DE3448257C2 - Cytoprotective action of prostacyclin derivatives on the kidney - Google Patents

Cytoprotective action of prostacyclin derivatives on the kidney

Info

Publication number
DE3448257C2
DE3448257C2 DE3448257A DE3448257A DE3448257C2 DE 3448257 C2 DE3448257 C2 DE 3448257C2 DE 3448257 A DE3448257 A DE 3448257A DE 3448257 A DE3448257 A DE 3448257A DE 3448257 C2 DE3448257 C2 DE 3448257C2
Authority
DE
Germany
Prior art keywords
group
atoms
kidney
general formula
straight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3448257A
Other languages
German (de)
English (en)
Inventor
Olaf Dr. 1000 Berlin De Loge
Guido Dr. Adler
Rolf Dr. 3550 Marburg De Schulte-Hermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of DE3448257C2 publication Critical patent/DE3448257C2/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE3448257A 1984-07-25 1984-07-25 Cytoprotective action of prostacyclin derivatives on the kidney Expired DE3448257C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843427797 DE3427797A1 (de) 1984-07-25 1984-07-25 Zytoprotektive wirkung von prostacyclin-derivaten an leber, bauchspeicheldruese und niere

Publications (1)

Publication Number Publication Date
DE3448257C2 true DE3448257C2 (en) 1988-08-18

Family

ID=6241773

Family Applications (3)

Application Number Title Priority Date Filing Date
DE3448257A Expired DE3448257C2 (en) 1984-07-25 1984-07-25 Cytoprotective action of prostacyclin derivatives on the kidney
DE19843427797 Granted DE3427797A1 (de) 1984-07-25 1984-07-25 Zytoprotektive wirkung von prostacyclin-derivaten an leber, bauchspeicheldruese und niere
DE8585903809T Expired - Lifetime DE3585282D1 (de) 1984-07-25 1985-07-18 Prostacyclin-derivate mit zytoprotektiver wirkung an der niere.

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE19843427797 Granted DE3427797A1 (de) 1984-07-25 1984-07-25 Zytoprotektive wirkung von prostacyclin-derivaten an leber, bauchspeicheldruese und niere
DE8585903809T Expired - Lifetime DE3585282D1 (de) 1984-07-25 1985-07-18 Prostacyclin-derivate mit zytoprotektiver wirkung an der niere.

Country Status (5)

Country Link
US (1) US5049582A (https=)
EP (1) EP0191792B1 (https=)
JP (1) JPH0649649B2 (https=)
DE (3) DE3448257C2 (https=)
WO (1) WO1986000808A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3631169A1 (de) * 1986-09-11 1988-03-24 Schering Ag Prostacyclinderivate enthaltende mittel fuer die topische anwendung
DE3740838A1 (de) * 1987-11-27 1989-06-08 Schering Ag Cyclodextrinclathrate von 5-cyano-prostacyclinderivaten und ihre verwendung als arzneimittel
ES2099093T3 (es) * 1988-12-23 1997-05-16 Teijin Ltd Uso de isocarbaciclinas para evitar o tratar enfermedades de organos.
US5364883A (en) * 1988-12-23 1994-11-15 Teijin Limited Isocarbocyclins for the treatment of liver and kidney diseases
JPH089544B2 (ja) * 1989-08-09 1996-01-31 株式会社上野製薬応用研究所 腸内排泄剤
DE4135193C1 (https=) * 1991-10-22 1993-03-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De
CA2099667C (en) * 1991-10-25 1999-04-13 Shinya Ueno Agent for treating hepatic diseases
EP0697169B1 (en) * 1993-05-07 2000-11-15 Chugai Seiyaku Kabushiki Kaisha Organ preservative
DE10253623B4 (de) * 2002-11-15 2006-03-09 Justus-Liebig-Universität Giessen Bioabbaubare kolloidale Partikel, insbesondere für pulmonale Applikationen
ES2622471T5 (es) 2003-05-22 2020-07-23 United Therapeutics Corp Compuestos y procedimientos para la administración de análogos de prostaciclina
CA2658382A1 (en) * 2006-07-18 2008-01-24 Bayer Schering Pharma Aktiengesellschaft 5-cyano-prostacyclin derivatives as agents for the treatment of autoimmune diseases
EP2269611B1 (en) * 2006-11-16 2016-03-23 Gemmus Pharma Inc. EP2 and EP4 agonists as agents for the treatment of influenza A viral infection
US7776896B2 (en) 2007-03-28 2010-08-17 Bayer Schering Pharma Aktiengesellschaft 5-cyano-prostacyclin derivatives as agents for the treatment of influenza a viral infection
JP2016517410A (ja) 2013-03-14 2016-06-16 ユナイテッド セラピューティクス コーポレイション トレプロスチニルの固体形態

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002234A1 (de) * 1977-11-25 1979-06-13 Schering Aktiengesellschaft Neue Prostacyclinderivate, ihre Herstellung und Anwendung
EP0011591A1 (de) * 1978-10-19 1980-05-28 Schering Aktiengesellschaft Neue Prostanderivate, ihre Herstellung und sie enthaltende Arzneimittel

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58164512A (ja) * 1982-03-25 1983-09-29 Ono Pharmaceut Co Ltd プロスタグランジン類似化合物を有効成分として含有する肝臓疾患治療剤
JPS58203911A (ja) * 1982-05-25 1983-11-28 Ono Pharmaceut Co Ltd プロスタグランジン類似化合物を有効成分として含有する細肪障害治療剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002234A1 (de) * 1977-11-25 1979-06-13 Schering Aktiengesellschaft Neue Prostacyclinderivate, ihre Herstellung und Anwendung
EP0011591A1 (de) * 1978-10-19 1980-05-28 Schering Aktiengesellschaft Neue Prostanderivate, ihre Herstellung und sie enthaltende Arzneimittel

Also Published As

Publication number Publication date
DE3585282D1 (de) 1992-03-05
WO1986000808A1 (fr) 1986-02-13
DE3427797A1 (de) 1986-02-06
US5049582A (en) 1991-09-17
EP0191792A1 (de) 1986-08-27
DE3427797C2 (https=) 1988-08-11
JPH0649649B2 (ja) 1994-06-29
JPS61502819A (ja) 1986-12-04
EP0191792B1 (de) 1992-01-22

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8339 Ceased/non-payment of the annual fee