DE3461797D1 - 1-phenylalkyl-4-(mercapto and carbamylthio)alkyl-piperazines and -homopiperazines and their use in the treatment of allergic diseases - Google Patents

1-phenylalkyl-4-(mercapto and carbamylthio)alkyl-piperazines and -homopiperazines and their use in the treatment of allergic diseases

Info

Publication number
DE3461797D1
DE3461797D1 DE8484106160T DE3461797T DE3461797D1 DE 3461797 D1 DE3461797 D1 DE 3461797D1 DE 8484106160 T DE8484106160 T DE 8484106160T DE 3461797 T DE3461797 T DE 3461797T DE 3461797 D1 DE3461797 D1 DE 3461797D1
Authority
DE
Germany
Prior art keywords
carbon atoms
alkyl
hydrogen
alkoxy
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484106160T
Other languages
English (en)
Inventor
Karl D Dr Hargrave
John P Dr Devlin
Edward L Dr Barsumian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BOEHRINGER INGELHEIM Ltd
Boehringer Ingelheim Corp
Original Assignee
BOEHRINGER INGELHEIM Ltd
Boehringer Ingelheim Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOEHRINGER INGELHEIM Ltd, Boehringer Ingelheim Corp filed Critical BOEHRINGER INGELHEIM Ltd
Application granted granted Critical
Publication of DE3461797D1 publication Critical patent/DE3461797D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE8484106160T 1983-05-31 1984-05-30 1-phenylalkyl-4-(mercapto and carbamylthio)alkyl-piperazines and -homopiperazines and their use in the treatment of allergic diseases Expired DE3461797D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49918883A 1983-05-31 1983-05-31

Publications (1)

Publication Number Publication Date
DE3461797D1 true DE3461797D1 (en) 1987-02-05

Family

ID=23984207

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484106160T Expired DE3461797D1 (en) 1983-05-31 1984-05-30 1-phenylalkyl-4-(mercapto and carbamylthio)alkyl-piperazines and -homopiperazines and their use in the treatment of allergic diseases

Country Status (24)

Country Link
EP (1) EP0127182B1 (de)
JP (1) JPS59227868A (de)
KR (1) KR900001188B1 (de)
AT (1) ATE24502T1 (de)
AU (1) AU566668B2 (de)
CA (1) CA1215979A (de)
CS (1) CS245792B2 (de)
DD (1) DD224591A5 (de)
DE (1) DE3461797D1 (de)
DK (1) DK163921C (de)
ES (1) ES8505981A1 (de)
FI (1) FI77238C (de)
GR (1) GR82001B (de)
HU (1) HU192405B (de)
IE (1) IE57841B1 (de)
IL (1) IL71970A (de)
NO (1) NO169895C (de)
NZ (1) NZ208334A (de)
PH (1) PH21555A (de)
PL (1) PL142332B1 (de)
PT (1) PT78667B (de)
SU (1) SU1355128A3 (de)
YU (1) YU43569B (de)
ZA (1) ZA844101B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692448A (en) * 1984-11-20 1987-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Bis(arylpiperazinyl)sulfur compounds
CA2180190A1 (en) * 1995-07-10 1997-01-11 Kazumi Ogata Benzylpiperazine derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1286198A (fr) * 1961-04-07 1962-03-02 Bayer Ag Procédé de fabrication d'esters s-alkyliques, à substituants basiques, de l'acide phénylthiocarbamique
GB952142A (en) * 1961-05-26 1964-03-11 Miles Lab Phenylpiperazinylalkyl carbamates

Also Published As

Publication number Publication date
PT78667B (en) 1986-09-08
ES532930A0 (es) 1985-06-16
KR840009089A (ko) 1984-12-24
DK268484A (da) 1984-12-01
CA1215979A (en) 1986-12-30
PT78667A (en) 1984-06-01
EP0127182A1 (de) 1984-12-05
DK163921C (da) 1992-09-21
ZA844101B (en) 1986-02-26
PH21555A (en) 1987-12-11
EP0127182B1 (de) 1986-12-30
AU2887884A (en) 1984-12-20
ES8505981A1 (es) 1985-06-16
PL142332B1 (en) 1987-10-31
ATE24502T1 (de) 1987-01-15
NZ208334A (en) 1987-02-20
SU1355128A3 (ru) 1987-11-23
FI77238C (fi) 1989-02-10
FI77238B (fi) 1988-10-31
DK163921B (da) 1992-04-21
IE841346L (en) 1984-11-30
NO169895C (no) 1992-08-19
PL247953A1 (en) 1985-03-26
FI842141A0 (fi) 1984-05-29
IE57841B1 (en) 1993-04-21
AU566668B2 (en) 1987-10-29
DK268484D0 (da) 1984-05-30
YU92584A (de) 1986-06-30
YU43569B (en) 1989-08-31
CS245792B2 (en) 1986-10-16
JPS59227868A (ja) 1984-12-21
KR900001188B1 (ko) 1990-02-27
NO169895B (no) 1992-05-11
FI842141A (fi) 1984-12-01
CS405984A2 (en) 1985-09-17
HU192405B (en) 1987-06-29
NO842154L (no) 1984-12-03
GR82001B (de) 1984-12-12
IL71970A (en) 1988-02-29
IL71970A0 (en) 1984-09-30
DD224591A5 (de) 1985-07-10
HUT34740A (en) 1985-04-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee