AT357702B - METHOD FOR PRODUCING A NEW CRYSTALLINE SHAPE OF FLUNISOLIDE - Google Patents
METHOD FOR PRODUCING A NEW CRYSTALLINE SHAPE OF FLUNISOLIDEInfo
- Publication number
- AT357702B AT357702B AT388376A AT388376A AT357702B AT 357702 B AT357702 B AT 357702B AT 388376 A AT388376 A AT 388376A AT 388376 A AT388376 A AT 388376A AT 357702 B AT357702 B AT 357702B
- Authority
- AT
- Austria
- Prior art keywords
- flunisolide
- producing
- new crystalline
- crystalline shape
- shape
- Prior art date
Links
- 229960000676 flunisolide Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58130075A | 1975-05-27 | 1975-05-27 | |
| US58130175A | 1975-05-27 | 1975-05-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA388376A ATA388376A (en) | 1979-12-15 |
| AT357702B true AT357702B (en) | 1980-07-25 |
Family
ID=27078279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT388376A AT357702B (en) | 1975-05-27 | 1976-05-26 | METHOD FOR PRODUCING A NEW CRYSTALLINE SHAPE OF FLUNISOLIDE |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS51144719A (en) |
| AT (1) | AT357702B (en) |
| AU (1) | AU506080B2 (en) |
| CA (1) | CA1075228A (en) |
| DE (2) | DE2624924C2 (en) |
| ES (1) | ES448220A1 (en) |
| FR (1) | FR2361900A1 (en) |
| GB (1) | GB1525181A (en) |
| HK (1) | HK8580A (en) |
| IL (1) | IL49652A (en) |
| MX (1) | MX3864E (en) |
| MY (1) | MY8000275A (en) |
| NL (1) | NL191234C (en) |
| NZ (1) | NZ180946A (en) |
| SE (1) | SE421426B (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK162530C (en) * | 1979-05-21 | 1992-03-30 | Syntex Corp | PROCEDURE FOR PREPARING A CRYSTALLINE MODIFICATION OF FLUNISOLIDE |
| EP0039369B1 (en) * | 1980-05-02 | 1983-06-15 | Schering Corporation | Beclomethasone ester solvates, process for their preparation, and preparation of a formulation |
| GB2127689B (en) * | 1982-10-05 | 1986-07-09 | Sandoz Ltd | Calcitonin inhalation compositions |
| US4782047A (en) * | 1986-05-22 | 1988-11-01 | Syntex Pharmaceuticals International Ltd. | Aqueous steroid formulations for nasal administration |
| US5707634A (en) * | 1988-10-05 | 1998-01-13 | Pharmacia & Upjohn Company | Finely divided solid crystalline powders via precipitation into an anti-solvent |
| DE68907062T2 (en) * | 1988-10-05 | 1993-10-07 | Upjohn Co | FINE DISTRIBUTED SOLID CRYSTALLINE POWDER BY DEPOSIT IN AN ANTI-SOLVENT. |
| DE4003272A1 (en) | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | NEW GAS MIXTURES AND THEIR USE IN MEDICINE PREPARATIONS |
| NZ312662A (en) * | 1995-06-27 | 2001-03-30 | Boehringer Ingelheim Kg | Pharmaceutical aerosol preparations in the form of stable ethanolic solutions of active substances for producing propellant free aerosols |
| DE19653969A1 (en) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | New aqueous pharmaceutical preparation for the production of propellant-free aerosols |
| US20010031244A1 (en) | 1997-06-13 | 2001-10-18 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
| DZ2947A1 (en) | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Pressure metered dose inhaler. |
| ES2439274T3 (en) * | 1999-03-03 | 2014-01-22 | Optinose As | Nasal Administration Device |
| IT1313553B1 (en) | 1999-07-23 | 2002-09-09 | Chiesi Farma Spa | OPTIMIZED FORMULATIONS CONSTITUTED BY SOLUTIONS OF STEROIDS GIVEN BY INHALATION. |
| IT1317846B1 (en) | 2000-02-22 | 2003-07-15 | Chiesi Farma Spa | FORMULATIONS CONTAINING AN ANTICOLINERGIC DRUG FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE BRONCOPNEUMOPATHY. |
| CA2411047C (en) | 2000-05-22 | 2009-08-04 | Chiesi Farmaceutici S.P.A. | Stable pharmaceutical solution formulations for pressurised metered dose inhalers |
| TR200401980T4 (en) | 2001-07-02 | 2004-09-21 | Chiesi Farmaceutici S.P.A. | Tobramycin formulation optimized for aerosol administration |
| JP5238779B2 (en) * | 2003-04-25 | 2013-07-17 | ロート製薬株式会社 | Nasal drops |
| JP4632687B2 (en) * | 2003-04-25 | 2011-02-16 | ロート製薬株式会社 | Nasal drops |
| EP1595531A1 (en) | 2004-05-13 | 2005-11-16 | CHIESI FARMACEUTICI S.p.A. | Stable pharmaceutical solution formulations for pressurized metered dose inhalers |
| US10953021B2 (en) | 2013-03-15 | 2021-03-23 | Lupin Limited | Topical compositions of flunisolide and methods of treatment |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3126375A (en) | 1964-03-24 | Chioacyl | ||
| GB933867A (en) * | 1958-12-08 | 1963-08-14 | American Cyanamid Co | Fluorinated steroids |
| US3282791A (en) | 1965-08-17 | 1966-11-01 | Merck & Co Inc | Inhalation aerosol suspension of anhydrous disodium dexamethasone phosphate, propellents, and sorbitan trioleate |
| US3592930A (en) | 1968-07-19 | 1971-07-13 | Syntex Corp | Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle |
| FR2038105A1 (en) * | 1969-04-01 | 1971-01-08 | Syntex Corp | Antiinflammatory steroid preparations |
| GB1429184A (en) * | 1972-04-20 | 1976-03-24 | Allen & Hanburys Ltd | Physically anti-inflammatory steroids for use in aerosols |
| DE2332663C2 (en) | 1973-06-23 | 1986-07-31 | Schering AG, 1000 Berlin und 4709 Bergkamen | Use of corticosteroid active ingredients for inhalation therapy |
| US3934013A (en) | 1975-02-21 | 1976-01-20 | Syntex (U.S.A.) Inc. | Pharmaceutical composition |
-
1976
- 1976-05-14 MX MX76234U patent/MX3864E/en unknown
- 1976-05-25 NZ NZ180946A patent/NZ180946A/en unknown
- 1976-05-25 SE SE7605927A patent/SE421426B/en not_active IP Right Cessation
- 1976-05-25 IL IL49652A patent/IL49652A/en unknown
- 1976-05-25 CA CA253,267A patent/CA1075228A/en not_active Expired
- 1976-05-25 ES ES448220A patent/ES448220A1/en not_active Expired
- 1976-05-26 AT AT388376A patent/AT357702B/en not_active IP Right Cessation
- 1976-05-26 NL NL7605699A patent/NL191234C/en not_active IP Right Cessation
- 1976-05-26 FR FR7616040A patent/FR2361900A1/en active Granted
- 1976-05-26 JP JP51061032A patent/JPS51144719A/en active Granted
- 1976-05-26 AU AU14301/76A patent/AU506080B2/en not_active Expired
- 1976-05-26 GB GB21936/76A patent/GB1525181A/en not_active Expired
- 1976-06-03 DE DE2624924A patent/DE2624924C2/en not_active Expired
- 1976-06-03 DE DE2661037A patent/DE2661037C2/de not_active Expired
-
1980
- 1980-03-06 HK HK85/80A patent/HK8580A/en unknown
- 1980-12-30 MY MY275/80A patent/MY8000275A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU506080B2 (en) | 1979-12-13 |
| IL49652A0 (en) | 1976-07-30 |
| NL7605699A (en) | 1976-11-30 |
| FR2361900B1 (en) | 1979-04-13 |
| MY8000275A (en) | 1980-12-31 |
| JPS6247880B2 (en) | 1987-10-09 |
| NZ180946A (en) | 1978-07-28 |
| NL191234C (en) | 1995-04-03 |
| FR2361900A1 (en) | 1978-03-17 |
| ES448220A1 (en) | 1977-11-01 |
| IL49652A (en) | 1979-05-31 |
| DE2624924C2 (en) | 1986-11-27 |
| SE421426B (en) | 1981-12-21 |
| JPS51144719A (en) | 1976-12-13 |
| MX3864E (en) | 1981-08-26 |
| DE2624924A1 (en) | 1977-12-15 |
| AU1430176A (en) | 1977-12-01 |
| NL191234B (en) | 1994-11-01 |
| GB1525181A (en) | 1978-09-20 |
| ATA388376A (en) | 1979-12-15 |
| DE2661037C2 (en) | 1989-04-06 |
| SE7605927L (en) | 1976-11-28 |
| CA1075228A (en) | 1980-04-08 |
| HK8580A (en) | 1980-03-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee | ||
| ELA | Expired due to lapse of time |