DE2967692D1 - Azabicycloalkyl derivatives - Google Patents

Azabicycloalkyl derivatives

Info

Publication number
DE2967692D1
DE2967692D1 DE8585115575T DE2967692T DE2967692D1 DE 2967692 D1 DE2967692 D1 DE 2967692D1 DE 8585115575 T DE8585115575 T DE 8585115575T DE 2967692 T DE2967692 T DE 2967692T DE 2967692 D1 DE2967692 D1 DE 2967692D1
Authority
DE
Germany
Prior art keywords
azabicycloalkyl
derivatives
azabicycloalkyl derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8585115575T
Other languages
English (en)
Inventor
Michael Stewart Hadley
Francis David King
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of DE2967692D1 publication Critical patent/DE2967692D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE8585115575T 1978-12-30 1979-12-20 Azabicycloalkyl derivatives Expired DE2967692D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB7850380 1978-12-30
GB7909262 1979-03-15
GB7927831 1979-08-09
EP79302978A EP0013138B1 (de) 1978-12-30 1979-12-20 Azabicycloalkyl-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen

Publications (1)

Publication Number Publication Date
DE2967692D1 true DE2967692D1 (de) 1989-12-14

Family

ID=27260652

Family Applications (3)

Application Number Title Priority Date Filing Date
DE7979302978T Expired DE2966476D1 (en) 1978-12-30 1979-12-20 Azabicycloalkyl derivatives, a process for their preparation and pharmaceutical compositions containing them
DE8282109116T Expired DE2967642D1 (de) 1978-12-30 1979-12-20 Azabicyclo alkyl derivatives
DE8585115575T Expired DE2967692D1 (de) 1978-12-30 1979-12-20 Azabicycloalkyl derivatives

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE7979302978T Expired DE2966476D1 (en) 1978-12-30 1979-12-20 Azabicycloalkyl derivatives, a process for their preparation and pharmaceutical compositions containing them
DE8282109116T Expired DE2967642D1 (de) 1978-12-30 1979-12-20 Azabicyclo alkyl derivatives

Country Status (14)

Country Link
US (5) US4273778A (de)
EP (3) EP0013138B1 (de)
AR (1) AR225301A1 (de)
AT (1) ATE24320T1 (de)
AU (2) AU527837B2 (de)
CA (2) CA1218062A (de)
DE (3) DE2966476D1 (de)
DK (1) DK553979A (de)
ES (1) ES487379A0 (de)
IE (2) IE49736B1 (de)
IL (1) IL59004A0 (de)
MX (1) MX6255E (de)
NZ (1) NZ192476A (de)
ZA (1) ZA797054B (de)

Families Citing this family (98)

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ZA818221B (en) * 1980-12-12 1982-10-27 Beecham Group Plc Pharmaceutical compounds
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EP0068700A1 (de) * 1981-06-29 1983-01-05 Beecham Group Plc Azabicycloalkylbenzamide, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE3275296D1 (en) * 1981-10-01 1987-03-05 Beecham Group Plc Azabicyclo-(3,3,1)-nonylbenzamide derivatives, processes for their preparation, and pharmaceutical compositions containing them
EP0083737A1 (de) * 1981-12-15 1983-07-20 Beecham Group Plc N-Azabicycloalkan-Benzamide, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammenstellungen
EP0093488A3 (de) * 1982-03-18 1984-05-23 Beecham Group Plc Nortropyl-Benzopyrrolinon-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
IE56226B1 (en) * 1982-04-14 1991-05-22 Beecham Group Plc Substituted azabicyclo compounds,process for their preparation and pharmaceutical compositions containing them
ZA832549B (en) * 1982-04-14 1988-09-28 Beecham Group Plc Pharmaceutically active compounds
DE3368061D1 (en) * 1982-05-11 1987-01-15 Beecham Group Plc Azabicycloalkane derivatives, their preparation and medicaments containing them
AU1508183A (en) * 1982-06-04 1983-12-08 Beecham Group Plc Benzamide and anilide derivatives of 8-azabicyclo-(3.2.1)- -octane
FR2531083B1 (fr) * 1982-06-29 1986-11-28 Sandoz Sa Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
EP0099194A3 (de) * 1982-07-03 1984-04-11 Beecham Group Plc Benzamide
JPS5936675A (ja) * 1982-07-13 1984-02-28 サンド・アクチエンゲゼルシヤフト 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
EP0101641A3 (de) * 1982-07-22 1984-03-28 Beecham Group Plc Sulphonylamino-aza-bicycloalkyl-Derivate
EP0102195A3 (de) * 1982-08-03 1984-04-11 Beecham Group Plc Substituierte Azabicycloalkyl-Derivate mit dopaminantagonistischer Wirkung
EP0126087A1 (de) * 1982-09-24 1984-11-28 Beecham Group Plc Amino-azabicycloalkyl-derivate als dopamin-antagonisten
GB8302483D0 (en) * 1983-01-29 1983-03-02 Beecham Group Plc Compounds
FR2546169B1 (fr) * 1983-05-20 1986-03-21 Delalande Sa N-oxydes de derives aminocycliques, leur procede de preparation et leur application en therapeutique
GB8317597D0 (en) * 1983-06-29 1983-08-03 Beecham Group Plc Pharmaceutical compounds
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DE3429830A1 (de) * 1983-08-26 1985-03-07 Sandoz-Patent-GmbH, 7850 Lörrach Automatische carbonsaeure- und sulfonsaeureester oder -amide
FR2557110B1 (fr) * 1983-12-23 1989-11-24 Sandoz Sa Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
DE3581725D1 (de) * 1984-12-14 1991-03-14 Hoechst Roussel Pharma Aminoacyllabdane, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel.
DE3587151T2 (de) * 1984-12-20 1993-07-15 Sandoz Ag Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.
US4698217A (en) * 1985-02-26 1987-10-06 Mobil Oil Corporation Crystalline silicate ZSM-58 and process for its preparation using a methyltropinium cation
DE3689974T2 (de) * 1985-03-14 1994-11-03 Beecham Group Plc Arzneimittel zur Behandlung von Emesis.
GB8516371D0 (en) * 1985-06-28 1985-07-31 Beecham Group Plc Compounds
GB8518236D0 (en) * 1985-07-19 1985-08-29 Beecham Group Plc Compounds
EP0220011A3 (de) * 1985-10-12 1990-01-03 Beecham Group Plc Verwendung von Azabicycloalkylbenzamiden zur Behandlung von Magen-Darmbewegungskrankheiten, Migräne, Emesis, Migränekopfschmerzen, Trigeminusneuralgie und Arhythmie
US4910193A (en) * 1985-12-16 1990-03-20 Sandoz Ltd. Treatment of gastrointestinal disorders
HU202108B (en) * 1986-07-30 1991-02-28 Sandoz Ag Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol
AT396870B (de) * 1986-08-07 1993-12-27 Sandoz Ag Verfahren zur herstellung einer galenischen formulierung zur nasalen verabreichung von serotoninantagonisten
DE3629598A1 (de) * 1986-08-30 1988-03-03 Boehringer Ingelheim Kg 3-brom-2,6-dimethoxibenzamide, ihre herstellung und verwendung
DE3822792C2 (de) * 1987-07-11 1997-11-27 Sandoz Ag Neue Verwendung von 5HT¶3¶-Antagonisten
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GB8727989D0 (en) * 1987-11-30 1988-01-06 Merck Sharp & Dohme Therapeutic agents
US5880260A (en) * 1988-11-18 1999-03-09 Oregon Health Sciences University Dopamine receptors and genes
EP0447483B1 (de) * 1988-11-18 1997-06-18 STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of Dopamin-rezeptoren und gene
US4920219A (en) * 1988-11-29 1990-04-24 Rorer Pharmaceutical Corp. Substituted saturated and unsaturated indole quinoline and benzazepine carboxamides and their use as pharmacological agents
US5070094A (en) * 1989-09-05 1991-12-03 G. D. Searle & Co. N-benzyltropaneamides
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IL100432A (en) * 1990-12-27 1996-01-19 Erba Carlo Spa Dihydrobenzopuran carboxamides, their preparation and pharmaceutical preparations containing them
EP0566609A1 (de) * 1991-01-09 1993-10-27 Smithkline Beecham Plc Stickstoffhaltige Bi-Und Tricyclen,Verfahren Und Zwischenprodukte zu ihrer Herstellung Und Diese Enthaltende Areneimittel
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CN103724343A (zh) 2004-03-25 2014-04-16 记忆药物公司 吲唑、苯并噻唑、苯并异噻唑、苯并异噁唑及其制备和用途
JP2007534692A (ja) 2004-04-22 2007-11-29 メモリー・ファーマシューティカルズ・コーポレイション インドール、１ｈ−インダゾール、１，２−ベンズイソキサゾール、１，２−ベンゾイソチアゾール、ならびにその調製および使用
RU2386633C2 (ru) 2004-05-07 2010-04-20 Мемори Фармасьютиклз Корпорейшн 1h-индазолы, бензотиазолы, 1, 2-бензоизоксазолы, 1, 2-бензоизотиазолы и хромоны и их получение и применения
CA2591817A1 (en) 2004-12-22 2006-06-29 Memory Pharmaceuticals Corporation Nicotinic alpha-7 receptor ligands and preparation and uses thereof
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
ES2400875T3 (es) * 2008-04-11 2013-04-15 Janssen Pharmaceutica N.V. Tiazolopiridin-2-iloxi-fenil y tiazolopirazin-2-iloxi-fenil aminas como moduladores de la leucotrieno A4 hidrolasa
NZ596137A (en) 2009-05-14 2013-08-30 Janssen Pharmaceutica Nv Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene a4 hydrolase
CN104860946A (zh) * 2015-05-14 2015-08-26 湖北生物医药产业技术研究院有限公司 Ccr5拮抗剂的制备方法
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FR2446823A1 (fr) * 1979-01-16 1980-08-14 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique

Also Published As

Publication number Publication date
DK553979A (da) 1980-08-15
EP0081054B1 (de) 1986-12-17
US4273778A (en) 1981-06-16
EP0220339B1 (de) 1989-11-08
CA1218062A (en) 1987-02-17
MX6255E (es) 1985-02-15
IL59004A0 (en) 1980-03-31
US4599420A (en) 1986-07-08
AU9135182A (en) 1983-03-10
NZ192476A (en) 1982-09-14
ES8101072A1 (es) 1980-12-01
IE792524L (en) 1980-06-30
EP0013138A1 (de) 1980-07-09
DE2966476D1 (en) 1984-01-12
IE49737B1 (en) 1985-12-11
EP0081054A3 (en) 1983-08-24
AU527837B2 (en) 1983-03-24
US4705858A (en) 1987-11-10
AU5425579A (en) 1980-07-03
AU543825B2 (en) 1985-05-02
US4544660A (en) 1985-10-01
AR225301A1 (es) 1982-03-15
ZA797054B (en) 1980-12-31
ES487379A0 (es) 1980-12-01
DE2967642D1 (de) 1987-01-29
ATE24320T1 (de) 1987-01-15
CA1220473A (en) 1987-04-14
US4336259A (en) 1982-06-22
EP0013138B1 (de) 1983-12-07
IE49736B1 (en) 1985-12-11
EP0220339A1 (de) 1987-05-06
EP0081054A2 (de) 1983-06-15

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