JPS57179141A - Bicyclic compound and its preparation - Google Patents
Bicyclic compound and its preparationInfo
- Publication number
- JPS57179141A JPS57179141A JP56064371A JP6437181A JPS57179141A JP S57179141 A JPS57179141 A JP S57179141A JP 56064371 A JP56064371 A JP 56064371A JP 6437181 A JP6437181 A JP 6437181A JP S57179141 A JPS57179141 A JP S57179141A
- Authority
- JP
- Japan
- Prior art keywords
- compound shown
- formula
- lower alkyl
- formulai
- enzyme capable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
NEW MATERIAL:A compound shown by the formulaI(R<1> and R<2> are H, OH, or lower alkoxy; R<3> is H or lower alkyl; R<4> is H or lower alkyl; R<5> is H, lower alkyl, or aralkyl; R<6> is OH, lower alkoxy, amino, etc.; m and n are 1 or 2), or its salt. EXAMPLE:N-( 1-Ethoxycarbonyl-8-phenylpropyl )-L-alanyl-N-( indane-2-yl )glycine hydrochloride. USE:Having inhibitory actions on an enzyme capable of converting angiotensin and an enzyme capable of decomposing bradykinin, useful as diagnosticum, preventive or remedy for hypertension, or as an anodyne. PROCESS:A compound shown by the formula II is condensed with a compound shown by the formula III by contact reduction, etc. in the presence of a catalyst such as Pt, etc., to give a compound shown by the formulaI. The reaction temperature is preferably -20-100 deg.C. The starting raw material, the compound shown by the formula II, is obtained by reducing a compound shown by the formula IV with a compound shown by the formula V.
Priority Applications (31)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56064371A JPS57179141A (en) | 1981-04-28 | 1981-04-28 | Bicyclic compound and its preparation |
AU76521/81A AU543804B2 (en) | 1980-10-31 | 1981-10-16 | Amides having bicyclic substituents on nitrogen |
US06/312,639 US4822818A (en) | 1980-10-31 | 1981-10-19 | Bicycle compounds, their production and use |
DE8181304940T DE3165862D1 (en) | 1980-10-31 | 1981-10-21 | Bicyclic compounds, their production and use |
AT81304940T ATE9220T1 (en) | 1980-10-31 | 1981-10-21 | BICYCLIC COMPOUNDS, THEIR PRODUCTION AND USE. |
IE2471/81A IE51918B1 (en) | 1980-10-31 | 1981-10-21 | Bicyclic compounds their production and use |
EP81304940A EP0051391B1 (en) | 1980-10-31 | 1981-10-21 | Bicyclic compounds, their production and use |
GB8131719A GB2086393B (en) | 1980-10-31 | 1981-10-21 | Bicyclic compounds |
FI813383A FI73698C (en) | 1980-10-31 | 1981-10-28 | Process for the preparation of novel pharmaceutically active N-indanylg lycin derivatives. |
PH26409A PH18357A (en) | 1980-10-31 | 1981-10-28 | Bicyclic compounds,their production and use |
MX7586A MX154997A (en) | 1980-10-31 | 1981-10-29 | PROCEDURE TO PREPARE BICYCLE COMPOUNDS |
HU813176A HU183652B (en) | 1980-10-31 | 1981-10-29 | Process for preparing bicyclic compounds |
KR1019810004142A KR880000890B1 (en) | 1980-10-31 | 1981-10-29 | Process for the preparation of bicyclic compound |
GR66380A GR75368B (en) | 1980-10-31 | 1981-10-29 | |
CA000389042A CA1287444C (en) | 1980-10-31 | 1981-10-29 | Bicyclic compounds, their production and use |
DK478181A DK164917C (en) | 1980-10-31 | 1981-10-29 | ANALOGY PROCEDURE FOR THE PREPARATION OF BICYCLICALLY SUBSTITUTED DIPEPTIDE DERIVATIVES AND THEIR PHARMACEUTICAL ACCEPTABLE SALTS |
NO813662A NO155133C (en) | 1980-10-31 | 1981-10-29 | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE DICYCLIC RELATIONS. |
IL64168A IL64168A0 (en) | 1980-10-31 | 1981-10-30 | Carboxamidoindan and naphthalene derivatives,their production and pharmaceutical compositions containing them |
NZ198826A NZ198826A (en) | 1980-10-31 | 1981-10-30 | Bicyclic compounds and pharmaceutical compositions |
PT73912A PT73912B (en) | 1980-10-31 | 1981-10-30 | Bicyclic compounds their production and use |
ES506714A ES8306710A1 (en) | 1980-10-31 | 1981-10-30 | Bicyclic compounds, their production and use. |
ES515269A ES515269A0 (en) | 1980-10-31 | 1982-08-26 | A PROCEDURE TO OBTAIN BICYCLE COMPOUNDS DERIVED FROM INDANO OR BENZOCICLOHEXANO. |
US06/494,061 US4474692A (en) | 1980-10-31 | 1983-05-12 | L-Alanyl-N-(indan-2-yl)glycine, its esters and salts thereof |
ES524148A ES8504671A1 (en) | 1980-10-31 | 1983-07-15 | Bicyclic compounds, their production and use. |
PH29829A PH21390A (en) | 1980-10-31 | 1983-10-12 | Process for producing l-alanyl-n-(indian-2-yl)glycine derivatives |
CA000468185A CA1287446C (en) | 1980-10-31 | 1984-11-19 | Bicyclic compounds, their production and use |
MY500/85A MY8500500A (en) | 1980-10-31 | 1985-12-30 | Bicyclic compounds their production and use |
NO862859A NO157103C (en) | 1980-10-31 | 1986-07-15 | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE DICYCLIC COMPOUNDS. |
KR1019860009085A KR880001007B1 (en) | 1980-10-31 | 1986-10-29 | Process for the preparation of bicyclic compound |
HK198/87A HK19887A (en) | 1980-10-31 | 1987-03-05 | Bicyclic compounds,their production and use |
US07/302,940 US5098892A (en) | 1980-10-31 | 1989-01-30 | Process for preparation of bicyclic compounds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56064371A JPS57179141A (en) | 1981-04-28 | 1981-04-28 | Bicyclic compound and its preparation |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3000087A Division JPS632963A (en) | 1987-02-12 | 1987-02-12 | Production of bicyclic compound |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57179141A true JPS57179141A (en) | 1982-11-04 |
JPH0223538B2 JPH0223538B2 (en) | 1990-05-24 |
Family
ID=13256352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56064371A Granted JPS57179141A (en) | 1980-10-31 | 1981-04-28 | Bicyclic compound and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57179141A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6251650A (en) * | 1985-08-27 | 1987-03-06 | チバ・ガイギ−・アクチエンゲゼルシヤフト | Hydropyridine derivative and 3-aminopropionic acid derivative, manufacture and use as drug |
-
1981
- 1981-04-28 JP JP56064371A patent/JPS57179141A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6251650A (en) * | 1985-08-27 | 1987-03-06 | チバ・ガイギ−・アクチエンゲゼルシヤフト | Hydropyridine derivative and 3-aminopropionic acid derivative, manufacture and use as drug |
JPH055828B2 (en) * | 1985-08-27 | 1993-01-25 | Ciba Geigy |
Also Published As
Publication number | Publication date |
---|---|
JPH0223538B2 (en) | 1990-05-24 |
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