DE2800496C2 - Radionuklidgenerator - Google Patents
RadionuklidgeneratorInfo
- Publication number
- DE2800496C2 DE2800496C2 DE2800496A DE2800496A DE2800496C2 DE 2800496 C2 DE2800496 C2 DE 2800496C2 DE 2800496 A DE2800496 A DE 2800496A DE 2800496 A DE2800496 A DE 2800496A DE 2800496 C2 DE2800496 C2 DE 2800496C2
- Authority
- DE
- Germany
- Prior art keywords
- generator
- column
- inlet
- generator column
- outlet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000463 material Substances 0.000 claims description 16
- 238000010521 absorption reaction Methods 0.000 claims description 6
- 239000006096 absorbing agent Substances 0.000 description 16
- 239000000243 solution Substances 0.000 description 11
- 238000010828 elution Methods 0.000 description 7
- 238000005192 partition Methods 0.000 description 7
- 230000005855 radiation Effects 0.000 description 6
- 239000012487 rinsing solution Substances 0.000 description 5
- NMFHJNAPXOMSRX-PUPDPRJKSA-N [(1r)-3-(3,4-dimethoxyphenyl)-1-[3-(2-morpholin-4-ylethoxy)phenyl]propyl] (2s)-1-[(2s)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate Chemical compound C([C@@H](OC(=O)[C@@H]1CCCCN1C(=O)[C@@H](CC)C=1C=C(OC)C(OC)=C(OC)C=1)C=1C=C(OCCN2CCOCC2)C=CC=1)CC1=CC=C(OC)C(OC)=C1 NMFHJNAPXOMSRX-PUPDPRJKSA-N 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 241001631457 Cannula Species 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 238000009206 nuclear medicine Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229910052713 technetium Inorganic materials 0.000 description 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/0005—Isotope delivery systems
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Control Of Eletrric Generators (AREA)
- Nuclear Medicine (AREA)
- External Artificial Organs (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Particle Accelerators (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2800496A DE2800496C2 (de) | 1978-01-05 | 1978-01-05 | Radionuklidgenerator |
| NO784199A NO151483C (no) | 1978-01-05 | 1978-12-13 | Radionuklid-generator |
| NL7812397A NL7812397A (nl) | 1978-01-05 | 1978-12-21 | Generator voor radioactieve atomen. |
| GB7849920A GB2013389B (en) | 1978-01-05 | 1978-12-22 | Radionuclide generator |
| SE7813399A SE7813399L (sv) | 1978-01-05 | 1978-12-28 | Radionuklid generator |
| DK585678A DK158174C (da) | 1978-01-05 | 1978-12-28 | Kernepartikelgenerator |
| CH1323878A CH638405A5 (de) | 1978-01-05 | 1978-12-28 | Radionuklidgenerator. |
| LU80730A LU80730A1 (fr) | 1978-01-05 | 1978-12-28 | Generateur de radionucleides |
| JP16463478A JPS54101094A (en) | 1978-01-05 | 1978-12-28 | Radioactive nuclide generator |
| IT52473/78A IT1111057B (it) | 1978-01-05 | 1978-12-28 | Perfezionamento nei generatori di radionuclidi |
| FR7836718A FR2414241A1 (fr) | 1978-01-05 | 1978-12-28 | Generateur de radionucleides pour la separation des substances radioactives |
| BE192634A BE873158A (fr) | 1978-01-05 | 1978-12-28 | Generateur de radionuclides |
| CA318,832A CA1122334A (en) | 1978-01-05 | 1978-12-29 | Radionuclide generator |
| US06/000,937 US4239970A (en) | 1978-01-05 | 1979-01-04 | Radionuclide generator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2800496A DE2800496C2 (de) | 1978-01-05 | 1978-01-05 | Radionuklidgenerator |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2800496A1 DE2800496A1 (de) | 1979-07-19 |
| DE2800496C2 true DE2800496C2 (de) | 1987-02-12 |
Family
ID=6029055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2800496A Expired DE2800496C2 (de) | 1978-01-05 | 1978-01-05 | Radionuklidgenerator |
Country Status (14)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4597951A (en) | 1984-08-16 | 1986-07-01 | E. R. Squibb & Sons, Inc. | Strontium-82/rubidium-82 generator |
| US4712618A (en) * | 1986-01-29 | 1987-12-15 | Halliburton Company | Multiple reservoir transportation assembly for radioactive substances, and related method |
| US4698510A (en) * | 1986-01-29 | 1987-10-06 | Halliburton Company | Multiple reservoir transportation assembly for radioactive substances, and related method |
| DE8621529U1 (de) * | 1986-08-11 | 1986-10-30 | Von Heyden GmbH, 8000 München | Dosiervorrichtung für Radionuklidgeneratoren |
| US5109160A (en) * | 1990-10-12 | 1992-04-28 | E. I. Du Pont De Nemours And Company | Sterilizable radionuclide generator and method for sterilizing the same |
| FR2681139B1 (fr) * | 1991-09-10 | 1993-11-05 | Matieres Nucleaires Cie Gle | Installation pour effectuer plusieurs reactions chimiques successives dans un meme recipient. |
| AT398653B (de) * | 1992-08-28 | 1995-01-25 | Cremisa Medizintechnik Ges M B | Nuklidgenerator |
| US6599484B1 (en) * | 2000-05-12 | 2003-07-29 | Cti, Inc. | Apparatus for processing radionuclides |
| US20060023829A1 (en) * | 2004-08-02 | 2006-02-02 | Battelle Memorial Institute | Medical radioisotopes and methods for producing the same |
| US7394074B2 (en) * | 2004-08-28 | 2008-07-01 | Bracco Diagnostics Inc. | Protective housing for radionuclide generator and combination thereof |
| CA2616832A1 (en) * | 2005-07-27 | 2007-02-08 | Mallinckrodt Inc. | Alignment adapter for use with a radioisotope generator and methods of using the same |
| US8317674B2 (en) | 2008-06-11 | 2012-11-27 | Bracco Diagnostics Inc. | Shielding assemblies for infusion systems |
| CN104784770B (zh) | 2008-06-11 | 2019-06-11 | 布拉科诊断公司 | 包括计算机辅助维护和/或操作的输注系统 |
| EP2430636B1 (en) | 2009-05-13 | 2014-02-12 | Lantheus Medical Imaging, Inc. | Radionuclide generator and method of sterilization |
| US9587292B2 (en) * | 2009-10-01 | 2017-03-07 | Advanced Applied Physics Solutions, Inc. | Method and apparatus for isolating the radioisotope molybdenum-99 |
| US9240253B2 (en) | 2010-04-07 | 2016-01-19 | Ge-Hitachi Nuclear Energy Americas Llc | Column geometry to maximize elution efficiencies for molybdenum-99 |
| CA2854820C (en) | 2011-12-08 | 2016-05-24 | Nordion (Canada) Inc. | Method of pre-treating an adsorbent for a chromatographic separation |
| CN117854793A (zh) | 2016-09-20 | 2024-04-09 | 布拉科诊断公司 | 具有检测γ和β发射的多检测器的放射性同位素递送系统 |
| WO2019191386A1 (en) | 2018-03-28 | 2019-10-03 | Bracco Diagnostics Inc. | Early detection of radioisotope generator end life |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2790512A (en) * | 1953-12-22 | 1957-04-30 | United Gas Corp | Process for dehydrating and removing adsorbable components from gas streams |
| US3655981A (en) * | 1968-11-29 | 1972-04-11 | Mallinckrodt Chemical Works | Closed system generation and containerization of radioisotopes for eluting a daughter radioisotope from a parent radioisotope |
| US3749556A (en) * | 1971-08-19 | 1973-07-31 | Medi Physics Inc | Radiopharmaceutical generator kit |
| DE2236565C3 (de) * | 1972-07-26 | 1979-05-03 | Hoechst Ag, 6000 Frankfurt | Vorrichtung zum Herstellen von sterilen, injizierbaren Eluaten durch Eluieren von Nuklidgeneratoren |
| NL165872C (nl) * | 1973-02-20 | 1981-05-15 | Byk Mallinckrodt Cil Bv | Isotopengenerator voor de produktie van 99m tc bevattende vloeistoffen. |
| CH616602A5 (US20110232667A1-20110929-C00004.png) * | 1975-09-22 | 1980-04-15 | Sulzer Ag | |
| US4041317A (en) * | 1976-05-19 | 1977-08-09 | E. R. Squibb & Sons, Inc. | Multiple pH alumina columns for molybdenum-99/technetium-99m generators |
-
1978
- 1978-01-05 DE DE2800496A patent/DE2800496C2/de not_active Expired
- 1978-12-13 NO NO784199A patent/NO151483C/no unknown
- 1978-12-21 NL NL7812397A patent/NL7812397A/xx not_active Application Discontinuation
- 1978-12-22 GB GB7849920A patent/GB2013389B/en not_active Expired
- 1978-12-28 BE BE192634A patent/BE873158A/xx not_active IP Right Cessation
- 1978-12-28 CH CH1323878A patent/CH638405A5/de not_active IP Right Cessation
- 1978-12-28 FR FR7836718A patent/FR2414241A1/fr active Granted
- 1978-12-28 IT IT52473/78A patent/IT1111057B/it active
- 1978-12-28 LU LU80730A patent/LU80730A1/xx unknown
- 1978-12-28 DK DK585678A patent/DK158174C/da not_active IP Right Cessation
- 1978-12-28 JP JP16463478A patent/JPS54101094A/ja active Pending
- 1978-12-28 SE SE7813399A patent/SE7813399L/xx unknown
- 1978-12-29 CA CA318,832A patent/CA1122334A/en not_active Expired
-
1979
- 1979-01-04 US US06/000,937 patent/US4239970A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NL7812397A (nl) | 1979-07-09 |
| GB2013389B (en) | 1982-10-13 |
| NO784199L (no) | 1979-07-06 |
| DK158174B (da) | 1990-04-02 |
| DK585678A (da) | 1979-07-06 |
| SE7813399L (sv) | 1979-07-06 |
| NO151483B (no) | 1985-01-02 |
| FR2414241A1 (fr) | 1979-08-03 |
| US4239970A (en) | 1980-12-16 |
| IT7852473A0 (it) | 1978-12-28 |
| NO151483C (no) | 1985-04-17 |
| DE2800496A1 (de) | 1979-07-19 |
| DK158174C (da) | 1990-09-03 |
| LU80730A1 (fr) | 1979-09-07 |
| FR2414241B1 (US20110232667A1-20110929-C00004.png) | 1984-01-20 |
| CH638405A5 (de) | 1983-09-30 |
| JPS54101094A (en) | 1979-08-09 |
| GB2013389A (en) | 1979-08-08 |
| BE873158A (fr) | 1979-04-17 |
| IT1111057B (it) | 1986-01-13 |
| CA1122334A (en) | 1982-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8125 | Change of the main classification |
Ipc: B01D 15/08 |
|
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: DU PONT DE NEMOURS (DEUTSCHLAND) GMBH, 6000 FRANKF |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: DU PONT DE NEMOURS (DEUTSCHLAND) GMBH, 61352 BAD H |
|
| 8339 | Ceased/non-payment of the annual fee |