JPS53149936A - Novel aminoalkylbenzene derivative process for preparing same medical composition and application thereof - Google Patents
Novel aminoalkylbenzene derivative process for preparing same medical composition and application thereofInfo
- Publication number
- JPS53149936A JPS53149936A JP5870678A JP5870678A JPS53149936A JP S53149936 A JPS53149936 A JP S53149936A JP 5870678 A JP5870678 A JP 5870678A JP 5870678 A JP5870678 A JP 5870678A JP S53149936 A JPS53149936 A JP S53149936A
- Authority
- JP
- Japan
- Prior art keywords
- aminoalkylbenzene
- novel
- application
- medical composition
- preparing same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
- C07C275/10—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
- C07C279/32—N-nitroguanidines
- C07C279/36—Substituted N-nitroguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
- C07C335/08—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB20660/77A GB1604674A (en) | 1977-05-17 | 1977-05-17 | Aminoalkyl-benzene derivatives |
GB4012977 | 1977-09-27 | ||
GB1744478 | 1978-05-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS53149936A true JPS53149936A (en) | 1978-12-27 |
JPH0112744B2 JPH0112744B2 (ja) | 1989-03-02 |
Family
ID=27257503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5870678A Granted JPS53149936A (en) | 1977-05-17 | 1978-05-17 | Novel aminoalkylbenzene derivative process for preparing same medical composition and application thereof |
Country Status (13)
Country | Link |
---|---|
JP (1) | JPS53149936A (ja) |
AU (2) | AU523496B2 (ja) |
CH (2) | CH643238A5 (ja) |
DE (1) | DE2821410A1 (ja) |
DK (1) | DK214878A (ja) |
ES (1) | ES469953A1 (ja) |
FI (1) | FI781490A (ja) |
FR (2) | FR2401135A1 (ja) |
IE (1) | IE46886B1 (ja) |
IT (1) | IT1156755B (ja) |
NL (1) | NL7805344A (ja) |
NZ (1) | NZ187235A (ja) |
SE (1) | SE443558B (ja) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS567760A (en) * | 1979-07-03 | 1981-01-27 | Teikoku Hormone Mfg Co Ltd | Novel n-substituted phenoxypropylamide compound |
JPS57165348A (en) * | 1981-04-06 | 1982-10-12 | Teikoku Hormone Mfg Co Ltd | Novel aminoalkylbenzene derivative |
JPS5988458A (ja) * | 1982-11-12 | 1984-05-22 | Toyama Chem Co Ltd | アミン誘導体およびその塩 |
US4871765A (en) * | 1987-08-28 | 1989-10-03 | Toyama Chemical Co., Ltd. | Amine derivative and its salt and anti-ulcer agent containing the same |
WO1993023360A1 (fr) * | 1992-05-12 | 1993-11-25 | Zeria Pharmaceutical Co., Ltd. | Nouveaux sels d'ammonium quaternaires et utilisation de ces sels comme medicament |
JP2011502983A (ja) * | 2007-11-01 | 2011-01-27 | アキュセラ インコーポレイテッド | 眼の疾患及び障害治療用のアミン誘導体化合物 |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4233302A (en) * | 1977-12-23 | 1980-11-11 | Glaxo Group Limited | Amine derivatives and pharmaceutical compositions containing them |
AR228941A1 (es) * | 1978-04-26 | 1983-05-13 | Glaxo Group Ltd | Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos |
FI68395C (fi) * | 1979-03-02 | 1985-09-10 | Glaxo Group Ltd | Foerfarande foer framstaellning av farmakologiskt verksamma trazolfoereningar |
US4293557A (en) | 1979-07-03 | 1981-10-06 | Teikoku Hormone Mfg. Co., Ltd. | Antiulcer phenoxypropylamine derivatives |
JPS568352A (en) * | 1979-07-03 | 1981-01-28 | Shionogi & Co Ltd | Aminoalkylvenzene derivative |
GB2063253B (en) * | 1979-10-22 | 1983-09-14 | Glaxo Group Ltd | Triazole derivatives processes for their production and pharmaceutical compositions containing them |
US4238487A (en) * | 1979-10-31 | 1980-12-09 | Merck & Co., Inc. | Aminoalkyl benzofuran derivatives |
FR2477537A1 (fr) * | 1980-03-07 | 1981-09-11 | Francaise Sucrerie | Nouvelles guanidines acylees, urees et urees substituees, leur procede de fabrication et leur application en tant que medicaments |
US4490533A (en) * | 1980-12-22 | 1984-12-25 | Merck & Co., Inc. | Aminoalkyl pyridine derivatives |
EP0057981A3 (en) * | 1981-02-09 | 1982-08-25 | Beecham Group Plc | Aromatic compounds, processes for their preparation and their use |
US4522943A (en) * | 1981-05-18 | 1985-06-11 | Bristol-Myers Company | Chemical compounds |
US4526973A (en) * | 1981-05-18 | 1985-07-02 | Bristol-Myers Company | Chemical compounds |
IE53068B1 (en) * | 1981-06-15 | 1988-05-25 | Merck & Co Inc | Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors |
DE3275291D1 (en) * | 1981-07-24 | 1987-03-05 | Glaxo Group Ltd | Heterocyclic derivatives |
US4411899A (en) * | 1981-12-21 | 1983-10-25 | Merck & Co., Inc. | Substituted derivatives of amino alkane diols as gastric secretion inhibitors |
JPH0639466B2 (ja) * | 1987-08-03 | 1994-05-25 | 杏林製薬株式会社 | ウレア誘導体 |
TWI328009B (en) | 2003-05-21 | 2010-08-01 | Glaxo Group Ltd | Quinoline derivatives as phosphodiesterase inhibitors |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5227757A (en) * | 1975-08-26 | 1977-03-02 | Kyowa Hakko Kogyo Co Ltd | Preparation of 6-aminomethylnaphthalene derivatives |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE636468A (ja) * | ||||
US2785201A (en) * | 1953-12-24 | 1957-03-12 | Personnes A Responsabilite Lim | Compounds of bis quaternary ammonium derivatives of phenylethylamine |
US3047628A (en) * | 1957-02-19 | 1962-07-31 | Hoffmann La Roche | Benzylamine derivatives |
GB993581A (en) * | 1960-03-03 | 1965-05-26 | Wellcome Found | Phenoxyalkylguanidines and their synthesis and pharmaceutical preparations containing them |
GB1338169A (en) * | 1971-03-09 | 1973-11-21 | Smith Kline French Lab | Ureas thioureas and guanidines |
GB1421792A (en) * | 1973-05-17 | 1976-01-21 | Smith Kline French Lab | Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them |
-
1978
- 1978-05-09 IE IE940/78A patent/IE46886B1/en unknown
- 1978-05-10 NZ NZ187235A patent/NZ187235A/xx unknown
- 1978-05-11 FI FI781490A patent/FI781490A/fi not_active Application Discontinuation
- 1978-05-12 AU AU36067/78A patent/AU523496B2/en not_active Expired
- 1978-05-16 SE SE7805591A patent/SE443558B/sv unknown
- 1978-05-16 CH CH531578A patent/CH643238A5/de not_active IP Right Cessation
- 1978-05-16 DK DK214878A patent/DK214878A/da unknown
- 1978-05-16 DE DE19782821410 patent/DE2821410A1/de not_active Withdrawn
- 1978-05-17 IT IT7849419A patent/IT1156755B/it active
- 1978-05-17 NL NL7805344A patent/NL7805344A/xx not_active Application Discontinuation
- 1978-05-17 ES ES469953A patent/ES469953A1/es not_active Expired
- 1978-05-17 FR FR7814594A patent/FR2401135A1/fr active Granted
- 1978-05-17 JP JP5870678A patent/JPS53149936A/ja active Granted
- 1978-10-03 FR FR7828239A patent/FR2398718A1/fr active Granted
-
1982
- 1982-05-25 AU AU84117/82A patent/AU541144B2/en not_active Expired
- 1982-12-22 CH CH749182A patent/CH643233A5/de not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5227757A (en) * | 1975-08-26 | 1977-03-02 | Kyowa Hakko Kogyo Co Ltd | Preparation of 6-aminomethylnaphthalene derivatives |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS567760A (en) * | 1979-07-03 | 1981-01-27 | Teikoku Hormone Mfg Co Ltd | Novel n-substituted phenoxypropylamide compound |
JPS609750B2 (ja) * | 1979-07-03 | 1985-03-12 | 帝国臓器製薬株式会社 | 新規なn−置換フエノキシプロピルアミド化合物 |
JPS57165348A (en) * | 1981-04-06 | 1982-10-12 | Teikoku Hormone Mfg Co Ltd | Novel aminoalkylbenzene derivative |
JPH0148259B2 (ja) * | 1981-04-06 | 1989-10-18 | Teikoku Hormone Mfg Co Ltd | |
JPS5988458A (ja) * | 1982-11-12 | 1984-05-22 | Toyama Chem Co Ltd | アミン誘導体およびその塩 |
US4923882A (en) * | 1982-11-12 | 1990-05-08 | Toyama Chemical Co., Ltd. | Novel amine derivatives, salts thereof and an anti-ulcer agent containing the same |
JPH0331714B2 (ja) * | 1982-11-12 | 1991-05-08 | Toyama Chemical Co Ltd | |
US4871765A (en) * | 1987-08-28 | 1989-10-03 | Toyama Chemical Co., Ltd. | Amine derivative and its salt and anti-ulcer agent containing the same |
WO1993023360A1 (fr) * | 1992-05-12 | 1993-11-25 | Zeria Pharmaceutical Co., Ltd. | Nouveaux sels d'ammonium quaternaires et utilisation de ces sels comme medicament |
JP2011502983A (ja) * | 2007-11-01 | 2011-01-27 | アキュセラ インコーポレイテッド | 眼の疾患及び障害治療用のアミン誘導体化合物 |
JP2015091842A (ja) * | 2007-11-01 | 2015-05-14 | アキュセラ インコーポレイテッド | 眼の疾患及び障害治療用のアミン誘導体化合物 |
US9452153B2 (en) | 2007-11-01 | 2016-09-27 | Acucela Inc. | Amine derivative compounds for treating ophthalmic diseases and disorders |
Also Published As
Publication number | Publication date |
---|---|
AU8411782A (en) | 1982-08-26 |
CH643238A5 (en) | 1984-05-30 |
CH643233A5 (en) | 1984-05-30 |
FR2398718A1 (fr) | 1979-02-23 |
DK214878A (da) | 1978-11-18 |
AU541144B2 (en) | 1984-12-20 |
NL7805344A (nl) | 1978-11-21 |
IT7849419A0 (it) | 1978-05-17 |
FI781490A (fi) | 1978-11-18 |
SE443558B (sv) | 1986-03-03 |
FR2401135A1 (fr) | 1979-03-23 |
AU523496B2 (en) | 1982-07-29 |
JPH0112744B2 (ja) | 1989-03-02 |
NZ187235A (en) | 1981-10-19 |
FR2401135B1 (ja) | 1983-08-19 |
IT1156755B (it) | 1987-02-04 |
IE780940L (en) | 1978-11-17 |
IE46886B1 (en) | 1983-10-19 |
AU3606778A (en) | 1979-11-15 |
DE2821410A1 (de) | 1978-11-30 |
ES469953A1 (es) | 1979-09-16 |
FR2398718B1 (ja) | 1982-10-15 |
SE7805591L (sv) | 1978-11-18 |
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