DE30815T1 - Hybridzellinie zur herstellung monoklonaler antikoerper gegen ein menschliches prothymozyt-antigen - Google Patents
Hybridzellinie zur herstellung monoklonaler antikoerper gegen ein menschliches prothymozyt-antigenInfo
- Publication number
- DE30815T1 DE30815T1 DE198080304350T DE80304350T DE30815T1 DE 30815 T1 DE30815 T1 DE 30815T1 DE 198080304350 T DE198080304350 T DE 198080304350T DE 80304350 T DE80304350 T DE 80304350T DE 30815 T1 DE30815 T1 DE 30815T1
- Authority
- DE
- Germany
- Prior art keywords
- cells
- mouse
- monoclonal antibody
- antibody
- hybridoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract 7
- 239000000427 antigen Substances 0.000 title claims abstract 3
- 102000036639 antigens Human genes 0.000 title claims abstract 3
- 108091007433 antigens Proteins 0.000 title claims abstract 3
- 210000004754 hybrid cell Anatomy 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 claims abstract 21
- 241000699670 Mus sp. Species 0.000 claims abstract 6
- 206010035226 Plasma cell myeloma Diseases 0.000 claims abstract 5
- 201000000050 myeloid neoplasm Diseases 0.000 claims abstract 5
- 230000001225 therapeutic effect Effects 0.000 claims abstract 2
- 210000004408 hybridoma Anatomy 0.000 claims 11
- 229940126619 mouse monoclonal antibody Drugs 0.000 claims 11
- 241000699666 Mus <mouse, genus> Species 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 7
- 210000001744 T-lymphocyte Anatomy 0.000 claims 5
- 230000004927 fusion Effects 0.000 claims 5
- 210000004989 spleen cell Anatomy 0.000 claims 5
- 208000009052 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 4
- 208000017414 Precursor T-cell acute lymphoblastic leukemia Diseases 0.000 claims 4
- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 claims 4
- 230000002093 peripheral effect Effects 0.000 claims 4
- 239000006228 supernatant Substances 0.000 claims 4
- 238000010367 cloning Methods 0.000 claims 3
- 230000007812 deficiency Effects 0.000 claims 3
- 206010025538 Malignant ascites Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 210000000952 spleen Anatomy 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 210000002798 bone marrow cell Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 238000003306 harvesting Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 210000005087 mononuclear cell Anatomy 0.000 claims 1
- 210000004287 null lymphocyte Anatomy 0.000 claims 1
- 230000009257 reactivity Effects 0.000 claims 1
- 210000004988 splenocyte Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Hybrid Cells (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/100,072 US4364935A (en) | 1979-12-04 | 1979-12-04 | Monoclonal antibody to a human prothymocyte antigen and methods of preparing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE30815T1 true DE30815T1 (de) | 1984-07-19 |
Family
ID=22277974
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8080304350T Expired DE3070655D1 (en) | 1979-12-04 | 1980-12-03 | Hybrid cell line for producing monoclonal antibody to a human prothymocyte antigen, antibody, method of preparation of this antibody, diagnostic and therapeutic uses, and pharmaceutical compositions comprising this antibody |
| DE198080304350T Pending DE30815T1 (de) | 1979-12-04 | 1980-12-03 | Hybridzellinie zur herstellung monoklonaler antikoerper gegen ein menschliches prothymozyt-antigen |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8080304350T Expired DE3070655D1 (en) | 1979-12-04 | 1980-12-03 | Hybrid cell line for producing monoclonal antibody to a human prothymocyte antigen, antibody, method of preparation of this antibody, diagnostic and therapeutic uses, and pharmaceutical compositions comprising this antibody |
Country Status (22)
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4806349A (en) * | 1979-12-04 | 1989-02-21 | Ortho Pharmaceutical Corporation | Hybrid cell line for producing monoclonal antibody to a human prothymocyte antigen, antibody, and methods |
| US4582797A (en) * | 1980-09-25 | 1986-04-15 | The Salk Institute For Biological Studies | Monoclonal antibodies specific for human hematopoietic cell surface glycoproteins |
| JPS5823847B2 (ja) * | 1981-02-06 | 1983-05-18 | 株式会社 林原生物化学研究所 | 抗ヒト蛋白質抗体の製造方法 |
| DE3105150A1 (de) * | 1981-02-12 | 1982-08-19 | Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg | Herstellung von anti-t-lymphozyten-globulin. |
| US4434156A (en) | 1981-10-26 | 1984-02-28 | The Salk Institute For Biological Studies | Monoclonal antibodies specific for the human transferrin receptor glycoprotein |
| USRE32011E (en) * | 1981-12-14 | 1985-10-22 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
| AU555146B2 (en) * | 1982-03-15 | 1986-09-11 | Trustees Of Columbia University In The City Of New York, The | Method for intorducing cloned, amplifiable genes into eucaryotic cells and for producing proteinaceous products materials |
| US4443427A (en) * | 1982-06-21 | 1984-04-17 | Sidney Farber Cancer Institute, Inc. | Monoclonal antibody |
| US4579827A (en) * | 1983-03-11 | 1986-04-01 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibodies to human gastrointestinal cancers and hybridoma method of production of the monoclonal antibodies |
| JPS60231699A (ja) * | 1983-11-09 | 1985-11-18 | Aichiken | 正常及び悪性ヒト造血器細胞に対するモノクローナル抗体 |
| FR2560212B1 (fr) * | 1984-02-24 | 1989-12-29 | Unicet | Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps |
| US5431897A (en) * | 1985-04-19 | 1995-07-11 | Sloan-Kettering Institute For Cancer Research | Method of imaging colorectal carcinoma lesion and composition for use therein |
| US4705687A (en) * | 1985-06-17 | 1987-11-10 | Ortho Pharmaceutical (Canada) Ltd. | Treatment of autoimmune diseases such as rheumatoid arthritis with suppressor factor |
| US4970299A (en) * | 1986-07-03 | 1990-11-13 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibodies selective for prostate cancer |
| US5601819A (en) * | 1988-08-11 | 1997-02-11 | The General Hospital Corporation | Bispecific antibodies for selective immune regulation and for selective immune cell binding |
| AU1539699A (en) * | 1997-11-24 | 1999-06-15 | Johnson T. Wong | Methods for treatment of hiv or other infections using a t cell or viral activator and anti-retroviral combination therapy |
| FR2878852B1 (fr) | 2000-09-28 | 2007-02-23 | Imtix Sangstat | Procede de production d'immunoglobulines anti-thymocytes humains |
| US7653260B2 (en) | 2004-06-17 | 2010-01-26 | Carl Zeis MicroImaging GmbH | System and method of registering field of view |
| US8582924B2 (en) | 2004-06-30 | 2013-11-12 | Carl Zeiss Microimaging Gmbh | Data structure of an image storage and retrieval system |
| JP5496669B2 (ja) * | 2006-09-01 | 2014-05-21 | ジェンティセル | リンパ除去化合物、および抗原配列を含みかつプロフェッショナル抗原提示細胞をターゲットとする分子を含んでなる、特異的ｃｔｌ応答を誘発する組成物 |
| US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| DK3029066T3 (da) | 2010-07-29 | 2019-05-20 | Xencor Inc | Antistoffer med modificerede isoelektriske punkter |
| US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| CA3211863A1 (en) | 2013-01-14 | 2014-07-17 | Xencor, Inc. | Novel heterodimeric proteins |
| US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
| US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
| US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
| US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
| US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
| US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
| CA2897987A1 (en) | 2013-01-15 | 2014-07-24 | Xencor, Inc. | Rapid clearance of antigen complexes using novel antibodies |
| US10106624B2 (en) | 2013-03-15 | 2018-10-23 | Xencor, Inc. | Heterodimeric proteins |
| US10519242B2 (en) | 2013-03-15 | 2019-12-31 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| CA3093606A1 (en) | 2013-03-15 | 2014-09-18 | Xencor, Inc. | Heterodimeric proteins for induction of t cells |
| EP3104882B1 (en) | 2014-02-14 | 2019-06-05 | Centrose, Llc | Extracellular targeted drug conjugates |
| EA201691925A1 (ru) | 2014-03-28 | 2017-06-30 | Ксенкор, Инк. | Биспецифические антитела, которые связываются с cd38 и cd3 |
| CN107406512A (zh) | 2014-11-26 | 2017-11-28 | Xencor公司 | 结合cd3和cd38的异二聚体抗体 |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| RS62332B1 (sr) | 2014-11-26 | 2021-10-29 | Xencor Inc | Heterodimerna antitela koja vezuju cd3 i cd20 |
| WO2016105450A2 (en) | 2014-12-22 | 2016-06-30 | Xencor, Inc. | Trispecific antibodies |
| US10227411B2 (en) | 2015-03-05 | 2019-03-12 | Xencor, Inc. | Modulation of T cells with bispecific antibodies and FC fusions |
| AU2016365742A1 (en) | 2015-12-07 | 2018-06-21 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and PSMA |
| JP7010854B2 (ja) | 2016-06-14 | 2022-01-26 | ゼンコア インコーポレイテッド | 二重特異性チェックポイント阻害剤抗体 |
| MX2018016265A (es) | 2016-06-28 | 2019-07-04 | Xencor Inc | Anticuerpos heterodimericos que se unen al receptor 2 de somatostatina. |
| US10793632B2 (en) | 2016-08-30 | 2020-10-06 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| CA3040504A1 (en) | 2016-10-14 | 2018-04-19 | Xencor, Inc. | Il15/il15ra heterodimeric fc-fusion proteins |
| CN111132733A (zh) | 2017-06-30 | 2020-05-08 | Xencor股份有限公司 | 含有IL-15/IL-15Rα和抗原结合结构域的靶向异源二聚体Fc融合蛋白 |
| AU2018366199A1 (en) | 2017-11-08 | 2020-05-28 | Xencor, Inc. | Bispecific and monospecific antibodies using novel anti-PD-1 sequences |
| US10981992B2 (en) | 2017-11-08 | 2021-04-20 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| AU2018390418B2 (en) | 2017-12-19 | 2023-12-21 | Xencor, Inc. | Engineered IL-2 Fc fusion proteins |
| WO2019195623A2 (en) | 2018-04-04 | 2019-10-10 | Xencor, Inc. | Heterodimeric antibodies that bind fibroblast activation protein |
| CN112437777A (zh) | 2018-04-18 | 2021-03-02 | Xencor股份有限公司 | 包含IL-15/IL-15RA Fc融合蛋白和TIM-3抗原结合结构域的靶向TIM-3的异源二聚体融合蛋白 |
| WO2019204665A1 (en) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and pd-1 antigen binding domains and uses thereof |
| EP3861016A2 (en) | 2018-10-03 | 2021-08-11 | Xencor, Inc. | Il-12 heterodimeric fc-fusion proteins |
| US11472890B2 (en) | 2019-03-01 | 2022-10-18 | Xencor, Inc. | Heterodimeric antibodies that bind ENPP3 and CD3 |
| WO2021231976A1 (en) | 2020-05-14 | 2021-11-18 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3 |
| CN117157319A (zh) | 2021-03-09 | 2023-12-01 | Xencor股份有限公司 | 结合cd3和cldn6的异二聚抗体 |
| US11859012B2 (en) | 2021-03-10 | 2024-01-02 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and GPC3 |
| CN114085818A (zh) * | 2021-11-19 | 2022-02-25 | 蔡开来 | 一种抗大熊猫Thy1单克隆抗体及其杂交瘤细胞株和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4196265A (en) * | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
| US4172124A (en) * | 1978-04-28 | 1979-10-23 | The Wistar Institute | Method of producing tumor antibodies |
| US4284412A (en) * | 1979-07-13 | 1981-08-18 | Ortho Diagnostics, Inc. | Method and apparatus for automated identification and enumeration of specified blood cell subclasses |
-
1979
- 1979-12-04 US US06/100,072 patent/US4364935A/en not_active Expired - Lifetime
-
1980
- 1980-11-21 CA CA000365175A patent/CA1183470A/en not_active Expired
- 1980-11-25 NZ NZ195647A patent/NZ195647A/en unknown
- 1980-12-02 GR GR63536A patent/GR72923B/el unknown
- 1980-12-03 DE DE8080304350T patent/DE3070655D1/de not_active Expired
- 1980-12-03 AU AU65012/80A patent/AU545223B2/en not_active Expired
- 1980-12-03 AT AT80304350T patent/ATE13317T1/de not_active IP Right Cessation
- 1980-12-03 ES ES497425A patent/ES8303097A1/es not_active Expired
- 1980-12-03 IL IL61624A patent/IL61624A/xx not_active IP Right Cessation
- 1980-12-03 YU YU3067/80A patent/YU45078B/xx unknown
- 1980-12-03 FI FI803757A patent/FI75365C/fi not_active IP Right Cessation
- 1980-12-03 ZA ZA00807567A patent/ZA807567B/xx unknown
- 1980-12-03 DE DE198080304350T patent/DE30815T1/de active Pending
- 1980-12-03 DK DK517380A patent/DK153954C/da not_active IP Right Cessation
- 1980-12-03 PH PH24938A patent/PH17510A/en unknown
- 1980-12-03 EP EP80304350A patent/EP0030815B1/en not_active Expired
- 1980-12-03 IE IE2511/80A patent/IE50725B1/en not_active IP Right Cessation
- 1980-12-03 PT PT72146A patent/PT72146B/pt unknown
- 1980-12-03 NO NO803661A patent/NO159888C/no not_active IP Right Cessation
- 1980-12-04 JP JP17032780A patent/JPS5695123A/ja active Granted
-
1986
- 1986-01-23 SG SG73/86A patent/SG7386G/en unknown
- 1986-04-03 HK HK243/86A patent/HK24386A/en not_active IP Right Cessation
- 1986-12-30 MY MY519/86A patent/MY8600519A/xx unknown
-
1988
- 1988-05-17 JP JP63118392A patent/JPS6413988A/ja active Granted
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