DE3585100D1 - N-aryl-n-(4-piperidinyl)amide und pharmazeutische zusammensetzungen und verfahren unter verwendung dieser verbindungen. - Google Patents

N-aryl-n-(4-piperidinyl)amide und pharmazeutische zusammensetzungen und verfahren unter verwendung dieser verbindungen.

Info

Publication number
DE3585100D1
DE3585100D1 DE8585302401T DE3585100T DE3585100D1 DE 3585100 D1 DE3585100 D1 DE 3585100D1 DE 8585302401 T DE8585302401 T DE 8585302401T DE 3585100 T DE3585100 T DE 3585100T DE 3585100 D1 DE3585100 D1 DE 3585100D1
Authority
DE
Germany
Prior art keywords
piperidinyl
amides
aryl
compounds
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585302401T
Other languages
German (de)
English (en)
Inventor
Bao-Shan Huang
Kirsten Hansen Deutsche
Nhora Lucia Lalinde
Ross Clark Terrell
Linas Vladas Kudzma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anaquest Inc
Original Assignee
Anaquest Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anaquest Inc filed Critical Anaquest Inc
Application granted granted Critical
Publication of DE3585100D1 publication Critical patent/DE3585100D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE8585302401T 1984-04-09 1985-04-04 N-aryl-n-(4-piperidinyl)amide und pharmazeutische zusammensetzungen und verfahren unter verwendung dieser verbindungen. Expired - Lifetime DE3585100D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59876984A 1984-04-09 1984-04-09
US06/707,433 US4584303A (en) 1984-04-09 1985-03-01 N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds

Publications (1)

Publication Number Publication Date
DE3585100D1 true DE3585100D1 (de) 1992-02-20

Family

ID=27083145

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585302401T Expired - Lifetime DE3585100D1 (de) 1984-04-09 1985-04-04 N-aryl-n-(4-piperidinyl)amide und pharmazeutische zusammensetzungen und verfahren unter verwendung dieser verbindungen.

Country Status (12)

Country Link
US (1) US4584303A (US08177716-20120515-C00003.png)
EP (1) EP0160422B1 (US08177716-20120515-C00003.png)
AU (1) AU575924B2 (US08177716-20120515-C00003.png)
CA (1) CA1281719C (US08177716-20120515-C00003.png)
DE (1) DE3585100D1 (US08177716-20120515-C00003.png)
DK (1) DK154085A (US08177716-20120515-C00003.png)
ES (2) ES8609251A1 (US08177716-20120515-C00003.png)
FI (1) FI851337L (US08177716-20120515-C00003.png)
GR (1) GR850848B (US08177716-20120515-C00003.png)
IL (1) IL74726A (US08177716-20120515-C00003.png)
NO (1) NO851393L (US08177716-20120515-C00003.png)
NZ (1) NZ211599A (US08177716-20120515-C00003.png)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2608602A1 (fr) * 1986-12-23 1988-06-24 Cerm Cent Europ Rech Mauvernay Nouvelles 3-piperidineamines ou 3-azepineamines substituees, leur preparation et leurs applications en therapeutique
US4916142A (en) * 1987-02-02 1990-04-10 Boc, Inc. N-heterocyclic-N-(4-piperidinyl)amides and pharmaceutical compositions and their use as analgesics
US4912109A (en) * 1987-02-02 1990-03-27 Boc, Inc. N-heterocyclic-N-(4-piperidinyl) amides and pharmaceutical compositions and methods employing such compounds
US4791112A (en) * 1987-02-02 1988-12-13 The Boc Group, Inc. N-heterocyclic-N-(4-piperidyl)amides and pharmaceutical compositions and methods employing such compounds
US4954506A (en) * 1987-02-02 1990-09-04 Boc, Inc. N-heterocyclic-N-(4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds
GB8708833D0 (en) * 1987-04-13 1987-05-20 Lilly S A E Organic compounds
US4921864A (en) * 1987-11-02 1990-05-01 Boc, Inc. 4-Phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
US4791121A (en) * 1987-11-02 1988-12-13 The Boc Group, Inc. 4-phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
USRE33495E (en) * 1987-11-02 1990-12-18 Boc, Inc. Stereoselective preparation of 3-substituted-4-anilino-piperidine compounds and derivatives
US5013742A (en) * 1987-11-02 1991-05-07 Boc, Inc. 4-phenyl-4-N-(phenyl) amido piperidine derivatives and pharmaceutical compositions and method employing such compounds
US4849521A (en) * 1987-11-02 1989-07-18 Boc, Inc. Stereoselective preparation of 3-substituted-4-piperidine compounds and derivatives
US4831192A (en) * 1987-12-31 1989-05-16 Boc, Inc. Methods of preparing 4-heteropentacyclic-4-(N-phenyl)amido) piperidine derivatives and intermediate compounds
US4791120A (en) * 1987-12-31 1988-12-13 The Boc Group, Inc. 4-heteropentacyclic-4-[N-(phenyl)amino] piperidine derivatives and pharmaceutical compositions and method employing such compounds
ES2054836T3 (es) * 1987-12-31 1994-08-16 Ohmeda Pharma Prod Compuestos de 4-heteropentaciclico-4-(fenil)amido-piperidina.
US4801615A (en) * 1987-12-31 1989-01-31 The Boc Group, Inc. 4-heterohexacyclic-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
US5019583A (en) * 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
US5053411A (en) * 1989-04-20 1991-10-01 Anaquest, Inc. N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
USRE34201E (en) * 1989-04-20 1993-03-23 Anaquest, Inc. N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
US5145967A (en) * 1989-04-20 1992-09-08 Anaquest, Inc. Method for preparing 4-alkoxyalkyl-4-phenylaminopiperdines and derivatives thereof
KR900016129A (ko) * 1989-04-20 1990-11-12 테리 아아르 커세트 4-알콕시알킬-4-아미노페닐피페리딘 및 그들의 유도체의 제조 방법
US5100903A (en) * 1989-05-12 1992-03-31 Anaquest, Inc. N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds
US4939161A (en) * 1989-05-12 1990-07-03 Boc, Inc. Analgesic N-aryl-N-[1-substituted-3,5-dimethyl-4-piperidinyl]amides
US4994471A (en) * 1989-05-12 1991-02-19 Boc, Inc. N-aryl-N-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds
IE903196A1 (en) * 1989-09-05 1991-03-13 Searle & Co Substituted n-benzylpiperidine amides
FR2662162B1 (fr) * 1990-05-18 1995-01-20 Adir Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5114715A (en) * 1990-11-29 1992-05-19 Sepracor Inc. Methods of use and compositions of (s)-isoflurane and (s)-desflurane
US5114714A (en) * 1990-11-29 1992-05-19 Sepracor, Inc. Methods of use and compositions of (r)-isoflurane and (r)-desflurane
US5130321A (en) * 1990-12-18 1992-07-14 Glaxo Inc. Analgesic n-phenyl-n-(3-or 1-3-me-4-piperidinyl)amides
US5214148A (en) * 1990-12-18 1993-05-25 Glaxo Inc. Analgesic N-phenyl-N-(3-OR1 -3-ME-4-piperidinyl)amides
AU666040B2 (en) * 1992-10-28 1996-01-25 Bayer Aktiengesellschaft Substituted 1-H-3-aryl-pyrrolidine-2,4-dione derivatives
FR2705674B1 (fr) * 1993-05-26 1996-01-05 Smithkline Beecham Labo Pharma Nouveaux composés et leur procédé de préparation et leur utilisation en tant que médicaments.
JPH09501404A (ja) * 1993-05-26 1997-02-10 スミスクライン・ビーチャム・ラボラトワール・ファルマソーティク 新規化合物
GB9316863D0 (en) * 1993-08-13 1993-09-29 Glaxo Group Ltd Chemical process
KR19990037220A (ko) * 1997-10-31 1999-05-25 타이도 나오카타 아릴아세트산 아미드 유도체 또는 그 염 및 이를 함유하는 의약
US6635661B2 (en) 2000-05-25 2003-10-21 Sepracor Inc. Heterocyclic analgesic compounds and methods of use thereof
US7361666B2 (en) * 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6677332B1 (en) * 1999-05-25 2004-01-13 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6376514B1 (en) * 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) * 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
CA2468529C (en) 2001-10-09 2011-03-01 Kyorin Pharmaceutical Co., Ltd. 4-(2-furoyl) aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same
CA2556589A1 (en) * 2004-02-24 2005-09-01 Bioaxone Therapeutique Inc. 4-substituted piperidine derivatives
WO2006055321A2 (en) * 2004-11-10 2006-05-26 Boehringer Ingelheim Chemicals, Inc. Process of making fentanyl intermediates
WO2008096189A2 (en) 2005-09-23 2008-08-14 M's Science Corporation Piperidine and piperazine derivatives
CN101312949A (zh) * 2005-11-17 2008-11-26 马林克罗特公司 合成瑞芬太尼的方法
DE602007010236D1 (de) 2006-01-27 2010-12-16 Ms Science Corp Piperidin- und piperazin-derivate
CA2670704A1 (en) * 2006-11-29 2008-06-05 Mallinckrodt Inc. New process for remifentanil synthesis
US20110009449A1 (en) * 2007-12-19 2011-01-13 Dan Peters N-aryl-n-piperidin-4-yl-propionamide derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
EP2234972A1 (en) * 2007-12-19 2010-10-06 NeuroSearch A/S N-aryl-n-piperidin-4-yl-propionamide derivatives and their use as opioid receptor ligands
WO2012037309A2 (en) * 2010-09-17 2012-03-22 Mallinckrodt Llc Improved process for the preparation of sufentanil base and related compounds
CN102249986B (zh) * 2011-02-28 2016-06-22 华东理工大学 N-苯乙基-4-苯胺基哌啶的制备方法
US20130281702A1 (en) * 2012-04-24 2013-10-24 Jonathan P. Pease Methods For Preparing Fentanyl And Fentanyl Intermediates
SG10201700952XA (en) 2013-03-13 2017-04-27 Harvard College Stapled and stitched polypeptides and uses thereof
US10149856B2 (en) 2015-01-26 2018-12-11 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
US10106525B2 (en) 2015-01-26 2018-10-23 BioAxone BioSciences, Inc. Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
US10857157B2 (en) 2015-01-26 2020-12-08 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
EP3442959A1 (en) * 2016-04-12 2019-02-20 Esteve Pharmaceuticals, S.A. Piperidinylalkylamide derivatives having multimodal activity against pain
WO2017178510A1 (en) * 2016-04-12 2017-10-19 Laboratorios Del Dr. Esteve, S.A. Arylamide derivatives having multimodal activity against pain
US11198680B2 (en) 2016-12-21 2021-12-14 BioAxone BioSciences, Inc. Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
US10537567B2 (en) 2017-07-11 2020-01-21 BioAxone BioSciences, Inc. Kinase inhibitors for treatment of disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE623427A (US08177716-20120515-C00003.png) * 1961-10-10
US3161637A (en) * 1961-10-10 1964-12-15 Res Lab Dr C Janssen N V 1-(gamma-aroyl-propyl)-4-(nu-arylcarbonyl amino) piperidines and related compounds
US3998834A (en) * 1975-03-14 1976-12-21 Janssen Pharmaceutica N.V. N-(4-piperidinyl)-n-phenylamides and -carbamates
US4196210A (en) * 1975-09-23 1980-04-01 Janssen Pharmaceutica N.V. N-Aryl-N-(1-L-4-piperidinyl)-arylacetamides
US4197303A (en) * 1975-09-23 1980-04-08 Janssen Pharmaceutica N.V. N-Aryl-N-(1-L-4-piperidinyl)-arylacetamides
FR2361880A1 (fr) * 1976-04-29 1978-03-17 Science Union & Cie Nouvelles 4-amino piperidines, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant
CA1183847A (en) * 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
KR100372064B1 (ko) * 1998-10-23 2003-02-14 가부시키가이샤 히타치세이사쿠쇼 가스 터빈 발전 설비 및 공기 증습 장치

Also Published As

Publication number Publication date
EP0160422B1 (en) 1992-01-08
EP0160422A1 (en) 1985-11-06
ES8609251A1 (es) 1986-09-01
CA1281719C (en) 1991-03-19
FI851337A0 (fi) 1985-04-03
GR850848B (US08177716-20120515-C00003.png) 1985-07-05
IL74726A (en) 1989-08-15
US4584303A (en) 1986-04-22
ES8705387A1 (es) 1987-05-01
IL74726A0 (en) 1985-06-30
DK154085A (da) 1985-10-10
FI851337L (fi) 1985-10-10
NO851393L (no) 1985-10-10
AU4039385A (en) 1986-01-16
ES552468A0 (es) 1987-05-01
NZ211599A (en) 1988-11-29
DK154085D0 (da) 1985-04-03
AU575924B2 (en) 1988-08-11
ES542023A0 (es) 1986-09-01

Similar Documents

Publication Publication Date Title
DE3585100D1 (de) N-aryl-n-(4-piperidinyl)amide und pharmazeutische zusammensetzungen und verfahren unter verwendung dieser verbindungen.
IT8720375A0 (it) Composizione stabilizzante per polietilene comprendente composti contenenti gruppi piperidinici e composti metallici
DK117689A (da) Fremgangsmaade til at give polyamidmaterialer pletmodstandsdygtighed
SE8801813D0 (sv) Pharmaceutical composition
MX9203099A (es) N-heterociclico-n-(4-piperidia)amidas y composiciones farmaceuticas y metodos que emplean dichos compuestos.
FI882981A (fi) Menetelmä ja laite injektointia varten
KR890701101A (ko) 제약학적 조성물
DE68907057D1 (de) Naehrstoffzusammensetzung und verfahren zu deren herstellung.
DE68926448D1 (de) Bildsensor und verfahren zu dessen herstellung
DE3876832D1 (de) Vorrichtung zum anbringen von lingualen und bukkalen befestigungsstuetzen.
IT1219457B (it) Metodo per iniettare sostanze adesive
MX9203505A (es) N-aril-n-(4-(1-alquilheterociclico)-piperidinil) amidas y composicines farmaceuticas y metodos que emplean dichos compuestos.
GB2236674B (en) Use of gamma amino butyric acid autoreceptor antagonists for the manufacture of medicaments
AU2660488A (en) 4-heteropentacyclic-4-{N-(phenyl)amido}piperidine derivatives and pharmaceutical compositions and method employing such compounds
DK667188A (da) Psykotrope acycliske amidderivater
DE3683249D1 (de) 2-aminosulfonyl-6-nitrobenzoesaeureester oder amide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ATA257989A (de) Befestigungselement und verfahren zu dessen herstellung
DK117789D0 (da) Fremgangsmaade til at give polyamidmaterialer pletmodstandsdygtighed
DK0412542T3 (da) Cycliske neurokinin-antagonister
DE3854938D1 (de) 4-Phenyl-4-(N-(2-fluorophenyl)amido)piperidin-Derivate
DE68905294D1 (de) Antimikrobische zusammensetzung und verfahren zu deren verwendung.
IT8522773A0 (it) Composizione farmaceutica contenente fosfocreatina e metodo per preparla.
ATA146488A (de) 2-methoxymethylpenemverbindungen, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
ATE71369T1 (de) N-aryl-n-(4-piperidinyl)amide und pharmazeutische zusammensetzungen und verfahren unter verwendung dieser verbindungen.
DE68925150D1 (de) Bipolartransistor und Verfahren zu dessen Herstellung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee