DE3313049A1 - Pharmakologisch wirksame biphosphonate, verfahren fuer ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen - Google Patents

Pharmakologisch wirksame biphosphonate, verfahren fuer ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen

Info

Publication number
DE3313049A1
DE3313049A1 DE19833313049 DE3313049A DE3313049A1 DE 3313049 A1 DE3313049 A1 DE 3313049A1 DE 19833313049 DE19833313049 DE 19833313049 DE 3313049 A DE3313049 A DE 3313049A DE 3313049 A1 DE3313049 A1 DE 3313049A1
Authority
DE
Germany
Prior art keywords
acid
amino
fluorine atom
biphosphonic
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19833313049
Other languages
German (de)
English (en)
Other versions
DE3313049C2 (enExample
Inventor
Sergio Rosini
Giorgio Pisa Staibano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD Overseas Manufacturing Co Ireland ULC
Original Assignee
Istituto Gentili SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26325111&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3313049(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from IT8220781A external-priority patent/IT1201087B/it
Application filed by Istituto Gentili SpA filed Critical Istituto Gentili SpA
Publication of DE3313049A1 publication Critical patent/DE3313049A1/de
Application granted granted Critical
Publication of DE3313049C2 publication Critical patent/DE3313049C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3856—Polyphosphonic acids containing halogen or nitro(so) substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19833313049 1982-04-15 1983-04-12 Pharmakologisch wirksame biphosphonate, verfahren fuer ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen Granted DE3313049A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8220781A IT1201087B (it) 1982-04-15 1982-04-15 Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
IT140383 1983-02-16

Publications (2)

Publication Number Publication Date
DE3313049A1 true DE3313049A1 (de) 1983-11-17
DE3313049C2 DE3313049C2 (enExample) 1991-07-25

Family

ID=26325111

Family Applications (2)

Application Number Title Priority Date Filing Date
DE1996175047 Active DE19675047I2 (de) 1982-04-15 1983-04-12 Pharmazeutische Zusammensetzung mit einem Gehalt an 4-amino-1-hydroxybutan-1, 1-biphosphonsaeure
DE19833313049 Granted DE3313049A1 (de) 1982-04-15 1983-04-12 Pharmakologisch wirksame biphosphonate, verfahren fuer ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE1996175047 Active DE19675047I2 (de) 1982-04-15 1983-04-12 Pharmazeutische Zusammensetzung mit einem Gehalt an 4-amino-1-hydroxybutan-1, 1-biphosphonsaeure

Country Status (1)

Country Link
DE (2) DE19675047I2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3500670A1 (de) * 1984-01-12 1985-07-18 Istituto Gentili S.P.A., Pisa Diphosphonate enthaltende arzneimittel
EP0175315A3 (en) * 1984-09-21 1986-07-16 Henkel Kommanditgesellschaft Auf Aktien 4-dimethylamino-1-hydroxybutane-1,1-diphosphonic acid, its water soluble salts, process for their preparation and its use
EP0723450A4 (en) * 1993-10-12 1998-07-01 Univ California INHIBITION OF URINARY CALCULATION DEVELOPMENT

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1813659A1 (de) * 1967-12-11 1969-07-03 Procter & Gamble Zusammensetzungen zur Verhinderung der anomalen Mobilisierung und Ablagerung von Calciumphosphat in Geweben
DE2405254A1 (de) * 1974-02-04 1975-08-14 Henkel & Cie Gmbh Pharmazeutische oder kosmetische praeparate
EP0001584A1 (de) * 1977-10-07 1979-05-02 Henkel Kommanditgesellschaft auf Aktien Hydroxydiphosphonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Komplexierungsmittel
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4330486A (en) * 1980-04-28 1982-05-18 University Of Iowa Reseach Foundation Bis(phosphonic acid) difluoromethane

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1813659A1 (de) * 1967-12-11 1969-07-03 Procter & Gamble Zusammensetzungen zur Verhinderung der anomalen Mobilisierung und Ablagerung von Calciumphosphat in Geweben
DE2405254A1 (de) * 1974-02-04 1975-08-14 Henkel & Cie Gmbh Pharmazeutische oder kosmetische praeparate
EP0001584A1 (de) * 1977-10-07 1979-05-02 Henkel Kommanditgesellschaft auf Aktien Hydroxydiphosphonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Komplexierungsmittel
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4330486A (en) * 1980-04-28 1982-05-18 University Of Iowa Reseach Foundation Bis(phosphonic acid) difluoromethane

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3500670A1 (de) * 1984-01-12 1985-07-18 Istituto Gentili S.P.A., Pisa Diphosphonate enthaltende arzneimittel
EP0175315A3 (en) * 1984-09-21 1986-07-16 Henkel Kommanditgesellschaft Auf Aktien 4-dimethylamino-1-hydroxybutane-1,1-diphosphonic acid, its water soluble salts, process for their preparation and its use
EP0723450A4 (en) * 1993-10-12 1998-07-01 Univ California INHIBITION OF URINARY CALCULATION DEVELOPMENT

Also Published As

Publication number Publication date
DE3313049C2 (enExample) 1991-07-25
DE19675047I2 (de) 2003-06-12

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8125 Change of the main classification

Ipc: A61K 31/66

D2 Grant after examination
8364 No opposition during term of opposition
V448 Application of spc

Free format text: PRODUCT NAME: ALENDRONAT-MONONATRIUM 3 H2O; REGISTRATION NO/DATE: 33408.00.00, 19960911

Spc suppl protection certif: 196 75 047

Filing date: 19961218

8327 Change in the person/name/address of the patent owner

Owner name: MSD OVERSEAS MANUFACTURING CO.(IRELAND), DUBLIN, I

V457 Spc granted

Free format text: PRODUCT NAME: ALENDRONAT-MONONATRIUM 3 H2O; REGISTRATION NO/DATE: 33408.00.00, 19960911

Spc suppl protection certif: 196 75 047

Filing date: 19961218

V460 Request of annulation for spc

Free format text: PRODUCT NAME: ALENDRONAT-MONONATRIUM 3 H2O; REGISTRATION NO/DATE: 33408.00.00, 19960911

Spc suppl protection certif: 196 75 047

Filing date: 19961218

V464 Spc expired

Free format text: PRODUCT NAME: ALENDRONAT-MONONATRIUM 3 H2O; REGISTRATION NO/DATE: 33408.00.00, 19960911

Spc suppl protection certif: 196 75 047

Filing date: 19961218

R040 Withdrawal/refusal of revocation action now final

Spc suppl protection certif: 19675047

Filing date: 19961218

Free format text: PRODUCT NAME: ALENDRONAT-MONONATRIUM 3 H 2 O; NAT. REGISTRATION NO/DATE: 33408.00.00 19960911 FIRST REGISTRATION: ITALIEN 029051012 029051024 029052014 029052026 029053016 029053028 029054018 029054020 19930716

Spc suppl protection certif: 19675047

Filing date: 19961218

Expiry date: 20030413

Extension date: 20080412

R069 Supplementary protection certificate granted

Free format text: PRODUCT NAME: ALENDRONAT-MONONATRIUM 3 H 2 O; NAT. REGISTRATION NO/DATE: 33408.00.00 19960911 FIRST REGISTRATION: ITALIEN 029051012 029051024 029052014 029052026 029053016 029053028 029054018 029054020 19930716

Spc suppl protection certif: 19675047

Filing date: 19961218

Expiry date: 20030413

Extension date: 20080412