DE3473266D1 - Method of preparing alpha-l-aspartyl-l-phenylalanine methyl ester and its hydrochloride - Google Patents
Method of preparing alpha-l-aspartyl-l-phenylalanine methyl ester and its hydrochlorideInfo
- Publication number
- DE3473266D1 DE3473266D1 DE8484303419T DE3473266T DE3473266D1 DE 3473266 D1 DE3473266 D1 DE 3473266D1 DE 8484303419 T DE8484303419 T DE 8484303419T DE 3473266 T DE3473266 T DE 3473266T DE 3473266 D1 DE3473266 D1 DE 3473266D1
- Authority
- DE
- Germany
- Prior art keywords
- aspartyl
- hydrochloride
- methyl ester
- phenylalanine methyl
- preparing alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58094477A JPS59219258A (ja) | 1983-05-28 | 1983-05-28 | α−L−アスパルチル−L−フエニルアラニンメチルエステル又はその塩酸塩の製法 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3473266D1 true DE3473266D1 (en) | 1988-09-15 |
Family
ID=14111354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8484303419T Expired DE3473266D1 (en) | 1983-05-28 | 1984-05-21 | Method of preparing alpha-l-aspartyl-l-phenylalanine methyl ester and its hydrochloride |
Country Status (7)
Country | Link |
---|---|
US (1) | US4606854A (de) |
EP (1) | EP0127411B1 (de) |
JP (1) | JPS59219258A (de) |
KR (1) | KR900008012B1 (de) |
CA (1) | CA1258749A (de) |
DE (1) | DE3473266D1 (de) |
IE (1) | IE57517B1 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59219258A (ja) * | 1983-05-28 | 1984-12-10 | Ajinomoto Co Inc | α−L−アスパルチル−L−フエニルアラニンメチルエステル又はその塩酸塩の製法 |
US4618695A (en) * | 1983-06-02 | 1986-10-21 | Ajinomoto Co., Inc. | Method of preparing methyl ester and its hydrochloride |
JPS60174799A (ja) * | 1984-02-21 | 1985-09-09 | Ajinomoto Co Inc | α−L−アスパルチル−L−フエニルアラニンメチルエステルの製造法 |
JPH07636B2 (ja) * | 1984-12-17 | 1995-01-11 | 三井東圧化学株式会社 | N−ホルミル−α−アスパルチルフエニルアラニンの製造法 |
CA1277098C (en) * | 1984-12-27 | 1990-11-27 | Mitsui Toatsu Chemicals, Inc. | Preparation process of -l-aspartyl-l-phenylalanine methyl ester |
AU561384B2 (en) * | 1985-03-26 | 1987-05-07 | Mitsui Toatsu Chemicals Inc. | Preparation of -l-aspartyl-l-phenylalanine methyl ester or hydrochloride thereof |
AU586669B2 (en) * | 1985-03-29 | 1989-07-20 | Mitsui Toatsu Chemicals Inc. | Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof |
US4677220A (en) * | 1985-10-31 | 1987-06-30 | Monsanto Company | Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester |
JPS6383098A (ja) * | 1986-09-27 | 1988-04-13 | Ajinomoto Co Inc | α−L−アスパルチル−L−フエニルアラニン又はその誘導体の製造方法 |
DE3780585T2 (de) * | 1986-12-05 | 1993-03-18 | Mitsui Toatsu Chemicals | Herstellung von alpha-l-aspartyl-l-phenylalanin-methylester oder deren hydrohalide. |
JPH0832719B2 (ja) * | 1986-12-19 | 1996-03-29 | 三井東圧化学株式会社 | 吸湿性の小さいα−L−アスパルチル−L−フエニルアラニンメチルエステルの製造法 |
JP2927070B2 (ja) * | 1991-05-23 | 1999-07-28 | 味の素株式会社 | α−L−アスパルチル−L−フェニルアラニンメチルエステルの製造方法 |
US6657073B1 (en) | 1999-08-18 | 2003-12-02 | Daesang Corporation | Crystallization of α-L-aspartyl-L-phenylalanine methyl ester |
KR102545317B1 (ko) | 2015-06-19 | 2023-06-21 | 사우디 아라비안 오일 컴퍼니 | 방오성 올리고머화 촉매 시스템 |
US11104621B2 (en) | 2016-01-07 | 2021-08-31 | Saudi Arabian Oil Company | Antifouling oligomerization catalyst systems |
US10280125B2 (en) | 2016-12-07 | 2019-05-07 | Sumitomo Chemical Company, Limited | Process for selective ethylene oligomerization with antifouling components |
KR102659762B1 (ko) | 2017-09-22 | 2024-04-24 | 사우디 아라비안 오일 컴퍼니 | 에틸렌 올리고머화를 위한 방오제 공촉매의 인라인 제조 방법 |
US11440980B2 (en) | 2020-07-22 | 2022-09-13 | Saudi Arabian Oil Company | Methods for forming ultra high molecular weight polyethylenes and methods for reducing contaminant content in such |
WO2022115754A1 (en) | 2020-11-30 | 2022-06-02 | Saudi Arabian Oil Company | Catalyst systems |
US11440857B2 (en) | 2020-11-30 | 2022-09-13 | Saudi Arabian Oil Company | Catalyst systems |
WO2022115751A1 (en) | 2020-11-30 | 2022-06-02 | Saudi Arabian Oil Company | Catalyst systems |
WO2022115750A1 (en) | 2020-11-30 | 2022-06-02 | Saudi Arabian Oil Company | Catalyst systems |
US11612883B2 (en) | 2020-11-30 | 2023-03-28 | Saudi Arabian Oil Company | Catalyst systems |
EP4294564A1 (de) | 2021-03-12 | 2023-12-27 | Saudi Arabian Oil Company | Katalysatorsysteme |
US11484871B1 (en) | 2021-08-26 | 2022-11-01 | Saudi Arabian Oil Company | Catalyst systems |
US11623901B1 (en) | 2022-08-31 | 2023-04-11 | Saudi Arabian Oil Company | Catalyst systems that include silyl ether moieties |
US11639321B1 (en) | 2022-08-31 | 2023-05-02 | Saudi Arabian Oil Company | Catalyst systems that include meta-alkoxy substituted n-aryl bis-diphosphinoamine ligands |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4941425B1 (de) * | 1970-10-26 | 1974-11-08 | ||
US3933781A (en) * | 1973-11-05 | 1976-01-20 | Monsanto Company | Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters |
MX4704E (es) * | 1976-12-27 | 1982-08-04 | Monsanto Co | Procedimiento mejorado para la preparacion de ester metilico de alfa-l-aspartil-l-fenilalanina |
US4173562A (en) * | 1976-12-27 | 1979-11-06 | Monsanto Company | Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester |
US4111925A (en) * | 1977-10-14 | 1978-09-05 | Monsanto Company | Hydrolysis of esters of α-L-aspartyl-L-phenylalanine |
JPS59219258A (ja) * | 1983-05-28 | 1984-12-10 | Ajinomoto Co Inc | α−L−アスパルチル−L−フエニルアラニンメチルエステル又はその塩酸塩の製法 |
-
1983
- 1983-05-28 JP JP58094477A patent/JPS59219258A/ja active Granted
-
1984
- 1984-05-17 US US06/611,531 patent/US4606854A/en not_active Expired - Lifetime
- 1984-05-21 IE IE1257/84A patent/IE57517B1/en not_active IP Right Cessation
- 1984-05-21 DE DE8484303419T patent/DE3473266D1/de not_active Expired
- 1984-05-21 EP EP84303419A patent/EP0127411B1/de not_active Expired
- 1984-05-25 CA CA000455146A patent/CA1258749A/en not_active Expired
- 1984-05-26 KR KR1019840002906A patent/KR900008012B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US4606854A (en) | 1986-08-19 |
KR900008012B1 (ko) | 1990-10-29 |
CA1258749A (en) | 1989-08-22 |
EP0127411A2 (de) | 1984-12-05 |
IE57517B1 (en) | 1992-10-07 |
JPH0363556B2 (de) | 1991-10-01 |
EP0127411B1 (de) | 1988-08-10 |
KR840009295A (ko) | 1984-12-26 |
IE841257L (en) | 1984-11-28 |
JPS59219258A (ja) | 1984-12-10 |
EP0127411A3 (en) | 1985-09-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Free format text: STREHL, P., DIPL.-ING. DIPL.-WIRTSCH.-ING. SCHUEBEL-HOPF, U., DIPL.-CHEM. DR.RER.NAT. GROENING, H., DIPL.-ING., PAT.-ANWAELTE, 8000 MUENCHEN |