DE2724211C2 - Tripeptidderivate und deren Verwendung - Google Patents
Tripeptidderivate und deren VerwendungInfo
- Publication number
- DE2724211C2 DE2724211C2 DE2724211A DE2724211A DE2724211C2 DE 2724211 C2 DE2724211 C2 DE 2724211C2 DE 2724211 A DE2724211 A DE 2724211A DE 2724211 A DE2724211 A DE 2724211A DE 2724211 C2 DE2724211 C2 DE 2724211C2
- Authority
- DE
- Germany
- Prior art keywords
- deep
- mmol
- arg
- pna
- gly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/10—Anilides
- C12Q2337/12—Para-Nitroanilides p-NA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/968—Plasmin, i.e. fibrinolysin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/972—Plasminogen activators
- G01N2333/9723—Urokinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/976—Trypsin; Chymotrypsin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
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- Wood Science & Technology (AREA)
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- Immunology (AREA)
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- Physics & Mathematics (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH681676A CH634662A5 (de) | 1976-05-28 | 1976-05-28 | Verwendung von tripeptidderivaten zur quantitativen bestimmung von plasminogen-aktivatoren. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2724211A1 DE2724211A1 (de) | 1977-12-01 |
| DE2724211C2 true DE2724211C2 (de) | 1987-03-05 |
Family
ID=4315468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2724211A Expired DE2724211C2 (de) | 1976-05-28 | 1977-05-27 | Tripeptidderivate und deren Verwendung |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US4190574A (enExample) |
| JP (1) | JPS5624520B2 (enExample) |
| AT (1) | AT368550B (enExample) |
| AU (1) | AU517375B2 (enExample) |
| BE (1) | BE855085A (enExample) |
| CA (1) | CA1086614A (enExample) |
| CH (1) | CH634662A5 (enExample) |
| DE (1) | DE2724211C2 (enExample) |
| DK (1) | DK149215C (enExample) |
| FR (1) | FR2353063A1 (enExample) |
| GB (1) | GB1589738A (enExample) |
| IL (1) | IL52124A (enExample) |
| IT (1) | IT1084992B (enExample) |
| LU (1) | LU77429A1 (enExample) |
| NL (1) | NL184849C (enExample) |
| NO (1) | NO156067C (enExample) |
| SE (1) | SE444173B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5415797A (en) * | 1977-06-14 | 1979-02-05 | Seikagaku Kogyo Co Ltd | Detection and measurement of toxin in cells |
| US4275153A (en) * | 1978-08-03 | 1981-06-23 | American Hospital Supply Corporation | Analytical fluorogenic substrates for proteolytic enzymes |
| JPS59499B2 (ja) * | 1978-11-02 | 1984-01-07 | 味の素株式会社 | ペプチド誘導体 |
| DE2903701C2 (de) * | 1979-01-31 | 1980-10-16 | Boehringer Mannheim Gmbh, 6800 Mannheim | Kontrollreagens für die Bestimmung der Heparinaktivität |
| CA1161431A (en) * | 1979-05-11 | 1984-01-31 | Lars G. Svendsen | Tripeptide derivatives |
| CA1161432A (en) * | 1980-02-12 | 1984-01-31 | Lars G. Svendsen | Tripeptide derivatives and their application in assaying enzymes |
| DK155051C (da) * | 1980-05-06 | 1989-07-03 | Pentapharm Ag | Tripeptidderivater samt fremgangsmaade til kvantitativ analyse for proteolytiske enzymer under anvendelse deraf |
| US4568636A (en) * | 1981-03-25 | 1986-02-04 | Pentapharm Ag | Tripeptide derivatives |
| JPS57177985U (enExample) * | 1981-04-30 | 1982-11-11 | ||
| DE3268329D1 (en) * | 1981-11-02 | 1986-02-13 | Pentapharm Ag | Process for the quantitative determination of the blood clotting factor xii in human plasma |
| NL8201987A (nl) * | 1982-05-13 | 1983-12-01 | Tno | Werkwijze voor het bepalen van de activiteit van plasminogeenactivator van het weefseltype, alsmede voor gebruik bij deze werkwijze geschikte combinatie van het "kit"-type. |
| DE3244030A1 (de) * | 1982-11-27 | 1984-05-30 | Behringwerke Ag, 3550 Marburg | Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung |
| DK201084A (da) * | 1983-04-28 | 1984-10-29 | Kimberly Clark Co | Fremgangsmaade til bestemmelse af cathepsin b i naervaerelse af andre proteolytiske enzymer, og forbindelser til anvendelse ved fremgangsmaaden |
| US4753879A (en) * | 1984-08-27 | 1988-06-28 | Biogen N.V. | Modified tissue plasminogen activators |
| JPS62126196A (ja) * | 1985-11-26 | 1987-06-08 | Nitto Boseki Co Ltd | 新規なα１−アンチトリプシン測定用化合物 |
| DE3804600A1 (de) * | 1988-02-13 | 1989-08-24 | Basf Ag | Mischung aus einer thrombolytisch wirkenden und einer antithrombotischen substanz |
| US5115099A (en) | 1988-06-14 | 1992-05-19 | Nitto Boseki Co., Ltd. | Substrates for determination of enzyme activity and intermediates for synthesis of the substrates as well as process for producing the intermediates |
| JPH06511082A (ja) * | 1991-09-18 | 1994-12-08 | アイオワ・ステート・ユニバーシティー・リサーチ・ファウンデーション・インコーポレーテッド | 二波長型光度計及びファイバオプチック検知器プローブ |
| US20030207402A1 (en) * | 1997-08-22 | 2003-11-06 | Erhard Kopetzki | Autocatalytically activatable zymogenic precursors of proteases and their use |
| EP1737819B1 (en) * | 2004-03-26 | 2010-12-22 | DSM IP Assets B.V. | Amino acid and peptide conjugates of arylalkylic acids for cosmetic use |
| CN119178757B (zh) * | 2024-09-03 | 2025-06-10 | 南京市第一医院 | 一种用于检测胰蛋白酶的双通道比色荧光复合探针及检测方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE380257B (sv) * | 1972-05-02 | 1975-11-03 | Bofors Ab | Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser |
| IL42124A (en) * | 1972-05-02 | 1977-02-28 | Kabi Ab | Substrate for the determination of proteolytic enzymes |
| DE2527932C2 (de) * | 1974-07-02 | 1983-04-21 | Pentapharm AG, 4052 Basel | Säureadditionssalze von Tripeptidderivaten und deren Verwendung als Substrate zur Bestimmung von Plasmakallikrein |
| SE407058B (sv) * | 1974-12-05 | 1979-03-12 | Kabi Ab | Nya kromogena enzymsubstrat for serinproteaser |
| CH622286A5 (enExample) * | 1975-06-23 | 1981-03-31 | Pentapharm Ag | |
| US4061625A (en) * | 1975-07-11 | 1977-12-06 | Ab Kabi | Novel chromogenic thrombin substrates |
| SE407571B (sv) * | 1975-07-11 | 1979-04-02 | Kabi Ab | Nya kromogena enzymsubstrat for serinproteaser |
-
1976
- 1976-05-28 CH CH681676A patent/CH634662A5/de not_active IP Right Cessation
-
1977
- 1977-05-19 IL IL52124A patent/IL52124A/xx unknown
- 1977-05-19 US US05/798,426 patent/US4190574A/en not_active Expired - Lifetime
- 1977-05-26 IT IT24038/77A patent/IT1084992B/it active
- 1977-05-26 AT AT0375877A patent/AT368550B/de not_active IP Right Cessation
- 1977-05-26 BE BE177947A patent/BE855085A/xx not_active IP Right Cessation
- 1977-05-26 LU LU77429A patent/LU77429A1/xx unknown
- 1977-05-27 GB GB22458/77A patent/GB1589738A/en not_active Expired
- 1977-05-27 NO NO771869A patent/NO156067C/no unknown
- 1977-05-27 JP JP6206677A patent/JPS5624520B2/ja not_active Expired
- 1977-05-27 CA CA279,358A patent/CA1086614A/en not_active Expired
- 1977-05-27 SE SE7706275A patent/SE444173B/xx not_active IP Right Cessation
- 1977-05-27 DK DK235577A patent/DK149215C/da not_active IP Right Cessation
- 1977-05-27 NL NLAANVRAGE7705891,A patent/NL184849C/xx not_active IP Right Cessation
- 1977-05-27 AU AU25571/77A patent/AU517375B2/en not_active Expired
- 1977-05-27 DE DE2724211A patent/DE2724211C2/de not_active Expired
- 1977-05-27 FR FR7716374A patent/FR2353063A1/fr active Granted
-
1979
- 1979-09-11 US US06/074,551 patent/US4278762A/en not_active Expired - Lifetime
Non-Patent Citations (13)
| Title |
|---|
| "Kurzes Lehrbuch der Biochemie" von P. KARLSON, Georg Thieme-Verlag, Stuttgart, 1967, Seite 70 |
| "Peptide Synthesis" von Miklos BODANSZKY et al., Interscience Publishers, 1966, Seiten 43 und 44, 163 - 165 |
| "The National Formulary XII", herausgegeben von "The American Pharmaceutical Association", Washington, D.C., 1965, Seiten 417 - 418 |
| Chem. Abstracts, 86, 1977, 116826 |
| Enzyme, 12, 1971, S. 311-321 |
| F.E. Smyrniotis et al. [Thromb. Diath et Haemorrh. Bd. III, 257 - 70 (1959)] |
| G. PATAKI, "Dünnschichtchromatographie in der Aminosäure- und Peptid-Chemie", Walter de Gruyter & Co., Berlin, 1966, S. 125 |
| I. Bjerrehuus, Scand. J. Clin. Lab. Invest. 4, 179 (1952) |
| I. Witt in "Biochemie der Blutgerinnung und Fibrinolyse", Verlag Chemie, Weinheim, 1975, S. 119 |
| L.F. Remmert et al., J. Biol. Chem. 181, 431 (1949) |
| Mullertz [Acta physiol. Scand. 26, 174 (1954)] |
| N.U. Bang et al., "Thrombosis and Bleeding Disorders", Georg Thieme Verlag, Stuttgart, 1971, S. 377 |
| W. Troll et al., Journal of Biological Chemistry 208, 85 (1954) |
Also Published As
| Publication number | Publication date |
|---|---|
| DK235577A (da) | 1977-11-29 |
| US4190574A (en) | 1980-02-26 |
| JPS52146694A (enExample) | 1977-12-06 |
| DK149215C (da) | 1986-08-04 |
| SE7706275L (sv) | 1977-11-29 |
| SE444173B (sv) | 1986-03-24 |
| NO156067C (no) | 1987-07-15 |
| GB1589738A (en) | 1981-05-20 |
| AU517375B2 (en) | 1981-07-30 |
| JPS5624520B2 (enExample) | 1981-06-06 |
| FR2353063A1 (fr) | 1977-12-23 |
| FR2353063B1 (enExample) | 1980-10-24 |
| DK149215B (da) | 1986-03-17 |
| AU2557177A (en) | 1978-11-30 |
| LU77429A1 (enExample) | 1977-09-09 |
| AT368550B (de) | 1982-10-25 |
| CA1086614A (en) | 1980-09-30 |
| US4278762A (en) | 1981-07-14 |
| IL52124A (en) | 1980-11-30 |
| IL52124A0 (en) | 1977-07-31 |
| NL184849B (nl) | 1989-06-16 |
| DE2724211A1 (de) | 1977-12-01 |
| IT1084992B (it) | 1985-05-28 |
| BE855085A (fr) | 1977-09-16 |
| NL184849C (nl) | 1989-11-16 |
| ATA375877A (de) | 1982-02-15 |
| NO771869L (no) | 1977-11-29 |
| NL7705891A (nl) | 1977-11-30 |
| NO156067B (no) | 1987-04-06 |
| CH634662A5 (de) | 1983-02-15 |
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