DE3104190A1 - Mittel zur steigerung der ovulationsrate von rindern und seine verwendung - Google Patents
Mittel zur steigerung der ovulationsrate von rindern und seine verwendungInfo
- Publication number
- DE3104190A1 DE3104190A1 DE19813104190 DE3104190A DE3104190A1 DE 3104190 A1 DE3104190 A1 DE 3104190A1 DE 19813104190 DE19813104190 DE 19813104190 DE 3104190 A DE3104190 A DE 3104190A DE 3104190 A1 DE3104190 A1 DE 3104190A1
- Authority
- DE
- Germany
- Prior art keywords
- steroid
- cattle
- immunogenic
- ovulation rate
- steroid derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000016087 ovulation Effects 0.000 title claims description 37
- 150000003431 steroids Chemical class 0.000 claims description 59
- 230000002163 immunogen Effects 0.000 claims description 41
- 241000283690 Bos taurus Species 0.000 claims description 34
- 239000003795 chemical substances by application Substances 0.000 claims description 31
- 102000004169 proteins and genes Human genes 0.000 claims description 23
- 108090000623 proteins and genes Proteins 0.000 claims description 23
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims description 14
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 claims description 13
- 239000003098 androgen Substances 0.000 claims description 13
- 229940011871 estrogen Drugs 0.000 claims description 11
- 239000000262 estrogen Substances 0.000 claims description 11
- 238000011282 treatment Methods 0.000 claims description 11
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 claims description 9
- 229960003399 estrone Drugs 0.000 claims description 9
- 239000002671 adjuvant Substances 0.000 claims description 8
- AEMFNILZOJDQLW-QAGGRKNESA-N androst-4-ene-3,17-dione Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 AEMFNILZOJDQLW-QAGGRKNESA-N 0.000 claims description 7
- 229960005471 androstenedione Drugs 0.000 claims description 7
- AEMFNILZOJDQLW-UHFFFAOYSA-N androstenedione Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 AEMFNILZOJDQLW-UHFFFAOYSA-N 0.000 claims description 7
- 229960003604 testosterone Drugs 0.000 claims description 7
- 150000008065 acid anhydrides Chemical class 0.000 claims description 5
- 150000008064 anhydrides Chemical class 0.000 claims description 5
- 210000002966 serum Anatomy 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- XSDCLHQDGODZPZ-WWNBULGVSA-N Estra-1,3,5-(10)-trien-17-one-3-oxyacetic acid Chemical compound OC(=O)COC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 XSDCLHQDGODZPZ-WWNBULGVSA-N 0.000 claims description 3
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 108010058846 Ovalbumin Proteins 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 229940092253 ovalbumin Drugs 0.000 claims description 2
- 230000001571 immunoadjuvant effect Effects 0.000 claims 2
- 239000000568 immunological adjuvant Substances 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 229920002491 Diethylaminoethyl-dextran Polymers 0.000 claims 1
- 241001465754 Metazoa Species 0.000 description 24
- 230000003053 immunization Effects 0.000 description 22
- 238000002649 immunization Methods 0.000 description 18
- 238000000034 method Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 150000003429 steroid acids Chemical class 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 229920002307 Dextran Polymers 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 238000000502 dialysis Methods 0.000 description 5
- 230000012173 estrus Effects 0.000 description 5
- 230000002611 ovarian Effects 0.000 description 5
- 210000001672 ovary Anatomy 0.000 description 5
- 230000035558 fertility Effects 0.000 description 4
- 229940088597 hormone Drugs 0.000 description 4
- 239000005556 hormone Substances 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 239000011541 reaction mixture Substances 0.000 description 4
- 102000008100 Human Serum Albumin Human genes 0.000 description 3
- 108091006905 Human Serum Albumin Proteins 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000001076 estrogenic effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 102000006771 Gonadotropins Human genes 0.000 description 2
- 108010086677 Gonadotropins Proteins 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000001548 androgenic effect Effects 0.000 description 2
- 229940030486 androgens Drugs 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 230000004720 fertilization Effects 0.000 description 2
- 239000002622 gonadotropin Substances 0.000 description 2
- 244000144980 herd Species 0.000 description 2
- 230000008105 immune reaction Effects 0.000 description 2
- 230000009027 insemination Effects 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 2
- 238000002559 palpation Methods 0.000 description 2
- 239000000583 progesterone congener Substances 0.000 description 2
- 229940095055 progestogen systemic hormonal contraceptives Drugs 0.000 description 2
- 150000003180 prostaglandins Chemical class 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000001568 sexual effect Effects 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 1
- -1 3-dimethylaminopropyl Chemical group 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 108700012941 GNRH1 Proteins 0.000 description 1
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 150000002167 estrones Chemical class 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 231100000508 hormonal effect Toxicity 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000005567 liquid scintillation counting Methods 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 210000001625 seminal vesicle Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical class OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 201000010653 vesiculitis Diseases 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPE224180 | 1980-02-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3104190A1 true DE3104190A1 (de) | 1981-12-10 |
Family
ID=3768427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19813104190 Withdrawn DE3104190A1 (de) | 1980-02-07 | 1981-02-06 | Mittel zur steigerung der ovulationsrate von rindern und seine verwendung |
Country Status (7)
| Country | Link |
|---|---|
| AR (1) | AR230572A1 (enrdf_load_stackoverflow) |
| BR (1) | BR8100722A (enrdf_load_stackoverflow) |
| DE (1) | DE3104190A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2475395A1 (enrdf_load_stackoverflow) |
| GB (1) | GB2068973B (enrdf_load_stackoverflow) |
| IE (1) | IE50857B1 (enrdf_load_stackoverflow) |
| NZ (1) | NZ196126A (enrdf_load_stackoverflow) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8428201D0 (en) * | 1984-11-08 | 1984-12-19 | Glaxo Group Ltd | Biological preparations |
| GR1004274B (el) | 2002-07-16 | 2003-06-23 | Medexis ���� | Συμπλοκα στεροειδων ορμονων με πρωτεινες: νεες ουσιες για την ειδικη ανιχνευση και καταστροφη καρκινικων κυτταρων προερχομενων απο στερεους ογκους και αιματολογικες κακοηθειες |
| AU2003281165B2 (en) | 2002-07-16 | 2006-08-03 | Bionature E.A. Limited | Steroid conjugates, preparation thereof and the use thereof |
| CN112920399A (zh) * | 2019-12-05 | 2021-06-08 | 广东菲鹏生物有限公司 | 吖啶化合物标记类固醇激素衍生物及其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL40670A (en) * | 1972-10-25 | 1977-05-31 | Yeda Res & Dev | 7alpha-carboxy alkylthio delta4-3-oxo-steroids conjugates of these with proteins preparation of antisera specific to steroids and analytical method based on these |
| JPS5819222B2 (ja) * | 1977-06-21 | 1983-04-16 | 森永乳業株式会社 | ステロイド−血清アルブミン複合体感作ラテックス粒子の製造法 |
| US4331657A (en) * | 1980-02-06 | 1982-05-25 | Commonwealth Scientific And Industrial Research Organization | Fecundity of domestic livestock |
-
1981
- 1981-01-27 NZ NZ196126A patent/NZ196126A/en unknown
- 1981-01-28 IE IE158/81A patent/IE50857B1/en unknown
- 1981-01-29 GB GB8102696A patent/GB2068973B/en not_active Expired
- 1981-02-06 AR AR284231A patent/AR230572A1/es active
- 1981-02-06 BR BR8100722A patent/BR8100722A/pt unknown
- 1981-02-06 FR FR8102398A patent/FR2475395A1/fr active Granted
- 1981-02-06 DE DE19813104190 patent/DE3104190A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| IE810158L (en) | 1981-08-07 |
| GB2068973A (en) | 1981-08-19 |
| BR8100722A (pt) | 1981-08-18 |
| NZ196126A (en) | 1985-05-31 |
| AR230572A1 (es) | 1984-05-31 |
| IE50857B1 (en) | 1986-08-06 |
| GB2068973B (en) | 1984-05-02 |
| FR2475395B1 (enrdf_load_stackoverflow) | 1985-01-04 |
| FR2475395A1 (fr) | 1981-08-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0309863B1 (de) | Mittel und Verfahren zur Auslösung einer Immunantwort auf GnRH und Immunsterilisation von Säugern | |
| DE69007616T2 (de) | Peptid, immunogene zusammensetzung und impfstoff oder medizinische zubereitung, eine methode zur immunisierung eines säugetieres gegen lhrh und methode zur verbesserung von mea. | |
| Hisaw et al. | Relation of the follicular and corpus luteum hormones in the production of progestational proliferation of the rabbit's uterus | |
| DE2732175C2 (de) | Oxytocin-Strukturanaloga und diese Verbindungen enthaltende pharmazeutische Mittel | |
| DE69730434T2 (de) | Immunstimulierende lipidformulierung | |
| DE2421943C2 (enrdf_load_stackoverflow) | ||
| Van Heuverswyn et al. | The Progesterone-Like Activity of Desoxycorticosterone. | |
| DE3104190A1 (de) | Mittel zur steigerung der ovulationsrate von rindern und seine verwendung | |
| EP0083925B1 (de) | Verfahren zur Behandlung der Azyklie bei Schafen oder Rindern | |
| US4331657A (en) | Fecundity of domestic livestock | |
| DE3539557A1 (de) | Biologische methode | |
| US4457914A (en) | Fecundity of domestic livestock | |
| DE69330884T2 (de) | Behandlung von unfruchtbarkeit und steigerung der befruchtungsfähigkeit männlicher säugetiere durch thymosin-peptid und seine antikörper | |
| DE69423016T2 (de) | Verfahren zur Steigerung der Gewichtszunahme von Säugetieren | |
| DE2045160A1 (de) | Verfahren zur Herstellung einer Lebendvaccine gegen die infektiöse Bursitis der Huhner | |
| DE2854723B2 (de) | Hetero-Impfstoff zur therapeutischen Behandlung des Trichomonas-Syndroms und Verfahren zu seiner Herstellung | |
| EP0463138B1 (de) | Arzneimittel zur verbesserung der ovarreaktionen und der eizell- und embryonen-produktion bei haussäugetieren in verbindung mit biotechnologichem embryonentransfer | |
| EP0072880B1 (en) | A composition for use in the control of ovulation of female bovines | |
| DE960579C (de) | Verfahren zur Herstellung eines in der Hitze sterilisierbaren Adrenocorticotropin-Praeparates | |
| DE2449653C2 (de) | Tiermastmittel | |
| EP0316320B1 (en) | Reduction of reproductive losses | |
| DE1940096A1 (de) | Verfahren zur Erhoehung der Traechtigkeitsrate und der Lebendgeburten bei Kuehen | |
| DE238995C (enrdf_load_stackoverflow) | ||
| DE2702914C2 (de) | Verwendung einer injizierbaren Sterilisierungslösung zum Sterilisieren männlicher Tiere | |
| DE2425678A1 (de) | Verfahren zur herstellung eines impfstoffs gegen infektioese pferdeanaemie |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8141 | Disposal/no request for examination |