DE2820938A1 - Neue imidazoazine und imidazodiazine - Google Patents

Neue imidazoazine und imidazodiazine

Info

Publication number
DE2820938A1
DE2820938A1 DE19782820938 DE2820938A DE2820938A1 DE 2820938 A1 DE2820938 A1 DE 2820938A1 DE 19782820938 DE19782820938 DE 19782820938 DE 2820938 A DE2820938 A DE 2820938A DE 2820938 A1 DE2820938 A1 DE 2820938A1
Authority
DE
Germany
Prior art keywords
compounds according
hydrogen
formula
butyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19782820938
Other languages
German (de)
English (en)
Inventor
John James Baldwin
Jun William Carl Lumma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2820938A1 publication Critical patent/DE2820938A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE19782820938 1977-05-16 1978-05-12 Neue imidazoazine und imidazodiazine Ceased DE2820938A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/796,958 US4166851A (en) 1977-05-16 1977-05-16 Certain imidazo(1,2a)pyridine derivatives

Publications (1)

Publication Number Publication Date
DE2820938A1 true DE2820938A1 (de) 1978-11-23

Family

ID=25169498

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782820938 Ceased DE2820938A1 (de) 1977-05-16 1978-05-12 Neue imidazoazine und imidazodiazine

Country Status (13)

Country Link
US (1) US4166851A (enExample)
JP (1) JPS53141292A (enExample)
BE (1) BE866841A (enExample)
CH (1) CH639662A5 (enExample)
DE (1) DE2820938A1 (enExample)
DK (1) DK180878A (enExample)
FR (1) FR2391215A1 (enExample)
GB (1) GB1601041A (enExample)
IE (1) IE46882B1 (enExample)
IT (1) IT1156737B (enExample)
LU (1) LU79651A1 (enExample)
NL (1) NL7804345A (enExample)
SE (1) SE7804777L (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0113236A1 (en) * 1982-12-27 1984-07-11 Eli Lilly And Company Substituted imidazopyrimidines-pyrazines, and -triazines
EP0185345A1 (de) * 1984-12-21 1986-06-25 Dr. Karl Thomae GmbH Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
EP0381132A1 (en) * 1989-01-31 1990-08-08 Takeda Chemical Industries, Ltd. Imidazopyridazines, their production and use
EP0471236A1 (en) * 1990-07-30 1992-02-19 Takeda Chemical Industries, Ltd. Imidazopyridine derivatives and their use
US5155108A (en) * 1990-01-31 1992-10-13 Takeda Chemical Industries, Ltd. Imidazopyridazines and use as antiasthmatic agents
US7196196B2 (en) 2001-09-14 2007-03-27 Basf Aktiengesellschaft Substituted imidazo[1, 2-a]-5,6,7,8-tetrahydropyridine-8-ones, method for their production and the use thereof for producing imidazo[1,2-a]pyridines

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4233301A (en) * 1977-05-16 1980-11-11 Merck & Co., Inc. Novel imidazoazines and imidazodiazines
US4210653A (en) * 1978-06-27 1980-07-01 Merck & Co., Inc. Pyridyloxypropanolamines
US4330543A (en) * 1978-12-14 1982-05-18 Merck & Co., Inc. Imidazoazines and imidazodiazines
US4656168A (en) * 1980-12-23 1987-04-07 Merck & Co., Inc. (3-aralkylamino-2-or-propoxy)heterocyclic compounds in method of effecting bronchodilation
US4331679A (en) * 1980-12-23 1982-05-25 Merck Sharp & Dohme (I.A.) Corp. (3-Aralkylamino-2-or-propoxy) heterocyclic compounds
US4349673A (en) * 1980-12-23 1982-09-14 Merck & Co., Inc. Benzoxazines
US4442094A (en) * 1980-12-23 1984-04-10 Merck & Co., Inc. (3-Aralkylamino-2-or-propoxy)heterocyclic compounds
US4391806A (en) * 1982-07-12 1983-07-05 The Dow Chemical Company Substituted tetrahydropyridazino-(1,6-A)benzimidazoles and use as bronchodilators
US4537889A (en) * 1982-12-27 1985-08-27 Eli Lilly And Company Inotropic agents
US4636502A (en) * 1982-12-27 1987-01-13 Eli Lilly And Company Methods of producing a positive inotropic effect or vasodilation by administration of 2-phenyl imidazo pyrimidines and pyrazines
GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds
US5420133A (en) * 1993-03-19 1995-05-30 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
US20070078136A1 (en) 2005-09-22 2007-04-05 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
CA2732520A1 (en) * 2008-08-05 2010-02-11 Merck Sharp & Dohme Corp. Therapeutic compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2406930A1 (de) * 1973-02-20 1974-08-22 Ciba Geigy Ag Neue heterocyclische verbindungen und verfahren zu ihrer herstellung
US3998835A (en) * 1975-04-08 1976-12-21 Sandoz Ltd. 1-Substituted amino-3-thieno-[3,2-c]pyridinyloxy-2-propanols

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4071630A (en) * 1975-04-08 1978-01-31 Sandoz Ltd. 1-Substituted-amino-3-(4-furo[3,2-c]pyridinyloxy)-2-propanols

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2406930A1 (de) * 1973-02-20 1974-08-22 Ciba Geigy Ag Neue heterocyclische verbindungen und verfahren zu ihrer herstellung
US3998835A (en) * 1975-04-08 1976-12-21 Sandoz Ltd. 1-Substituted amino-3-thieno-[3,2-c]pyridinyloxy-2-propanols

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0113236A1 (en) * 1982-12-27 1984-07-11 Eli Lilly And Company Substituted imidazopyrimidines-pyrazines, and -triazines
EP0185345A1 (de) * 1984-12-21 1986-06-25 Dr. Karl Thomae GmbH Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
EP0381132A1 (en) * 1989-01-31 1990-08-08 Takeda Chemical Industries, Ltd. Imidazopyridazines, their production and use
US5202324A (en) * 1989-01-31 1993-04-13 Takeda Chemical Industries, Ltd. Imidazopyridazines
US5155108A (en) * 1990-01-31 1992-10-13 Takeda Chemical Industries, Ltd. Imidazopyridazines and use as antiasthmatic agents
EP0471236A1 (en) * 1990-07-30 1992-02-19 Takeda Chemical Industries, Ltd. Imidazopyridine derivatives and their use
US5244908A (en) * 1990-07-30 1993-09-14 Takeda Chemical Industries, Ltd. Imidazopyridine derivatives and their pharmaceutical use
US5395839A (en) * 1990-07-30 1995-03-07 Takeda Chemical Industries, Ltd. Imidazopyridine derivatives and their use
US5587383A (en) * 1990-07-30 1996-12-24 Takeda Chemical Industries, Ltd. Imidazopyridine derivatives and their use
US7196196B2 (en) 2001-09-14 2007-03-27 Basf Aktiengesellschaft Substituted imidazo[1, 2-a]-5,6,7,8-tetrahydropyridine-8-ones, method for their production and the use thereof for producing imidazo[1,2-a]pyridines

Also Published As

Publication number Publication date
JPS53141292A (en) 1978-12-08
NL7804345A (nl) 1978-11-20
IT1156737B (it) 1987-02-04
BE866841A (fr) 1978-11-09
SE7804777L (sv) 1978-11-17
JPS623153B2 (enExample) 1987-01-23
LU79651A1 (fr) 1979-02-02
IE46882B1 (en) 1983-10-19
DK180878A (da) 1978-11-17
FR2391215B1 (enExample) 1981-12-11
IE780923L (en) 1978-11-16
IT7849338A0 (it) 1978-05-12
US4166851A (en) 1979-09-04
GB1601041A (en) 1981-10-21
CH639662A5 (de) 1983-11-30
FR2391215A1 (fr) 1978-12-15

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8131 Rejection