SE421426B - SET TO MAKE A UNIQUE CRYSTALLINIC POLYMORPH FORM OF ALFA-FLUOR-11BETA, 21-DIHYDROXY-16ALFA, 17ALFA-ISOPROPYLENDIOXY-1,4-DIENE-3,20-DION - Google Patents

SET TO MAKE A UNIQUE CRYSTALLINIC POLYMORPH FORM OF ALFA-FLUOR-11BETA, 21-DIHYDROXY-16ALFA, 17ALFA-ISOPROPYLENDIOXY-1,4-DIENE-3,20-DION

Info

Publication number
SE421426B
SE421426B SE7605927A SE7605927A SE421426B SE 421426 B SE421426 B SE 421426B SE 7605927 A SE7605927 A SE 7605927A SE 7605927 A SE7605927 A SE 7605927A SE 421426 B SE421426 B SE 421426B
Authority
SE
Sweden
Prior art keywords
isopropylendioxy
16alfa
17alfa
crystallinic
11beta
Prior art date
Application number
SE7605927A
Other languages
Swedish (sv)
Other versions
SE7605927L (en
Inventor
J H Fried
R E Jones
G T Haringer
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of SE7605927L publication Critical patent/SE7605927L/en
Publication of SE421426B publication Critical patent/SE421426B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
SE7605927A 1975-05-27 1976-05-25 SET TO MAKE A UNIQUE CRYSTALLINIC POLYMORPH FORM OF ALFA-FLUOR-11BETA, 21-DIHYDROXY-16ALFA, 17ALFA-ISOPROPYLENDIOXY-1,4-DIENE-3,20-DION SE421426B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58130075A 1975-05-27 1975-05-27
US58130175A 1975-05-27 1975-05-27

Publications (2)

Publication Number Publication Date
SE7605927L SE7605927L (en) 1976-11-28
SE421426B true SE421426B (en) 1981-12-21

Family

ID=27078279

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7605927A SE421426B (en) 1975-05-27 1976-05-25 SET TO MAKE A UNIQUE CRYSTALLINIC POLYMORPH FORM OF ALFA-FLUOR-11BETA, 21-DIHYDROXY-16ALFA, 17ALFA-ISOPROPYLENDIOXY-1,4-DIENE-3,20-DION

Country Status (15)

Country Link
JP (1) JPS51144719A (en)
AT (1) AT357702B (en)
AU (1) AU506080B2 (en)
CA (1) CA1075228A (en)
DE (2) DE2661037C2 (en)
ES (1) ES448220A1 (en)
FR (1) FR2361900A1 (en)
GB (1) GB1525181A (en)
HK (1) HK8580A (en)
IL (1) IL49652A (en)
MX (1) MX3864E (en)
MY (1) MY8000275A (en)
NL (1) NL191234C (en)
NZ (1) NZ180946A (en)
SE (1) SE421426B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK162530C (en) * 1979-05-21 1992-03-30 Syntex Corp PROCEDURE FOR PREPARING A CRYSTALLINE MODIFICATION OF FLUNISOLIDE
ATE3774T1 (en) * 1980-05-02 1983-06-15 Schering Corporation BECLOMETHASONE ESTER SOLVATE, PROCESS FOR THEIR PREPARATION AND PREPARATION OF A FORMULATION.
GB2127689B (en) * 1982-10-05 1986-07-09 Sandoz Ltd Calcitonin inhalation compositions
US4782047A (en) * 1986-05-22 1988-11-01 Syntex Pharmaceuticals International Ltd. Aqueous steroid formulations for nasal administration
US5707634A (en) * 1988-10-05 1998-01-13 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
HU209603B (en) * 1988-10-05 1994-09-28 Upjohn Co Process for production of solid powders in finalydivided microcristallin form
DE4003272A1 (en) 1990-02-03 1991-08-08 Boehringer Ingelheim Kg NEW GAS MIXTURES AND THEIR USE IN MEDICINE PREPARATIONS
ES2183001T3 (en) * 1995-06-27 2003-03-16 Boehringer Ingelheim Pharma NEW PREPARED DRUG STABLE FOR THE PRODUCTION OF AEROSOLS EXEMPT FROM GAS PROPULSOR.
DE19653969A1 (en) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg New aqueous pharmaceutical preparation for the production of propellant-free aerosols
US20010031244A1 (en) 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
DZ2947A1 (en) 1998-11-25 2004-03-15 Chiesi Farma Spa Pressure metered dose inhaler.
AU766410B2 (en) * 1999-03-03 2003-10-16 Optinose As Nasal delivery device
IT1313553B1 (en) * 1999-07-23 2002-09-09 Chiesi Farma Spa OPTIMIZED FORMULATIONS CONSTITUTED BY SOLUTIONS OF STEROIDS GIVEN BY INHALATION.
IT1317846B1 (en) 2000-02-22 2003-07-15 Chiesi Farma Spa FORMULATIONS CONTAINING AN ANTICOLINERGIC DRUG FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE BRONCOPNEUMOPATHY.
CZ303833B6 (en) 2000-05-22 2013-05-22 Chiesi Farmaceutici S.P.A. Aerosol composition
DE60103527T2 (en) 2001-07-02 2005-06-16 Chiesi Farmaceutici S.P.A. Optimized tobramycin formulation for aerosol formation
JP4632687B2 (en) * 2003-04-25 2011-02-16 ロート製薬株式会社 Nasal drops
JP5238779B2 (en) * 2003-04-25 2013-07-17 ロート製薬株式会社 Nasal drops
EP1595531A1 (en) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
CA2905587A1 (en) * 2013-03-15 2014-09-18 Medicis Pharmaceutical Corporation Topical compositions of flunisolide and methods of treatment

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) * 1964-03-24 Chioacyl
GB933867A (en) * 1958-12-08 1963-08-14 American Cyanamid Co Fluorinated steroids
US3282791A (en) * 1965-08-17 1966-11-01 Merck & Co Inc Inhalation aerosol suspension of anhydrous disodium dexamethasone phosphate, propellents, and sorbitan trioleate
US3592930A (en) * 1968-07-19 1971-07-13 Syntex Corp Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle
DE2015300A1 (en) * 1969-04-01 1970-10-29 Syntex Corp., Panania;PM topical anti-inflammatory preparations and methods of their use
GB1429184A (en) * 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
DE2332663C2 (en) * 1973-06-23 1986-07-31 Schering AG, 1000 Berlin und 4709 Bergkamen Use of corticosteroid active ingredients for inhalation therapy
US3934013A (en) 1975-02-21 1976-01-20 Syntex (U.S.A.) Inc. Pharmaceutical composition

Also Published As

Publication number Publication date
MY8000275A (en) 1980-12-31
MX3864E (en) 1981-08-26
JPS51144719A (en) 1976-12-13
DE2624924A1 (en) 1977-12-15
ES448220A1 (en) 1977-11-01
IL49652A (en) 1979-05-31
NZ180946A (en) 1978-07-28
FR2361900A1 (en) 1978-03-17
AU506080B2 (en) 1979-12-13
HK8580A (en) 1980-03-14
SE7605927L (en) 1976-11-28
DE2624924C2 (en) 1986-11-27
IL49652A0 (en) 1976-07-30
FR2361900B1 (en) 1979-04-13
GB1525181A (en) 1978-09-20
NL7605699A (en) 1976-11-30
CA1075228A (en) 1980-04-08
ATA388376A (en) 1979-12-15
DE2661037C2 (en) 1989-04-06
AT357702B (en) 1980-07-25
NL191234C (en) 1995-04-03
NL191234B (en) 1994-11-01
AU1430176A (en) 1977-12-01
JPS6247880B2 (en) 1987-10-09

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