DE3543123C2 - - Google Patents
Info
- Publication number
- DE3543123C2 DE3543123C2 DE3543123A DE3543123A DE3543123C2 DE 3543123 C2 DE3543123 C2 DE 3543123C2 DE 3543123 A DE3543123 A DE 3543123A DE 3543123 A DE3543123 A DE 3543123A DE 3543123 C2 DE3543123 C2 DE 3543123C2
- Authority
- DE
- Germany
- Prior art keywords
- pulse
- time
- spin
- time reversal
- phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 claims description 41
- 238000011161 development Methods 0.000 claims description 32
- 238000010168 coupling process Methods 0.000 claims description 28
- 238000005859 coupling reaction Methods 0.000 claims description 28
- 230000008878 coupling Effects 0.000 claims description 26
- 238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 claims description 17
- 230000005284 excitation Effects 0.000 claims description 14
- 230000010355 oscillation Effects 0.000 claims description 11
- 230000010363 phase shift Effects 0.000 claims description 10
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 claims description 8
- 230000003993 interaction Effects 0.000 claims description 4
- 238000011835 investigation Methods 0.000 claims description 4
- 230000008859 change Effects 0.000 claims description 3
- 238000012585 nuclear overhauser effect spectroscopy experiment Methods 0.000 claims description 3
- 230000002123 temporal effect Effects 0.000 claims description 3
- 230000018109 developmental process Effects 0.000 description 29
- 238000001228 spectrum Methods 0.000 description 11
- 125000004429 atom Chemical group 0.000 description 8
- 238000004611 spectroscopical analysis Methods 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- 238000000819 phase cycle Methods 0.000 description 6
- 238000005481 NMR spectroscopy Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 230000005540 biological transmission Effects 0.000 description 3
- 230000008030 elimination Effects 0.000 description 3
- 238000003379 elimination reaction Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000011158 quantitative evaluation Methods 0.000 description 3
- 101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 description 2
- 102100024028 Progonadoliberin-1 Human genes 0.000 description 2
- 101000996723 Sus scrofa Gonadotropin-releasing hormone receptor Proteins 0.000 description 2
- 238000002247 constant time method Methods 0.000 description 2
- 239000007819 coupling partner Substances 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 238000012573 2D experiment Methods 0.000 description 1
- 101100207331 Arabidopsis thaliana TPPI gene Proteins 0.000 description 1
- OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000004111 multi quantum spectroscopy Methods 0.000 description 1
- 238000000140 multiple quantum filter Methods 0.000 description 1
- 238000005016 nuclear Overhauser enhanced spectroscopy Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000004324 time-proportional phase incrementation Methods 0.000 description 1
- 238000001551 total correlation spectroscopy Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000002096 two-dimensional nuclear Overhauser enhancement spectroscopy Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/46—NMR spectroscopy
- G01R33/4633—Sequences for multi-dimensional NMR
Landscapes
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Geophysics And Detection Of Objects (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853543123 DE3543123A1 (de) | 1985-12-06 | 1985-12-06 | Verfahren zur aufnahme von kernresonanzspektren |
| EP86116361A EP0224854B1 (de) | 1985-12-06 | 1986-11-25 | Verfahren zur Aufnahme von Kernresonanzspektren |
| DE8686116361T DE3685305D1 (de) | 1985-12-06 | 1986-11-25 | Verfahren zur aufnahme von kernresonanzspektren. |
| US06/937,949 US4774467A (en) | 1985-12-06 | 1986-12-04 | Method for recording nuclear magnetic resonance spectra |
| JP61289125A JPH0614016B2 (ja) | 1985-12-06 | 1986-12-05 | 核磁気共鳴スペクトルの検出方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853543123 DE3543123A1 (de) | 1985-12-06 | 1985-12-06 | Verfahren zur aufnahme von kernresonanzspektren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3543123A1 DE3543123A1 (de) | 1987-06-11 |
| DE3543123C2 true DE3543123C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-05-03 |
Family
ID=6287780
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19853543123 Granted DE3543123A1 (de) | 1985-12-06 | 1985-12-06 | Verfahren zur aufnahme von kernresonanzspektren |
| DE8686116361T Expired - Lifetime DE3685305D1 (de) | 1985-12-06 | 1986-11-25 | Verfahren zur aufnahme von kernresonanzspektren. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8686116361T Expired - Lifetime DE3685305D1 (de) | 1985-12-06 | 1986-11-25 | Verfahren zur aufnahme von kernresonanzspektren. |
Country Status (4)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10144661A1 (de) * | 2001-09-11 | 2003-04-10 | Forschungsverbund Berlin Ev | Vorrichtung und Verfahren zur Zuordnung der NMR-Signale von Polypeptiden |
| CN109884107A (zh) * | 2019-01-15 | 2019-06-14 | 厦门大学 | 一种测量同核间接偶合网络的方法 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3837317A1 (de) * | 1988-11-03 | 1990-05-10 | Philips Patentverwaltung | Kernresonanzspektroskopieverfahren und anordnung zur durchfuehrung des verfahrens |
| US5111819A (en) * | 1988-11-25 | 1992-05-12 | General Electric | Nmr imaging of metabolites using a multiple quantum excitation sequence |
| DE3839820A1 (de) * | 1988-11-25 | 1990-05-31 | Spectrospin Ag | Verfahren zum selektiven anregen von nmr-signalen |
| DE3940633A1 (de) * | 1989-12-08 | 1991-06-13 | Spectrospin Ag | Gauss-impuls-kaskade |
| US5229718A (en) * | 1991-01-17 | 1993-07-20 | Bruker Instruments, Inc. | Method for increasing resolution in solid-state nmr spectra of abundant nuclei |
| US5668734A (en) * | 1995-04-10 | 1997-09-16 | The Uab Research Foundation | Method for analyzing 2D transferred noesy spectra of molecules undergoing multistate conformational exchange |
| USD475799S1 (en) | 2002-05-16 | 2003-06-10 | Alert Lite Safety Products Co., Inc. | Articulating arm light |
| GB0308586D0 (en) * | 2003-04-14 | 2003-05-21 | Amersham Health R & D Ab | Method and arrangements in NMR spectroscopy |
| US7622919B2 (en) * | 2006-07-31 | 2009-11-24 | Schlumberger Technology Corporation | Nuclear magnetic resonance measurement techniques in non-uniform fields |
| US9733326B2 (en) * | 2007-11-07 | 2017-08-15 | University of Pittsburgh—of the Commonwealth System of Higher Education | Selective zero-quantum coherence transfer (Sel-ZQC) method for metabolite imaging in a poorly shimmed magnet field without susceptibility artifact |
| US9285443B2 (en) * | 2007-11-07 | 2016-03-15 | University of Pittsburgh—of the Commonwealth System of Higher Education | MSC-SelMQC method for simultaneous mapping of polyunsaturated fatty acids, lactate and choline in high fat tissues |
| EP2549285B1 (en) * | 2011-07-18 | 2015-12-16 | Bruker BioSpin AG | Fourier tickling for homonuclear decoupling in NMR |
| CN106872506B (zh) * | 2017-03-15 | 2018-05-18 | 厦门大学 | 一种抵抗不均匀磁场的超快速核磁共振二维j谱方法 |
| JP7357516B2 (ja) * | 2019-11-21 | 2023-10-06 | 富士フイルムヘルスケア株式会社 | 磁気共鳴撮像装置、及び、その制御方法 |
| CN112834548B (zh) * | 2021-01-08 | 2022-08-19 | 上海纽迈电子科技有限公司 | 一种交联密度测量方法及装置 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4134058A (en) * | 1977-11-28 | 1979-01-09 | Varian Associates, Inc. | Selective detection of multiple quantum transitions in nuclear magnetic resonance |
| US4238735A (en) * | 1979-02-21 | 1980-12-09 | Varian Associates, Inc. | Indirect detection of nuclear spins of low gyromagentic ratio coupled to spins of high gyromagnetic ratio |
| US4345207A (en) * | 1980-04-24 | 1982-08-17 | The United States Of America As Represented By The Secretary Of The Navy | Method and apparatus for obtaining enhanced NMR signals |
| DE3143625C2 (de) * | 1981-11-04 | 1985-11-28 | Spectrospin AG, Fällanden, Zürich | Verfahren zur Aufnahme von Kernresonanzspektren von Molekülen in einem zweidimensionalen Frequenzbereich und Kernresonanzspektrometer zur Durchführung des Verfahrens |
| US4521732A (en) * | 1982-03-16 | 1985-06-04 | Pegg David T | Pulse sequence for use in performing nuclear magnetic resonance spectroscopy |
| US4613949A (en) * | 1984-02-17 | 1986-09-23 | General Electric Company | Composite pulses for time reversal in NMR imaging |
| JPS60211343A (ja) * | 1984-04-05 | 1985-10-23 | Jeol Ltd | 核磁気共鳴測定方法 |
-
1985
- 1985-12-06 DE DE19853543123 patent/DE3543123A1/de active Granted
-
1986
- 1986-11-25 EP EP86116361A patent/EP0224854B1/de not_active Expired - Lifetime
- 1986-11-25 DE DE8686116361T patent/DE3685305D1/de not_active Expired - Lifetime
- 1986-12-04 US US06/937,949 patent/US4774467A/en not_active Expired - Lifetime
- 1986-12-05 JP JP61289125A patent/JPH0614016B2/ja not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10144661A1 (de) * | 2001-09-11 | 2003-04-10 | Forschungsverbund Berlin Ev | Vorrichtung und Verfahren zur Zuordnung der NMR-Signale von Polypeptiden |
| DE10144661C2 (de) * | 2001-09-11 | 2003-08-14 | Forschungsverbund Berlin Ev | Vorrichtung und Verfahren zur Zuordnung der NMR-Signale von Polypeptiden |
| CN109884107A (zh) * | 2019-01-15 | 2019-06-14 | 厦门大学 | 一种测量同核间接偶合网络的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3543123A1 (de) | 1987-06-11 |
| US4774467A (en) | 1988-09-27 |
| JPH0614016B2 (ja) | 1994-02-23 |
| DE3685305D1 (de) | 1992-06-17 |
| JPS62137554A (ja) | 1987-06-20 |
| EP0224854A2 (de) | 1987-06-10 |
| EP0224854B1 (de) | 1992-05-13 |
| EP0224854A3 (en) | 1989-12-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |