FR2361900A1 - New form of flunisolide crystallizes and its applications as a drug - Google Patents

New form of flunisolide crystallizes and its applications as a drug

Info

Publication number
FR2361900A1
FR2361900A1 FR7616040A FR7616040A FR2361900A1 FR 2361900 A1 FR2361900 A1 FR 2361900A1 FR 7616040 A FR7616040 A FR 7616040A FR 7616040 A FR7616040 A FR 7616040A FR 2361900 A1 FR2361900 A1 FR 2361900A1
Authority
FR
France
Prior art keywords
gt
lt
flunisolide
crystallizes
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7616040A
Other languages
French (fr)
Other versions
FR2361900B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US58130075A priority Critical
Priority to US58130175A priority
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of FR2361900A1 publication Critical patent/FR2361900A1/en
Application granted granted Critical
Publication of FR2361900B1 publication Critical patent/FR2361900B1/fr
Application status is Expired legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/0026Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Abstract

<P>L'invention concerne une forme polymorphe cristalline exceptionnelle de flunisolide obtenue en mettant une des autres formes polymorphes du flunisolide solide en contact avec un liquide approprié dans lequel le flunisolide n'est pratiquement pas soluble, en particulier, le << Fréon 12 >> ou le << Fréon 114 >>, ou encore en recristallisant la forme cristalline exceptionnelle dans un solvant approprié tel que le chlorure de méthylène. <P> The invention relates to an exceptional crystalline polymorphic form of flunisolide obtained by bringing one of the other polymorphic forms of flunisolide solid into contact with a suitable liquid wherein the flunisolide is substantially not soluble, in particular, Freon << 12 >> or << >> Freon 114, or recrystallizing the exceptional crystalline form in a suitable solvent such as methylene chloride. Cette forme cristalline est stable dans des aérosols tels que des mélanges de Fréons. This crystalline form is stable in aerosols such as mixtures of Freons. </P><P>Application au traitement des troubles respiratoires.</P> </ P> <P> is useful for treating respiratory disorders. </ P>
FR7616040A 1975-05-27 1976-05-26 Expired FR2361900B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US58130075A true 1975-05-27 1975-05-27
US58130175A true 1975-05-27 1975-05-27

Publications (2)

Publication Number Publication Date
FR2361900A1 true FR2361900A1 (en) 1978-03-17
FR2361900B1 FR2361900B1 (en) 1979-04-13

Family

ID=27078279

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7616040A Expired FR2361900B1 (en) 1975-05-27 1976-05-26

Country Status (15)

Country Link
JP (1) JPS6247880B2 (en)
AT (1) AT357702B (en)
AU (1) AU506080B2 (en)
CA (1) CA1075228A (en)
DE (2) DE2661037C2 (en)
ES (1) ES448220A1 (en)
FR (1) FR2361900B1 (en)
GB (1) GB1525181A (en)
HK (1) HK8580A (en)
IL (1) IL49652A (en)
MX (1) MX3864E (en)
MY (1) MY8000275A (en)
NL (1) NL191234C (en)
NZ (1) NZ180946A (en)
SE (1) SE421426B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0039369A1 (en) * 1980-05-02 1981-11-11 Schering Corporation Beclomethasone ester solvates, process for their preparation, and preparation of a formulation

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL189201C (en) * 1979-05-21 1993-02-01 Syntex Corp A process for the preparation of a crystalline form of flunisolide.
GB2127689B (en) * 1982-10-05 1986-07-09 Sandoz Ltd Calcitonin inhalation compositions
US4782047A (en) * 1986-05-22 1988-11-01 Syntex Pharmaceuticals International Ltd. Aqueous steroid formulations for nasal administration
EP0437451B1 (en) * 1988-10-05 1993-06-09 The Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
US5707634A (en) * 1988-10-05 1998-01-13 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
DE4003272A1 (en) 1990-02-03 1991-08-08 Boehringer Ingelheim Kg New propellant mixtures and their use in drug preparations
PL186196B1 (en) * 1995-06-27 2003-11-28 Boehringer Ingelheim Kg Novel stable preparations of therapeutic agents for obtaining aerosols without gaseous propellant
DE19653969A1 (en) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg New aqueous pharmaceutical preparation for producing propellant-free aerosols
US20010031244A1 (en) 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
DZ2947A1 (en) 1998-11-25 2004-03-15 Chiesi Farma Spa pressurized meter dose inhaler.
IT1313553B1 (en) * 1999-07-23 2002-09-09 Chiesi Farma Spa Formulations optimized consist of dasomministrare steroids solutions for inhalation.
IT1317846B1 (en) 2000-02-22 2003-07-15 Chiesi Farma Spa Formulations containing an anticholinergic drug for chronic obstructive pulmonary disease trattamentodella.
HU230804B1 (en) 2000-05-22 2018-06-28 Chiesi Farm Spa Stable pharmaceutical solution formulations for pressurised metered dose inhalers
ES2222294T3 (en) 2001-07-02 2005-02-01 Chiesi Farmaceutici S.P.A. Optimized formulation for tobramycin aerosol administration.
JP4632687B2 (en) * 2003-04-25 2011-02-23 ロート製薬株式会社 Nasal drops
JP5238779B2 (en) * 2003-04-25 2013-07-17 ロート製薬株式会社 Nasal drops
EP1595531A1 (en) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
CA2905587A1 (en) * 2013-03-15 2014-09-18 Medicis Pharmaceutical Corporation Topical compositions of flunisolide and methods of treatment
US20140274982A1 (en) * 2013-03-15 2014-09-18 Medicis Pharmaceutical Corporation Topical compositions of flunisolide and methods of treatment

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2320111A1 (en) * 1972-04-20 1973-10-31 Allen & Hanburys Ltd Solvated crystalline, anti-inflammatory steroids, processes for their preparation, and these materials containing aerosol formulations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) * 1964-03-24 Chioacyl
GB933867A (en) * 1958-12-08 1963-08-14 American Cyanamid Co Fluorinated steroids
US3282791A (en) * 1965-08-17 1966-11-01 Merck & Co Inc Inhalation aerosol suspension of anhydrous disodium dexamethasone phosphate, propellents, and sorbitan trioleate
US3592930A (en) * 1968-07-19 1971-07-13 Syntex Corp Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle
DE2015300A1 (en) * 1969-04-01 1970-10-29
DE2332663C2 (en) * 1973-06-23 1986-07-31 Schering Ag, 1000 Berlin Und 4709 Bergkamen, De
US3934013A (en) * 1975-02-21 1976-01-20 Syntex (U.S.A.) Inc. Pharmaceutical composition

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2320111A1 (en) * 1972-04-20 1973-10-31 Allen & Hanburys Ltd Solvated crystalline, anti-inflammatory steroids, processes for their preparation, and these materials containing aerosol formulations

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0039369A1 (en) * 1980-05-02 1981-11-11 Schering Corporation Beclomethasone ester solvates, process for their preparation, and preparation of a formulation

Also Published As

Publication number Publication date
CA1075228A (en) 1980-04-08
NL191234B (en) 1994-11-01
AU1430176A (en) 1977-12-01
SE421426B (en) 1981-12-21
FR2361900B1 (en) 1979-04-13
DE2624924A1 (en) 1977-12-15
NL191234C (en) 1995-04-03
MX3864E (en) 1981-08-26
NZ180946A (en) 1978-07-28
HK8580A (en) 1980-03-14
SE7605927L (en) 1976-11-28
DE2624924C2 (en) 1986-11-27
DE2661037C2 (en) 1989-04-06
NL7605699A (en) 1976-11-30
MY8000275A (en) 1980-12-31
ATA388376A (en) 1979-12-15
JPS51144719A (en) 1976-12-13
CA1075228A1 (en)
GB1525181A (en) 1978-09-20
AT357702B (en) 1980-07-25
ES448220A1 (en) 1977-11-01
IL49652A (en) 1979-05-31
JPS6247880B2 (en) 1987-10-09
AU506080B2 (en) 1979-12-13
IL49652D0 (en) 1976-07-30

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Legal Events

Date Code Title Description
TP Transmission of property
CC Supplementary certificate of protection laid open to the public (law of 25 june 1990)

Free format text: 92C0217, 920519

CB Supplementary certificate of protection granted (law of 25 june 1990)

Free format text: 92C0217, 760526

CL Concession to grant licenses