DE3586075D1 - Verfahren zur bestimmung von endotoxin. - Google Patents

Verfahren zur bestimmung von endotoxin.

Info

Publication number
DE3586075D1
DE3586075D1 DE8585107877T DE3586075T DE3586075D1 DE 3586075 D1 DE3586075 D1 DE 3586075D1 DE 8585107877 T DE8585107877 T DE 8585107877T DE 3586075 T DE3586075 T DE 3586075T DE 3586075 D1 DE3586075 D1 DE 3586075D1
Authority
DE
Germany
Prior art keywords
time
gelation
light amount
transmitted light
gelation point
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585107877T
Other languages
English (en)
Inventor
Yoshitsugu Sakata
Haruki Oishi
Yasumichi Hatayama
Hirome Shiraishi
Kazuya Yanagisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Wako Pure Chemical Corp
Original Assignee
Wako Pure Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP13244584A external-priority patent/JPS6111641A/ja
Priority claimed from JP28161684A external-priority patent/JPS61159162A/ja
Application filed by Wako Pure Chemical Industries Ltd filed Critical Wako Pure Chemical Industries Ltd
Application granted granted Critical
Publication of DE3586075D1 publication Critical patent/DE3586075D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
    • G01N21/83—Turbidimetric titration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/04—Batch operation; multisample devices
    • G01N2201/0407—Batch operation; multisample devices with multiple optical units, e.g. one per sample
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE8585107877T 1984-06-27 1985-06-25 Verfahren zur bestimmung von endotoxin. Expired - Lifetime DE3586075D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP13244584A JPS6111641A (ja) 1984-06-27 1984-06-27 エンドトキシンの測定方法および装置
JP28161684A JPS61159162A (ja) 1984-12-28 1984-12-28 エンドトキシンの測定方法

Publications (1)

Publication Number Publication Date
DE3586075D1 true DE3586075D1 (de) 1992-06-25

Family

ID=26467021

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8585107877T Expired - Lifetime DE3586075D1 (de) 1984-06-27 1985-06-25 Verfahren zur bestimmung von endotoxin.
DE89114580T Expired - Fee Related DE3587510T2 (de) 1984-06-27 1985-06-25 Gerät zur Messung von Endotoxin.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE89114580T Expired - Fee Related DE3587510T2 (de) 1984-06-27 1985-06-25 Gerät zur Messung von Endotoxin.

Country Status (4)

Country Link
US (1) US4740460A (de)
EP (2) EP0347951B1 (de)
AT (2) ATE92630T1 (de)
DE (2) DE3586075D1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4936682A (en) * 1987-08-11 1990-06-26 Associates Of Cape Cod, Inc. Instrument for independently and kinetically measuring light transpassion through a plurality of samples
JPH0715474B2 (ja) * 1988-02-27 1995-02-22 和光純薬工業株式会社 エンドトキシンの測定法
EP0350273B1 (de) * 1988-07-05 1994-07-13 Wako Pure Chemical Industries Ltd Verfahren zur Bestimmung von Endotoxinen
US5342785A (en) * 1988-07-05 1994-08-30 Tanabe Seiyaku Co., Ltd. Method for determining pyrogen content
US5306641A (en) * 1990-07-27 1994-04-26 Saccocio Edward J Apparatus and method for determining gel rate of polymerizable compositions
US5167145B1 (en) * 1990-09-19 2000-05-23 David M Butler Measurement of blood coagulation time using infrared electromagnetic energy
US5522255A (en) * 1993-08-31 1996-06-04 Boehringer Mannheim Corporation Fluid dose, flow and coagulation sensor for medical instrument
US5526111A (en) * 1993-08-31 1996-06-11 Boehringer Mannheim Corporation Method and apparatus for calculating a coagulation characteristic of a sample of blood a blood fraction or a control
EP0731354A4 (de) * 1993-11-22 1997-12-17 Seikagaku Kogyo Co Ltd Verfahren zur bestimmung einer mit limulus-reagenz reagierenden substanz
US5637474A (en) * 1994-10-31 1997-06-10 Wako Pure Chemical Industries, Ltd. Process for measuring amount of endotoxin or (1→3)-β-D-glucan by kinetic turbidimetric method
US6118541A (en) * 1998-04-13 2000-09-12 Dade Behring Inc. Method to determine the effectiveness of a chemical mixing system
CN1296714C (zh) * 2003-04-09 2007-01-24 中国科学院大连化学物理研究所 测定鲎试剂灵敏度的方法
AU2004290384A1 (en) * 2003-11-07 2005-05-26 Cambrex Bio Science Walkersville, Inc. On-line apparatus and method for determining endotoxin levels
CN100383528C (zh) * 2004-07-02 2008-04-23 中国科学院大连化学物理研究所 一种通过测定浊度值来进行细菌内毒素检查的方法
JP5208107B2 (ja) * 2007-04-20 2013-06-12 和光純薬工業株式会社 微量検体測定用硝子セルバイアル
US20100129260A1 (en) * 2007-05-01 2010-05-27 Yoshiaki Shirasawa Gelation measuring apparatus and sample cell
JP5188311B2 (ja) * 2008-07-30 2013-04-24 興和株式会社 生物由来の生理活性物質の測定方法及び測定装置
US8507282B2 (en) * 2009-03-13 2013-08-13 Kowa Company, Ltd. Method for measuring physiologically active substance of biological origin, program for implementing the same, and apparatus for measuring physiologically active substance of biological origin
CA2843219C (en) * 2011-09-01 2018-02-20 Fresenius Medical Care Holdings, Inc. Kit for sampling and detection of endotoxin in aqueous solution
CN104215745A (zh) * 2014-09-21 2014-12-17 四川制药制剂有限公司 注射用盐酸头孢替安中细菌内毒素含量的测定方法
US11892397B2 (en) * 2017-10-17 2024-02-06 Board Of Regents, The University Of Texas System Endotoxin testing assay and method of same

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3458287A (en) * 1965-04-29 1969-07-29 Medical Laboratory Automation Method and means of determining endpoint times in blood clotting tests
US4038029A (en) * 1976-01-20 1977-07-26 Worthington Biochemical Corporation Limulus lysate turbidity test for pyrogens
FR2344841A1 (fr) * 1976-03-16 1977-10-14 Ucc Union Chimique Cont Correcteur electronique du temps de coagulation du sang
US4268171A (en) * 1977-07-18 1981-05-19 Beckman Instruments, Inc. Method determining concentration in rate nephelometric immunochemical analysis
JPS54108693A (en) * 1978-02-14 1979-08-25 Mitsubishi Chem Ind Method and device for optically measuring antigennantibody reaction
US4205954A (en) * 1978-05-26 1980-06-03 Warner-Lambert Company Kinetic latex agglutinometry
IT1105662B (it) * 1978-09-07 1985-11-04 Salus Istituto Diagnostico Di Apparecchiatura per studiare e fenomeni della emocoagulazione e dell'aggregazione delle piastrine
DE3005923A1 (de) * 1980-02-16 1981-09-03 Compur-Electronic GmbH, 8000 München Photometrisches verfahren und photometrische vorrichtung zur bestimmung von reaktionsablaeufen
IT1208062B (it) * 1981-03-23 1989-06-06 Croce F Dr Salus Ricerca Dei fenomeni di emocoagulazione, dispositivo di rivelazione ottica concentrazione, ed aggregazione delle piastrine o simili.
JPS589050A (ja) * 1981-07-10 1983-01-19 Japan Organo Co Ltd エンドトキシン含有量の測定方法および装置
EP0083617A1 (de) * 1981-07-11 1983-07-20 JOCHIMSEN, Siegfried Blutgerinnungszeitmessgerät und verfahren zum erfassen und messen der blutgerinnungszeit
JPS58135459A (ja) * 1982-02-05 1983-08-12 Dai Ichi Seiyaku Co Ltd エンドトキシンの定量法
US4454752A (en) * 1982-06-21 1984-06-19 Medical Laboratory Automation, Inc. Test circuit for use in coagulation instrument
JPS5942451A (ja) * 1982-09-01 1984-03-09 Japan Organo Co Ltd エンドトキシンの定量分析法

Also Published As

Publication number Publication date
ATE92630T1 (de) 1993-08-15
EP0347951B1 (de) 1993-08-04
DE3587510T2 (de) 1994-03-03
EP0173021A2 (de) 1986-03-05
EP0347951A3 (en) 1990-06-06
US4740460A (en) 1988-04-26
EP0173021B1 (de) 1992-05-20
EP0347951A2 (de) 1989-12-27
EP0173021A3 (en) 1986-10-08
DE3587510D1 (de) 1993-09-09
ATE76507T1 (de) 1992-06-15

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