ES8800602A1 - Un procedimiento para preparar un anticuerpo monocional. - Google Patents
Un procedimiento para preparar un anticuerpo monocional.Info
- Publication number
- ES8800602A1 ES8800602A1 ES550251A ES550251A ES8800602A1 ES 8800602 A1 ES8800602 A1 ES 8800602A1 ES 550251 A ES550251 A ES 550251A ES 550251 A ES550251 A ES 550251A ES 8800602 A1 ES8800602 A1 ES 8800602A1
- Authority
- ES
- Spain
- Prior art keywords
- sign
- human
- beta
- small cell
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3023—Lung
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/828—Cancer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
METODO DE PREPARACION DE ANTICUERPOS MONOCLONALES. COMPRENDE LA OBTENCION DE HIBRIDOMAS MEDIANTE FUSION DE CELULA REPRODUCTORA DE ANTICUERPOS PROCEDENTE DEL BAZO DE UN ANIMAL INMUNIZADO CON EFUSIONES PLEURALES, CELULAS CULTIVADAS O TEJIDO DE PULMON DE UN PACIENTE QUE TIENE CARCINOMA DE PULMON DE CELULAS NO PEQUEÑAS, CON UN MIELOMA; PROPAGACION DEL HIBRIDOMA IN VIVO; Y RECUPERAR LOS ANTICUERPOS MONOCLONALES PRODUCIDOS POR EL HIBRIDOMA. ESTOS ANTICUERPOS TIENEN APLICACIONES PARA DIAGNOSIS PRECOZ DEL CANCER DE PULMON, LA DEFINICION DE SU GRADO DE EXTENSION Y SU TRATAMIENTO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/684,759 US4935495A (en) | 1984-12-21 | 1984-12-21 | Monoclonal antibodies to the L6 glycolipid antigenic determinant found on human non-small cell lung carcinomas |
US06/776,321 US4906562A (en) | 1984-12-21 | 1985-10-18 | Monocolonal antibodies and antigen for human non-small cell lung carcinomas |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8800602A1 true ES8800602A1 (es) | 1987-11-16 |
ES550251A0 ES550251A0 (es) | 1987-11-16 |
Family
ID=27103432
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES550251A Expired ES8800602A1 (es) | 1984-12-21 | 1985-12-20 | Un procedimiento para preparar un anticuerpo monocional. |
ES557140A Expired ES8707797A1 (es) | 1984-12-21 | 1986-10-16 | Un metodo para determinar la presencia de celulas malignas en una muestra que se sospecha que contiene tales celulas |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES557140A Expired ES8707797A1 (es) | 1984-12-21 | 1986-10-16 | Un metodo para determinar la presencia de celulas malignas en una muestra que se sospecha que contiene tales celulas |
Country Status (23)
Country | Link |
---|---|
US (1) | US4906562A (es) |
EP (1) | EP0207963B1 (es) |
JP (1) | JPH09191878A (es) |
KR (1) | KR910000956B1 (es) |
AT (1) | ATE77701T1 (es) |
AU (1) | AU601360B2 (es) |
CA (1) | CA1335796C (es) |
DE (1) | DE3586262T2 (es) |
DK (1) | DK168049B1 (es) |
ES (2) | ES8800602A1 (es) |
FI (2) | FI98736C (es) |
GB (1) | GB2180256B (es) |
GR (1) | GR853054B (es) |
HU (1) | HUT42637A (es) |
IE (1) | IE58572B1 (es) |
IL (1) | IL77291A (es) |
NO (1) | NO174718C (es) |
NZ (1) | NZ214542A (es) |
OA (1) | OA08412A (es) |
PH (1) | PH25742A (es) |
PT (1) | PT81744B (es) |
WO (1) | WO1986003838A1 (es) |
YU (1) | YU45294B (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4675287A (en) * | 1984-07-26 | 1987-06-23 | Scripps Clinic And Research Foundation | Monoclonal antibody directed to human ganglioside GD2 |
EP0173648A3 (en) * | 1984-08-30 | 1988-04-27 | Ciba-Geigy Ag | New monoclonal antibodies to glycoconjugates, processes for their production, and applications |
IL76877A (en) * | 1984-11-02 | 1991-11-21 | Oncogen | Diagnostic method for the determination of human non-small cell lung carcinomas employing novel monoclonal antibodies and compositions containing said antibodies |
US5614610A (en) * | 1984-12-21 | 1997-03-25 | Oncogen | Tumor immunotherapy using anti-idiotypic antibodies |
AU601680B2 (en) * | 1985-05-28 | 1990-09-20 | Joseph P. Brown | Monoclonal antibodies for human non-small cell lung carcinomas |
EP0234122A3 (en) * | 1986-02-21 | 1989-03-22 | Oncogen Limited Partnership | Tumor therapy with biologically active anti-tumor antibodies |
IL84285A (en) * | 1986-10-27 | 1993-03-15 | Int Genetic Engineering | Chimeric antibody with specificity to human tumor antigen |
NZ225599A (en) | 1987-08-04 | 1991-09-25 | Bristol Myers Co | Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells |
AU632469B2 (en) * | 1988-04-04 | 1993-01-07 | Johns Hopkins University, The | A method for early detection of lung cancer |
US5173292A (en) * | 1988-06-14 | 1992-12-22 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibodies which specifically recognize galactosyl-globoside, compositions containing same and methods of using same |
US5171665A (en) * | 1989-04-17 | 1992-12-15 | Oncogen | Monoclonal antibody to novel antigen associated with human tumors |
US5192551A (en) * | 1989-05-02 | 1993-03-09 | Johns Hopkins University | Neutral glycolipid as an adsorbent for enteric viral pathogens |
CA2015862A1 (en) * | 1989-05-04 | 1990-11-04 | Gajanan Nilaver | Cell surface antigen that binds with l6 monoclonal antibody |
CA2040513A1 (en) * | 1990-04-16 | 1991-10-17 | Robert C. Bast, Jr. | Method of diagnosing cancer |
US5165922A (en) * | 1990-05-22 | 1992-11-24 | Bristol-Myers Squibb Company | Synergistic tumor therapy with combinations of biologically active anti-tumor antibodies and chemotherapy |
US5597707A (en) * | 1993-04-15 | 1997-01-28 | Bristol-Myers Squibb Company | Tumor associated antigen recognized by the murine monoclonal antibody L6, its oligonucleotide sequence and methods for their use |
US7745159B2 (en) * | 1999-02-26 | 2010-06-29 | Nathalie B Scholler | Methods and compositions for diagnosing carcinomas |
US6117981A (en) * | 1999-06-03 | 2000-09-12 | Cytoclonal Pharmaceutics, Inc. | Hybridomas for lung cancer marker and monoclonal antibodies thereof |
US7491801B2 (en) * | 2000-09-01 | 2009-02-17 | International Bioimmune Systems, Inc. | Identification and development of specific monoclonal antibodies to squamous cell carcinoma |
US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
US7754208B2 (en) * | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US20030133939A1 (en) * | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US20040058445A1 (en) * | 2001-04-26 | 2004-03-25 | Ledbetter Jeffrey Alan | Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB |
US20030219436A1 (en) * | 2002-03-15 | 2003-11-27 | Ledbetter Jeffrey A. | Compositions and methods to regulate an immune response using CD83 gene expressed in tumors and using soluble CD83-Ig fusion protein |
US7754209B2 (en) | 2003-07-26 | 2010-07-13 | Trubion Pharmaceuticals | Binding constructs and methods for use thereof |
PT2298815E (pt) * | 2005-07-25 | 2015-07-16 | Emergent Product Dev Seattle | Moléculas de ligaçao especificas para cd37 e especificas para cd20 |
MX2008015524A (es) * | 2006-06-12 | 2009-01-13 | Trubion Pharmaceuticals Inc | Proteinas de union multivalentes monocatenarias con funcion efectora. |
WO2009126944A1 (en) | 2008-04-11 | 2009-10-15 | Trubion Pharmaceuticals, Inc. | Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof |
JP2012508774A (ja) * | 2008-11-13 | 2012-04-12 | エマージェント プロダクト デベロップメント シアトル, エルエルシー | Cd37免疫治療薬併用療法およびその使用 |
PT2768308T (pt) | 2011-10-14 | 2018-07-24 | Univ Texas | Compostos e substratos anti-tumorais nqo1 |
US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
AU2014251043B2 (en) * | 2013-04-09 | 2020-01-16 | The Board Of Regents Of The University Of Texas System | Tumor-selective combination therapy |
MY197562A (en) | 2015-09-21 | 2023-06-23 | Aptevo Res & Development Llc | Cd3 binding polypeptides |
US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
WO2020247054A1 (en) | 2019-06-05 | 2020-12-10 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4507391A (en) * | 1982-04-02 | 1985-03-26 | Sloan-Kettering Institute For Cancer Research | Method for detecting the presence of GD3 ganglioside |
US4579827A (en) * | 1983-03-11 | 1986-04-01 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibodies to human gastrointestinal cancers and hybridoma method of production of the monoclonal antibodies |
US4569788A (en) * | 1983-05-18 | 1986-02-11 | The United States Of America As Represented By The Department Of Health And Human Services | Monoclonal antibodies against non small cell lung cancer |
JPS6057254A (ja) * | 1983-09-09 | 1985-04-03 | Dainabotsuto Kk | 免疫学的測定法による糖脂質の定量方法 |
US4675287A (en) * | 1984-07-26 | 1987-06-23 | Scripps Clinic And Research Foundation | Monoclonal antibody directed to human ganglioside GD2 |
IL76877A (en) * | 1984-11-02 | 1991-11-21 | Oncogen | Diagnostic method for the determination of human non-small cell lung carcinomas employing novel monoclonal antibodies and compositions containing said antibodies |
JPS61258173A (ja) * | 1985-05-10 | 1986-11-15 | Akira Taniuchi | モノクロ−ナル抗体およびその製法ならびに用途 |
AU601680B2 (en) * | 1985-05-28 | 1990-09-20 | Joseph P. Brown | Monoclonal antibodies for human non-small cell lung carcinomas |
-
1985
- 1985-10-18 US US06/776,321 patent/US4906562A/en not_active Expired - Lifetime
- 1985-12-10 CA CA000497251A patent/CA1335796C/en not_active Expired - Lifetime
- 1985-12-11 IL IL77291A patent/IL77291A/xx not_active IP Right Cessation
- 1985-12-13 NZ NZ214542A patent/NZ214542A/en unknown
- 1985-12-13 AU AU53124/86A patent/AU601360B2/en not_active Ceased
- 1985-12-13 WO PCT/US1985/002441 patent/WO1986003838A1/en active IP Right Grant
- 1985-12-13 EP EP86900473A patent/EP0207963B1/en not_active Expired - Lifetime
- 1985-12-13 DE DE8686900473T patent/DE3586262T2/de not_active Expired - Lifetime
- 1985-12-13 GB GB8619900A patent/GB2180256B/en not_active Expired
- 1985-12-13 AT AT86900473T patent/ATE77701T1/de not_active IP Right Cessation
- 1985-12-13 HU HU86569A patent/HUT42637A/hu unknown
- 1985-12-17 PH PH33200A patent/PH25742A/en unknown
- 1985-12-18 GR GR853054A patent/GR853054B/el unknown
- 1985-12-18 IE IE322085A patent/IE58572B1/en not_active IP Right Cessation
- 1985-12-19 YU YU1996/85A patent/YU45294B/xx unknown
- 1985-12-20 ES ES550251A patent/ES8800602A1/es not_active Expired
- 1985-12-20 PT PT81744A patent/PT81744B/pt not_active IP Right Cessation
- 1985-12-31 KR KR1019860700504A patent/KR910000956B1/ko not_active IP Right Cessation
-
1986
- 1986-07-29 NO NO863071A patent/NO174718C/no unknown
- 1986-08-19 DK DK393886A patent/DK168049B1/da not_active IP Right Cessation
- 1986-08-20 FI FI863375A patent/FI98736C/fi not_active IP Right Cessation
- 1986-08-20 FI FI863375D patent/FI88808C/fi not_active IP Right Cessation
- 1986-09-18 OA OA58956A patent/OA08412A/xx unknown
- 1986-10-16 ES ES557140A patent/ES8707797A1/es not_active Expired
-
1995
- 1995-10-27 JP JP7280811A patent/JPH09191878A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8707797A1 (es) | Un metodo para determinar la presencia de celulas malignas en una muestra que se sospecha que contiene tales celulas | |
GB2182949A (en) | Monoclonal antibodies and antigens for human non-small cell lung carcinomas | |
GB2176890B (en) | Monoclonal antibodies for human non-small cell lung carcinomas |