DE3471934D1 - 7-(pyrrol-1-yl)-1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 7-(pyrrol-1-yl)-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivatives, their preparation and use as medicaments - Google Patents
7-(pyrrol-1-yl)-1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 7-(pyrrol-1-yl)-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivatives, their preparation and use as medicamentsInfo
- Publication number
- DE3471934D1 DE3471934D1 DE8484401391T DE3471934T DE3471934D1 DE 3471934 D1 DE3471934 D1 DE 3471934D1 DE 8484401391 T DE8484401391 T DE 8484401391T DE 3471934 T DE3471934 T DE 3471934T DE 3471934 D1 DE3471934 D1 DE 3471934D1
- Authority
- DE
- Germany
- Prior art keywords
- dihydro
- ethyl
- carboxylic acid
- pyrrol
- oxoquinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- DJTQLICBCLDMAC-UHFFFAOYSA-N 1-ethyl-4-oxo-7-pyrrol-1-yl-1,8-naphthyridine-3-carboxylic acid Chemical class N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC=C1N1C=CC=C1 DJTQLICBCLDMAC-UHFFFAOYSA-N 0.000 title abstract 2
- FELNOORDZDEBLV-UHFFFAOYSA-N 1-ethyl-4-oxo-7-pyrrol-1-ylquinoline-3-carboxylic acid Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC=C1N1C=CC=C1 FELNOORDZDEBLV-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- -1 alkali metal salts Chemical class 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052757 nitrogen Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8311250A FR2548664B1 (fr) | 1983-07-06 | 1983-07-06 | Derives 7-(pyrrol-l-yl) des acides l-ethyl-1,4-dihydro-4-oxoquinoleine-3-carboxyliques et l-ethyl-1,4-dihydro-4-oxo-(1,8-naphtyridine)-3-carboxyliques substitues, leur preparation et leur application en tant que medicaments |
| FR8402145A FR2559484B2 (fr) | 1983-07-06 | 1984-02-13 | Nouveau derive 7-(pyrrol-1-yl) de l'acide 1-ethyl-1,4-dihydro-4-oxo-(1,8-naphtyridin)-3-carboxylique, sa preparation et son application en tant que medicament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3471934D1 true DE3471934D1 (en) | 1988-07-14 |
Family
ID=26223521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8484401391T Expired DE3471934D1 (en) | 1983-07-06 | 1984-06-29 | 7-(pyrrol-1-yl)-1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 7-(pyrrol-1-yl)-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivatives, their preparation and use as medicaments |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4552882A (de) |
| EP (1) | EP0134165B1 (de) |
| KR (1) | KR880002355B1 (de) |
| AT (1) | ATE34982T1 (de) |
| AU (1) | AU564326B2 (de) |
| BR (1) | BR8403342A (de) |
| CA (1) | CA1256876A (de) |
| CS (1) | CS244139B2 (de) |
| DD (1) | DD223150A5 (de) |
| DE (1) | DE3471934D1 (de) |
| DK (1) | DK163126C (de) |
| ES (1) | ES8503335A1 (de) |
| FR (1) | FR2559484B2 (de) |
| GR (1) | GR81646B (de) |
| HK (1) | HK10491A (de) |
| HU (1) | HU189916B (de) |
| MX (1) | MX156436A (de) |
| NO (1) | NO163329C (de) |
| PL (1) | PL143730B1 (de) |
| PT (1) | PT78854B (de) |
| YU (1) | YU43577B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2574404B1 (fr) * | 1984-12-12 | 1987-04-24 | Provesan Sa | Derives 1-substitues de l'acide 6-fluoro-7-(pyrrol-1-yl)-1,4-dihydro-4-oxoquinoleine-3-carboxylique, leur preparation et leur application en tant que medicaments |
| DE3519286A1 (de) * | 1985-05-30 | 1986-12-04 | Bayer Ag, 5090 Leverkusen | 7-azolyl-1-cyclopropyl-1,4-dihydro-4-oxo-3- chinolincarbonsaeuren und -1,8-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| US4692454A (en) * | 1986-02-03 | 1987-09-08 | Warner-Lambert Company | Opthalmic use of quinolone antibiotics |
| DE3615767A1 (de) * | 1986-05-10 | 1987-11-12 | Bayer Ag | Verfahren zur herstellung von 4-hydroxy-chinolin-3-carbonsaeuren |
| FR2607504B1 (fr) * | 1986-12-02 | 1989-01-27 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5262417A (en) * | 1988-12-06 | 1993-11-16 | The Upjohn Company | Antibacterial quinolone compounds |
| ES2051225B1 (es) * | 1992-07-23 | 1994-12-16 | Esteve Quimica Sa | Procedimiento de preparacion del acido 1-etil-6-fluoro-7-(pirrol-1-il) -1,4-dihidro-4-oxo-3-quinoleincarboxilico. |
| EP2147679B1 (de) | 2001-07-25 | 2014-06-25 | Raptor Pharmaceutical, Inc. | Zusammensetzungen für den Blut-Hirn-Schrankentransport |
| DK1889198T3 (da) | 2005-04-28 | 2015-02-09 | Proteus Digital Health Inc | Farma-informatiksystem |
| WO2008036682A2 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
| DK2398500T3 (da) | 2009-02-20 | 2019-05-13 | 2 Bbb Medicines B V | Glutathion-baseret lægemiddelafgivelsessystem |
| IL255113B (en) | 2009-05-06 | 2022-09-01 | Laboratory Skin Care Inc | Preparations for administration through the skin that include complexes of an active substance with calcium phosphate and methods of using them |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| CN104803975A (zh) * | 2015-04-24 | 2015-07-29 | 河南大学 | 一种氨甲基三唑取代的二氟喹诺酮羧酸类衍生物及其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1006521A (en) * | 1972-12-18 | 1977-03-08 | Minoru Sugita | Piperazine derivatives and process for preparing them |
| JPS5233694A (en) * | 1975-09-09 | 1977-03-14 | Dai Ichi Seiyaku Co Ltd | Process for preparation of 6_nitro-1,8-naphthyridine derivatives |
| AR223983A1 (es) * | 1978-08-25 | 1981-10-15 | Dainippon Pharmaceutical Co | Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico |
| JPS5649382A (en) * | 1979-09-28 | 1981-05-02 | Dainippon Pharmaceut Co Ltd | 6-fluoro-7-cyclic amino-1,8-naphthylidine derivative and its salt |
-
1984
- 1984-02-13 FR FR8402145A patent/FR2559484B2/fr not_active Expired
- 1984-06-15 AU AU29425/84A patent/AU564326B2/en not_active Ceased
- 1984-06-20 US US06/622,647 patent/US4552882A/en not_active Expired - Fee Related
- 1984-06-26 CA CA000457471A patent/CA1256876A/en not_active Expired
- 1984-06-27 ES ES533749A patent/ES8503335A1/es not_active Expired
- 1984-06-28 MX MX201827A patent/MX156436A/es unknown
- 1984-06-29 EP EP84401391A patent/EP0134165B1/de not_active Expired
- 1984-06-29 AT AT84401391T patent/ATE34982T1/de active
- 1984-06-29 DE DE8484401391T patent/DE3471934D1/de not_active Expired
- 1984-07-03 PL PL1984248545A patent/PL143730B1/pl unknown
- 1984-07-03 GR GR75174A patent/GR81646B/el unknown
- 1984-07-04 NO NO842717A patent/NO163329C/no unknown
- 1984-07-05 HU HU842641A patent/HU189916B/hu not_active IP Right Cessation
- 1984-07-05 BR BR8403342A patent/BR8403342A/pt unknown
- 1984-07-05 PT PT78854A patent/PT78854B/pt unknown
- 1984-07-05 DD DD84264967A patent/DD223150A5/de not_active IP Right Cessation
- 1984-07-05 DK DK331384A patent/DK163126C/da not_active IP Right Cessation
- 1984-07-06 KR KR1019840003918A patent/KR880002355B1/ko not_active IP Right Cessation
- 1984-07-06 YU YU1190/84A patent/YU43577B/xx unknown
- 1984-07-06 CS CS845285A patent/CS244139B2/cs unknown
-
1991
- 1991-02-06 HK HK104/91A patent/HK10491A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR8403342A (pt) | 1985-06-18 |
| YU119084A (en) | 1986-12-31 |
| NO163329C (no) | 1990-05-09 |
| YU43577B (en) | 1989-08-31 |
| ES533749A0 (es) | 1985-03-01 |
| NO842717L (no) | 1985-01-07 |
| DK163126B (da) | 1992-01-20 |
| HUT34482A (en) | 1985-03-28 |
| PT78854B (fr) | 1986-10-23 |
| CS528584A2 (en) | 1985-08-31 |
| FR2559484B2 (fr) | 1986-09-26 |
| GR81646B (de) | 1984-12-11 |
| DD223150A5 (de) | 1985-06-05 |
| FR2559484A2 (fr) | 1985-08-16 |
| AU2942584A (en) | 1985-01-10 |
| PL248545A1 (en) | 1985-07-16 |
| PL143730B1 (en) | 1988-03-31 |
| US4552882A (en) | 1985-11-12 |
| HU189916B (en) | 1986-08-28 |
| DK163126C (da) | 1992-06-15 |
| ATE34982T1 (de) | 1988-06-15 |
| KR850001198A (ko) | 1985-03-16 |
| EP0134165B1 (de) | 1988-06-08 |
| NO163329B (no) | 1990-01-29 |
| DK331384A (da) | 1985-01-07 |
| EP0134165A3 (en) | 1985-10-09 |
| AU564326B2 (en) | 1987-08-06 |
| EP0134165A2 (de) | 1985-03-13 |
| KR880002355B1 (ko) | 1988-10-29 |
| MX156436A (es) | 1988-08-22 |
| ES8503335A1 (es) | 1985-03-01 |
| DK331384D0 (da) | 1984-07-05 |
| HK10491A (en) | 1991-02-13 |
| CA1256876A (en) | 1989-07-04 |
| PT78854A (fr) | 1984-08-01 |
| CS244139B2 (en) | 1986-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: LABORATORIOS DEL DR. ESTEVE S.A., BARCELONA, ES |
|
| 8328 | Change in the person/name/address of the agent |
Free format text: GRUENECKER, A., DIPL.-ING. KINKELDEY, H., DIPL.-ING. DR.-ING. STOCKMAIR, W., DIPL.-ING. DR.-ING. AE.E. CAL TECH SCHUMANN, K., DIPL.-PHYS. DR.RER.NAT. JAKOB, P., DIPL.-ING. BEZOLD, G., DIPL.-CHEM. DR.RER.NAT. MEISTER, W., DIPL.-ING. HILGERS, H., DIPL.-ING. MEYER-PLATH, H., DIPL.-ING. DR.-ING. EHNOLD, A., DIPL.-ING. SCHUSTER, T., DIPL.-PHYS. GOLDBACH, K., DIPL.-ING.DR.-ING. AUFENANGER, M., DIPL.-ING. KLITZSCH, G., DIPL.-ING. VOGELSANG-WENKE, H., DIPL.-CHEM. DIPL.-BIOL.UNIV. DR.RER.NAT., PAT.-ANWAE |
|
| 8339 | Ceased/non-payment of the annual fee |