DE3249628A1 - - Google Patents
Info
- Publication number
- DE3249628A1 DE3249628A1 DE19823249628 DE3249628A DE3249628A1 DE 3249628 A1 DE3249628 A1 DE 3249628A1 DE 19823249628 DE19823249628 DE 19823249628 DE 3249628 A DE3249628 A DE 3249628A DE 3249628 A1 DE3249628 A1 DE 3249628A1
- Authority
- DE
- Germany
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1854—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety
- C07C273/1863—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety from urea
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/14—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP461081A JPS57118542A (en) | 1981-01-17 | 1981-01-17 | Preparation of n-substituted amide compound |
JP19844181A JPS58103348A (ja) | 1981-12-11 | 1981-12-11 | N−アルキル置換不飽和アミド化合物の製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3249628A1 true DE3249628A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1985-03-28 |
DE3249628C2 DE3249628C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-12-13 |
Family
ID=26338415
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3249628A Expired - Lifetime DE3249628C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1981-01-17 | 1982-01-12 | |
DE19823200648 Granted DE3200648A1 (de) | 1981-01-17 | 1982-01-12 | Verfahren zur herstellung von n-substituierten amidverbindungen |
DE3249630A Expired DE3249630C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1981-01-17 | 1982-01-12 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19823200648 Granted DE3200648A1 (de) | 1981-01-17 | 1982-01-12 | Verfahren zur herstellung von n-substituierten amidverbindungen |
DE3249630A Expired DE3249630C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1981-01-17 | 1982-01-12 |
Country Status (6)
Families Citing this family (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5118846A (en) * | 1990-04-27 | 1992-06-02 | The Standard Oil Company | Synthesis of N-disubstituted amides by reaction of amides with certain organic hydroxyl compounds |
US5447728A (en) * | 1992-06-15 | 1995-09-05 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
US5578323A (en) * | 1992-06-15 | 1996-11-26 | Emisphere Technologies, Inc. | Proteinoid carriers and methods for preparation and use thereof |
US5451410A (en) * | 1993-04-22 | 1995-09-19 | Emisphere Technologies, Inc. | Modified amino acids for encapsulating active agents |
US6331318B1 (en) * | 1994-09-30 | 2001-12-18 | Emisphere Technologies Inc. | Carbon-substituted diketopiperazine delivery systems |
US6221367B1 (en) | 1992-06-15 | 2001-04-24 | Emisphere Technologies, Inc. | Active agent transport systems |
US6099856A (en) * | 1992-06-15 | 2000-08-08 | Emisphere Technologies, Inc. | Active agent transport systems |
US5714167A (en) * | 1992-06-15 | 1998-02-03 | Emisphere Technologies, Inc. | Active agent transport systems |
US5693338A (en) * | 1994-09-29 | 1997-12-02 | Emisphere Technologies, Inc. | Diketopiperazine-based delivery systems |
US5629020A (en) | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
US5443841A (en) * | 1992-06-15 | 1995-08-22 | Emisphere Technologies, Inc. | Proteinoid microspheres and methods for preparation and use thereof |
US5541155A (en) * | 1994-04-22 | 1996-07-30 | Emisphere Technologies, Inc. | Acids and acid salts and their use in delivery systems |
US6916489B2 (en) * | 1992-06-15 | 2005-07-12 | Emisphere Technologies, Inc. | Active agent transport systems |
US5792451A (en) * | 1994-03-02 | 1998-08-11 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
US5811127A (en) * | 1992-06-15 | 1998-09-22 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
US5401516A (en) * | 1992-12-21 | 1995-03-28 | Emisphere Technologies, Inc. | Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof |
DE4302860A1 (de) * | 1993-01-22 | 1994-08-04 | Chemie Linz Deutschland | N-Cyclische und N,N'dicyclische Harnstoffe |
AT400566B (de) * | 1993-01-22 | 1996-01-25 | Chemie Linz Gmbh | Verwendung und verfahren zur herstellung von n-cyclischen und n,n'-dicyclischen harnstoffen |
US5643957A (en) * | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5958457A (en) * | 1993-04-22 | 1999-09-28 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
US6461643B2 (en) | 1993-04-22 | 2002-10-08 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
EP1077070A3 (en) * | 1993-04-22 | 2001-05-23 | Emisphere Technologies, Inc. | Oral drug delivery compositions |
US5709861A (en) * | 1993-04-22 | 1998-01-20 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
DE4404222A1 (de) * | 1994-02-10 | 1995-08-17 | Bayer Ag | Verwendung von Dicarbonsäure-bis-dimethylamiden als Kristallisationsinhibitoren |
US6090958A (en) * | 1995-03-31 | 2000-07-18 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5866536A (en) * | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6001347A (en) | 1995-03-31 | 1999-12-14 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5989539A (en) * | 1995-03-31 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5650386A (en) * | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
CN1151836C (zh) * | 1995-03-31 | 2004-06-02 | 艾米斯菲尔技术有限公司 | 用作传送活性剂的化合物和组合物 |
US5965121A (en) * | 1995-03-31 | 1999-10-12 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
WO1997036480A1 (en) | 1996-03-29 | 1997-10-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5820881A (en) * | 1995-04-28 | 1998-10-13 | Emisphere Technologies, Inc. | Microspheres of diamide-dicarboxylic acids |
US5750147A (en) | 1995-06-07 | 1998-05-12 | Emisphere Technologies, Inc. | Method of solubilizing and encapsulating itraconazole |
US5667806A (en) * | 1995-06-07 | 1997-09-16 | Emisphere Technologies, Inc. | Spray drying method and apparatus |
US5824345A (en) * | 1995-06-07 | 1998-10-20 | Emisphere Technologies, Inc. | Fragrances and flavorants |
US6051258A (en) * | 1995-06-07 | 2000-04-18 | Emisphere Technologies, Inc. | Proteinoid emulsions and methods for preparation and use thereof |
GB9514031D0 (en) * | 1995-07-10 | 1995-09-06 | Zeneca Ltd | Chemical process |
DE19681560T1 (de) * | 1995-09-11 | 1998-08-20 | Emisphere Tech Inc | Verfahren zur Herstellung von omega-Aminoalkansäure-Derivaten aus Cycloalkanonen |
AU3828597A (en) | 1996-06-14 | 1998-01-07 | Emisphere Technologies, Inc. | Microencapsulated fragrances and method for preparation |
US6358504B1 (en) | 1997-02-07 | 2002-03-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5939381A (en) * | 1997-02-07 | 1999-08-17 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5804688A (en) * | 1997-02-07 | 1998-09-08 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5990166A (en) * | 1997-02-07 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5876710A (en) * | 1997-02-07 | 1999-03-02 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
US6313088B1 (en) | 1997-02-07 | 2001-11-06 | Emisphere Technologies, Inc. | 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents |
US5879681A (en) * | 1997-02-07 | 1999-03-09 | Emisphere Technolgies Inc. | Compounds and compositions for delivering active agents |
US6060513A (en) * | 1997-02-07 | 2000-05-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5863944A (en) * | 1997-04-30 | 1999-01-26 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5962710A (en) * | 1997-05-09 | 1999-10-05 | Emisphere Technologies, Inc. | Method of preparing salicyloylamino acids |
US6991798B1 (en) | 1998-08-07 | 2006-01-31 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
NZ509410A (en) * | 1998-08-07 | 2003-08-29 | Emisphere Tech Inc | Compounds and compositions for delivering active agents |
US6967250B1 (en) * | 1998-08-31 | 2005-11-22 | Amersham Biosciences Corp | Energy transfer dyes |
EP1149066B1 (en) | 1999-02-05 | 2005-11-09 | Emisphere Technologies, Inc. | Method of preparing alkylated salicylamides |
EP1175390B1 (en) * | 1999-04-05 | 2005-02-02 | Emisphere Technologies, Inc. | Disodium salts, monohydrates, and ethanol solvates |
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
US7129274B1 (en) | 1999-11-05 | 2006-10-31 | Emisphere Technologies Inc. | Phenoxy carboxylic acid compounds and compositions for delivering active agents |
US7279597B1 (en) | 1999-11-05 | 2007-10-09 | Emisphere Technologies, Inc. | Phenyl amine carboxylic acid compounds and compositions for delivering active agents |
AU2274201A (en) * | 1999-12-16 | 2001-06-25 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
EP1246792B1 (en) | 2000-01-13 | 2014-08-13 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6369249B1 (en) * | 2000-02-02 | 2002-04-09 | Council Of Scientific & Industrial Research | Process for the preparation of N-substituted acrylamides |
EP1299348B1 (en) * | 2000-06-29 | 2008-04-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6562994B2 (en) | 2000-09-21 | 2003-05-13 | Bristol-Myers Squibb Co. | Process for the preparation of N-(substituted phenyl)-3-alkyl-,aryl- and heteroarylsulfonyl-2-hydroxy-2-alkyl- and haloalkylpropanamide compounds |
AU2003220125B2 (en) | 2002-03-20 | 2006-06-15 | Mannkind Corporation | Inhalation apparatus |
EP1539675B1 (en) * | 2002-08-29 | 2013-11-06 | Temple University - Of The Commonwealth System of Higher Education | Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof |
US7214825B2 (en) * | 2003-10-17 | 2007-05-08 | Honeywell International Inc. | O-(3-chloropropenyl) hydroxylamine free base |
JP2005209106A (ja) * | 2004-01-26 | 2005-08-04 | Nec Corp | 携帯通信端末、受信メール管理方法、プログラムおよび記録媒体 |
WO2007008226A2 (en) * | 2004-08-17 | 2007-01-18 | The President And Fellows Of Harvard College | Palladium-catalyzed carbon-carbon bond forming reactions |
KR101273120B1 (ko) | 2004-08-20 | 2013-06-13 | 맨카인드 코포레이션 | 다이케토피페라진 합성의 촉매 작용 |
ES2540886T3 (es) | 2004-08-23 | 2015-07-14 | Mannkind Corporation | Sales de dicetopiperazina para la administración de fármacos |
WO2007011722A2 (en) | 2005-07-15 | 2007-01-25 | President And Fellows Of Harvard College | Reaction discovery system |
HUE028623T2 (en) | 2005-09-14 | 2016-12-28 | Mannkind Corp | Active substance formulation method based on increasing the affinity of the active ingredient for binding to the surface of crystalline microparticles |
US8039431B2 (en) | 2006-02-22 | 2011-10-18 | Mannkind Corporation | Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
CA2982550C (en) | 2008-06-13 | 2020-08-25 | Mannkind Corporation | A dry powder inhaler and system for drug delivery |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
BR122020002400B1 (pt) | 2008-06-20 | 2021-12-07 | Mannkind Corporation | Sistema de detecção de inalação de pó seco e sistema de monitoramento acoplável para um inalador de pó seco |
TWI494123B (zh) | 2008-08-11 | 2015-08-01 | Mannkind Corp | 超快起作用胰島素之用途 |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
DK2405963T3 (da) | 2009-03-11 | 2013-12-16 | Mannkind Corp | Apparat, system og fremgangsmåde til at måle modstand i en inhalator |
KR20180079458A (ko) | 2009-06-12 | 2018-07-10 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
JP5784622B2 (ja) | 2009-11-03 | 2015-09-24 | マンカインド コーポレ−ション | 吸入活動をシミュレートするための装置及び方法 |
RU2531455C2 (ru) | 2010-06-21 | 2014-10-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
JP6133270B2 (ja) | 2011-04-01 | 2017-05-24 | マンカインド コーポレイション | 薬剤カートリッジのためのブリスター包装 |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
MX2014004983A (es) | 2011-10-24 | 2014-09-22 | Mannkid Corp | Metodos y composiciones para tratar dolor. |
WO2014012069A2 (en) | 2012-07-12 | 2014-01-16 | Mannkind Corporation | Dry powder drug delivery systems and methods |
US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
ES2928365T3 (es) | 2013-03-15 | 2022-11-17 | Mannkind Corp | Composiciones de dicetopiperazina microcristalina, métodos de preparación y uso del mismo |
CN114848614A (zh) | 2013-07-18 | 2022-08-05 | 曼金德公司 | 热稳定性干粉药物组合物和方法 |
US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
CN105579480B (zh) | 2013-09-30 | 2019-02-22 | 诺华股份有限公司 | 用于制备吸收uv的眼用透镜的方法 |
US9568645B2 (en) | 2013-09-30 | 2017-02-14 | Novartis Ag | Silicone hydrogel lenses with relatively-long thermal stability |
CA2921303C (en) | 2013-09-30 | 2018-04-24 | Novartis Ag | Silicone hydrogel lenses with relatively-long thermal stability |
WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3057861A (en) * | 1962-10-09 | Basic derivatives of trifluoromethyl- | ||
US3084191A (en) * | 1957-08-26 | 1963-04-02 | American Cyanamid Co | N-substituted acrylamide |
NL297737A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1962-09-11 | |||
US3534099A (en) * | 1967-05-25 | 1970-10-13 | Gulf Research Development Co | Process for making n - substituted and n,n-substituted carboxylic acid amides |
GB1285390A (en) * | 1969-12-23 | 1972-08-16 | Pharmacia Ab | Improvements in the n-alkylation of acylated amino compounds |
GB1359673A (en) * | 1971-06-09 | 1974-07-10 | Procter & Gamble Ltd | Quaternary ammonium compounds and surface treating compositions |
US3852350A (en) * | 1972-09-05 | 1974-12-03 | Goodyear Tire & Rubber | Process of preparing amides |
US4008066A (en) * | 1974-04-08 | 1977-02-15 | Ciba-Geigy Corporation | Phenylaminoacetamides for regulating plant growth |
US4113774A (en) * | 1977-09-09 | 1978-09-12 | Sterling Drug Inc. | N-(Dichloroacetyl) diamine compounds and process of preparing same |
US4258196A (en) * | 1978-04-17 | 1981-03-24 | Monsanto Company | Process for the production of tertiary 2-haloacetamides |
US4288592A (en) * | 1979-04-30 | 1981-09-08 | American Cyanamid Company | Process for preparing amides by reaction in presence of molecular sieve |
-
1982
- 1982-01-07 GB GB8200372A patent/GB2092136B/en not_active Expired
- 1982-01-12 DE DE3249628A patent/DE3249628C2/de not_active Expired - Lifetime
- 1982-01-12 DE DE19823200648 patent/DE3200648A1/de active Granted
- 1982-01-12 CH CH155/82A patent/CH648288A5/de not_active IP Right Cessation
- 1982-01-12 DE DE3249630A patent/DE3249630C2/de not_active Expired
- 1982-01-13 NL NLAANVRAGE8200109,A patent/NL187805C/xx not_active IP Right Cessation
- 1982-01-15 FR FR8200623A patent/FR2498182B1/fr not_active Expired
-
1986
- 1986-07-02 US US06/881,087 patent/US4835312A/en not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
Beilstein, Handbuch der organischen Chemie, 1935, S. 55 * |
Also Published As
Publication number | Publication date |
---|---|
DE3249628C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-12-13 |
GB2092136A (en) | 1982-08-11 |
NL187805B (nl) | 1991-08-16 |
FR2498182B1 (fr) | 1985-09-06 |
US4835312A (en) | 1989-05-30 |
CH648288A5 (de) | 1985-03-15 |
DE3249630C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1989-06-01 |
NL187805C (nl) | 1992-01-16 |
DE3200648A1 (de) | 1982-09-02 |
GB2092136B (en) | 1985-06-05 |
NL8200109A (nl) | 1982-08-16 |
FR2498182A1 (fr) | 1982-07-23 |
DE3200648C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1987-07-02 |
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