JPS51144719A - Preparation of crystalline frunisolide and ittcontaining composition - Google Patents

Preparation of crystalline frunisolide and ittcontaining composition

Info

Publication number
JPS51144719A
JPS51144719A JP51061032A JP6103276A JPS51144719A JP S51144719 A JPS51144719 A JP S51144719A JP 51061032 A JP51061032 A JP 51061032A JP 6103276 A JP6103276 A JP 6103276A JP S51144719 A JPS51144719 A JP S51144719A
Authority
JP
Japan
Prior art keywords
ittcontaining
frunisolide
crystalline
preparation
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP51061032A
Other languages
Japanese (ja)
Other versions
JPS6247880B2 (en
Inventor
Eichi Furiido Jiyon
Ii Jiyoonzu Richiyaado
Tei Haringaa Gisera
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of JPS51144719A publication Critical patent/JPS51144719A/en
Publication of JPS6247880B2 publication Critical patent/JPS6247880B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
JP51061032A 1975-05-27 1976-05-26 Preparation of crystalline frunisolide and ittcontaining composition Granted JPS51144719A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58130175A 1975-05-27 1975-05-27
US58130075A 1975-05-27 1975-05-27

Publications (2)

Publication Number Publication Date
JPS51144719A true JPS51144719A (en) 1976-12-13
JPS6247880B2 JPS6247880B2 (en) 1987-10-09

Family

ID=27078279

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51061032A Granted JPS51144719A (en) 1975-05-27 1976-05-26 Preparation of crystalline frunisolide and ittcontaining composition

Country Status (15)

Country Link
JP (1) JPS51144719A (en)
AT (1) AT357702B (en)
AU (1) AU506080B2 (en)
CA (1) CA1075228A (en)
DE (2) DE2624924C2 (en)
ES (1) ES448220A1 (en)
FR (1) FR2361900A1 (en)
GB (1) GB1525181A (en)
HK (1) HK8580A (en)
IL (1) IL49652A (en)
MX (1) MX3864E (en)
MY (1) MY8000275A (en)
NL (1) NL191234C (en)
NZ (1) NZ180946A (en)
SE (1) SE421426B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004339213A (en) * 2003-04-25 2004-12-02 Rohto Pharmaceut Co Ltd Nasal drop
JP2010280722A (en) * 2003-04-25 2010-12-16 Rohto Pharmaceut Co Ltd Nasal drop
JP2016515525A (en) * 2013-03-15 2016-05-30 メディシス ファーマシューティカル コーポレイション Flunisolide topical composition and method of treatment

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH643567A5 (en) * 1979-05-21 1984-06-15 Syntex Corp METHOD FOR PRODUCING A CRYSTALLINE SHAPE OF FLUNISOLIDE.
ATE3774T1 (en) * 1980-05-02 1983-06-15 Schering Corporation BECLOMETHASONE ESTER SOLVATE, PROCESS FOR THEIR PREPARATION AND PREPARATION OF A FORMULATION.
GB2127689B (en) * 1982-10-05 1986-07-09 Sandoz Ltd Calcitonin inhalation compositions
US4782047A (en) * 1986-05-22 1988-11-01 Syntex Pharmaceuticals International Ltd. Aqueous steroid formulations for nasal administration
DE68907062T2 (en) * 1988-10-05 1993-10-07 Upjohn Co FINE DISTRIBUTED SOLID CRYSTALLINE POWDER BY DEPOSIT IN AN ANTI-SOLVENT.
US5707634A (en) * 1988-10-05 1998-01-13 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
DE4003272A1 (en) 1990-02-03 1991-08-08 Boehringer Ingelheim Kg NEW GAS MIXTURES AND THEIR USE IN MEDICINE PREPARATIONS
IL122752A (en) * 1995-06-27 2001-07-24 Boehringer Ingelheim Kg Stable compositions for generating propellant-free aerosols
DE19653969A1 (en) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg New aqueous pharmaceutical preparation for the production of propellant-free aerosols
US20010031244A1 (en) 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
DZ2947A1 (en) 1998-11-25 2004-03-15 Chiesi Farma Spa Pressure metered dose inhaler.
IT1313553B1 (en) * 1999-07-23 2002-09-09 Chiesi Farma Spa OPTIMIZED FORMULATIONS CONSTITUTED BY SOLUTIONS OF STEROIDS GIVEN BY INHALATION.
IT1317846B1 (en) 2000-02-22 2003-07-15 Chiesi Farma Spa FORMULATIONS CONTAINING AN ANTICOLINERGIC DRUG FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE BRONCOPNEUMOPATHY.
BR0015884A (en) 2000-05-22 2003-07-08 Chiesi Farma Spa Formulations of stable pharmaceutical solutions for pressurized metered dose inhalers
SI1273292T1 (en) 2001-07-02 2004-12-31 Chiesi Farmaceutici S.P.A. Optimised formulation of tobramycin for aerosolization
EP1595531A1 (en) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB933867A (en) * 1958-12-08 1963-08-14 American Cyanamid Co Fluorinated steroids

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) * 1964-03-24 Chioacyl
US3282791A (en) 1965-08-17 1966-11-01 Merck & Co Inc Inhalation aerosol suspension of anhydrous disodium dexamethasone phosphate, propellents, and sorbitan trioleate
US3592930A (en) * 1968-07-19 1971-07-13 Syntex Corp Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle
FR2038105A1 (en) 1969-04-01 1971-01-08 Syntex Corp Antiinflammatory steroid preparations
GB1429184A (en) * 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
DE2332663C2 (en) 1973-06-23 1986-07-31 Schering AG, 1000 Berlin und 4709 Bergkamen Use of corticosteroid active ingredients for inhalation therapy
US3934013A (en) * 1975-02-21 1976-01-20 Syntex (U.S.A.) Inc. Pharmaceutical composition

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB933867A (en) * 1958-12-08 1963-08-14 American Cyanamid Co Fluorinated steroids

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004339213A (en) * 2003-04-25 2004-12-02 Rohto Pharmaceut Co Ltd Nasal drop
JP2010280722A (en) * 2003-04-25 2010-12-16 Rohto Pharmaceut Co Ltd Nasal drop
JP4632687B2 (en) * 2003-04-25 2011-02-16 ロート製薬株式会社 Nasal drops
JP2016515525A (en) * 2013-03-15 2016-05-30 メディシス ファーマシューティカル コーポレイション Flunisolide topical composition and method of treatment

Also Published As

Publication number Publication date
MX3864E (en) 1981-08-26
FR2361900B1 (en) 1979-04-13
HK8580A (en) 1980-03-14
AU506080B2 (en) 1979-12-13
IL49652A0 (en) 1976-07-30
NL191234B (en) 1994-11-01
SE421426B (en) 1981-12-21
DE2624924A1 (en) 1977-12-15
NZ180946A (en) 1978-07-28
CA1075228A (en) 1980-04-08
NL7605699A (en) 1976-11-30
JPS6247880B2 (en) 1987-10-09
DE2661037C2 (en) 1989-04-06
FR2361900A1 (en) 1978-03-17
AU1430176A (en) 1977-12-01
NL191234C (en) 1995-04-03
AT357702B (en) 1980-07-25
SE7605927L (en) 1976-11-28
GB1525181A (en) 1978-09-20
ATA388376A (en) 1979-12-15
DE2624924C2 (en) 1986-11-27
ES448220A1 (en) 1977-11-01
IL49652A (en) 1979-05-31
MY8000275A (en) 1980-12-31

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