JPS57179141A - Bicyclic compound and its preparation - Google Patents

Bicyclic compound and its preparation

Info

Publication number
JPS57179141A
JPS57179141A JP56064371A JP6437181A JPS57179141A JP S57179141 A JPS57179141 A JP S57179141A JP 56064371 A JP56064371 A JP 56064371A JP 6437181 A JP6437181 A JP 6437181A JP S57179141 A JPS57179141 A JP S57179141A
Authority
JP
Japan
Prior art keywords
compound shown
formula
lower alkyl
formulai
enzyme capable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56064371A
Other languages
Japanese (ja)
Other versions
JPH0223538B2 (en
Inventor
Yoshikazu Oka
Kohei Nishikawa
Akio Miyake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP56064371A priority Critical patent/JPS57179141A/en
Priority to AU76521/81A priority patent/AU543804B2/en
Priority to US06/312,639 priority patent/US4822818A/en
Priority to DE8181304940T priority patent/DE3165862D1/en
Priority to AT81304940T priority patent/ATE9220T1/en
Priority to IE2471/81A priority patent/IE51918B1/en
Priority to EP81304940A priority patent/EP0051391B1/en
Priority to GB8131719A priority patent/GB2086393B/en
Priority to FI813383A priority patent/FI73698C/en
Priority to PH26409A priority patent/PH18357A/en
Priority to DK478181A priority patent/DK164917C/en
Priority to HU813176A priority patent/HU183652B/en
Priority to KR1019810004142A priority patent/KR880000890B1/en
Priority to GR66380A priority patent/GR75368B/el
Priority to CA000389042A priority patent/CA1287444C/en
Priority to MX7586A priority patent/MX154997A/en
Priority to NO813662A priority patent/NO155133C/en
Priority to IL64168A priority patent/IL64168A0/en
Priority to NZ198826A priority patent/NZ198826A/en
Priority to PT73912A priority patent/PT73912B/en
Priority to ES506714A priority patent/ES8306710A1/en
Priority to ES515269A priority patent/ES515269A0/en
Publication of JPS57179141A publication Critical patent/JPS57179141A/en
Priority to US06/494,061 priority patent/US4474692A/en
Priority to ES524148A priority patent/ES8504671A1/en
Priority to PH29829A priority patent/PH21390A/en
Priority to CA000468185A priority patent/CA1287446C/en
Priority to MY500/85A priority patent/MY8500500A/en
Priority to NO862859A priority patent/NO157103C/en
Priority to KR1019860009085A priority patent/KR880001007B1/en
Priority to HK198/87A priority patent/HK19887A/en
Priority to US07/302,940 priority patent/US5098892A/en
Publication of JPH0223538B2 publication Critical patent/JPH0223538B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:A compound shown by the formulaI(R<1> and R<2> are H, OH, or lower alkoxy; R<3> is H or lower alkyl; R<4> is H or lower alkyl; R<5> is H, lower alkyl, or aralkyl; R<6> is OH, lower alkoxy, amino, etc.; m and n are 1 or 2), or its salt. EXAMPLE:N-( 1-Ethoxycarbonyl-8-phenylpropyl )-L-alanyl-N-( indane-2-yl )glycine hydrochloride. USE:Having inhibitory actions on an enzyme capable of converting angiotensin and an enzyme capable of decomposing bradykinin, useful as diagnosticum, preventive or remedy for hypertension, or as an anodyne. PROCESS:A compound shown by the formula II is condensed with a compound shown by the formula III by contact reduction, etc. in the presence of a catalyst such as Pt, etc., to give a compound shown by the formulaI. The reaction temperature is preferably -20-100 deg.C. The starting raw material, the compound shown by the formula II, is obtained by reducing a compound shown by the formula IV with a compound shown by the formula V.
JP56064371A 1980-10-31 1981-04-28 Bicyclic compound and its preparation Granted JPS57179141A (en)

Priority Applications (31)

Application Number Priority Date Filing Date Title
JP56064371A JPS57179141A (en) 1981-04-28 1981-04-28 Bicyclic compound and its preparation
AU76521/81A AU543804B2 (en) 1980-10-31 1981-10-16 Amides having bicyclic substituents on nitrogen
US06/312,639 US4822818A (en) 1980-10-31 1981-10-19 Bicycle compounds, their production and use
DE8181304940T DE3165862D1 (en) 1980-10-31 1981-10-21 Bicyclic compounds, their production and use
AT81304940T ATE9220T1 (en) 1980-10-31 1981-10-21 BICYCLIC COMPOUNDS, THEIR PRODUCTION AND USE.
IE2471/81A IE51918B1 (en) 1980-10-31 1981-10-21 Bicyclic compounds their production and use
EP81304940A EP0051391B1 (en) 1980-10-31 1981-10-21 Bicyclic compounds, their production and use
GB8131719A GB2086393B (en) 1980-10-31 1981-10-21 Bicyclic compounds
FI813383A FI73698C (en) 1980-10-31 1981-10-28 Process for the preparation of novel pharmaceutically active N-indanylg lycin derivatives.
PH26409A PH18357A (en) 1980-10-31 1981-10-28 Bicyclic compounds,their production and use
MX7586A MX154997A (en) 1980-10-31 1981-10-29 PROCEDURE TO PREPARE BICYCLE COMPOUNDS
HU813176A HU183652B (en) 1980-10-31 1981-10-29 Process for preparing bicyclic compounds
KR1019810004142A KR880000890B1 (en) 1980-10-31 1981-10-29 Process for the preparation of bicyclic compound
GR66380A GR75368B (en) 1980-10-31 1981-10-29
CA000389042A CA1287444C (en) 1980-10-31 1981-10-29 Bicyclic compounds, their production and use
DK478181A DK164917C (en) 1980-10-31 1981-10-29 ANALOGY PROCEDURE FOR THE PREPARATION OF BICYCLICALLY SUBSTITUTED DIPEPTIDE DERIVATIVES AND THEIR PHARMACEUTICAL ACCEPTABLE SALTS
NO813662A NO155133C (en) 1980-10-31 1981-10-29 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE DICYCLIC RELATIONS.
IL64168A IL64168A0 (en) 1980-10-31 1981-10-30 Carboxamidoindan and naphthalene derivatives,their production and pharmaceutical compositions containing them
NZ198826A NZ198826A (en) 1980-10-31 1981-10-30 Bicyclic compounds and pharmaceutical compositions
PT73912A PT73912B (en) 1980-10-31 1981-10-30 Bicyclic compounds their production and use
ES506714A ES8306710A1 (en) 1980-10-31 1981-10-30 Bicyclic compounds, their production and use.
ES515269A ES515269A0 (en) 1980-10-31 1982-08-26 A PROCEDURE TO OBTAIN BICYCLE COMPOUNDS DERIVED FROM INDANO OR BENZOCICLOHEXANO.
US06/494,061 US4474692A (en) 1980-10-31 1983-05-12 L-Alanyl-N-(indan-2-yl)glycine, its esters and salts thereof
ES524148A ES8504671A1 (en) 1980-10-31 1983-07-15 Bicyclic compounds, their production and use.
PH29829A PH21390A (en) 1980-10-31 1983-10-12 Process for producing l-alanyl-n-(indian-2-yl)glycine derivatives
CA000468185A CA1287446C (en) 1980-10-31 1984-11-19 Bicyclic compounds, their production and use
MY500/85A MY8500500A (en) 1980-10-31 1985-12-30 Bicyclic compounds their production and use
NO862859A NO157103C (en) 1980-10-31 1986-07-15 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE DICYCLIC COMPOUNDS.
KR1019860009085A KR880001007B1 (en) 1980-10-31 1986-10-29 Process for the preparation of bicyclic compound
HK198/87A HK19887A (en) 1980-10-31 1987-03-05 Bicyclic compounds,their production and use
US07/302,940 US5098892A (en) 1980-10-31 1989-01-30 Process for preparation of bicyclic compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56064371A JPS57179141A (en) 1981-04-28 1981-04-28 Bicyclic compound and its preparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP3000087A Division JPS632963A (en) 1987-02-12 1987-02-12 Production of bicyclic compound

Publications (2)

Publication Number Publication Date
JPS57179141A true JPS57179141A (en) 1982-11-04
JPH0223538B2 JPH0223538B2 (en) 1990-05-24

Family

ID=13256352

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56064371A Granted JPS57179141A (en) 1980-10-31 1981-04-28 Bicyclic compound and its preparation

Country Status (1)

Country Link
JP (1) JPS57179141A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6251650A (en) * 1985-08-27 1987-03-06 チバ・ガイギ−・アクチエンゲゼルシヤフト Hydropyridine derivative and 3-aminopropionic acid derivative, manufacture and use as drug

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6251650A (en) * 1985-08-27 1987-03-06 チバ・ガイギ−・アクチエンゲゼルシヤフト Hydropyridine derivative and 3-aminopropionic acid derivative, manufacture and use as drug
JPH055828B2 (en) * 1985-08-27 1993-01-25 Ciba Geigy

Also Published As

Publication number Publication date
JPH0223538B2 (en) 1990-05-24

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