DE3367091D1 - A process for preparing nicotinonitriles and intermediates used therein - Google Patents

A process for preparing nicotinonitriles and intermediates used therein

Info

Publication number
DE3367091D1
DE3367091D1 DE8383104984T DE3367091T DE3367091D1 DE 3367091 D1 DE3367091 D1 DE 3367091D1 DE 8383104984 T DE8383104984 T DE 8383104984T DE 3367091 T DE3367091 T DE 3367091T DE 3367091 D1 DE3367091 D1 DE 3367091D1
Authority
DE
Germany
Prior art keywords
nicotinonitriles
preparing
intermediates used
intermediates
preparing nicotinonitriles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383104984T
Other languages
English (en)
Inventor
Karl Olaf Gelotte
Baldev Singh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis US LLC
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/381,062 external-priority patent/US4413127A/en
Priority claimed from US06/381,162 external-priority patent/US4417054A/en
Priority claimed from US06/471,961 external-priority patent/US4469871A/en
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Application granted granted Critical
Publication of DE3367091D1 publication Critical patent/DE3367091D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8383104984T 1982-05-24 1983-05-19 A process for preparing nicotinonitriles and intermediates used therein Expired DE3367091D1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/381,062 US4413127A (en) 1982-05-24 1982-05-24 Preparation of 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(pyridinyl)nicotinonitriles
US06/381,162 US4417054A (en) 1982-05-24 1982-05-24 2-(Lower-alkoxy)-1-(pyridinyl)ethenyl lower-alkyl ketones
US06/471,961 US4469871A (en) 1982-05-24 1983-03-03 Process for preparing 2-(lower-alkoxy)-1-(pyridinyl) ethenyl lower-alkyl ketones

Publications (1)

Publication Number Publication Date
DE3367091D1 true DE3367091D1 (en) 1986-11-27

Family

ID=27409519

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383104984T Expired DE3367091D1 (en) 1982-05-24 1983-05-19 A process for preparing nicotinonitriles and intermediates used therein

Country Status (14)

Country Link
EP (1) EP0095152B1 (de)
KR (2) KR890001543B1 (de)
AU (1) AU559149B2 (de)
DE (1) DE3367091D1 (de)
DK (1) DK157488C (de)
ES (2) ES8506693A1 (de)
FI (1) FI80021C (de)
GR (1) GR78573B (de)
HK (1) HK79591A (de)
IE (1) IE55135B1 (de)
IL (1) IL68671A (de)
NO (1) NO163008C (de)
NZ (1) NZ204175A (de)
PT (1) PT76710B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4976774A (en) * 1984-07-20 1990-12-11 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations 1-(4'-pyridyl)-4-pyridone, its derivatives and herbicidal use thereof
CN111377858B (zh) * 2018-12-30 2023-04-07 鲁南制药集团股份有限公司 一种米力农的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2824121A (en) * 1954-11-04 1958-02-18 Kay Fries Chemicals Inc Process for preparation of oxy alkylidene compounds
US4072746A (en) * 1975-10-14 1978-02-07 Sterling Drug Inc. 3-Amino-5-(pyridinyl)-2(1H)-pyridinones
DE2909287A1 (de) * 1979-03-09 1980-09-18 Bayer Ag 3-substituierte pyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide
US4223149A (en) * 1979-07-26 1980-09-16 Sterling Drug Inc. Process for producing 3-cyano-5-(pyridinyl)-2(1H)-pyridinones
US4313951A (en) * 1979-11-26 1982-02-02 Sterling Drug Inc. 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor
US4310670A (en) * 1980-02-26 1982-01-12 Sterling Drug Inc. Low-temperature, aqueous conversion of 4-picoline derivative to 5-cyano-[3,4'-bipyridin]-6(1H)-one
NZ196573A (en) * 1980-03-28 1984-03-16 Sterling Drug Inc 6-pyrid-(3 or 4)-yl-(1h or 3h)-imidazo (4,5-b)pyridines
US4347363A (en) * 1981-09-17 1982-08-31 Sterling Drug Inc. Process for preparing 1,2-dihydro-6-methyl-2-oxo-5-(pyridinyl)nicotinonitriles

Also Published As

Publication number Publication date
NO163008B (no) 1989-12-11
IL68671A (en) 1986-07-31
PT76710A (en) 1983-06-01
EP0095152B1 (de) 1986-10-22
NO831638L (no) 1983-11-25
FI831730L (fi) 1983-11-25
KR880002354B1 (ko) 1988-10-29
ES522506A0 (es) 1985-08-01
KR890001543B1 (ko) 1989-05-08
DK224283A (da) 1983-11-25
KR850001191A (ko) 1985-03-16
PT76710B (en) 1985-12-27
FI831730A0 (fi) 1983-05-17
ES8506693A1 (es) 1985-08-01
AU559149B2 (en) 1987-02-26
NO163008C (no) 1990-03-21
AU1442383A (en) 1983-12-01
FI80021B (fi) 1989-12-29
EP0095152A1 (de) 1983-11-30
DK224283D0 (da) 1983-05-19
DK157488C (da) 1990-06-11
IE55135B1 (en) 1990-06-06
ES535990A0 (es) 1985-10-16
IL68671A0 (en) 1983-09-30
GR78573B (de) 1984-09-27
DK157488B (da) 1990-01-15
IE831155L (en) 1983-11-24
ES8601132A1 (es) 1985-10-16
FI80021C (fi) 1990-04-10
HK79591A (en) 1991-10-18
NZ204175A (en) 1985-12-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI PHARMACEUTICALS, INC. (N.D.GES.D. STAATES D

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO INC.(N.D.GES.D.STAATES DELAWARE)