DE2724211C2 - Tripeptidderivate und deren Verwendung - Google Patents

Tripeptidderivate und deren Verwendung

Info

Publication number
DE2724211C2
DE2724211C2 DE2724211A DE2724211A DE2724211C2 DE 2724211 C2 DE2724211 C2 DE 2724211C2 DE 2724211 A DE2724211 A DE 2724211A DE 2724211 A DE2724211 A DE 2724211A DE 2724211 C2 DE2724211 C2 DE 2724211C2
Authority
DE
Germany
Prior art keywords
deep
mmol
arg
pna
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2724211A
Other languages
German (de)
English (en)
Other versions
DE2724211A1 (de
Inventor
Lars Gundro Reinach Basel Svendsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM Nutritional Products AG
Original Assignee
Pentapharm AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pentapharm AG filed Critical Pentapharm AG
Publication of DE2724211A1 publication Critical patent/DE2724211A1/de
Application granted granted Critical
Publication of DE2724211C2 publication Critical patent/DE2724211C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/968—Plasmin, i.e. fibrinolysin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/972—Plasminogen activators
    • G01N2333/9723—Urokinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/976—Trypsin; Chymotrypsin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE2724211A 1976-05-28 1977-05-27 Tripeptidderivate und deren Verwendung Expired DE2724211C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH681676A CH634662A5 (de) 1976-05-28 1976-05-28 Verwendung von tripeptidderivaten zur quantitativen bestimmung von plasminogen-aktivatoren.

Publications (2)

Publication Number Publication Date
DE2724211A1 DE2724211A1 (de) 1977-12-01
DE2724211C2 true DE2724211C2 (de) 1987-03-05

Family

ID=4315468

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2724211A Expired DE2724211C2 (de) 1976-05-28 1977-05-27 Tripeptidderivate und deren Verwendung

Country Status (17)

Country Link
US (2) US4190574A (enExample)
JP (1) JPS5624520B2 (enExample)
AT (1) AT368550B (enExample)
AU (1) AU517375B2 (enExample)
BE (1) BE855085A (enExample)
CA (1) CA1086614A (enExample)
CH (1) CH634662A5 (enExample)
DE (1) DE2724211C2 (enExample)
DK (1) DK149215C (enExample)
FR (1) FR2353063A1 (enExample)
GB (1) GB1589738A (enExample)
IL (1) IL52124A (enExample)
IT (1) IT1084992B (enExample)
LU (1) LU77429A1 (enExample)
NL (1) NL184849C (enExample)
NO (1) NO156067C (enExample)
SE (1) SE444173B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5415797A (en) * 1977-06-14 1979-02-05 Seikagaku Kogyo Co Ltd Detection and measurement of toxin in cells
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
JPS59499B2 (ja) * 1978-11-02 1984-01-07 味の素株式会社 ペプチド誘導体
DE2903701C2 (de) * 1979-01-31 1980-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Kontrollreagens für die Bestimmung der Heparinaktivität
CA1161431A (en) * 1979-05-11 1984-01-31 Lars G. Svendsen Tripeptide derivatives
CA1161432A (en) * 1980-02-12 1984-01-31 Lars G. Svendsen Tripeptide derivatives and their application in assaying enzymes
DK155051C (da) * 1980-05-06 1989-07-03 Pentapharm Ag Tripeptidderivater samt fremgangsmaade til kvantitativ analyse for proteolytiske enzymer under anvendelse deraf
US4568636A (en) * 1981-03-25 1986-02-04 Pentapharm Ag Tripeptide derivatives
JPS57177985U (enExample) * 1981-04-30 1982-11-11
EP0078764B1 (de) * 1981-11-02 1986-01-02 Pentapharm A.G. Verfahren zur quantitativen Bestimmung von Blutgerinnungsfaktor XII in Humanplasma
NL8201987A (nl) * 1982-05-13 1983-12-01 Tno Werkwijze voor het bepalen van de activiteit van plasminogeenactivator van het weefseltype, alsmede voor gebruik bij deze werkwijze geschikte combinatie van het "kit"-type.
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
DK201084A (da) * 1983-04-28 1984-10-29 Kimberly Clark Co Fremgangsmaade til bestemmelse af cathepsin b i naervaerelse af andre proteolytiske enzymer, og forbindelser til anvendelse ved fremgangsmaaden
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
JPS62126196A (ja) * 1985-11-26 1987-06-08 Nitto Boseki Co Ltd 新規なα１−アンチトリプシン測定用化合物
DE3804600A1 (de) * 1988-02-13 1989-08-24 Basf Ag Mischung aus einer thrombolytisch wirkenden und einer antithrombotischen substanz
US5115099A (en) 1988-06-14 1992-05-19 Nitto Boseki Co., Ltd. Substrates for determination of enzyme activity and intermediates for synthesis of the substrates as well as process for producing the intermediates
WO1993006459A1 (en) * 1991-09-18 1993-04-01 Iowa State University Research Foundation, Inc. Dual-wavelength photometer and fiber optic sensor probe
US20030207402A1 (en) * 1997-08-22 2003-11-06 Erhard Kopetzki Autocatalytically activatable zymogenic precursors of proteases and their use
ES2355571T3 (es) * 2004-03-26 2011-03-29 Dsm Ip Assets B.V. Conjugados de ácidos arilalquílicos con aminoácidos y péptidos para usos cosméticos.
CN119178757B (zh) * 2024-09-03 2025-06-10 南京市第一医院 一种用于检测胰蛋白酶的双通道比色荧光复合探针及检测方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
SE380258B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser
DE2527932C2 (de) * 1974-07-02 1983-04-21 Pentapharm AG, 4052 Basel Säureadditionssalze von Tripeptidderivaten und deren Verwendung als Substrate zur Bestimmung von Plasmakallikrein
SE407058B (sv) * 1974-12-05 1979-03-12 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
CH622286A5 (enExample) * 1975-06-23 1981-03-31 Pentapharm Ag
SE407571B (sv) * 1975-07-11 1979-04-02 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
US4061625A (en) * 1975-07-11 1977-12-06 Ab Kabi Novel chromogenic thrombin substrates

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
"Kurzes Lehrbuch der Biochemie" von P. KARLSON, Georg Thieme-Verlag, Stuttgart, 1967, Seite 70
"Peptide Synthesis" von Miklos BODANSZKY et al., Interscience Publishers, 1966, Seiten 43 und 44, 163 - 165
"The National Formulary XII", herausgegeben von "The American Pharmaceutical Association", Washington, D.C., 1965, Seiten 417 - 418
Chem. Abstracts, 86, 1977, 116826
Enzyme, 12, 1971, S. 311-321
F.E. Smyrniotis et al. [Thromb. Diath et Haemorrh. Bd. III, 257 - 70 (1959)]
G. PATAKI, "Dünnschichtchromatographie in der Aminosäure- und Peptid-Chemie", Walter de Gruyter & Co., Berlin, 1966, S. 125
I. Bjerrehuus, Scand. J. Clin. Lab. Invest. 4, 179 (1952)
I. Witt in "Biochemie der Blutgerinnung und Fibrinolyse", Verlag Chemie, Weinheim, 1975, S. 119
L.F. Remmert et al., J. Biol. Chem. 181, 431 (1949)
Mullertz [Acta physiol. Scand. 26, 174 (1954)]
N.U. Bang et al., "Thrombosis and Bleeding Disorders", Georg Thieme Verlag, Stuttgart, 1971, S. 377
W. Troll et al., Journal of Biological Chemistry 208, 85 (1954)

Also Published As

Publication number Publication date
CH634662A5 (de) 1983-02-15
JPS5624520B2 (enExample) 1981-06-06
CA1086614A (en) 1980-09-30
AT368550B (de) 1982-10-25
DK149215C (da) 1986-08-04
NO156067C (no) 1987-07-15
ATA375877A (de) 1982-02-15
DK235577A (da) 1977-11-29
IL52124A0 (en) 1977-07-31
JPS52146694A (enExample) 1977-12-06
NL184849C (nl) 1989-11-16
NL184849B (nl) 1989-06-16
FR2353063B1 (enExample) 1980-10-24
US4278762A (en) 1981-07-14
SE7706275L (sv) 1977-11-29
SE444173B (sv) 1986-03-24
NO156067B (no) 1987-04-06
BE855085A (fr) 1977-09-16
FR2353063A1 (fr) 1977-12-23
AU517375B2 (en) 1981-07-30
NO771869L (no) 1977-11-29
US4190574A (en) 1980-02-26
IT1084992B (it) 1985-05-28
DE2724211A1 (de) 1977-12-01
DK149215B (da) 1986-03-17
GB1589738A (en) 1981-05-20
AU2557177A (en) 1978-11-30
NL7705891A (nl) 1977-11-30
IL52124A (en) 1980-11-30
LU77429A1 (enExample) 1977-09-09

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Legal Events

Date Code Title Description
OD Request for examination
8128 New person/name/address of the agent

Representative=s name: VON FUENER, A., DIPL.-CHEM. DR.RER.NAT. EBBINGHAUS

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee