D1 DE3586987 D1 DE 3586987D1 DE 8585308265 T DE8585308265 T DE 8585308265T DE 3586987 T DE3586987 T DE 3586987T DE 3586987 D1 DE3586987 D1 DE 3586987D1
- Authority
- DE
- Germany
- Prior art keywords
- sup
- recombinant proteins
- products
- promoting
- sub
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/811—Interferon
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/679,121 US4572798A (en) | 1984-12-06 | 1984-12-06 | Method for promoting disulfide bond formation in recombinant proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3586987D1 true DE3586987D1 (de) | 1993-02-25 |
DE3586987T2 DE3586987T2 (de) | 1993-05-13 |
Family
ID=24725645
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8585308265T Expired - Lifetime DE3586987T2 (de) | 1984-12-06 | 1985-11-13 | Methode zur foerderung einer disulfidverbindung in rekombinanten proteinen und formulationen, welche diese produkte enthalten. |
Country Status (13)
Country | Link |
---|---|
US (1) | US4572798A (de) |
EP (1) | EP0185459B1 (de) |
JP (1) | JPH0696600B2 (de) |
KR (1) | KR940003475B1 (de) |
AT (1) | ATE84540T1 (de) |
AU (1) | AU594930B2 (de) |
BR (1) | BR8506101A (de) |
CA (1) | CA1248300A (de) |
DE (1) | DE3586987T2 (de) |
ES (1) | ES8700271A1 (de) |
GB (1) | GB2168055B (de) |
IN (1) | IN163025B (de) |
ZA (1) | ZA859001B (de) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4925919A (en) * | 1984-04-25 | 1990-05-15 | Roland Mertelsmann | Purified interleukin 2 |
US4992271A (en) * | 1982-09-23 | 1991-02-12 | Cetus Corporation | Formulation for lipophilic IL-2 proteins |
US4853332A (en) * | 1982-10-19 | 1989-08-01 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins |
US4569790A (en) * | 1984-03-28 | 1986-02-11 | Cetus Corporation | Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions |
DE3583880D1 (de) * | 1984-04-09 | 1991-10-02 | Takeda Chemical Industries Ltd | Stabile interleukin-2-zusammensetzung. |
US4908433A (en) * | 1984-04-25 | 1990-03-13 | Sloan-Kettering Institute For Cancer Research | Uses of interleukin-2 |
US4908434A (en) * | 1984-04-25 | 1990-03-13 | Sloan-Kettering Institute For Cancer Research | Process for preparing purified interleukin-2 |
US4572798A (en) * | 1984-12-06 | 1986-02-25 | Cetus Corporation | Method for promoting disulfide bond formation in recombinant proteins |
GB8508340D0 (en) * | 1985-03-29 | 1985-05-09 | Creighton T E | Production of protein |
US5425940A (en) * | 1986-04-09 | 1995-06-20 | Cetus Oncology Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
DE3621828A1 (de) * | 1986-06-28 | 1988-01-14 | Biotest Pharma Gmbh | Stabilisierung eines fuer therapeutische zwecke, insbesondere beim menschen, bestimmten interleukin-2-praeparates sowie dieses praeparat enthaltende stabilisierte waessrige loesung oder feststoff |
US4683293A (en) * | 1986-10-20 | 1987-07-28 | Phillips Petroleum Company | Purification of pichia produced lipophilic proteins |
US4929700A (en) * | 1987-04-16 | 1990-05-29 | Cetus Corporation | Production of purified, biologically active, bacterially produced recombinant human CSF-1 |
CA1339757C (en) | 1987-04-16 | 1998-03-17 | Robert F. Halenbeck | Production of purified biologically active, bacterially produced recombinant human csf-1 |
US4961969A (en) * | 1987-05-11 | 1990-10-09 | Cetus Corporation | Process for recovering microbially produced interferon-β |
DE3855986T2 (de) * | 1987-05-11 | 1998-02-05 | Chiron Corp | Prozess zur gewinnung von gereinigtem, oxidiertem, renaturiertem, rekombinantem interleukin-2 aus mikroorganismen |
US4931543A (en) * | 1987-05-11 | 1990-06-05 | Cetus Corporation | Process for recovering microbially produced interleukin-2 |
US4801691A (en) * | 1987-05-15 | 1989-01-31 | International Minerals & Chemical Corp. | Method for removing sodium dodecyl sulfate from sodium dodecyl sulfate solubilized protein solutions |
JP2669859B2 (ja) * | 1987-08-04 | 1997-10-29 | 協和醗酵工業株式会社 | タンパク質の再活性化法 |
US5759815A (en) * | 1988-02-11 | 1998-06-02 | Creative Biomolecules, Inc. | Production of platelet derived growth factor (PDGF) an muteins thereof |
CA1340586C (en) * | 1988-09-23 | 1999-06-08 | Cetus Corporation | Process for recovering microbially produced interferon-beta |
JP2517100B2 (ja) * | 1989-03-08 | 1996-07-24 | 協和醗酵工業株式会社 | ヒト顆粒球コロニ―刺激因子活性を有する蛋白質の精製法 |
US5204256A (en) * | 1989-09-06 | 1993-04-20 | Behringwerke Aktiengesellschaft | Process for the purification of plasminogen activator inhibitor 2 (pai-2) |
JPH05501500A (ja) * | 1989-10-18 | 1993-03-25 | クリエイティブ・バイオマリキュールズ・インコーポレーテッド | TGF―βの生合成構築物 |
GB8927546D0 (en) * | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
US5830452A (en) * | 1990-11-20 | 1998-11-03 | Chiron Corporation | Method for enhancing the anti-tumor therapeutic index of interleukin-2 |
JP3021040B2 (ja) * | 1990-11-23 | 2000-03-15 | ヘキスト・マリオン・ルセル | 少なくとも1個の分子内ジスルフィド結合を含有する蛋白質を相当する還元された組替え蛋白質を5.0以下のpHで酸化することによって製造する方法 |
IT1245063B (it) * | 1991-04-12 | 1994-09-13 | Ferruzzi Ricerca & Tec | Procedimento per l'ossidazione di carboidrati |
US5466781A (en) * | 1991-05-24 | 1995-11-14 | Chiron Therapeutics | Process for purifying bacterially produced M-CSF |
US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
FR2684878B1 (fr) * | 1991-12-12 | 1994-02-11 | Roussel Uclaf | Composition pharmaceutique stabilisee d'il2 humaine recombinante non glycosylee sous forme reduite et son procede de preparation. |
US20030171292A1 (en) * | 1992-06-01 | 2003-09-11 | Creasey Abla A. | Method for using lipoprotein associated coagulation inhibitor to treat sepsis |
US6063764A (en) * | 1992-06-01 | 2000-05-16 | Washington University & Chiron Corp. | Method for using lipoprotein associated coagulation inhibitor to treat sepsis |
AU687763B2 (en) * | 1992-10-20 | 1998-03-05 | Central Laboratory Of The Netherlands Red Cross Blood Transfusion Service | Interleukin-6 receptor antagonists |
WO1995004823A1 (en) * | 1993-08-04 | 1995-02-16 | Ciba-Geigy Ag | High molecular weight desulphatohirudin |
US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
US5545723A (en) * | 1994-03-15 | 1996-08-13 | Biogen Inc. | Muteins of IFN-β |
TW517059B (en) | 1994-07-25 | 2003-01-11 | Ciba Geigy Ag | New process for the production of biologically active protein |
DE19547933A1 (de) * | 1995-12-22 | 1997-06-26 | Boehringer Mannheim Gmbh | Multimere Formen von IL-16, Verfahren zu ihrer Herstellung und Verwendung |
AU735459B2 (en) | 1997-01-30 | 2001-07-12 | University Of Virginia Patent Foundation | Cysteine-depleted peptides recognized by A3-restricted cytotoxic lymphocytes, and uses therefor |
US7270809B2 (en) | 1997-07-14 | 2007-09-18 | Bolder Biotechnology, Inc. | Cysteine variants of alpha interferon-2 |
US20080076706A1 (en) | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
US6753165B1 (en) | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
ATE375363T1 (de) | 1997-07-14 | 2007-10-15 | Bolder Biotechnology Inc | Derivate des wachstumshormons und verwandte proteine |
GB9806632D0 (en) * | 1998-03-28 | 1998-05-27 | Stevenson Robert | Peptide factor |
US8288126B2 (en) | 1999-01-14 | 2012-10-16 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
IL144259A0 (en) * | 1999-01-14 | 2002-05-23 | Bolder Biotechnology Inc | Methods for making proteins containing free cysteine residues |
US6808902B1 (en) * | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
EP1935431A3 (de) | 2000-05-15 | 2008-08-13 | Health Research, Inc. | Krebsbehandlungen unter Verwendung einer Kombination aus einem HER2-Antikörper und Interleukin-2 |
US6887462B2 (en) | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
MXPA04003547A (es) * | 2001-10-15 | 2004-07-22 | Chiron Corp | Tratamiento de sepsis mediante administracion de dosis bajas de inhibidor de via factor de tejido. |
RU2006104023A (ru) * | 2003-07-11 | 2006-07-27 | Шеринг Акциенгезельшафт (De) | УЛУЧШЕННЫЕ РЕКОМБИНАНТНЫЕ ПОЛИПЕПТИДЫ ЧЕЛОВЕЧЕСКОГО ИНТЕРФЕРОНА -БЕТА-1b |
PT1682178E (pt) | 2003-11-04 | 2010-10-21 | Novartis Vaccines & Diagnostic | Métodos de terapêutica para cancros que expressam o antigénio cd40 |
US20080286279A1 (en) * | 2004-03-17 | 2008-11-20 | Chiron Corporation | Treatment of Severe Community-Acquired Pneumonia by Administration of Tissue Factor Pathway Inhibitor (Tfpi) |
KR20190140090A (ko) | 2007-07-09 | 2019-12-18 | 제넨테크, 인크. | 폴리펩티드의 재조합 생산 동안의 디술피드 결합 환원의 방지 |
WO2009045553A1 (en) * | 2007-10-05 | 2009-04-09 | Barofold, Inc. | High pressure treatment of aggregated interferons |
PT2424889E (pt) | 2009-04-30 | 2015-11-12 | Ablynx Nv | Método de produção de anticorpos de domínio |
WO2011005488A1 (en) * | 2009-06-22 | 2011-01-13 | Amgen Inc. | Refolding proteins using a chemically controlled redox state |
JP2012531428A (ja) | 2009-06-25 | 2012-12-10 | アムジエン・インコーポレーテツド | 哺乳類以外の系で発現されるタンパク質の捕獲精製プロセス |
WO2012088446A1 (en) | 2010-12-22 | 2012-06-28 | Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
GB201101794D0 (en) * | 2011-02-02 | 2011-03-16 | Fermentas Uab | Protein production |
EP3049445A4 (de) | 2013-09-24 | 2017-10-25 | Medicenna Therapeutics, Inc. | Interleukin-2-fusionsproteine und verwendungen davon |
WO2015164815A1 (en) | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
US10806773B2 (en) | 2014-10-09 | 2020-10-20 | Dana-Farber Cancer Institute, Inc. | Multiple-variable IL-2 dose regimen for treating immune disorders |
CA3056630A1 (en) | 2017-03-15 | 2018-09-20 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
CN111010866A (zh) | 2017-05-24 | 2020-04-14 | 潘迪恩治疗公司 | 靶向免疫耐受性 |
EP3641814A4 (de) | 2017-06-19 | 2021-06-23 | Medicenna Therapeutics Inc. | Verwendungen und verfahren für il-2-superagonisten, agonisten und fusionen davon |
US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
EP3775927B1 (de) * | 2018-03-28 | 2024-02-07 | Two-Tag Holdings Pty Ltd | Verfahren zur messung der relativen oxidationswerte eines proteins |
AU2020279240A1 (en) | 2019-05-20 | 2021-12-23 | Pandion Operations, Inc. | MAdCAM targeted immunotolerance |
AU2021207652B2 (en) | 2020-01-14 | 2023-08-03 | Synthekine, Inc. | Biased IL2 muteins methods and compositions |
US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4450103A (en) * | 1982-03-01 | 1984-05-22 | Cetus Corporation | Process for recovering human IFN-β from a transformed microorganism |
JPS5927858A (ja) * | 1982-08-05 | 1984-02-14 | Nippon Shinyaku Co Ltd | ポリペプチドの製法 |
US4490289A (en) * | 1982-09-16 | 1984-12-25 | Hoffmann-La Roche Inc. | Homogeneous human interleukin 2 |
US4462940A (en) * | 1982-09-23 | 1984-07-31 | Cetus Corporation | Process for the recovery of human β-interferon-like polypeptides |
IL90047A (en) * | 1982-10-19 | 1992-12-01 | Cetus Oncology Corp | Cysteine-depleted biologically active muteins other than interferon - ' |
FI82266C (fi) * | 1982-10-19 | 1991-02-11 | Cetus Corp | Foerfarande foer framstaellning av il-2 -mutein. |
IE56372B1 (en) * | 1982-12-22 | 1991-07-03 | Genentech Inc | Microbially produced rennet methods for its production and plasmids used for its production |
US4530787A (en) * | 1984-03-28 | 1985-07-23 | Cetus Corporation | Controlled oxidation of microbially produced cysteine-containing proteins |
US4569790A (en) * | 1984-03-28 | 1986-02-11 | Cetus Corporation | Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions |
US4572798A (en) * | 1984-12-06 | 1986-02-25 | Cetus Corporation | Method for promoting disulfide bond formation in recombinant proteins |
-
1984
- 1984-12-06 US US06/679,121 patent/US4572798A/en not_active Expired - Lifetime
-
1985
- 1985-11-13 EP EP85308265A patent/EP0185459B1/de not_active Expired - Lifetime
- 1985-11-13 AT AT85308265T patent/ATE84540T1/de not_active IP Right Cessation
- 1985-11-13 DE DE8585308265T patent/DE3586987T2/de not_active Expired - Lifetime
- 1985-11-13 IN IN806/CAL/85A patent/IN163025B/en unknown
- 1985-11-13 GB GB08528017A patent/GB2168055B/en not_active Expired
- 1985-11-19 AU AU50052/85A patent/AU594930B2/en not_active Expired
- 1985-11-20 CA CA000495774A patent/CA1248300A/en not_active Expired
- 1985-11-21 ES ES549135A patent/ES8700271A1/es not_active Expired
- 1985-11-25 ZA ZA859001A patent/ZA859001B/xx unknown
- 1985-11-26 JP JP60263973A patent/JPH0696600B2/ja not_active Expired - Lifetime
- 1985-11-27 KR KR1019850008860A patent/KR940003475B1/ko not_active IP Right Cessation
- 1985-12-05 BR BR8506101A patent/BR8506101A/pt unknown
Also Published As
Publication number | Publication date |
---|---|
ES8700271A1 (es) | 1986-09-01 |
US4572798A (en) | 1986-02-25 |
GB2168055A (en) | 1986-06-11 |
EP0185459B1 (de) | 1993-01-13 |
EP0185459A3 (en) | 1989-02-08 |
KR860005015A (ko) | 1986-07-16 |
CA1248300A (en) | 1989-01-03 |
ATE84540T1 (de) | 1993-01-15 |
JPS61140600A (ja) | 1986-06-27 |
AU5005285A (en) | 1986-06-12 |
BR8506101A (pt) | 1986-08-19 |
DE3586987T2 (de) | 1993-05-13 |
GB8528017D0 (en) | 1985-12-18 |
ES549135A0 (es) | 1986-09-01 |
AU594930B2 (en) | 1990-03-22 |
ZA859001B (en) | 1986-08-27 |
EP0185459A2 (de) | 1986-06-25 |
KR940003475B1 (ko) | 1994-04-22 |
GB2168055B (en) | 1988-12-29 |
JPH0696600B2 (ja) | 1994-11-30 |
IN163025B (de) | 1988-07-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3586987D1 (de) | Methode zur foerderung einer disulfidverbindung in rekombinanten proteinen und formulationen, welche diese produkte enthalten. | |
US4530787B1 (de) | ||
DK0559632T3 (da) | Fremgangsmåde til fremstilling af vævsfaktorreaktionsvejsinhibitor | |
ATE106247T1 (de) | Formulierung für rekombinantes beta-interferon, verfahren zur gewinnung und stabilisierung des beta-interferons und dessen verwendung. | |
ES8603271A1 (es) | Un metodo de producir una composicion de interleuquina-2 | |
HUT47977A (en) | Polipeptides, process for their production and process for production of medical compositions containing such active substances | |
MY101972A (en) | Primate interleukin - 4 | |
DE3687763D1 (de) | Oxidationsbestaendige il-2-muteine und ihre herstellung, diese muteine enthaltende zusammensetzungen, solche muteine kodierende dns-sequenzen und expressionsvektoren und korrespondierende transformierte wirtzellen. | |
ES2073735T3 (es) | Nuevos analogos de la cadena b del factor de crecimiento derivado de plaquetas y metodo para su produccion homogenea. | |
DK0646321T3 (da) | Dyrefoderadditiv og fremgangsmåde til fremstilling deraf | |
TW275066B (de) | ||
ATE72582T1 (de) | Oxidationsresistente muteine von beta-interferon, deren herstellung und diese muteine enthaltende praeparate. | |
Bandara et al. | Chondrocyte activation by interleukin-1: Analysis of the synergistic properties of fibroblast growth factor and phorbol myristate acetate | |
ATE101654T1 (de) | Verfahren zur gewinnung von mikrobiell hergestelltem beta-interferon. | |
SE8800989D0 (sv) | Dietary composition and process for preparing same | |
SE8800990D0 (sv) | Skin-regenerating cosmetic compositon and process for preparing same | |
SE8800988D0 (sv) | Pharmaceutical compositons acting on the heart and cardiovascular system and process for preparing same | |
EP0185282A3 (de) | Pyridyl-thionophosphorsäureester | |
Maskos | The bifunctional α-amylase/trypsin inhibitor from Ragi: three-dimensional structure, inhibitory properties and oxidative folding in vivo and in vitro | |
World Health Organization | INTERNATIONAL HEALTH REGULATIONS (1969) 1 | |
SU1591247A1 (ru) | Катализатор для окисления сернистых соединений в водно-щелочной среде | |
Khesin et al. | Ribonuclease activity in preparations of human leukocyte interferon | |
ATE15651T1 (de) | Verwendung von aminosaeuren als pflanzenwachstums- promotoren und promotor-zusammensetzung. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: CHIRON CORP. (N.D.GES.D. STAATES DELAWARE), EMERYV |