NZ196126A - Increasing ovulation rate in female cattle - Google Patents
Increasing ovulation rate in female cattleInfo
- Publication number
- NZ196126A NZ196126A NZ196126A NZ19612681A NZ196126A NZ 196126 A NZ196126 A NZ 196126A NZ 196126 A NZ196126 A NZ 196126A NZ 19612681 A NZ19612681 A NZ 19612681A NZ 196126 A NZ196126 A NZ 196126A
- Authority
- NZ
- New Zealand
- Prior art keywords
- steroid
- composition
- cattle
- androgen
- immunogenic
- Prior art date
Links
- 241000283690 Bos taurus Species 0.000 title claims description 41
- 230000016087 ovulation Effects 0.000 title claims description 39
- 150000003431 steroids Chemical class 0.000 claims description 83
- 230000002163 immunogen Effects 0.000 claims description 49
- 239000000203 mixture Substances 0.000 claims description 47
- 238000000034 method Methods 0.000 claims description 33
- 102000004169 proteins and genes Human genes 0.000 claims description 31
- 108090000623 proteins and genes Proteins 0.000 claims description 31
- 239000003098 androgen Substances 0.000 claims description 24
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 claims description 23
- 241001465754 Metazoa Species 0.000 claims description 22
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims description 22
- 239000000262 estrogen Substances 0.000 claims description 21
- AEMFNILZOJDQLW-QAGGRKNESA-N androst-4-ene-3,17-dione Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 AEMFNILZOJDQLW-QAGGRKNESA-N 0.000 claims description 13
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 claims description 11
- 230000002378 acidificating effect Effects 0.000 claims description 11
- 229960005471 androstenedione Drugs 0.000 claims description 11
- 229960003399 estrone Drugs 0.000 claims description 11
- 229960003604 testosterone Drugs 0.000 claims description 11
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 10
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 10
- AEMFNILZOJDQLW-UHFFFAOYSA-N androstenedione Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 AEMFNILZOJDQLW-UHFFFAOYSA-N 0.000 claims description 10
- 230000012173 estrus Effects 0.000 claims description 10
- 230000001571 immunoadjuvant effect Effects 0.000 claims description 9
- 239000000568 immunological adjuvant Substances 0.000 claims description 9
- 239000002671 adjuvant Substances 0.000 claims description 6
- 229940088597 hormone Drugs 0.000 claims description 6
- 239000005556 hormone Substances 0.000 claims description 6
- 108010010803 Gelatin Proteins 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 235000019322 gelatine Nutrition 0.000 claims description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims description 4
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims description 4
- 239000000583 progesterone congener Substances 0.000 claims description 4
- 150000003180 prostaglandins Chemical class 0.000 claims description 4
- 108010058846 Ovalbumin Proteins 0.000 claims description 3
- 229940092253 ovalbumin Drugs 0.000 claims description 3
- 230000001592 luteinising effect Effects 0.000 claims 2
- 239000003488 releasing hormone Substances 0.000 claims 2
- 230000001360 synchronised effect Effects 0.000 claims 2
- 229920002491 Diethylaminoethyl-dextran Polymers 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- BFUWRLFOXRAWGF-UHFFFAOYSA-N ethylsulfanylformic acid Chemical compound CCSC(O)=O BFUWRLFOXRAWGF-UHFFFAOYSA-N 0.000 claims 1
- 238000002649 immunization Methods 0.000 description 21
- 230000003053 immunization Effects 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 230000002611 ovarian Effects 0.000 description 6
- 229920002307 Dextran Polymers 0.000 description 5
- 238000000502 dialysis Methods 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 4
- 210000004246 corpus luteum Anatomy 0.000 description 4
- 230000035558 fertility Effects 0.000 description 4
- 244000144972 livestock Species 0.000 description 4
- 210000001672 ovary Anatomy 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000011541 reaction mixture Substances 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000001548 androgenic effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000021615 conjugation Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 230000001076 estrogenic effect Effects 0.000 description 2
- 244000144980 herd Species 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 230000005847 immunogenicity Effects 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 230000009027 insemination Effects 0.000 description 2
- 238000002559 palpation Methods 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
- 108700012941 GNRH1 Proteins 0.000 description 1
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 1
- 235000019738 Limestone Nutrition 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000031708 Saprospiraceae Species 0.000 description 1
- 229940030486 androgens Drugs 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 230000006003 cornification Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000004720 fertilization Effects 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 231100000508 hormonal effect Toxicity 0.000 description 1
- 230000009851 immunogenic response Effects 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000006028 limestone Substances 0.000 description 1
- 238000005567 liquid scintillation counting Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- CXHHBNMLPJOKQD-UHFFFAOYSA-N methyl hydrogen carbonate Chemical compound COC(O)=O CXHHBNMLPJOKQD-UHFFFAOYSA-N 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229940066827 pertussis vaccine Drugs 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 210000001625 seminal vesicle Anatomy 0.000 description 1
- 229960004509 serum gonadotrophin Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 150000003429 steroid acids Chemical class 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical class OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 201000010653 vesiculitis Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPE224180 | 1980-02-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ196126A true NZ196126A (en) | 1985-05-31 |
Family
ID=3768427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ196126A NZ196126A (en) | 1980-02-07 | 1981-01-27 | Increasing ovulation rate in female cattle |
Country Status (7)
| Country | Link |
|---|---|
| AR (1) | AR230572A1 (enrdf_load_stackoverflow) |
| BR (1) | BR8100722A (enrdf_load_stackoverflow) |
| DE (1) | DE3104190A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2475395A1 (enrdf_load_stackoverflow) |
| GB (1) | GB2068973B (enrdf_load_stackoverflow) |
| IE (1) | IE50857B1 (enrdf_load_stackoverflow) |
| NZ (1) | NZ196126A (enrdf_load_stackoverflow) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8428201D0 (en) * | 1984-11-08 | 1984-12-19 | Glaxo Group Ltd | Biological preparations |
| GR1004274B (el) | 2002-07-16 | 2003-06-23 | Medexis ���� | Συμπλοκα στεροειδων ορμονων με πρωτεινες: νεες ουσιες για την ειδικη ανιχνευση και καταστροφη καρκινικων κυτταρων προερχομενων απο στερεους ογκους και αιματολογικες κακοηθειες |
| AU2003281165B2 (en) | 2002-07-16 | 2006-08-03 | Bionature E.A. Limited | Steroid conjugates, preparation thereof and the use thereof |
| CN112920399A (zh) * | 2019-12-05 | 2021-06-08 | 广东菲鹏生物有限公司 | 吖啶化合物标记类固醇激素衍生物及其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL40670A (en) * | 1972-10-25 | 1977-05-31 | Yeda Res & Dev | 7alpha-carboxy alkylthio delta4-3-oxo-steroids conjugates of these with proteins preparation of antisera specific to steroids and analytical method based on these |
| JPS5819222B2 (ja) * | 1977-06-21 | 1983-04-16 | 森永乳業株式会社 | ステロイド−血清アルブミン複合体感作ラテックス粒子の製造法 |
| US4331657A (en) * | 1980-02-06 | 1982-05-25 | Commonwealth Scientific And Industrial Research Organization | Fecundity of domestic livestock |
-
1981
- 1981-01-27 NZ NZ196126A patent/NZ196126A/en unknown
- 1981-01-28 IE IE158/81A patent/IE50857B1/en unknown
- 1981-01-29 GB GB8102696A patent/GB2068973B/en not_active Expired
- 1981-02-06 AR AR284231A patent/AR230572A1/es active
- 1981-02-06 BR BR8100722A patent/BR8100722A/pt unknown
- 1981-02-06 FR FR8102398A patent/FR2475395A1/fr active Granted
- 1981-02-06 DE DE19813104190 patent/DE3104190A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| IE810158L (en) | 1981-08-07 |
| GB2068973A (en) | 1981-08-19 |
| BR8100722A (pt) | 1981-08-18 |
| AR230572A1 (es) | 1984-05-31 |
| IE50857B1 (en) | 1986-08-06 |
| GB2068973B (en) | 1984-05-02 |
| FR2475395B1 (enrdf_load_stackoverflow) | 1985-01-04 |
| DE3104190A1 (de) | 1981-12-10 |
| FR2475395A1 (fr) | 1981-08-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4161519A (en) | Process for preparing an antipregnancy vaccine | |
| JP3177246B2 (ja) | 未去勢のオスの家畜に対する抗ｌｈｒｈ免疫方法と、そのためのペプチド | |
| CA2255888A1 (en) | Modulating the activity of hormones or their receptors - peptides, antibodies, vaccines and uses thereof | |
| AU1101788A (en) | Anti-reproductive hormone | |
| US4966888A (en) | hCG-hLH receptor and hCG-hLH receptor-hCG complex as antigens, antibodies thereto and contraceptive vaccine | |
| Talwar | Immunological approaches to contraception and promotion of fertility | |
| US4331657A (en) | Fecundity of domestic livestock | |
| CH622426A5 (en) | Contraceptive composition | |
| JPH04503663A (ja) | 避妊方法とその組成物 | |
| WO1988000056A1 (en) | Composition and method for immunological castration and spaying | |
| NZ196126A (en) | Increasing ovulation rate in female cattle | |
| Saxena et al. | Effect of immunization with bovine luteinizing hormone receptor on ovarian function in cats | |
| GB2166951A (en) | Steroidal immunogens for increasing ovulation in sows | |
| EP0072880B1 (en) | A composition for use in the control of ovulation of female bovines | |
| US4457914A (en) | Fecundity of domestic livestock | |
| JPH11515013A (ja) | 合成複合ワクチンの免疫原性担体としてのシュードモナスエクソトキシン | |
| US4749567A (en) | Method and product for increasing fertility in sheep using milk protein conjugates | |
| CA1298553C (en) | Reduction of reproductive losses | |
| Turkstra et al. | Active immunisation against gonadotropin-releasing hormone, an active tool to block the fertility axis in mammals | |
| AU7642387A (en) | Composition and method for immunological castration and spaying | |
| Hoskinson et al. | Effects of antibodies to steroid hormones on reproductive events of sheep and cattle | |
| Eppleston et al. | Effect of Anti-oestradiol-17B Antibodies on the Reproductive Response of Ewes Superovulated with PMSG | |
| Scaramuzzi et al. | The reproductive performance of Border Leicester× Merino ewes immunized against testosterone and cortisol | |
| Hoskinson et al. | Hormone immunoneutralization and the manipulation of animal productivity: a perspective. | |
| Chang | THE REGULATION OF REPRODUCTION IN CATTLE BY AN ANTIESTROGEN, OR ACTIVE IMMUNIZATION AGAINST PROSTAGLANDIN F (2ALPHA) AND OVARIAN STEROIDS |