DE3463502D1 - New azulene derivatives useful as anti-ulcerative and anti-flammatory agents - Google Patents

New azulene derivatives useful as anti-ulcerative and anti-flammatory agents

Info

Publication number
DE3463502D1
DE3463502D1 DE8484305775T DE3463502T DE3463502D1 DE 3463502 D1 DE3463502 D1 DE 3463502D1 DE 8484305775 T DE8484305775 T DE 8484305775T DE 3463502 T DE3463502 T DE 3463502T DE 3463502 D1 DE3463502 D1 DE 3463502D1
Authority
DE
Germany
Prior art keywords
ulcerative
derivatives useful
azulene derivatives
flammatory agents
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484305775T
Other languages
English (en)
Inventor
Kahei Takase
Masafumi Yasunami
Tsuyoshi Tomiyama
Akira Tomiyama
Takashi Yanagisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kotobuki Seiyaku Co Ltd
Original Assignee
Kotobuki Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP15318783A external-priority patent/JPS6048960A/ja
Priority claimed from JP1402884A external-priority patent/JPS60158160A/ja
Application filed by Kotobuki Seiyaku Co Ltd filed Critical Kotobuki Seiyaku Co Ltd
Application granted granted Critical
Publication of DE3463502D1 publication Critical patent/DE3463502D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/47—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having at least one of the sulfo groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8484305775T 1983-08-24 1984-08-23 New azulene derivatives useful as anti-ulcerative and anti-flammatory agents Expired DE3463502D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15318783A JPS6048960A (ja) 1983-08-24 1983-08-24 アズレン誘導体及びその製法並びにこの化合物を有効成分とする抗潰瘍剤
JP1402884A JPS60158160A (ja) 1984-01-28 1984-01-28 アズレン誘導体スルホン酸塩、抗潰瘍、抗炎症剤及びその製法

Publications (1)

Publication Number Publication Date
DE3463502D1 true DE3463502D1 (en) 1987-06-11

Family

ID=26349908

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484305775T Expired DE3463502D1 (en) 1983-08-24 1984-08-23 New azulene derivatives useful as anti-ulcerative and anti-flammatory agents

Country Status (13)

Country Link
US (1) US4595694A (de)
EP (1) EP0147915B1 (de)
KR (1) KR920000956B1 (de)
AR (1) AR240554A1 (de)
AU (1) AU571554B2 (de)
CA (1) CA1228862A (de)
DE (1) DE3463502D1 (de)
DK (1) DK169870B1 (de)
ES (1) ES535381A0 (de)
HU (1) HU195478B (de)
NO (1) NO158673C (de)
PT (1) PT79119B (de)
SU (1) SU1311618A3 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5081152A (en) * 1989-07-05 1992-01-14 Kotobuki Seiyaku Co., Ltd. Azulene derivatives as thromboxane a2 and prostaglandin endoperoxide receptor antagonist
EP0887077A1 (de) * 1997-06-27 1998-12-30 Roche Diagnostics GmbH Verwendung von Azulenderivaten als Metalloproteaseinhibitoren
US6420435B1 (en) 1999-11-01 2002-07-16 Joe S. Wilkins, Jr. Method for treating gastrointestinal disorders
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
US7041706B2 (en) * 2002-04-19 2006-05-09 Wilkins Jr Joe S Method for treating crohn's disease
EP2392258B1 (de) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-Informatiksystem
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
WO2010129819A2 (en) 2009-05-06 2010-11-11 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1227896B (de) * 1965-12-02 1966-11-03 Degussa Verfahren zur Herstellung wasserloeslicher stabiler Salze von Azulensulfonsaeureamiden
US3816612A (en) * 1967-03-23 1974-06-11 Degussa Process for the production of basically reacting pharmaceuticals
US3974299A (en) * 1974-07-08 1976-08-10 Dynapol Ionic sweetener
US4283347A (en) * 1979-04-13 1981-08-11 Scm Corporation Para-menth-1-ene-7-sulfonic acid and salts thereof
US4224240A (en) * 1979-04-13 1980-09-23 Scm Corporation Preparation of para-menth-1-ene-7-sulfonate salts and corresponding acids

Also Published As

Publication number Publication date
KR920000956B1 (ko) 1992-01-31
PT79119B (en) 1986-07-17
US4595694A (en) 1986-06-17
HU195478B (en) 1988-05-30
ES8506607A1 (es) 1985-07-16
DK377984A (da) 1985-02-25
DK169870B1 (da) 1995-03-20
NO158673B (no) 1988-07-11
HUT37393A (en) 1985-12-28
NO843377L (no) 1985-02-25
AU3139684A (en) 1985-02-28
PT79119A (en) 1984-09-01
CA1228862A (en) 1987-11-03
SU1311618A3 (ru) 1987-05-15
ES535381A0 (es) 1985-07-16
NO158673C (no) 1988-10-19
DK377984D0 (da) 1984-08-03
EP0147915A1 (de) 1985-07-10
EP0147915B1 (de) 1987-05-06
AU571554B2 (en) 1988-04-21
KR850001731A (ko) 1985-04-01
AR240554A1 (es) 1990-05-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition