DE2821410A1 - Aminoalkylbenzolderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zubereitungen - Google Patents

Aminoalkylbenzolderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zubereitungen

Info

Publication number
DE2821410A1
DE2821410A1 DE19782821410 DE2821410A DE2821410A1 DE 2821410 A1 DE2821410 A1 DE 2821410A1 DE 19782821410 DE19782821410 DE 19782821410 DE 2821410 A DE2821410 A DE 2821410A DE 2821410 A1 DE2821410 A1 DE 2821410A1
Authority
DE
Germany
Prior art keywords
formula
compounds
hydrogen
methyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19782821410
Other languages
German (de)
English (en)
Inventor
John Bradshaw
John Watson Clitherow
Michael Martin-Smith
Barry John Price
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allen and Hanburys Ltd
Original Assignee
Allen and Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB20660/77A external-priority patent/GB1604674A/en
Application filed by Allen and Hanburys Ltd filed Critical Allen and Hanburys Ltd
Publication of DE2821410A1 publication Critical patent/DE2821410A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/10—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
    • C07C279/32—N-nitroguanidines
    • C07C279/36—Substituted N-nitroguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/08—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
DE19782821410 1977-05-17 1978-05-16 Aminoalkylbenzolderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zubereitungen Withdrawn DE2821410A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB20660/77A GB1604674A (en) 1977-05-17 1977-05-17 Aminoalkyl-benzene derivatives
GB4012977 1977-09-27
GB1744478 1978-05-03

Publications (1)

Publication Number Publication Date
DE2821410A1 true DE2821410A1 (de) 1978-11-30

Family

ID=27257503

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782821410 Withdrawn DE2821410A1 (de) 1977-05-17 1978-05-16 Aminoalkylbenzolderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zubereitungen

Country Status (13)

Country Link
JP (1) JPS53149936A (sv)
AU (2) AU523496B2 (sv)
CH (2) CH643238A5 (sv)
DE (1) DE2821410A1 (sv)
DK (1) DK214878A (sv)
ES (1) ES469953A1 (sv)
FI (1) FI781490A (sv)
FR (2) FR2401135A1 (sv)
IE (1) IE46886B1 (sv)
IT (1) IT1156755B (sv)
NL (1) NL7805344A (sv)
NZ (1) NZ187235A (sv)
SE (1) SE443558B (sv)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002930A1 (en) * 1977-12-23 1979-07-11 Glaxo Group Limited Amine derivatives, their preparation and pharmaceutical compositions containing them
EP0023578A1 (en) * 1979-07-03 1981-02-11 Shionogi & Co., Ltd. Aminoalkylbenzene derivatives, process for their preparation and pharmaceutical compositions
US4293557A (en) 1979-07-03 1981-10-06 Teikoku Hormone Mfg. Co., Ltd. Antiulcer phenoxypropylamine derivatives
EP0055179A1 (en) * 1980-12-22 1982-06-30 Merck & Co. Inc. Aminoalkyl pyridine derivatives
EP0057981A2 (en) * 1981-02-09 1982-08-18 Beecham Group Plc Aromatic compounds, processes for their preparation and their use
EP0067436A2 (en) * 1981-06-15 1982-12-22 Merck & Co. Inc. Diamino isothiazole -1-oxides and -1,1-dioxides as gastric secretion inhibitors
EP0071434A2 (en) * 1981-07-24 1983-02-09 Glaxo Group Limited Heterocyclic derivatives
EP0082376A2 (en) * 1981-12-21 1983-06-29 Merck & Co. Inc. Substituted derivatives of amino alkane diols as gastric secretion inhibitors
US4442110A (en) * 1978-04-26 1984-04-10 Glaxo Group Limited 1H-1,2,4-Triazole-3,5-diamine derivatives and use as selective histamine H2 -antagonists
EP0016565B1 (en) * 1979-03-02 1984-05-23 Glaxo Group Limited 1,2,4-triazole derivatives, processes for their production and pharmaceutical compositions containing them
EP0029311B1 (en) * 1979-10-31 1985-01-23 Merck & Co. Inc. Aminoalkyl benzofuran derivatives, their production and compositions containing them
EP0029303B1 (en) * 1979-10-22 1985-01-30 Glaxo Group Limited 1,2,4-triazole derivatives, processes for their production and pharmaceutical compositions containing them
US4522943A (en) * 1981-05-18 1985-06-11 Bristol-Myers Company Chemical compounds
US4526973A (en) * 1981-05-18 1985-07-02 Bristol-Myers Company Chemical compounds
EP1944305A1 (en) 2003-05-21 2008-07-16 Glaxo Group Limited Quinoline derivatives as phosphodiesterase inhibitors
EP2111223A1 (en) * 2007-11-01 2009-10-28 Acucela, Inc. Amine derivative compounds for treating ophthalmic diseases and disorders

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS609750B2 (ja) * 1979-07-03 1985-03-12 帝国臓器製薬株式会社 新規なｎ−置換フエノキシプロピルアミド化合物
FR2477537A1 (fr) * 1980-03-07 1981-09-11 Francaise Sucrerie Nouvelles guanidines acylees, urees et urees substituees, leur procede de fabrication et leur application en tant que medicaments
JPS57165348A (en) * 1981-04-06 1982-10-12 Teikoku Hormone Mfg Co Ltd Novel aminoalkylbenzene derivative
JPS5988458A (ja) * 1982-11-12 1984-05-22 Toyama Chem Co Ltd アミン誘導体およびその塩
JPH0639466B2 (ja) * 1987-08-03 1994-05-25 杏林製薬株式会社 ウレア誘導体
JPH01131172A (ja) * 1987-08-28 1989-05-24 Toyama Chem Co Ltd アミン誘導体およびその塩、それらの製造法、並びにそれらを含有する抗潰瘍剤
WO1993023360A1 (fr) * 1992-05-12 1993-11-25 Zeria Pharmaceutical Co., Ltd. Nouveaux sels d'ammonium quaternaires et utilisation de ces sels comme medicament

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE636468A (sv) *
US2785201A (en) * 1953-12-24 1957-03-12 Personnes A Responsabilite Lim Compounds of bis quaternary ammonium derivatives of phenylethylamine
US3047628A (en) * 1957-02-19 1962-07-31 Hoffmann La Roche Benzylamine derivatives
GB993581A (en) * 1960-03-03 1965-05-26 Wellcome Found Phenoxyalkylguanidines and their synthesis and pharmaceutical preparations containing them
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
JPS5227757A (en) * 1975-08-26 1977-03-02 Kyowa Hakko Kogyo Co Ltd Preparation of 6-aminomethylnaphthalene derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICHTS ERMITTELT *

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002930A1 (en) * 1977-12-23 1979-07-11 Glaxo Group Limited Amine derivatives, their preparation and pharmaceutical compositions containing them
US4442110A (en) * 1978-04-26 1984-04-10 Glaxo Group Limited 1H-1,2,4-Triazole-3,5-diamine derivatives and use as selective histamine H2 -antagonists
EP0016565B1 (en) * 1979-03-02 1984-05-23 Glaxo Group Limited 1,2,4-triazole derivatives, processes for their production and pharmaceutical compositions containing them
EP0023578A1 (en) * 1979-07-03 1981-02-11 Shionogi & Co., Ltd. Aminoalkylbenzene derivatives, process for their preparation and pharmaceutical compositions
US4293557A (en) 1979-07-03 1981-10-06 Teikoku Hormone Mfg. Co., Ltd. Antiulcer phenoxypropylamine derivatives
EP0029303B1 (en) * 1979-10-22 1985-01-30 Glaxo Group Limited 1,2,4-triazole derivatives, processes for their production and pharmaceutical compositions containing them
EP0029311B1 (en) * 1979-10-31 1985-01-23 Merck & Co. Inc. Aminoalkyl benzofuran derivatives, their production and compositions containing them
EP0055179A1 (en) * 1980-12-22 1982-06-30 Merck & Co. Inc. Aminoalkyl pyridine derivatives
US4427685A (en) 1981-02-09 1984-01-24 Beecham Group P.L.C. Cycloalkylamino derivatives and their use in the treatment of peptic ulcers and the like
EP0057981A2 (en) * 1981-02-09 1982-08-18 Beecham Group Plc Aromatic compounds, processes for their preparation and their use
EP0057981A3 (en) * 1981-02-09 1982-08-25 Beecham Group Plc Aromatic compounds, processes for their preparation and their use
US4526973A (en) * 1981-05-18 1985-07-02 Bristol-Myers Company Chemical compounds
US4522943A (en) * 1981-05-18 1985-06-11 Bristol-Myers Company Chemical compounds
EP0067436A3 (en) * 1981-06-15 1983-01-19 Merck & Co. Inc. Diamino isothiazole -1-oxides and -1,1-dioxides as gastric secretion inhibitors
EP0067436A2 (en) * 1981-06-15 1982-12-22 Merck & Co. Inc. Diamino isothiazole -1-oxides and -1,1-dioxides as gastric secretion inhibitors
EP0071434A2 (en) * 1981-07-24 1983-02-09 Glaxo Group Limited Heterocyclic derivatives
EP0071434A3 (en) * 1981-07-24 1983-05-04 Glaxo Group Limited Heterocyclic derivatives
EP0082376A2 (en) * 1981-12-21 1983-06-29 Merck & Co. Inc. Substituted derivatives of amino alkane diols as gastric secretion inhibitors
EP0082376A3 (en) * 1981-12-21 1984-08-22 Merck & Co. Inc. Substituted derivatives of amino alkane diols as gastric secretion inhibitors
EP1944305A1 (en) 2003-05-21 2008-07-16 Glaxo Group Limited Quinoline derivatives as phosphodiesterase inhibitors
EP2111223A1 (en) * 2007-11-01 2009-10-28 Acucela, Inc. Amine derivative compounds for treating ophthalmic diseases and disorders
EP2111223A4 (en) * 2007-11-01 2012-08-15 Acucela Inc AMIN DERIVATIVE COMPOUNDS FOR THE TREATMENT OF EYE DISEASES AND DRESSES
US8450527B2 (en) 2007-11-01 2013-05-28 Acucela Inc. Amine derivative compounds for treating ophthalmic diseases and disorders
US8716529B2 (en) 2007-11-01 2014-05-06 Acucela Inc. Amine derivative compounds for treating ophthalmic diseases and disorders
US9056849B2 (en) 2007-11-01 2015-06-16 Acucela Inc. Amine derivative compounds for treating ophthalmic diseases and disorders
US9452153B2 (en) 2007-11-01 2016-09-27 Acucela Inc. Amine derivative compounds for treating ophthalmic diseases and disorders

Also Published As

Publication number Publication date
JPS53149936A (en) 1978-12-27
FR2401135A1 (fr) 1979-03-23
AU541144B2 (en) 1984-12-20
FI781490A (fi) 1978-11-18
IT1156755B (it) 1987-02-04
IE46886B1 (en) 1983-10-19
DK214878A (da) 1978-11-18
FR2401135B1 (sv) 1983-08-19
AU523496B2 (en) 1982-07-29
NZ187235A (en) 1981-10-19
SE443558B (sv) 1986-03-03
FR2398718B1 (sv) 1982-10-15
AU3606778A (en) 1979-11-15
ES469953A1 (es) 1979-09-16
AU8411782A (en) 1982-08-26
IE780940L (en) 1978-11-17
NL7805344A (nl) 1978-11-21
CH643233A5 (en) 1984-05-30
CH643238A5 (en) 1984-05-30
SE7805591L (sv) 1978-11-18
IT7849419A0 (it) 1978-05-17
FR2398718A1 (fr) 1979-02-23
JPH0112744B2 (sv) 1989-03-02

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