JPS567760A - Novel n-substituted phenoxypropylamide compound - Google Patents
Novel n-substituted phenoxypropylamide compoundInfo
- Publication number
- JPS567760A JPS567760A JP8342679A JP8342679A JPS567760A JP S567760 A JPS567760 A JP S567760A JP 8342679 A JP8342679 A JP 8342679A JP 8342679 A JP8342679 A JP 8342679A JP S567760 A JPS567760 A JP S567760A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- substituted
- phenoxypropylamide
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:N-Substituted phenoxypropylamide compounds of formula I [R is H, CH3, or C2H5; Y is 1-pyrrolidinyl, 1-piperidinyl, 1-perhydroazepinyl and 1- perhydroazocinyl which may have substitution groups (OH or CH2 OH); Z is H, or CH3 or C2H5 which may have substitution groups (OH or NH2); provided that R is C2H5 when Y is unsubstituted 1-pyrrolidinyl] and their salts.
EXAMPLE: N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl] formamide.
USE: Antiulcerative agents having excellent inhibitory activity of gastric acid secretion owing to the antagonistic activity to histamine H2-acceptor.
PROCESS: A compound of formula I is obtained by the reaction of novel compound of formula II and a compound of formula Z-COOH or their reactive derivatives. The compound of formula II can be obtained by the reaction of a compound of formula III with a compound of formula Y'-H(Y' is non-substituted Y).
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP54083426A JPS609750B2 (en) | 1979-07-03 | 1979-07-03 | Novel N-substituted phenoxypropylamide compounds |
US06/164,017 US4293557A (en) | 1979-07-03 | 1980-06-30 | Antiulcer phenoxypropylamine derivatives |
EP80103742A EP0024510B1 (en) | 1979-07-03 | 1980-07-01 | Phenoxypropyl amine derivatives, process for their preparation, and pharmaceutical compositions containing them |
DE8080103742T DE3065362D1 (en) | 1979-07-03 | 1980-07-01 | Phenoxypropyl amine derivatives, process for their preparation, and pharmaceutical compositions containing them |
IN537/MAS/86A IN163755B (en) | 1979-07-03 | 1986-07-15 | |
SG758/86A SG75886G (en) | 1979-07-03 | 1986-09-19 | Phenoxypropyl amine derivatives, process for their preparation, and pharmaceutical compositions containing them |
KE367086A KE3670A (en) | 1979-07-03 | 1986-10-14 | Phenoxypropyl amine derivatives,process for their preparation,and pharmaceutical compositions containing them |
HK953/86A HK95386A (en) | 1979-07-03 | 1986-12-11 | Phenoxypropyl amine derivatives,process for their preparation,and pharmaceutical compositions containing them |
MY563/87A MY8700563A (en) | 1979-07-03 | 1987-12-30 | Phenoxypropyl amine derivatives process for their preparation and pharmaceutical compositions containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP54083426A JPS609750B2 (en) | 1979-07-03 | 1979-07-03 | Novel N-substituted phenoxypropylamide compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS567760A true JPS567760A (en) | 1981-01-27 |
JPS609750B2 JPS609750B2 (en) | 1985-03-12 |
Family
ID=13802105
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54083426A Expired JPS609750B2 (en) | 1979-07-03 | 1979-07-03 | Novel N-substituted phenoxypropylamide compounds |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS609750B2 (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53149936A (en) * | 1977-05-17 | 1978-12-27 | Allen & Hanburys Ltd | Novel aminoalkylbenzene derivative process for preparing same medical composition and application thereof |
-
1979
- 1979-07-03 JP JP54083426A patent/JPS609750B2/en not_active Expired
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53149936A (en) * | 1977-05-17 | 1978-12-27 | Allen & Hanburys Ltd | Novel aminoalkylbenzene derivative process for preparing same medical composition and application thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS609750B2 (en) | 1985-03-12 |
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