DE3575724D1 - Quinolizinon-verbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel. - Google Patents

Quinolizinon-verbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.

Info

Publication number
DE3575724D1
DE3575724D1 DE8585103596T DE3575724T DE3575724D1 DE 3575724 D1 DE3575724 D1 DE 3575724D1 DE 8585103596 T DE8585103596 T DE 8585103596T DE 3575724 T DE3575724 T DE 3575724T DE 3575724 D1 DE3575724 D1 DE 3575724D1
Authority
DE
Germany
Prior art keywords
production
products containing
medicinal products
quinolizinone
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8585103596T
Other languages
German (de)
English (en)
Inventor
Yoshihiko Kitaura
Teruo Oku
Hideo Hirai
Toshiyuki Yamamoto
Masashi Hashimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848408292A external-priority patent/GB8408292D0/en
Priority claimed from GB848429710A external-priority patent/GB8429710D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE3575724D1 publication Critical patent/DE3575724D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE8585103596T 1984-03-30 1985-03-26 Quinolizinon-verbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel. Expired - Fee Related DE3575724D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848408292A GB8408292D0 (en) 1984-03-30 1984-03-30 Quinolizinone compound
GB848429710A GB8429710D0 (en) 1984-11-23 1984-11-23 Pharmaceutical composition

Publications (1)

Publication Number Publication Date
DE3575724D1 true DE3575724D1 (de) 1990-03-08

Family

ID=26287537

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585103596T Expired - Fee Related DE3575724D1 (de) 1984-03-30 1985-03-26 Quinolizinon-verbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.

Country Status (4)

Country Link
US (2) US4650804A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0157346B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (4) JPS63284174A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3575724D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4889848A (en) * 1984-11-06 1989-12-26 Hoffmann-La Roche Inc. Tricyclic pyridine derivatives
CA1317945C (en) * 1985-12-13 1993-05-18 Ulf Fischer Tricyclic pyridazopyridone derivatives
US4877795A (en) * 1987-01-30 1989-10-31 Kissei Pharmaceutical Co., Ltd. 4H-quinolizin-4-one compounds useful for the treatment of allergic bronchial asthma, allergic rhinitis atropic dermatitis and the like
EP0294599A3 (de) * 1987-06-12 1990-05-09 F. Hoffmann-La Roche Ag Tricyclische Pyridonderivate
US4806525A (en) * 1987-06-18 1989-02-21 Mavi S.R.L. Formulation comprising gelatin and glycine for treating the dryness of skin
ZA885263B (en) * 1987-07-28 1989-03-29 Fujisawa Pharmaceutical Co Crystalline monohydrate of sodium n-(1h-tetrazol-5-yl)-1-phenoxy-4h-quinolizin-4-one-3-carboxamide
US4921857A (en) * 1987-09-18 1990-05-01 Merck & Co., Inc. 4-Oxo-4h-quinolizine-3-carboxylic acids and derivatives thereof
US4904657A (en) * 1987-09-24 1990-02-27 Kissei Pharmaceutical Co., Ltd. 4H-quinolizin-4-one compounds exhibiting therapeutic activities
AU616916B2 (en) * 1987-11-20 1991-11-14 Kissei Pharmaceutical Co. Ltd. 4h-quinolizin-4-one compounds exhibiting therapeutic activities
US4940715A (en) * 1988-05-17 1990-07-10 Kissei Pharmaceutical Co., Ltd. 5H-pyrazolo[4,3-A] quinolizin-5-one compounds exhibiting therapeutic activities
IE911472A1 (en) * 1990-05-02 1991-11-06 Abbott Lab Quinolizinone type compounds
US5726182A (en) * 1990-05-02 1998-03-10 Abbott Laboratories Quinolizinone type compounds
US5643920A (en) * 1992-04-27 1997-07-01 Mochida Pharmaceutical Co., Ltd. Tricyclic compound having anti-allergic activities
WO1994013289A1 (fr) * 1992-12-10 1994-06-23 Tsentr Po Khimii Lekarstvennykh Sredstv Compose pharmaceutique a proprietes antiulcereuses
FI960157A7 (fi) * 1993-07-13 1996-01-12 Janssen Pharmaceutica Nv Allergianvastaisia imidatsoatsepiineja
US5869500A (en) * 1996-12-13 1999-02-09 Hoffmann-La Roche Inc. Pyridone compounds useful in treating Alzheimer's disease
HK1040076A1 (zh) 1998-09-21 2002-05-24 希雷生物化学有限公司 作为整联蛋白抑制剂的喹嗪酮
US6706528B2 (en) * 2000-03-24 2004-03-16 The United States Of America As Represented By The Department Of Health And Human Services Fluorescent magnesium indicators
PT2465537T (pt) 2002-10-10 2016-08-03 Ono Pharmaceutical Co Microsferas compreendendo ono-1301
US7745459B2 (en) * 2004-09-21 2010-06-29 Japan Tobacco Inc. Quinolizinone compound and use thereof as HIV integrase inhibitor
WO2006110477A2 (en) * 2005-04-07 2006-10-19 Astrum Therapeutics Pty. Ltd. Compounds to treat amyloidosis and prevent death of beta-cells in type 2 diabetes mellitus
MX2007014114A (es) 2005-05-10 2008-03-14 Intermune Inc Derivados de piridona para modular el sistema de proteina cinasa activada por estres.
KR100785088B1 (ko) 2006-05-23 2007-12-12 한국과학기술연구원 두 개의 엑소 메틸렌을 가지는 고리가 접합된 락탐화합물과이의 제조방법
TW200838534A (en) 2007-02-07 2008-10-01 Astellas Pharma Inc Treatment for irritable bowel syndrome
CA2712946A1 (en) * 2008-02-13 2009-08-20 Merck Sharp & Dohme Corp. Quinolizidinone m1 receptor positive allosteric modulators
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
CA2738812A1 (en) * 2008-10-06 2010-04-15 Merck Sharp & Dohme Corp. Quinolizidinone m1 receptor positive allosteric modulators
US8754220B2 (en) * 2009-11-20 2014-06-17 Merck Sharp & Dohme Corp. Quinolizidinone carboxamide M1 receptor positive allosteric modulators
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CN110452216B (zh) 2014-04-02 2022-08-26 英特穆恩公司 抗纤维化吡啶酮类

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1433151A (en) * 1973-04-05 1976-04-22 Allen & Hanburys Ltd Benzo-ij-quinolizines
IE52670B1 (en) * 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation

Also Published As

Publication number Publication date
JPS63284174A (ja) 1988-11-21
JPH0649701B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1994-06-29
JPH039113B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-02-07
US4650804A (en) 1987-03-17
JPH039088B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-02-07
EP0157346A2 (en) 1985-10-09
EP0157346A3 (en) 1986-02-05
JPH0215029A (ja) 1990-01-18
EP0157346B1 (en) 1990-01-31
US4698349A (en) 1987-10-06
JPH01193268A (ja) 1989-08-03

Similar Documents

Publication Publication Date Title
DE3575724D1 (de) Quinolizinon-verbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
DE3582447D1 (de) Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte.
DE3584281D1 (de) Tripeptidyl-argininaldehyde, verfahren zu ihrer herstellung und diese enthaltende arzneimittel sowie n-(monoalkyl)- und n,n-di-(alkyl)-xxx-l-prolin-dipeptide.
ATE7910T1 (de) Substituierte iminodisaeuren, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
DE3582952D1 (de) Dihydropyridin-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE3576500D1 (de) Carbostyrilverbindungen, diese enthaltende zubereitungen und verfahren zu ihrer herstellung.
PT80476A (de) Neue aminotetralinderivate diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE68908374D1 (de) Propenonoximether, verfahren zu dessen herstellung sowie diese enthaltende arzneinmittel.
DE3485860D1 (de) Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
DE3770982D1 (de) Diphosphonsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel.
ATE32459T1 (de) Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE3577199D1 (de) Semicarbazidderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
DE3579000D1 (de) Imidazolylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
ATE60767T1 (de) Aminoacyllabdane, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel.
DE3576686D1 (de) Chinolinone, verfahren zu ihrer herstellung und die sie enthaltenden pharmazeutischen praeparate.
DE3483308D1 (de) Semicarbazid-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ATE13668T1 (de) Pyrrolidin-derivat, verfahren und zwischenprodukte zu dessen herstellung und dieses enthaltende arzneimittel.
LU78814A1 (de) Arzneimittel zur bekaempfung von ulcera,oximether und verfahren zu ihrer herstellung
LU79168A1 (de) Benzylpyrimidine,verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3484023D1 (de) Azolylmethylcycloalkane, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
EP0069154A4 (en) Novel thiazole compounds, process for their preparation, and medicinal composition containing same.
ATE6250T1 (de) Substituierte phenoxy-aminopropanol-derivate, zwischenprodukte und verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel.
DE3481418D1 (de) Substituierte spiropyridinderivate, diese enthaltende pharmazeutische zubereitungen, verfahren zu ihrer herstellung und zubereitungen.
DE3586817D1 (de) 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
PT74077B (de) N-pyrimidinyl-carbaminsaureester verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee