DE2661037C2 - - Google Patents

Info

Publication number
DE2661037C2
DE2661037C2 DE2661037A DE2661037A DE2661037C2 DE 2661037 C2 DE2661037 C2 DE 2661037C2 DE 2661037 A DE2661037 A DE 2661037A DE 2661037 A DE2661037 A DE 2661037A DE 2661037 C2 DE2661037 C2 DE 2661037C2
Authority
DE
Germany
Prior art keywords
flunisolide
propellant
aerosol
powder
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2661037A
Other languages
German (de)
English (en)
Inventor
John H. Palo Alto Calif. Us Fried
Richard E. Woodside Calif. Us Jones
Gisela T. Cupertino Calif. Us Haringer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of DE2661037C2 publication Critical patent/DE2661037C2/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
DE2661037A 1975-05-27 1976-06-03 Expired DE2661037C2 (enExample)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58130075A 1975-05-27 1975-05-27
US58130175A 1975-05-27 1975-05-27

Publications (1)

Publication Number Publication Date
DE2661037C2 true DE2661037C2 (enExample) 1989-04-06

Family

ID=27078279

Family Applications (2)

Application Number Title Priority Date Filing Date
DE2661037A Expired DE2661037C2 (enExample) 1975-05-27 1976-06-03
DE2624924A Expired DE2624924C2 (de) 1975-05-27 1976-06-03 Verfahren zur Herstellung einer neuen kristallinen Form von Flunisolid und diese enthaltende Aerosolzusammnesetzung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE2624924A Expired DE2624924C2 (de) 1975-05-27 1976-06-03 Verfahren zur Herstellung einer neuen kristallinen Form von Flunisolid und diese enthaltende Aerosolzusammnesetzung

Country Status (15)

Country Link
JP (1) JPS51144719A (enExample)
AT (1) AT357702B (enExample)
AU (1) AU506080B2 (enExample)
CA (1) CA1075228A (enExample)
DE (2) DE2661037C2 (enExample)
ES (1) ES448220A1 (enExample)
FR (1) FR2361900A1 (enExample)
GB (1) GB1525181A (enExample)
HK (1) HK8580A (enExample)
IL (1) IL49652A (enExample)
MX (1) MX3864E (enExample)
MY (1) MY8000275A (enExample)
NL (1) NL191234C (enExample)
NZ (1) NZ180946A (enExample)
SE (1) SE421426B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19653969A1 (de) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2457303A1 (fr) * 1979-05-21 1980-12-19 Syntex Corp Procede de preparation d'une forme cristalline de flunisolide, le produit obtenu et son utilisation comme produit pharmaceutique
EP0039369B1 (en) * 1980-05-02 1983-06-15 Schering Corporation Beclomethasone ester solvates, process for their preparation, and preparation of a formulation
GB2127689B (en) * 1982-10-05 1986-07-09 Sandoz Ltd Calcitonin inhalation compositions
US4782047A (en) * 1986-05-22 1988-11-01 Syntex Pharmaceuticals International Ltd. Aqueous steroid formulations for nasal administration
JP2843857B2 (ja) * 1988-10-05 1999-01-06 ファルマシア・アンド・アップジョン・カンパニー 反溶剤への沈澱を介する微細分化固体結晶性粉末
US5707634A (en) * 1988-10-05 1998-01-13 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
DE4003272A1 (de) 1990-02-03 1991-08-08 Boehringer Ingelheim Kg Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen
RU2223750C2 (ru) * 1995-06-27 2004-02-20 Берингер Ингельхайм КГ Лекарственная композиция в виде раствора, предназначенная для получения способного к ингаляции аэрозоля
US20010031244A1 (en) 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
DZ2947A1 (fr) 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
HK1039459B (en) * 1999-03-03 2005-05-13 Optinose As Nasal delivery device
IT1313553B1 (it) 1999-07-23 2002-09-09 Chiesi Farma Spa Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione.
IT1317846B1 (it) 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
IL152955A0 (en) 2000-05-22 2003-06-24 Chiesi Farma Spa Stable pharmaceutical solution formulations for pressurised metered dose inhalers
DE60103527T2 (de) 2001-07-02 2005-06-16 Chiesi Farmaceutici S.P.A. Optimierte Tobramycin-Formulierung zur Aerosolbildung
JP4632687B2 (ja) * 2003-04-25 2011-02-16 ロート製薬株式会社 点鼻剤
JP5238779B2 (ja) * 2003-04-25 2013-07-17 ロート製薬株式会社 点鼻剤
EP1595531A1 (en) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
EP2968572A1 (en) 2013-03-15 2016-01-20 Medicis Pharmaceutical Corporation Topical compositions of flunisolide and methods of treatment

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) * 1964-03-24 Chioacyl
US3282791A (en) * 1965-08-17 1966-11-01 Merck & Co Inc Inhalation aerosol suspension of anhydrous disodium dexamethasone phosphate, propellents, and sorbitan trioleate
DE2015300A1 (de) * 1969-04-01 1970-10-29 Syntex Corp., Panania;PM örtliche, entzündungshemmende Präparate und Verfahren zu ihrer Verwendung
US3592930A (en) * 1968-07-19 1971-07-13 Syntex Corp Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle
DE2320111A1 (de) * 1972-04-20 1973-10-31 Allen & Hanburys Ltd Solvatisierte, kristalline, antiinflammatorisch wirkende steroide, verfahren zu deren herstellung und diese materialien enthaltende aerosolformulierungen
DE2332663A1 (de) * 1973-06-23 1975-01-16 Schering Ag Kortikoidhaltige inhalationsmittel
US3934013A (en) * 1975-02-21 1976-01-20 Syntex (U.S.A.) Inc. Pharmaceutical composition

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB933867A (en) * 1958-12-08 1963-08-14 American Cyanamid Co Fluorinated steroids

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) * 1964-03-24 Chioacyl
US3282791A (en) * 1965-08-17 1966-11-01 Merck & Co Inc Inhalation aerosol suspension of anhydrous disodium dexamethasone phosphate, propellents, and sorbitan trioleate
US3592930A (en) * 1968-07-19 1971-07-13 Syntex Corp Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle
DE2015300A1 (de) * 1969-04-01 1970-10-29 Syntex Corp., Panania;PM örtliche, entzündungshemmende Präparate und Verfahren zu ihrer Verwendung
DE2320111A1 (de) * 1972-04-20 1973-10-31 Allen & Hanburys Ltd Solvatisierte, kristalline, antiinflammatorisch wirkende steroide, verfahren zu deren herstellung und diese materialien enthaltende aerosolformulierungen
DE2332663A1 (de) * 1973-06-23 1975-01-16 Schering Ag Kortikoidhaltige inhalationsmittel
US3934013A (en) * 1975-02-21 1976-01-20 Syntex (U.S.A.) Inc. Pharmaceutical composition

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Disease 109, 1974, S.538-543 *
J. Allergy 33, 1, 1974, S.1-5 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19653969A1 (de) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole

Also Published As

Publication number Publication date
NL191234B (nl) 1994-11-01
IL49652A0 (en) 1976-07-30
DE2624924C2 (de) 1986-11-27
JPS51144719A (en) 1976-12-13
MY8000275A (en) 1980-12-31
AT357702B (de) 1980-07-25
JPS6247880B2 (enExample) 1987-10-09
AU1430176A (en) 1977-12-01
ATA388376A (de) 1979-12-15
FR2361900B1 (enExample) 1979-04-13
DE2624924A1 (de) 1977-12-15
SE421426B (sv) 1981-12-21
FR2361900A1 (fr) 1978-03-17
CA1075228A (en) 1980-04-08
ES448220A1 (es) 1977-11-01
IL49652A (en) 1979-05-31
SE7605927L (sv) 1976-11-28
AU506080B2 (en) 1979-12-13
NZ180946A (en) 1978-07-28
HK8580A (en) 1980-03-14
NL191234C (nl) 1995-04-03
NL7605699A (nl) 1976-11-30
GB1525181A (en) 1978-09-20
MX3864E (es) 1981-08-26

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