DE3142853A1 - Feste arzneizubereitungen mit nifedipin und verfahren zu ihrer herstellung - Google Patents

Feste arzneizubereitungen mit nifedipin und verfahren zu ihrer herstellung

Info

Publication number
DE3142853A1
DE3142853A1 DE19813142853 DE3142853A DE3142853A1 DE 3142853 A1 DE3142853 A1 DE 3142853A1 DE 19813142853 DE19813142853 DE 19813142853 DE 3142853 A DE3142853 A DE 3142853A DE 3142853 A1 DE3142853 A1 DE 3142853A1
Authority
DE
Germany
Prior art keywords
weight
nifedipine
parts
solid
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19813142853
Other languages
German (de)
English (en)
Other versions
DE3142853C2 (enrdf_load_stackoverflow
Inventor
Ahmed Dr. 5090 Leverkusen Hegasy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE19813142853 priority Critical patent/DE3142853A1/de
Priority to DE8282109572T priority patent/DE3270785D1/de
Priority to AT82109572T priority patent/ATE19353T1/de
Priority to EP82109572A priority patent/EP0078430B2/de
Priority to JP57186884A priority patent/JPS5883617A/ja
Priority to CA000414265A priority patent/CA1184118A/en
Publication of DE3142853A1 publication Critical patent/DE3142853A1/de
Priority to US06/864,677 priority patent/US4882144A/en
Priority to JP61223924A priority patent/JPS62228017A/ja
Priority to US07/247,009 priority patent/US4892730A/en
Priority to US07/355,617 priority patent/US4981683A/en
Application granted granted Critical
Publication of DE3142853C2 publication Critical patent/DE3142853C2/de
Priority to US07/647,611 priority patent/USRE33963E/en
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19813142853 1981-10-29 1981-10-29 Feste arzneizubereitungen mit nifedipin und verfahren zu ihrer herstellung Granted DE3142853A1 (de)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE19813142853 DE3142853A1 (de) 1981-10-29 1981-10-29 Feste arzneizubereitungen mit nifedipin und verfahren zu ihrer herstellung
DE8282109572T DE3270785D1 (en) 1981-10-29 1982-10-16 Process for preparing solid fast-releasing drug formulations of dihydropyridines
AT82109572T ATE19353T1 (de) 1981-10-29 1982-10-16 Verfahren zur herstellung von festen, schnellfreisetzenden arzneizubereitungen mit dihydropyridinen.
EP82109572A EP0078430B2 (de) 1981-10-29 1982-10-16 Verfahren zur Herstellung von festen, schnellfreisetzenden Arzneizubereitungen mit Dihydropyridinen
JP57186884A JPS5883617A (ja) 1981-10-29 1982-10-26 ジヒドロピリジンを含有する固体の迅速放出性薬剤調製物及びその製造方法
CA000414265A CA1184118A (en) 1981-10-29 1982-10-27 Solid, rapidly released medicament preparations containing dihydropyridines, and processes for their preparation
US06/864,677 US4882144A (en) 1981-10-29 1986-05-19 Solid, rapidly released medicament preparations containing dihydropyridines, and processes for their preparation
JP61223924A JPS62228017A (ja) 1981-10-29 1986-09-24 ジヒドロピリジンを含有する固体の迅速放出性薬剤調製物の製造方法
US07/247,009 US4892730A (en) 1981-10-29 1988-09-20 Processes for preparation of solid, rapidly released medicament preparations containing dihydropyridines
US07/355,617 US4981683A (en) 1981-10-29 1989-05-23 Solid, rapidly released medicament preparations containing dihydropyridines, and processes for their preparation
US07/647,611 USRE33963E (en) 1981-10-29 1991-01-28 Solid rapidly released medicament preparations containing dihydropyridines, and processes for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813142853 DE3142853A1 (de) 1981-10-29 1981-10-29 Feste arzneizubereitungen mit nifedipin und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
DE3142853A1 true DE3142853A1 (de) 1983-05-11
DE3142853C2 DE3142853C2 (enrdf_load_stackoverflow) 1989-06-29

Family

ID=6145080

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19813142853 Granted DE3142853A1 (de) 1981-10-29 1981-10-29 Feste arzneizubereitungen mit nifedipin und verfahren zu ihrer herstellung

Country Status (2)

Country Link
JP (2) JPS5883617A (enrdf_load_stackoverflow)
DE (1) DE3142853A1 (enrdf_load_stackoverflow)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4562069A (en) * 1983-05-21 1985-12-31 Bayer Aktiengesellschaft Two-phase formulation
US4665081A (en) * 1982-12-02 1987-05-12 Takada Seiyaku Kabushiki Kaisha Solid nifedipine preparations and a process for preparing same
US4724141A (en) * 1984-09-11 1988-02-09 Bayer Aktiengesellschaft Preparation of solid medicament formulation containing nitrendipine
US4794111A (en) * 1984-05-23 1988-12-27 Bayer Aktiengesellschaft Dihydropyridine preparations containing β-blockers
US5543099A (en) * 1994-09-29 1996-08-06 Hallmark Pharmaceutical, Inc. Process to manufacture micronized nifedipine granules for sustained release medicaments

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3142853A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen mit nifedipin und verfahren zu ihrer herstellung
DE3424553A1 (de) * 1984-07-04 1986-01-09 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen mit dihydropyridinen und verfahren zu ihrer herstellung
DE19515972A1 (de) * 1995-05-02 1996-11-07 Bayer Ag Arzneizubereitungen mit kontrollierter Freisetzung und Verfahren zu ihrer Herstellung
TW527195B (en) 1997-10-09 2003-04-11 Ssp Co Ltd Fast-soluble solid pharmaceutical combinations
JP4509118B2 (ja) * 2004-10-06 2010-07-21 エルメッド エーザイ株式会社 医薬組成物及びその製造方法、並びに医薬組成物におけるジヒドロピリジン系化合物の安定化方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2121805A1 (enrdf_load_stackoverflow) * 1971-01-13 1972-08-25 Sandoz Sa
DE2822822A1 (de) * 1977-05-25 1978-12-07 Ducellier & Cie Scheibenwischer-wischblatt insbesondere fuer kraftfahrzeuge

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5283919A (en) * 1976-01-01 1977-07-13 Sandoz Ag Pharmaceutical tablet
JPS5420127A (en) * 1977-07-14 1979-02-15 Yamanouchi Pharmaceut Co Ltd Solid nifedipine preparaton
GB1579818A (en) * 1977-06-07 1980-11-26 Yamanouchi Pharma Co Ltd Nifedipine-containing solid preparation composition
JPS542316A (en) * 1977-06-07 1979-01-09 Yamanouchi Pharmaceut Co Ltd Solid pharmaceutical composition containing nifedipene
DE2815578C2 (de) * 1978-04-11 1986-01-16 Bayer Ag, 5090 Leverkusen Neue pharmazeutische Verwendung von Nimodipin
DE3142853A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen mit nifedipin und verfahren zu ihrer herstellung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2121805A1 (enrdf_load_stackoverflow) * 1971-01-13 1972-08-25 Sandoz Sa
DE2822822A1 (de) * 1977-05-25 1978-12-07 Ducellier & Cie Scheibenwischer-wischblatt insbesondere fuer kraftfahrzeuge

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
C.A. 78, 140375 m *
C.A. 86, 195218 h *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4665081A (en) * 1982-12-02 1987-05-12 Takada Seiyaku Kabushiki Kaisha Solid nifedipine preparations and a process for preparing same
US4562069A (en) * 1983-05-21 1985-12-31 Bayer Aktiengesellschaft Two-phase formulation
US4794111A (en) * 1984-05-23 1988-12-27 Bayer Aktiengesellschaft Dihydropyridine preparations containing β-blockers
US4724141A (en) * 1984-09-11 1988-02-09 Bayer Aktiengesellschaft Preparation of solid medicament formulation containing nitrendipine
US5543099A (en) * 1994-09-29 1996-08-06 Hallmark Pharmaceutical, Inc. Process to manufacture micronized nifedipine granules for sustained release medicaments

Also Published As

Publication number Publication date
JPS62228017A (ja) 1987-10-06
JPS5883617A (ja) 1983-05-19
JPH0338248B2 (enrdf_load_stackoverflow) 1991-06-10
DE3142853C2 (enrdf_load_stackoverflow) 1989-06-29

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8363 Opposition against the patent
8330 Complete disclaimer