DE3165862D1 - Bicyclic compounds, their production and use - Google Patents

Bicyclic compounds, their production and use

Info

Publication number
DE3165862D1
DE3165862D1 DE8181304940T DE3165862T DE3165862D1 DE 3165862 D1 DE3165862 D1 DE 3165862D1 DE 8181304940 T DE8181304940 T DE 8181304940T DE 3165862 T DE3165862 T DE 3165862T DE 3165862 D1 DE3165862 D1 DE 3165862D1
Authority
DE
Germany
Prior art keywords
production
bicyclic compounds
bicyclic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181304940T
Other languages
English (en)
Inventor
Yoshikazu Oka
Kohei Nishikawa
Akio Miyake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP55154394A external-priority patent/JPS5777651A/ja
Priority claimed from JP56064371A external-priority patent/JPS57179141A/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE3165862D1 publication Critical patent/DE3165862D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE8181304940T 1980-10-31 1981-10-21 Bicyclic compounds, their production and use Expired DE3165862D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP55154394A JPS5777651A (en) 1980-10-31 1980-10-31 Indane derivative and its preparation
JP56064371A JPS57179141A (en) 1981-04-28 1981-04-28 Bicyclic compound and its preparation

Publications (1)

Publication Number Publication Date
DE3165862D1 true DE3165862D1 (en) 1984-10-11

Family

ID=26405485

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181304940T Expired DE3165862D1 (en) 1980-10-31 1981-10-21 Bicyclic compounds, their production and use

Country Status (19)

Country Link
US (3) US4822818A (de)
EP (1) EP0051391B1 (de)
KR (1) KR880000890B1 (de)
AU (1) AU543804B2 (de)
CA (1) CA1287444C (de)
DE (1) DE3165862D1 (de)
DK (1) DK164917C (de)
ES (3) ES8306710A1 (de)
FI (1) FI73698C (de)
GB (1) GB2086393B (de)
GR (1) GR75368B (de)
HK (1) HK19887A (de)
HU (1) HU183652B (de)
IE (1) IE51918B1 (de)
MY (1) MY8500500A (de)
NO (1) NO155133C (de)
NZ (1) NZ198826A (de)
PH (2) PH18357A (de)
PT (1) PT73912B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906615A (en) * 1980-12-18 1990-03-06 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
US4610816A (en) * 1980-12-18 1986-09-09 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
US4596791A (en) * 1983-03-16 1986-06-24 Usv Pharmaceutical Corp. Compounds for treating hypertension
US4666906A (en) * 1983-03-16 1987-05-19 Usv Pharmaceutical Corporation Compounds for treating hypertension
AT387717B (de) * 1983-03-16 1989-03-10 Immuno Ag Verfahren zum bestimmen von unvertraeglichkeitsreaktionen verursachenden substanzen in therapeutisch und prophylaktisch anzuwendenden blutprodukten sowie verwendung des verfahrens
US4564612A (en) * 1983-04-22 1986-01-14 Takeda Chemical Industries, Ltd. Condensed, seven-membered ring compounds and their use
US4638000A (en) * 1983-08-12 1987-01-20 Takeda Chemical Industries, Ltd. Condensed seven-membered ring compounds, their production and use
IL72523A (en) * 1983-08-12 1988-06-30 Takeda Chemical Industries Ltd 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them
GB8414987D0 (en) * 1984-06-12 1984-07-18 Beecham Group Plc Active compounds
EP0187037A3 (de) * 1984-12-21 1988-03-23 Takeda Chemical Industries, Ltd. Piperidinderivate, deren Herstellung und Benützung
DK100788A (da) * 1987-03-04 1988-09-05 Takeda Chemical Industries Ltd Fremgangsmaade til fremstilling af indanderivater
EP0284510A3 (de) * 1987-03-24 1990-08-22 Asahi Breweries, Ltd. N-[N-alpha-(1(S)-carboxy-3-cyclohexylpropyl)-L-lysyl]-N-cyclopentylglycin als antihypertensives Mittel
US4956490A (en) * 1989-03-09 1990-09-11 Merck & Co., Inc. Process for preparing benzylpyruvic acids and esters
IT1232160B (it) * 1989-07-31 1992-01-25 Sigma Tau Ind Farmaceuti 2-(n-acil)ammino-6,7-dimetossi tetraline, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' antiipertensiva che le contengono
DE4021108A1 (de) * 1990-07-03 1992-01-09 Bayer Ag Optisch aktive n-(alpha)-fluoracryloyl-aminosaeure-derivate, ihre herstellung, die daraus hergestellten optisch aktiven polymeren und deren verwendung zur spaltung von racematen
DE4123248C2 (de) * 1991-07-13 1996-03-07 Degussa Verfahren zur Herstellung von N-substituierten alpha-Aminosäuren und alpha-Aminosäure-Derivaten
US5977160A (en) * 1992-04-10 1999-11-02 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
TWI243164B (en) * 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
KR20030046079A (ko) * 2001-12-05 2003-06-12 주식회사 코오롱 고순도 염산 델라프릴의 신규한 정제방법
EP1617835B1 (de) * 2003-04-30 2011-09-28 Wellstat Therapeutics Corporation Verbindungen zur behandlung von stoffwechselstörungen
CA2526730A1 (en) * 2003-05-30 2004-12-09 Ranbaxy Laboratories Limited Substituted pyrrole derivatives
SG166829A1 (en) * 2005-11-08 2010-12-29 Ranbaxy Lab Ltd Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
AR059838A1 (es) * 2006-03-14 2008-04-30 Ranbaxy Lab Ltd Formulaciones para dosis estabilizantes de estatina
ITMI20061364A1 (it) * 2006-07-13 2008-01-14 Dipharma Spa Procedimento per la preparazione di delapril
BRPI0714361A2 (pt) * 2006-07-14 2013-03-26 Ranbaxy Lab Ltd polimorfo cristalino, composiÇço farmacÊutica contendo o mesmo, mÉtodo para sua preparaÇço e mÉtodo de tratamento
WO2014202659A1 (en) 2013-06-21 2014-12-24 Sanofi-Aventis Deutschland Gmbh Process for the preparation of amides of n-[1-(s)-(ethoxycarbonyl)-3-phenylpropyl]-l-alanine
WO2022238507A1 (en) * 2021-05-11 2022-11-17 Awakn Ls Europe Holdings Limited Therapeutic aminoindane compounds and compositions

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
FR2395998A1 (fr) * 1977-06-29 1979-01-26 Yoshitomi Pharmaceutical Nouveaux derives de la thiazolidine et leur application dans le traitement de l'hypertension
LU78804A1 (de) * 1977-12-30 1979-07-20 Byk Gulden Lomberg Chem Fab N-substituierte w-aminoalkanoyl-w-aminoalkansaeuren,ihre verwendung und verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
US4243678A (en) * 1977-12-30 1981-01-06 Byk Gulden Lomberg Chemische Fabrik Gmbh Acylhydrocarbylaminoalkanoic acids, compositions and uses
US4316896A (en) * 1978-09-07 1982-02-23 Merck & Co., Inc. Aminoacid derivatives as antihypertensives
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4256761A (en) * 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides
DE3040021A1 (de) * 1980-10-23 1982-05-13 Windmöller & Hölscher, 4540 Lengerich Vorrichtung zum bilden und stapeln von von einer folienschlauchbahn abgetrennten abschnitten
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4820729A (en) * 1981-03-30 1989-04-11 Rorer Pharmaceutical Corporation N-substituted-amido-amino acids

Also Published As

Publication number Publication date
DK164917C (da) 1993-02-01
ES515269A0 (es) 1983-12-01
MY8500500A (en) 1985-12-31
DK164917B (da) 1992-09-07
PT73912B (en) 1983-01-25
ES506714A0 (es) 1983-06-01
AU543804B2 (en) 1985-05-02
FI73698C (fi) 1987-11-09
ES524148A0 (es) 1985-05-01
NO155133C (no) 1987-02-18
GR75368B (de) 1984-07-13
IE51918B1 (en) 1987-04-29
NO813662L (no) 1982-05-03
KR880000890B1 (ko) 1988-05-30
EP0051391B1 (de) 1984-09-05
US4822818A (en) 1989-04-18
IE812471L (en) 1982-04-30
ES8401445A1 (es) 1983-12-01
NZ198826A (en) 1984-07-06
PH21390A (en) 1987-10-15
FI813383L (fi) 1982-05-01
HU183652B (en) 1984-05-28
PT73912A (en) 1981-11-01
PH18357A (en) 1985-06-05
ES8504671A1 (es) 1985-05-01
DK478181A (da) 1982-05-01
GB2086393B (en) 1984-01-11
AU7652181A (en) 1982-05-06
US5098892A (en) 1992-03-24
NO155133B (no) 1986-11-10
US4474692A (en) 1984-10-02
EP0051391A1 (de) 1982-05-12
HK19887A (en) 1987-03-13
CA1287444C (en) 1991-08-06
ES8306710A1 (es) 1983-06-01
FI73698B (fi) 1987-07-31
GB2086393A (en) 1982-05-12
KR830007514A (ko) 1983-10-21

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee