DE3586262D1 - Monoklonale antikoerper und antigen fuer menschliche lungenkarzinome vom nichtkleinen zellentyp. - Google Patents

Monoklonale antikoerper und antigen fuer menschliche lungenkarzinome vom nichtkleinen zellentyp.

Info

Publication number
DE3586262D1
DE3586262D1 DE8686900473T DE3586262T DE3586262D1 DE 3586262 D1 DE3586262 D1 DE 3586262D1 DE 8686900473 T DE8686900473 T DE 8686900473T DE 3586262 T DE3586262 T DE 3586262T DE 3586262 D1 DE3586262 D1 DE 3586262D1
Authority
DE
Germany
Prior art keywords
human
beta
small cell
monoclonal antibodies
antigas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686900473T
Other languages
English (en)
Other versions
DE3586262T2 (de
Inventor
Ingegerd Hellstrom
Josep P Brown
Diane Horn
Karl E Hellstrom
Peter Linsley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncogen LP
Original Assignee
Oncogen LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/684,759 external-priority patent/US4935495A/en
Application filed by Oncogen LP filed Critical Oncogen LP
Publication of DE3586262D1 publication Critical patent/DE3586262D1/de
Application granted granted Critical
Publication of DE3586262T2 publication Critical patent/DE3586262T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3023—Lung
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/828—Cancer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE8686900473T 1984-12-21 1985-12-13 Monoklonale antikoerper und antigen fuer menschliche lungenkarzinome vom nichtkleinen zellentyp. Expired - Lifetime DE3586262T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/684,759 US4935495A (en) 1984-12-21 1984-12-21 Monoclonal antibodies to the L6 glycolipid antigenic determinant found on human non-small cell lung carcinomas
US06/776,321 US4906562A (en) 1984-12-21 1985-10-18 Monocolonal antibodies and antigen for human non-small cell lung carcinomas
PCT/US1985/002441 WO1986003838A1 (en) 1984-12-21 1985-12-13 Monoclonal antibodies and antigen for human non-small cell lung carcinomas

Publications (2)

Publication Number Publication Date
DE3586262D1 true DE3586262D1 (de) 1992-07-30
DE3586262T2 DE3586262T2 (de) 1992-12-10

Family

ID=27103432

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686900473T Expired - Lifetime DE3586262T2 (de) 1984-12-21 1985-12-13 Monoklonale antikoerper und antigen fuer menschliche lungenkarzinome vom nichtkleinen zellentyp.

Country Status (23)

Country Link
US (1) US4906562A (de)
EP (1) EP0207963B1 (de)
JP (1) JPH09191878A (de)
KR (1) KR910000956B1 (de)
AT (1) ATE77701T1 (de)
AU (1) AU601360B2 (de)
CA (1) CA1335796C (de)
DE (1) DE3586262T2 (de)
DK (1) DK168049B1 (de)
ES (2) ES8800602A1 (de)
FI (2) FI88808C (de)
GB (1) GB2180256B (de)
GR (1) GR853054B (de)
HU (1) HUT42637A (de)
IE (1) IE58572B1 (de)
IL (1) IL77291A (de)
NO (1) NO174718C (de)
NZ (1) NZ214542A (de)
OA (1) OA08412A (de)
PH (1) PH25742A (de)
PT (1) PT81744B (de)
WO (1) WO1986003838A1 (de)
YU (1) YU45294B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675287A (en) * 1984-07-26 1987-06-23 Scripps Clinic And Research Foundation Monoclonal antibody directed to human ganglioside GD2
EP0173648A3 (de) * 1984-08-30 1988-04-27 Ciba-Geigy Ag Monoklonale Antikörper gegen Glykokonjugate, Verfahren zu ihrer Herstellung und Verwendungen
IL76877A (en) * 1984-11-02 1991-11-21 Oncogen Diagnostic method for the determination of human non-small cell lung carcinomas employing novel monoclonal antibodies and compositions containing said antibodies
US5614610A (en) * 1984-12-21 1997-03-25 Oncogen Tumor immunotherapy using anti-idiotypic antibodies
AU601680B2 (en) * 1985-05-28 1990-09-20 Joseph P. Brown Monoclonal antibodies for human non-small cell lung carcinomas
EP0234122A3 (de) * 1986-02-21 1989-03-22 Oncogen Limited Partnership Tumortherapie mit biologisch aktiven Anti-Tumor-Antikörpern
IL84285A (en) * 1986-10-27 1993-03-15 Int Genetic Engineering Chimeric antibody with specificity to human tumor antigen
NZ225599A (en) 1987-08-04 1991-09-25 Bristol Myers Co Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells
AU632469B2 (en) * 1988-04-04 1993-01-07 Johns Hopkins University, The A method for early detection of lung cancer
US5173292A (en) * 1988-06-14 1992-12-22 Sloan-Kettering Institute For Cancer Research Monoclonal antibodies which specifically recognize galactosyl-globoside, compositions containing same and methods of using same
US5171665A (en) * 1989-04-17 1992-12-15 Oncogen Monoclonal antibody to novel antigen associated with human tumors
US5192551A (en) * 1989-05-02 1993-03-09 Johns Hopkins University Neutral glycolipid as an adsorbent for enteric viral pathogens
CA2015862A1 (en) * 1989-05-04 1990-11-04 Gajanan Nilaver Cell surface antigen that binds with l6 monoclonal antibody
CA2040513A1 (en) * 1990-04-16 1991-10-17 Robert C. Bast, Jr. Method of diagnosing cancer
US5165922A (en) * 1990-05-22 1992-11-24 Bristol-Myers Squibb Company Synergistic tumor therapy with combinations of biologically active anti-tumor antibodies and chemotherapy
US5597707A (en) * 1993-04-15 1997-01-28 Bristol-Myers Squibb Company Tumor associated antigen recognized by the murine monoclonal antibody L6, its oligonucleotide sequence and methods for their use
US7745159B2 (en) * 1999-02-26 2010-06-29 Nathalie B Scholler Methods and compositions for diagnosing carcinomas
US6117981A (en) * 1999-06-03 2000-09-12 Cytoclonal Pharmaceutics, Inc. Hybridomas for lung cancer marker and monoclonal antibodies thereof
EP1320551A4 (de) * 2000-09-01 2006-12-20 Internat Bioimmune Systems Inc Identifikation und entwicklung von spezifischen monoklonalen antikörpern gegen plattenepithelkarzinom
US7754208B2 (en) * 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US7829084B2 (en) * 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US20030133939A1 (en) * 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US20040058445A1 (en) * 2001-04-26 2004-03-25 Ledbetter Jeffrey Alan Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB
US20030219436A1 (en) * 2002-03-15 2003-11-27 Ledbetter Jeffrey A. Compositions and methods to regulate an immune response using CD83 gene expressed in tumors and using soluble CD83-Ig fusion protein
US7754209B2 (en) 2003-07-26 2010-07-13 Trubion Pharmaceuticals Binding constructs and methods for use thereof
UA97469C2 (uk) * 2005-07-25 2012-02-27 Емерджент Продакт Дівелопмент Сіетл, Елелсі Гуманізована специфічна до cd37 зв'язувальна молекула імуноглобуліну
NZ573646A (en) * 2006-06-12 2012-04-27 Wyeth Llc Single-chain multivalent binding proteins with effector function
NZ603059A (en) * 2008-04-11 2014-07-25 Emergent Product Dev Seattle Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
KR20110083730A (ko) * 2008-11-13 2011-07-20 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 Ｃｄ37 면역치료제 병용 요법 및 이의 용도
HUE039247T2 (hu) * 2011-10-14 2018-12-28 Univ Illinois Vegyületek és tumorellenes NQO1-szubsztrátok
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
CA2909091C (en) * 2013-04-09 2021-11-02 The Board Of Trustees Of The University Of Illinois Tumor-selective combination therapy
US11352426B2 (en) 2015-09-21 2022-06-07 Aptevo Research And Development Llc CD3 binding polypeptides
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507391A (en) * 1982-04-02 1985-03-26 Sloan-Kettering Institute For Cancer Research Method for detecting the presence of GD3 ganglioside
US4579827A (en) * 1983-03-11 1986-04-01 Sloan-Kettering Institute For Cancer Research Monoclonal antibodies to human gastrointestinal cancers and hybridoma method of production of the monoclonal antibodies
US4569788A (en) * 1983-05-18 1986-02-11 The United States Of America As Represented By The Department Of Health And Human Services Monoclonal antibodies against non small cell lung cancer
JPS6057254A (ja) * 1983-09-09 1985-04-03 Dainabotsuto Kk 免疫学的測定法による糖脂質の定量方法
US4675287A (en) * 1984-07-26 1987-06-23 Scripps Clinic And Research Foundation Monoclonal antibody directed to human ganglioside GD2
IL76877A (en) * 1984-11-02 1991-11-21 Oncogen Diagnostic method for the determination of human non-small cell lung carcinomas employing novel monoclonal antibodies and compositions containing said antibodies
JPS61258173A (ja) * 1985-05-10 1986-11-15 Akira Taniuchi モノクロ−ナル抗体およびその製法ならびに用途
AU601680B2 (en) * 1985-05-28 1990-09-20 Joseph P. Brown Monoclonal antibodies for human non-small cell lung carcinomas

Also Published As

Publication number Publication date
IL77291A (en) 1992-01-15
NZ214542A (en) 1991-07-26
AU601360B2 (en) 1990-09-13
NO863071L (no) 1986-07-29
EP0207963B1 (de) 1992-06-24
FI98736B (fi) 1997-04-30
FI88808B (fi) 1993-03-31
IE58572B1 (en) 1993-10-06
KR870700139A (ko) 1987-03-14
OA08412A (en) 1988-06-30
HUT42637A (en) 1987-07-28
YU199685A (en) 1988-12-31
FI98736C (fi) 1997-08-11
ES557140A0 (es) 1987-08-16
GB2180256B (en) 1989-08-31
FI863375A (fi) 1986-08-20
ES8707797A1 (es) 1987-08-16
ATE77701T1 (de) 1992-07-15
DK393886A (da) 1986-08-19
NO863071D0 (no) 1986-07-29
FI88808C (fi) 1993-07-12
GR853054B (de) 1986-04-15
FI863375A0 (fi) 1986-08-20
NO174718B (no) 1994-03-14
DK393886D0 (da) 1986-08-19
NO174718C (no) 1994-06-22
GB2180256A (en) 1987-03-25
ES550251A0 (es) 1987-11-16
PH25742A (en) 1991-10-18
JPH09191878A (ja) 1997-07-29
AU5312486A (en) 1986-07-22
DE3586262T2 (de) 1992-12-10
PT81744B (pt) 1987-11-30
KR910000956B1 (ko) 1991-02-19
EP0207963A4 (de) 1988-08-29
CA1335796C (en) 1995-06-06
IE853220L (en) 1986-06-21
DK168049B1 (da) 1994-01-24
US4906562A (en) 1990-03-06
WO1986003838A1 (en) 1986-07-03
PT81744A (en) 1986-01-02
ES8800602A1 (es) 1987-11-16
YU45294B (en) 1992-05-28
GB8619900D0 (en) 1986-09-24
EP0207963A1 (de) 1987-01-14

Similar Documents

Publication Publication Date Title
DE3586262D1 (de) Monoklonale antikoerper und antigen fuer menschliche lungenkarzinome vom nichtkleinen zellentyp.
GB2182949A (en) Monoclonal antibodies and antigens for human non-small cell lung carcinomas
FI862242A (fi) Monoklonala antikroppar foer ej-smaocelliga lungkraeftsvulster hos maenniska.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee