DE3575145D1 - Antibiotikum-a-40926-komplex und seine reinen faktoren pa, pb, a, b und bo. - Google Patents

Antibiotikum-a-40926-komplex und seine reinen faktoren pa, pb, a, b und bo.

Info

Publication number
DE3575145D1
DE3575145D1 DE8585112406T DE3575145T DE3575145D1 DE 3575145 D1 DE3575145 D1 DE 3575145D1 DE 8585112406 T DE8585112406 T DE 8585112406T DE 3575145 T DE3575145 T DE 3575145T DE 3575145 D1 DE3575145 D1 DE 3575145D1
Authority
DE
Germany
Prior art keywords
antibiotic
factor
substances
complex
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585112406T
Other languages
English (en)
Inventor
Enrico Selva
Luciano Gastaldo
Grazia Beretta
Angelo Borghi
Beth P Goldstein
Vittorio Arioli
Giovanni Cassani
Francesco Parenti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vicuron Pharmaceuticals LLC
Original Assignee
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit SpA filed Critical Lepetit SpA
Application granted granted Critical
Publication of DE3575145D1 publication Critical patent/DE3575145D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/03—Actinomadura

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8585112406T 1984-10-11 1985-10-01 Antibiotikum-a-40926-komplex und seine reinen faktoren pa, pb, a, b und bo. Expired - Lifetime DE3575145D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848425685A GB8425685D0 (en) 1984-10-11 1984-10-11 Antibiotic a 40926 complex

Publications (1)

Publication Number Publication Date
DE3575145D1 true DE3575145D1 (de) 1990-02-08

Family

ID=10568022

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585112406T Expired - Lifetime DE3575145D1 (de) 1984-10-11 1985-10-01 Antibiotikum-a-40926-komplex und seine reinen faktoren pa, pb, a, b und bo.

Country Status (22)

Country Link
US (1) US4935238A (de)
EP (1) EP0177882B1 (de)
JP (2) JPH0637508B2 (de)
KR (1) KR940009280B1 (de)
AT (1) ATE49215T1 (de)
AU (1) AU599308B2 (de)
CA (1) CA1317900C (de)
DE (1) DE3575145D1 (de)
DK (1) DK161092C (de)
ES (1) ES8609352A1 (de)
FI (1) FI81117C (de)
GB (1) GB8425685D0 (de)
GR (1) GR852442B (de)
HU (1) HU194317B (de)
IE (1) IE58708B1 (de)
IL (1) IL76596A (de)
MY (1) MY100880A (de)
NO (1) NO164111C (de)
NZ (1) NZ213775A (de)
PH (1) PH23013A (de)
PT (1) PT81288B (de)
ZA (1) ZA857697B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8531846D0 (en) * 1985-12-30 1986-02-05 Lepetit Spa Antibiotic a 40926 mannosyl aglycon
GB8608798D0 (en) * 1986-04-11 1986-05-14 Lepetit Spa Recovery of glycopeptide antibiotics from aqueous solutions
GB8608809D0 (en) * 1986-04-11 1986-05-14 Lepetit Spa Antibiotic
DK363587A (da) * 1986-07-30 1988-01-31 Smithkline Beckman Corp Antibiotika og fremstilling heraf under anvendelseaf actinomadura parvosata
GB8621912D0 (en) * 1986-09-11 1986-10-15 Lepetit Spa Increasing ratio of components of anti-biotic complex
GR871488B (en) * 1986-10-10 1987-11-12 Lepetit Spa New antibiotics
US5135857A (en) * 1987-07-03 1992-08-04 Gruppo Lepetit S.P.A. Process for the preparation of de-mannosyl teicoplanin derivatives
PH27266A (en) * 1989-03-14 1993-05-04 Fujisawa Pharmaceutical Co WS7622, A,B,C and D substances and pharmaceutical composition containing same
EP0560795B1 (de) * 1990-12-05 1996-02-21 GRUPPO LEPETIT S.p.A. 38-decarboxy-38-hydroxymethylderivate von teicoplaninantibiotika, und verfahren zu deren herstellung
JP3314930B2 (ja) 1991-03-27 2002-08-19 バイオサーチ・イタリア・ソチエタ・ペル・アチオニ 抗生物質ａ４０９２６エステル誘導体
US5606036A (en) * 1991-03-27 1997-02-25 Gruppo Lepetit Spa Antibiotic A 40926 ester derivatives
US5750509A (en) * 1991-07-29 1998-05-12 Gruppo Lepetit S.P.A. Amide derivatives of antibiotic A 40926
ES2224173T3 (es) * 1995-07-05 2005-03-01 Aventis Bulk S.P.A. Purificacion de antibioticos dalbaheptidos por enfoque isoelectrico.
US6218505B1 (en) 1996-04-23 2001-04-17 Biosearch Italia S.P.A. Chemical process for preparing amide derivatives of antibiotic A 40926
EP1413626A1 (de) * 2002-10-23 2004-04-28 Vicuron Pharmaceuticals, Inc. Gene und Proteine für die Biosyntese von dem glycopeptidischen Antibiotikum A40926
US7119061B2 (en) 2002-11-18 2006-10-10 Vicuron Pharmaceuticals, Inc. Dalbavancin compositions for treatment of bacterial infections
US20060074014A1 (en) 2002-11-18 2006-04-06 Vicuron Pharmaceuticals Inc. Dalbavancin compositions for treatment of bacterial infections
US20050130909A1 (en) * 2002-11-18 2005-06-16 Luigi Colombo Dalbavancin compositions for treatment of bacterial infections
CN110183519B (zh) * 2019-05-06 2023-04-11 大邦(湖南)生物制药有限公司 一种达巴万星关键中间体a40926的分离纯化方法
CN110156876A (zh) * 2019-05-25 2019-08-23 聊城大学 一种适合工业化生产的高纯度a40926b0制备方法
MA56197A (fr) * 2019-06-13 2022-04-20 Regeneron Pharma Procédés d'élimination de composants indésirables pendant des processus chromatographiques en plusieurs étapes
CN110940763B (zh) * 2019-12-19 2022-07-26 宜昌东阳光生化制药有限公司 分离纯化达巴万星前体a40926的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4195079A (en) * 1979-01-31 1980-03-25 Pfizer Inc. New polycyclic ether antibiotic
CA1183789A (en) * 1981-08-04 1985-03-12 Kiyoshi Isono Antibiotic 76-11, process for the production thereof, anticoccidiosis agent and domestic animals growth accelerator comprising the same as an effective ingredient
US4578271A (en) * 1982-05-24 1986-03-25 Fujisawa Pharmaceutical Co., Ltd. Biologically active WS 6049 substances, a process for the production thereof and their pharmaceutical compositions
GR78648B (de) * 1982-07-26 1984-09-27 Bristol Myers Co

Also Published As

Publication number Publication date
FI81117C (fi) 1990-09-10
HUT39480A (en) 1986-09-29
AU599308B2 (en) 1990-07-19
PT81288B (pt) 1987-10-20
ES547766A0 (es) 1986-09-01
JPH0637508B2 (ja) 1994-05-18
PH23013A (en) 1989-03-03
EP0177882A3 (en) 1987-05-27
DK457385A (da) 1986-04-12
NO164111B (no) 1990-05-21
NZ213775A (en) 1989-03-29
IE58708B1 (en) 1993-11-03
JPH06225757A (ja) 1994-08-16
FI853914A0 (fi) 1985-10-08
EP0177882B1 (de) 1990-01-03
IL76596A0 (en) 1986-02-28
KR860003342A (ko) 1986-05-23
KR940009280B1 (ko) 1994-10-06
ATE49215T1 (de) 1990-01-15
MY100880A (en) 1991-05-16
NO164111C (no) 1990-08-29
DK457385D0 (da) 1985-10-08
US4935238A (en) 1990-06-19
EP0177882A2 (de) 1986-04-16
DK161092B (da) 1991-05-27
JPS61148188A (ja) 1986-07-05
FI81117B (fi) 1990-05-31
GB8425685D0 (en) 1984-11-14
FI853914L (fi) 1986-04-12
DK161092C (da) 1991-11-18
ES8609352A1 (es) 1986-09-01
HU194317B (en) 1988-01-28
NO854018L (no) 1986-04-14
CA1317900C (en) 1993-05-18
ZA857697B (en) 1986-07-30
IE852489L (en) 1986-04-11
JP2572937B2 (ja) 1997-01-16
PT81288A (en) 1985-11-01
IL76596A (en) 1992-05-25
GR852442B (de) 1986-02-03
AU4819585A (en) 1986-04-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BIOSEARCH ITALIA S.P.A., GERENZANO, IT

8327 Change in the person/name/address of the patent owner

Owner name: VICURON PHARMACEUTTICALS INC.(N.D.GES.STAATES DELA

8328 Change in the person/name/address of the agent

Representative=s name: VOSSIUS & PARTNER, 81675 MUENCHEN