DE3051094C2 - - Google Patents

Info

Publication number
DE3051094C2
DE3051094C2 DE3051094A DE3051094A DE3051094C2 DE 3051094 C2 DE3051094 C2 DE 3051094C2 DE 3051094 A DE3051094 A DE 3051094A DE 3051094 A DE3051094 A DE 3051094A DE 3051094 C2 DE3051094 C2 DE 3051094C2
Authority
DE
Germany
Prior art keywords
radical
methyl
carbon atoms
ester
vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3051094A
Other languages
German (de)
English (en)
Inventor
Hector F. Deluca
Heinrich K. Madison Wis. Us Schnoes
Joseph L. Dallas Tex. Us Napoli
Mary A. Madison Wis. Us Fivizzani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of DE3051094C2 publication Critical patent/DE3051094C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE3051094A 1979-05-21 1980-04-29 Expired DE3051094C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/041,080 US4269777A (en) 1979-05-21 1979-05-21 Isotopically labeled vitamin D derivatives and processes for preparing same

Publications (1)

Publication Number Publication Date
DE3051094C2 true DE3051094C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-05-18

Family

ID=21914616

Family Applications (2)

Application Number Title Priority Date Filing Date
DE803045287T Granted DE3045287T1 (de) 1979-05-21 1980-04-29 Isotopically labeled vitamin d derivatives and processes for preparing same
DE3051094A Expired DE3051094C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1979-05-21 1980-04-29

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE803045287T Granted DE3045287T1 (de) 1979-05-21 1980-04-29 Isotopically labeled vitamin d derivatives and processes for preparing same

Country Status (9)

Country Link
US (1) US4269777A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS56500538A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1152488A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE3045287T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (3) FR2457283A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (4) GB2083043B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (3) IE50426B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (3) IL69420A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1980002562A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4360470A (en) * 1980-10-22 1982-11-23 Hoffmann-La Roche Inc. Process and intermediates for the synthesis of Vitamin D3 metabolites and chenodeoxycholic acid
US4411833A (en) * 1982-05-26 1983-10-25 Wisconsin Alumni Research Foundation Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
US5036061A (en) * 1983-05-09 1991-07-30 Deluca Hector F Process for the preparation of 1 alpha,25-dihydroxylated vitamin D2 and related compounds
WO1984004527A1 (en) * 1983-05-09 1984-11-22 Wisconsin Alumni Res Found PROCESS FOR THE PREPARATION OF 1alpha,25-DIHYDROXYLATED VITAMIN D2 AND RELATED COMPOUNDS
US4585741A (en) * 1983-08-25 1986-04-29 Clevinger Brian L Method of assay for vitamin D metabolites
US4661294A (en) * 1985-03-18 1987-04-28 The General Hospital Corporation Biologically active 1-thio derivatives of vitamin D
US5247123A (en) * 1987-09-14 1993-09-21 Hoffmann-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
US4898855A (en) * 1987-09-14 1990-02-06 Hoffman-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
JPH02274A (ja) * 1987-10-14 1990-01-05 Toyo Jozo Co Ltd 新規な２５−ヒドロキシビタミンｄ↓３誘導体およびその製造法およびそれを用いた定量法
US5202266A (en) * 1987-10-14 1993-04-13 Asahi Kasei Kogyo Kabushiki Kaisha 25-hydroxy vitamin D3 derivatives, process for their production, and assay method using the same
US5532228A (en) * 1990-02-06 1996-07-02 Schering Aktiengesellschaft Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents
GB9623569D0 (en) * 1996-11-13 1997-01-08 Immunodiagnostic Systems Ltd Vitamin D immumoassay systems
AU2003256515A1 (en) * 2002-07-12 2004-02-02 Morehouse School Of Medicine Method for identifying salt-sensitive persons
HUE044033T2 (hu) * 2003-05-30 2019-09-30 Perkinelmer Health Sci Inc Izotóposan jelölt, kémiailag stabil reagensek és a szintézisükre szolgáló eljárás
ES2331289B2 (es) * 2008-06-27 2010-06-25 Universidade De Santiago De Compostela Compuestos de la vitamina d deuterados.
NZ599216A (en) * 2009-10-02 2014-01-31 Wisconsin Alumni Res Found 1-desoxy-2-methylene-19-nor-vitamin d analogs and their uses
EP4245369A3 (en) 2011-09-08 2023-11-22 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
SI3461834T1 (sl) 2013-03-13 2021-11-30 Sage Therapeutics, Inc. Nevroaktivni steroidi
EP4306114A1 (en) 2014-06-18 2024-01-17 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US10696712B2 (en) * 2015-07-06 2020-06-30 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
RU2021100377A (ru) 2015-07-06 2021-05-18 Сейдж Терапьютикс, Инк. Оксистеролы и способы их применения
CA2991214C (en) 2015-07-06 2024-04-30 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
DK3481846T3 (da) 2016-07-07 2021-08-16 Sage Therapeutics Inc 11-substituerede 24-hydroxysteroler til anvendelse til behandling af nmda-relaterede tilstande
MX392270B (es) 2016-09-30 2025-03-24 Sage Therapeutics Inc Oxisteroles sustituidos en c7 y metodos de uso de los mismos.
IL293231B1 (en) 2016-10-18 2025-06-01 Sage Therapeutics Inc Oxysterols and methods of use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2012167A1 (de) * 1969-03-17 1970-10-01 The Upjohn Co., Kalamazoo, Mich. (V.St.A.) Pf 17.03.69 V.St.v.Amerika 807929 Neue Steroide und Verfahren zu ihrer Herstellung
DE2933189T1 (de) * 1978-01-16 1980-12-18 Wisconsin Alumni Res Found Process for preparing 1a-hydroxylated compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2129011A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1971-03-11 1972-10-27 Roussel Uclaf
US4119647A (en) * 1977-04-11 1978-10-10 Hoffmann-La Roche Inc. 25-Hydroxycholecalciferol-23,24-3 H and process for the preparation thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2012167A1 (de) * 1969-03-17 1970-10-01 The Upjohn Co., Kalamazoo, Mich. (V.St.A.) Pf 17.03.69 V.St.v.Amerika 807929 Neue Steroide und Verfahren zu ihrer Herstellung
DE2933189T1 (de) * 1978-01-16 1980-12-18 Wisconsin Alumni Res Found Process for preparing 1a-hydroxylated compounds

Also Published As

Publication number Publication date
IE50424B1 (en) 1986-04-16
JPS56500538A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1981-04-23
IL60055A0 (en) 1980-07-31
GB2083043B (en) 1983-06-29
GB2082587A (en) 1982-03-10
GB2082587B (en) 1983-08-03
FR2485022A1 (fr) 1981-12-24
IL69420A (en) 1984-11-30
GB2083043A (en) 1982-03-17
FR2457283B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1983-03-11
IE50425B1 (en) 1986-04-16
CA1152488A (en) 1983-08-23
DE3045287C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1988-11-10
DE3045287T1 (de) 1982-02-18
GB2077736A (en) 1981-12-23
WO1980002562A1 (en) 1980-11-27
IL60055A (en) 1984-11-30
GB2077736B (en) 1983-06-29
IL69420A0 (en) 1983-11-30
IE801058L (en) 1980-11-21
FR2479214A1 (fr) 1981-10-02
US4269777A (en) 1981-05-26
FR2479214B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1985-04-12
FR2457283A1 (fr) 1980-12-19
GB2052509A (en) 1981-01-28
IE50426B1 (en) 1986-04-16
FR2485022B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1983-12-09
GB2052509B (en) 1983-06-29

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D2 Grant after examination
8364 No opposition during term of opposition