DE2840461A1 - Verfahren zur herstellung von arzneimittelzubereitungen, kosmetischen oder diagnostischen praeparaten durch gefriertrocknen - Google Patents

Verfahren zur herstellung von arzneimittelzubereitungen, kosmetischen oder diagnostischen praeparaten durch gefriertrocknen

Info

Publication number
DE2840461A1
DE2840461A1 DE19782840461 DE2840461A DE2840461A1 DE 2840461 A1 DE2840461 A1 DE 2840461A1 DE 19782840461 DE19782840461 DE 19782840461 DE 2840461 A DE2840461 A DE 2840461A DE 2840461 A1 DE2840461 A1 DE 2840461A1
Authority
DE
Germany
Prior art keywords
freeze
complex system
microcrystalline complex
drying
microcrystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19782840461
Other languages
German (de)
English (en)
Other versions
DE2840461C2 (enExample
Inventor
Angelo Prof Erbeia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Publication of DE2840461A1 publication Critical patent/DE2840461A1/de
Application granted granted Critical
Publication of DE2840461C2 publication Critical patent/DE2840461C2/de
Granted legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0283—Matrix particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/22—Gas releasing
    • A61K2800/222—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/524—Preservatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/65—Characterized by the composition of the particulate/core
    • A61K2800/652—The particulate/core comprising organic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Mathematical Physics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Drying Of Solid Materials (AREA)
DE19782840461 1977-09-19 1978-09-16 Verfahren zur herstellung von arzneimittelzubereitungen, kosmetischen oder diagnostischen praeparaten durch gefriertrocknen Granted DE2840461A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7728193A FR2403078A1 (fr) 1977-09-19 1977-09-19 Nouveau procede de preparation de formes pharmaceutiques, cosmetiques ou de diagnostic

Publications (2)

Publication Number Publication Date
DE2840461A1 true DE2840461A1 (de) 1979-03-29
DE2840461C2 DE2840461C2 (enExample) 1988-10-06

Family

ID=9195532

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782840461 Granted DE2840461A1 (de) 1977-09-19 1978-09-16 Verfahren zur herstellung von arzneimittelzubereitungen, kosmetischen oder diagnostischen praeparaten durch gefriertrocknen

Country Status (15)

Country Link
US (1) US4178695A (enExample)
JP (1) JPS5495720A (enExample)
BE (1) BE870548A (enExample)
CA (1) CA1097209A (enExample)
CH (1) CH633445A5 (enExample)
DE (1) DE2840461A1 (enExample)
DK (1) DK154528C (enExample)
ES (1) ES473459A1 (enExample)
FR (1) FR2403078A1 (enExample)
GB (1) GB2004182B (enExample)
IE (1) IE47020B1 (enExample)
IT (1) IT1106901B (enExample)
LU (1) LU80251A1 (enExample)
NL (1) NL186675C (enExample)
SE (1) SE444645B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0657170A1 (de) * 1993-12-09 1995-06-14 ASTA Medica Aktiengesellschaft Erzeugnisse zur Anwendung von initial hohen Dosen von Cetrorelix und Herstellung einer Kombinationspackung zur Verwendung bei Therapie von Krankheiten

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CA1209477A (en) * 1981-03-26 1986-08-12 Bruce E. Haeger Composition of matter comprising a lyophilized preparation of a penicillin derivative
US4429542A (en) * 1981-08-10 1984-02-07 Hoxan Corporation Method of freezing fertilized ova, spermatozoa or the like and apparatus therefor
JPS58154547A (ja) * 1982-03-09 1983-09-14 Nippon Shinyaku Co Ltd アズレン誘導体の安定化法
ES8502863A1 (es) * 1982-09-10 1985-02-01 Glaxo Group Ltd Un procedimiento para la produccion de un recipiente hermeticamente cerrado que contiene al menos un antibiotico de beta-lactama.
FR2539626B2 (fr) * 1983-01-25 1985-06-21 Lafon Labor Nouveau procede de preparation de formes galeniques utiles notamment en therapeutique, dietetique, cosmetique et diagnostic, et formes obtenues selon ce procede
US4642903A (en) * 1985-03-26 1987-02-17 R. P. Scherer Corporation Freeze-dried foam dosage form
US4712310A (en) * 1986-09-15 1987-12-15 E. I. Du Pont De Nemours And Company Co-spray technique
IL86892A (en) * 1987-07-08 1993-04-04 Lafon Labor Filter comprising a material obtained by freeze-drying, its preparation and its use, especially in pharmacy
JP2865320B2 (ja) * 1989-08-07 1999-03-08 株式会社資生堂 固型化粧料組成物
FR2670675B1 (fr) * 1990-12-20 1993-04-16 Lafon Labor Procede de preparation de formes pharmaceutiques stables a base d'acide acetylsalicylique ou de ses sels.
IL101007A (en) * 1992-02-18 1997-08-14 Pharmos Ltd Dry stable compositions prepared by lyophilization
FR2702968B1 (fr) * 1993-03-23 1995-06-23 Lafon Labor Procédé de préparation de particules renfermant un ingrédient actif par extrusion et lyophilisation .
US20040013613A1 (en) * 2001-05-18 2004-01-22 Jain Rajeev A Rapidly disintegrating solid oral dosage form
US8236352B2 (en) 1998-10-01 2012-08-07 Alkermes Pharma Ireland Limited Glipizide compositions
US6316029B1 (en) 2000-05-18 2001-11-13 Flak Pharma International, Ltd. Rapidly disintegrating solid oral dosage form
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
AR034204A1 (es) * 2001-01-26 2004-02-04 Schering Corp Composiciones y combinaciones de acido nicotinico y derivados del mismo con inhibidor(es) de la absorcion de los esteroles, y el uso de los mismos para preparar medicamentos para el tratamiento para indicaciones vasculares
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
CN1582168A (zh) * 2001-01-26 2005-02-16 先灵公司 用于治疗血管性疾病的固醇吸收抑制剂与心血管药剂的组合
RU2756946C2 (ru) * 2001-01-26 2021-10-07 Мерк Шарп И Доум Корп. Применение замещенных азетидинонов для лечения ситостеролемии
AU2002247019C1 (en) * 2001-01-26 2017-05-11 Organon Llc Combinations of peroxisome proliferator-activated receptor (PPAR) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
ES2296894T3 (es) * 2001-01-26 2008-05-01 Schering Corporation Combinaciones de ezetimiba con aspirina para tratar estados vasculares.
ATE369851T1 (de) * 2001-01-26 2007-09-15 Schering Corp Kombinationen von gallensäuresequestriermitteln und hemmern der sterolabsorption zur behandlung von kardiovaskulären indikationen
EP1392287B8 (en) * 2001-05-25 2007-01-10 Schering Corporation Use of substituted azetidinone derivatives in the treatment of Alzheimer's disease
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
DE60216300T2 (de) * 2001-09-21 2007-06-28 Schering Corp. Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
DE60229406D1 (de) * 2001-09-21 2008-11-27 Schering Corp Verfahren zur behandlung oder verhinderung von vaskulärer entzündung mit sterol-absorbierungs- inhibitor(en)
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
ATE371442T1 (de) * 2001-10-12 2007-09-15 Elan Pharma Int Ltd Zusammensetzungen mit einer kombination aus eigenschaften sofortiger freisetzung und kontrollierter freisetzung
WO2003080023A2 (en) * 2002-03-20 2003-10-02 Elan Pharma International Limited Fast dissolving dosage forms having reduced friability
CA2504878A1 (en) * 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorption inhibitors for the treatment of demyelination
MXPA05009502A (es) * 2003-03-07 2005-10-18 Schering Corp Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
EP1601668B1 (en) * 2003-03-07 2008-08-27 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
MXPA05009501A (es) 2003-03-07 2005-10-18 Schering Corp Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
WO2004105809A1 (en) * 2003-05-22 2004-12-09 Elan Pharma International Ltd. Sterilization of dispersions of nanoparticulate active agents with gamma radiation
WO2005046797A2 (en) * 2003-11-05 2005-05-26 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
EP1713854A2 (en) * 2004-01-28 2006-10-25 Unilever Plc Porous materials and method of production thereof
US7491263B2 (en) 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
EP1870649A1 (en) 2006-06-20 2007-12-26 Octapharma AG Lyophilisation targetting defined residual moisture by limited desorption energy levels
US20090238867A1 (en) * 2007-12-13 2009-09-24 Scott Jenkins Nanoparticulate Anidulafungin Compositions and Methods for Making the Same
FR2945950A1 (fr) 2009-05-27 2010-12-03 Elan Pharma Int Ltd Compositions de nanoparticules anticancereuses et procedes pour les preparer
EP4135659A1 (en) 2020-04-16 2023-02-22 Tavanta Therapeutics Hungary Incorporated Methods and compositions for treating prostate cancer
CN114532542A (zh) * 2022-02-24 2022-05-27 山东坦途农业科技有限公司 一种夹心冻干赋型制剂及其制备方法
FR3160664A1 (fr) 2024-03-27 2025-10-03 Stellantis Auto Sas Structure avant de véhicule automobile et véhicule automobile comportant une telle structure avant

Citations (1)

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Publication number Priority date Publication date Assignee Title
DE1900995A1 (de) * 1969-01-09 1970-08-27 Struthers Scient And Internat Gefriertrocknungsverfahren fuer Nahrungsmittel und dabei erhaltene Produkte

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US2984992A (en) * 1954-07-28 1961-05-23 Union Carbide Corp Apparatus for freeze dehydration of liquid bearing solids
US3309779A (en) * 1966-02-02 1967-03-21 Fmc Corp Dehydration of solids-bearing liquids
GB1190319A (en) * 1968-08-15 1970-05-06 George Jarvis Tooby Method for Dehydrating Materials
FR2036890B1 (enExample) * 1969-04-15 1973-01-12 Orsymonde
NL6915749A (en) * 1969-10-17 1971-04-20 Powdered products from fruit and vegetable juices aqs - vegetable extracts such as coffee, tea, etc having porous
FR2068447A1 (en) * 1969-11-26 1971-08-27 Orsymonde Dehydrated pharmaceutical comps by - lyophilisation
US3673698A (en) * 1970-11-25 1972-07-04 Albert S Guerard Process for freeze drying with carbon dioxide
JPS503381A (enExample) * 1973-05-11 1975-01-14
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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
DE1900995A1 (de) * 1969-01-09 1970-08-27 Struthers Scient And Internat Gefriertrocknungsverfahren fuer Nahrungsmittel und dabei erhaltene Produkte

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0657170A1 (de) * 1993-12-09 1995-06-14 ASTA Medica Aktiengesellschaft Erzeugnisse zur Anwendung von initial hohen Dosen von Cetrorelix und Herstellung einer Kombinationspackung zur Verwendung bei Therapie von Krankheiten
US5663145A (en) * 1993-12-09 1997-09-02 Asta Medica Aktiengesellschaft Products for administering an initial high dose of Cetrorelix and producing a combination package for use when treating diseases

Also Published As

Publication number Publication date
JPS62884B2 (enExample) 1987-01-10
LU80251A1 (fr) 1979-03-07
NL186675B (nl) 1990-09-03
DK333678A (da) 1979-03-20
DK154528C (da) 1989-04-10
SE444645B (sv) 1986-04-28
IE47020B1 (en) 1983-11-30
NL186675C (nl) 1991-02-01
IT7851099A0 (it) 1978-09-15
CH633445A5 (fr) 1982-12-15
SE7808007L (sv) 1979-03-20
DE2840461C2 (enExample) 1988-10-06
FR2403078B1 (enExample) 1981-07-03
DK154528B (da) 1988-11-21
ES473459A1 (es) 1979-10-16
IT1106901B (it) 1985-11-18
JPS5495720A (en) 1979-07-28
IE781341L (en) 1979-03-19
BE870548A (fr) 1979-03-19
NL7809522A (nl) 1979-03-21
US4178695A (en) 1979-12-18
FR2403078A1 (fr) 1979-04-13
GB2004182B (en) 1982-03-24
CA1097209A (en) 1981-03-10
GB2004182A (en) 1979-03-28

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D2 Grant after examination
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