DE2713389A1 - Neuartige xanthinverbindungen und dieselben enthaltende pharmazeutische zubereitung - Google Patents

Neuartige xanthinverbindungen und dieselben enthaltende pharmazeutische zubereitung

Info

Publication number
DE2713389A1
DE2713389A1 DE19772713389 DE2713389A DE2713389A1 DE 2713389 A1 DE2713389 A1 DE 2713389A1 DE 19772713389 DE19772713389 DE 19772713389 DE 2713389 A DE2713389 A DE 2713389A DE 2713389 A1 DE2713389 A1 DE 2713389A1
Authority
DE
Germany
Prior art keywords
methyl
butyl
dimethyl
xanthine
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19772713389
Other languages
German (de)
English (en)
Other versions
DE2713389C2 (pt
Inventor
Julius Diamond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cooper Laboratories Inc
Original Assignee
Cooper Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/672,388 external-priority patent/US4120947A/en
Priority claimed from US05/672,437 external-priority patent/US4089959A/en
Application filed by Cooper Laboratories Inc filed Critical Cooper Laboratories Inc
Publication of DE2713389A1 publication Critical patent/DE2713389A1/de
Application granted granted Critical
Publication of DE2713389C2 publication Critical patent/DE2713389C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19772713389 1976-03-31 1977-03-23 Neuartige xanthinverbindungen und dieselben enthaltende pharmazeutische zubereitung Granted DE2713389A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/672,388 US4120947A (en) 1976-03-31 1976-03-31 Xanthine compounds and method of treating bronchospastic and allergic diseases
US05/672,437 US4089959A (en) 1976-03-31 1976-03-31 Long-acting xanthine bronchodilators and antiallergy agents

Publications (2)

Publication Number Publication Date
DE2713389A1 true DE2713389A1 (de) 1977-10-13
DE2713389C2 DE2713389C2 (pt) 1992-03-19

Family

ID=27100746

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772713389 Granted DE2713389A1 (de) 1976-03-31 1977-03-23 Neuartige xanthinverbindungen und dieselben enthaltende pharmazeutische zubereitung

Country Status (5)

Country Link
JP (1) JPS52122396A (pt)
CA (1) CA1077932A (pt)
DE (1) DE2713389A1 (pt)
FR (1) FR2346353A1 (pt)
GB (1) GB1561005A (pt)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0001735A1 (en) * 1977-10-14 1979-05-02 Aktiebolaget DRACO Xanthine derivatives having antiallergic activity and pharmacological preparations containing them
US4325956A (en) * 1978-10-20 1982-04-20 Aktiebolaget Draco Method and pharmaceutical preparation for treating chronic obstructive airway disease and cardiac disease, and intermediates for the preparation of therapeutically active xanthine derivatives
US4548818A (en) * 1978-10-20 1985-10-22 Kjellin Per G Composition and methods for the treatment of chronic obstructive airway disease and cardiac disease using 3-alkylxanthines

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8002910L (sv) * 1980-04-18 1981-10-19 Draco Ab 3,8-dialkylxantiner, forfarande for deras framstellning, beredning och metoder for behandling av kronisk obstruktiv luftvegssjukdom och kardiovaskulera sjukdomar
CH643260A5 (fr) * 1980-05-02 1984-05-30 Nestle Sa 1-allyl-3-butyl-8-methylxanthine, procede de preparation et utilisation dans un medicament.
FR2611716A1 (fr) * 1987-03-06 1988-09-09 Uriach Cia Sa J Derives de diisobutylxanthine substituee en position 7 utiles comme bronchodilatateurs, procede pour leur preparation et composition pharmaceutique les contenant
US5321029A (en) * 1988-11-14 1994-06-14 Beecham-Wuelfing Gmbh & Co.K.G. Xanthines
GB8826595D0 (en) * 1988-11-14 1988-12-21 Beecham Wuelfing Gmbh & Co Kg Active compounds
IT1229195B (it) * 1989-03-10 1991-07-25 Poli Ind Chimica Spa Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche.
GB9312853D0 (en) 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5591776A (en) 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5922751A (en) 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
AU4527996A (en) 1994-12-13 1996-07-03 Euro-Celtique S.A. Trisubstituted thioxanthines
WO1996018399A1 (en) 1994-12-13 1996-06-20 Euro-Celtique, S.A. Aryl thioxanthines
US6166041A (en) 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5864037A (en) 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2729643A (en) * 1956-01-03 J-disubstmjied and i

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2729643A (en) * 1956-01-03 J-disubstmjied and i

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. Med. Chem., 1971, 14,1202-05 *
Mol. Pharmacol., 1970, 6, 597-603 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0001735A1 (en) * 1977-10-14 1979-05-02 Aktiebolaget DRACO Xanthine derivatives having antiallergic activity and pharmacological preparations containing them
JPS5479296A (en) * 1977-10-14 1979-06-25 Draco Ab Xanthine derivative
US4233303A (en) 1977-10-14 1980-11-11 Aktiebolaget Draco Xanthine derivatives
US4325956A (en) * 1978-10-20 1982-04-20 Aktiebolaget Draco Method and pharmaceutical preparation for treating chronic obstructive airway disease and cardiac disease, and intermediates for the preparation of therapeutically active xanthine derivatives
US4548818A (en) * 1978-10-20 1985-10-22 Kjellin Per G Composition and methods for the treatment of chronic obstructive airway disease and cardiac disease using 3-alkylxanthines

Also Published As

Publication number Publication date
DE2713389C2 (pt) 1992-03-19
JPS52122396A (en) 1977-10-14
FR2346353B1 (pt) 1980-03-07
FR2346353A1 (fr) 1977-10-28
GB1561005A (en) 1980-02-13
CA1077932A (en) 1980-05-20
JPS5720313B2 (pt) 1982-04-27

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Legal Events

Date Code Title Description
OD Request for examination
OGA New person/name/address of the applicant
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee