HUE039247T2 - Vegyületek és tumorellenes NQO1-szubsztrátok - Google Patents
Vegyületek és tumorellenes NQO1-szubsztrátokInfo
- Publication number
- HUE039247T2 HUE039247T2 HUE12840771A HUE12840771A HUE039247T2 HU E039247 T2 HUE039247 T2 HU E039247T2 HU E12840771 A HUE12840771 A HU E12840771A HU E12840771 A HUE12840771 A HU E12840771A HU E039247 T2 HUE039247 T2 HU E039247T2
- Authority
- HU
- Hungary
- Prior art keywords
- tumor
- compounds
- nqo1
- substrates
- nqo1 substrates
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 101150075804 nqo1 gene Proteins 0.000 title 1
- 239000000758 substrate Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161547166P | 2011-10-14 | 2011-10-14 | |
| US201261662163P | 2012-06-20 | 2012-06-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE039247T2 true HUE039247T2 (hu) | 2018-12-28 |
Family
ID=48082500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE12840771A HUE039247T2 (hu) | 2011-10-14 | 2012-10-12 | Vegyületek és tumorellenes NQO1-szubsztrátok |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US9233960B2 (hu) |
| EP (1) | EP2768308B8 (hu) |
| CA (1) | CA2887648C (hu) |
| DK (1) | DK2768308T3 (hu) |
| ES (1) | ES2678649T3 (hu) |
| HU (1) | HUE039247T2 (hu) |
| PL (1) | PL2768308T3 (hu) |
| PT (1) | PT2768308T (hu) |
| TR (1) | TR201810152T4 (hu) |
| WO (1) | WO2013056073A1 (hu) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014251043B2 (en) | 2013-04-09 | 2020-01-16 | The Board Of Regents Of The University Of Texas System | Tumor-selective combination therapy |
| US9920069B2 (en) | 2014-03-17 | 2018-03-20 | The Board Of Trustees Of The University Of Illinois | Compounds for treatment of fluoroquinolone-resistant bacteria |
| WO2017108339A1 (en) | 2015-12-21 | 2017-06-29 | Dsm Ip Assets B.V. | Intermolecular reaction of propargyl ethers with dimethylfuran in the presence of gold(i) complexes |
| WO2017156519A1 (en) | 2016-03-11 | 2017-09-14 | The Board Of Trustees Of The University Of Illinois | Small-molecules active against gram-negative bacteria |
| CN109689060A (zh) * | 2016-06-27 | 2019-04-26 | 系统肿瘤学有限公司 | 组合化学治疗 |
| US11274106B2 (en) | 2017-06-23 | 2022-03-15 | The Board Of Trustees Of The University Of Illinois | Topoisomerase inhibitors with antibacterial and anticancer activity |
| WO2019113345A1 (en) * | 2017-12-06 | 2019-06-13 | Spyro Mousses | Combination of cancer therapeutics for treatment of cancer and hyperproliferative diseases |
| JP7406300B2 (ja) * | 2018-11-12 | 2023-12-27 | 信越化学工業株式会社 | ヨウ素含有ケイ素化合物の製造方法 |
| CN109485646A (zh) * | 2018-12-12 | 2019-03-19 | 中国药科大学 | 一种苯并噻唑醌类化合物及其制备方法和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4906562A (en) * | 1984-12-21 | 1990-03-06 | Oncogen | Monocolonal antibodies and antigen for human non-small cell lung carcinomas |
| ES2088822B1 (es) | 1994-02-24 | 1997-08-01 | Univ Madrid Complutense | Nuevos derivados antraquinonicos con actividad antitumoral y sus aplicaciones. |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6924312B2 (en) | 2001-07-10 | 2005-08-02 | Synta Pharmaceuticals Corp. | Taxol enhancer compounds |
| PT2619331T (pt) * | 2010-09-22 | 2018-06-01 | Univ Texas | Métodos de tratamento de cancro incluindo rastreio de nqo1 |
| GB201021494D0 (en) * | 2010-12-20 | 2011-02-02 | Univ Cardiff | Compounds |
-
2012
- 2012-10-12 PT PT128407715T patent/PT2768308T/pt unknown
- 2012-10-12 US US14/351,861 patent/US9233960B2/en active Active
- 2012-10-12 DK DK12840771.5T patent/DK2768308T3/en active
- 2012-10-12 HU HUE12840771A patent/HUE039247T2/hu unknown
- 2012-10-12 CA CA2887648A patent/CA2887648C/en active Active
- 2012-10-12 ES ES12840771.5T patent/ES2678649T3/es active Active
- 2012-10-12 WO PCT/US2012/059988 patent/WO2013056073A1/en active Application Filing
- 2012-10-12 PL PL12840771T patent/PL2768308T3/pl unknown
- 2012-10-12 EP EP12840771.5A patent/EP2768308B8/en active Active
- 2012-10-12 TR TR2018/10152T patent/TR201810152T4/tr unknown
-
2016
- 2016-01-11 US US14/993,029 patent/US9611266B2/en active Active
-
2017
- 2017-03-09 US US15/454,377 patent/US9925180B2/en active Active
-
2018
- 2018-03-23 US US15/933,671 patent/US10285986B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20160122348A1 (en) | 2016-05-05 |
| WO2013056073A1 (en) | 2013-04-18 |
| US9233960B2 (en) | 2016-01-12 |
| CA2887648A1 (en) | 2013-04-18 |
| EP2768308A4 (en) | 2015-06-17 |
| DK2768308T3 (en) | 2018-07-23 |
| TR201810152T4 (tr) | 2018-08-27 |
| US10285986B2 (en) | 2019-05-14 |
| EP2768308B8 (en) | 2018-08-01 |
| US20180207150A1 (en) | 2018-07-26 |
| ES2678649T3 (es) | 2018-08-14 |
| PT2768308T (pt) | 2018-07-24 |
| EP2768308B1 (en) | 2018-04-18 |
| EP2768308A1 (en) | 2014-08-27 |
| CA2887648C (en) | 2020-01-21 |
| US9925180B2 (en) | 2018-03-27 |
| US20150011509A1 (en) | 2015-01-08 |
| PL2768308T3 (pl) | 2018-12-31 |
| US9611266B2 (en) | 2017-04-04 |
| US20170182030A1 (en) | 2017-06-29 |
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