DE2719770C3 - Verwendung von Koüagenen zur Herstellung von ophthalmischen pharmazeutischen Zusammensetzungen mit langsamen Freigabeeigenschaften - Google Patents
Verwendung von Koüagenen zur Herstellung von ophthalmischen pharmazeutischen Zusammensetzungen mit langsamen FreigabeeigenschaftenInfo
- Publication number
- DE2719770C3 DE2719770C3 DE2719770A DE2719770A DE2719770C3 DE 2719770 C3 DE2719770 C3 DE 2719770C3 DE 2719770 A DE2719770 A DE 2719770A DE 2719770 A DE2719770 A DE 2719770A DE 2719770 C3 DE2719770 C3 DE 2719770C3
- Authority
- DE
- Germany
- Prior art keywords
- collagen
- collagens
- water
- ophthalmic
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title claims 5
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 102000008186 Collagen Human genes 0.000 claims description 48
- 108010035532 Collagen Proteins 0.000 claims description 48
- 229920001436 collagen Polymers 0.000 claims description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 239000003814 drug Substances 0.000 claims description 18
- 229940079593 drug Drugs 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 14
- QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 claims description 13
- QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 claims description 13
- 229960001416 pilocarpine Drugs 0.000 claims description 13
- 239000006185 dispersion Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 239000002244 precipitate Substances 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 7
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- 210000001747 pupil Anatomy 0.000 claims description 6
- 239000003513 alkali Substances 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 4
- 235000011152 sodium sulphate Nutrition 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 3
- 108090000790 Enzymes Proteins 0.000 claims description 3
- 238000005119 centrifugation Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 2
- 238000005063 solubilization Methods 0.000 claims description 2
- 230000007928 solubilization Effects 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 230000002378 acidificating effect Effects 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 239000012876 carrier material Substances 0.000 claims 2
- 230000036039 immunity Effects 0.000 claims 2
- 210000002435 tendon Anatomy 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022873 Ocular disease Diseases 0.000 claims 1
- 238000007605 air drying Methods 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 229940012356 eye drops Drugs 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 238000011085 pressure filtration Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 13
- 239000000047 product Substances 0.000 description 7
- 230000004410 intraocular pressure Effects 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
- 230000002035 prolonged effect Effects 0.000 description 5
- 229960003485 ribostamycin Drugs 0.000 description 4
- NSKGQURZWSPSBC-NLZFXWNVSA-N ribostamycin Chemical compound N[C@H]1[C@H](O)[C@@H](O)[C@H](CN)O[C@@H]1O[C@@H]1[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](CO)O2)O)[C@H](O)[C@@H](N)C[C@H]1N NSKGQURZWSPSBC-NLZFXWNVSA-N 0.000 description 4
- 208000010412 Glaucoma Diseases 0.000 description 3
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 3
- 229960003957 dexamethasone Drugs 0.000 description 3
- 229960004716 idoxuridine Drugs 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000003889 eye drop Substances 0.000 description 2
- 210000000744 eyelid Anatomy 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 229960002139 pilocarpine hydrochloride Drugs 0.000 description 2
- RNAICSBVACLLGM-GNAZCLTHSA-N pilocarpine hydrochloride Chemical compound Cl.C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C RNAICSBVACLLGM-GNAZCLTHSA-N 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 230000001179 pupillary effect Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 241000347881 Kadua laxiflora Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP51057298A JPS597684B2 (ja) | 1976-05-20 | 1976-05-20 | コラ−ゲンを用いた眼用徐放性制御医薬剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2719770A1 DE2719770A1 (de) | 1977-12-08 |
| DE2719770B2 DE2719770B2 (de) | 1980-05-29 |
| DE2719770C3 true DE2719770C3 (de) | 1981-02-19 |
Family
ID=13051636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2719770A Expired DE2719770C3 (de) | 1976-05-20 | 1977-05-03 | Verwendung von Koüagenen zur Herstellung von ophthalmischen pharmazeutischen Zusammensetzungen mit langsamen Freigabeeigenschaften |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS597684B2 (https=) |
| DE (1) | DE2719770C3 (https=) |
| ES (1) | ES459244A1 (https=) |
| FR (1) | FR2374915A1 (https=) |
| GB (1) | GB1556097A (https=) |
| SE (1) | SE425592B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4279812A (en) * | 1979-09-12 | 1981-07-21 | Seton Company | Process for preparing macromolecular biologically active collagen |
| JPS56122317A (en) * | 1980-02-29 | 1981-09-25 | Koken:Kk | Drug transporting material and its preparation |
| US4281654A (en) * | 1980-04-07 | 1981-08-04 | Alza Corporation | Drug delivery system for controlled ocular therapy |
| JPS5755146A (en) * | 1980-09-17 | 1982-04-01 | Koken Kk | Drug conveyor |
| JPS60214730A (ja) * | 1984-04-05 | 1985-10-28 | Grelan Pharmaceut Co Ltd | 軟膏基剤 |
| IL95942A0 (en) * | 1989-10-13 | 1991-07-18 | Syntex Inc | Collagen-containing ophthalmic formulation |
| DE4414755C2 (de) * | 1994-04-27 | 2000-11-16 | Lohmann Therapie Syst Lts | Kollagenzubereitung zur gesteuerten Abgabe von Wirkstoffen, Verfahren und Verwendung |
-
1976
- 1976-05-20 JP JP51057298A patent/JPS597684B2/ja not_active Expired
-
1977
- 1977-04-28 GB GB17714/77A patent/GB1556097A/en not_active Expired
- 1977-05-03 DE DE2719770A patent/DE2719770C3/de not_active Expired
- 1977-05-17 SE SE7705812A patent/SE425592B/xx not_active IP Right Cessation
- 1977-05-18 ES ES459244A patent/ES459244A1/es not_active Expired
- 1977-05-18 FR FR7715385A patent/FR2374915A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| SE7705812L (sv) | 1977-11-21 |
| JPS52143216A (en) | 1977-11-29 |
| SE425592B (sv) | 1982-10-18 |
| JPS597684B2 (ja) | 1984-02-20 |
| DE2719770B2 (de) | 1980-05-29 |
| ES459244A1 (es) | 1979-06-01 |
| FR2374915B1 (https=) | 1981-12-11 |
| DE2719770A1 (de) | 1977-12-08 |
| GB1556097A (en) | 1979-11-21 |
| FR2374915A1 (fr) | 1978-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| C3 | Grant after two publication steps (3rd publication) |