DE2646677C2 - Verfahren zum Tempern von gefrorenem, Heparin führendem tierischem Gewebe - Google Patents
Verfahren zum Tempern von gefrorenem, Heparin führendem tierischem GewebeInfo
- Publication number
- DE2646677C2 DE2646677C2 DE19762646677 DE2646677A DE2646677C2 DE 2646677 C2 DE2646677 C2 DE 2646677C2 DE 19762646677 DE19762646677 DE 19762646677 DE 2646677 A DE2646677 A DE 2646677A DE 2646677 C2 DE2646677 C2 DE 2646677C2
- Authority
- DE
- Germany
- Prior art keywords
- tissue
- heparin
- frozen
- temperature
- time
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims description 31
- 241001465754 Metazoa Species 0.000 title claims description 17
- 238000000137 annealing Methods 0.000 title claims description 4
- 229960002897 heparin Drugs 0.000 claims description 52
- 229920000669 heparin Polymers 0.000 claims description 52
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 51
- 238000002955 isolation Methods 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 210000004072 lung Anatomy 0.000 description 24
- 238000000855 fermentation Methods 0.000 description 15
- 230000004151 fermentation Effects 0.000 description 15
- 238000011084 recovery Methods 0.000 description 13
- 239000004744 fabric Substances 0.000 description 11
- 238000005496 tempering Methods 0.000 description 9
- 230000008569 process Effects 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 235000015278 beef Nutrition 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 235000019645 odor Nutrition 0.000 description 4
- 239000002510 pyrogen Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 3
- 230000001143 conditioned effect Effects 0.000 description 3
- 230000003750 conditioning effect Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 238000005189 flocculation Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 238000010257 thawing Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000005238 degreasing Methods 0.000 description 2
- 230000016615 flocculation Effects 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 230000002906 microbiologic effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 101150034533 ATIC gene Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000009924 canning Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62780775A | 1975-10-31 | 1975-10-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2646677A1 DE2646677A1 (de) | 1977-05-05 |
| DE2646677C2 true DE2646677C2 (de) | 1985-11-07 |
Family
ID=24516213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19762646677 Expired DE2646677C2 (de) | 1975-10-31 | 1976-10-15 | Verfahren zum Tempern von gefrorenem, Heparin führendem tierischem Gewebe |
Country Status (8)
| Country | Link |
|---|---|
| AU (1) | AU512447B2 (da) |
| CA (1) | CA1078766A (da) |
| DE (1) | DE2646677C2 (da) |
| DK (1) | DK490476A (da) |
| FR (1) | FR2329677A1 (da) |
| GB (1) | GB1505238A (da) |
| IE (1) | IE44542B1 (da) |
| IT (1) | IT1075975B (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU177887B (en) * | 1979-03-21 | 1982-01-28 | Richter Gedeon Vegyeszet | Process for preparing a raw material containing heparin |
| CN105886397B (zh) * | 2016-06-30 | 2019-09-03 | 南通欣宇光肠衣有限公司 | 一种高效提取肝素钠酶膜耦合酶解装置 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2410084A (en) * | 1943-12-09 | 1946-10-29 | Upjohn Co | Recovery of heparin |
| US2623001A (en) * | 1949-04-07 | 1952-12-23 | Bengt E G V Sylven | Preparing heparin |
| US2539544A (en) * | 1950-01-03 | 1951-01-30 | Levin | Simultaneous defatting and dehydrating of fatty substances |
| US2884358A (en) * | 1957-04-22 | 1959-04-28 | Southern California Gland Co | Process for preparing crude heparin |
| FR1334096A (fr) * | 1962-09-14 | 1963-08-02 | Forest Laboratories | Procédé de préparation d'héparinoïdes |
-
1976
- 1976-10-15 DE DE19762646677 patent/DE2646677C2/de not_active Expired
- 1976-10-22 IE IE233576A patent/IE44542B1/en unknown
- 1976-10-25 GB GB4425276A patent/GB1505238A/en not_active Expired
- 1976-10-27 FR FR7632418A patent/FR2329677A1/fr active Granted
- 1976-10-29 CA CA264,455A patent/CA1078766A/en not_active Expired
- 1976-10-29 DK DK490476A patent/DK490476A/da not_active Application Discontinuation
- 1976-10-29 IT IT6961076A patent/IT1075975B/it active
- 1976-11-01 AU AU19190/76A patent/AU512447B2/en not_active Expired
Non-Patent Citations (1)
| Title |
|---|
| NICHTS-ERMITTELT |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2329677A1 (fr) | 1977-05-27 |
| GB1505238A (en) | 1978-03-30 |
| IE44542B1 (en) | 1981-12-30 |
| DK490476A (da) | 1977-05-01 |
| IT1075975B (it) | 1985-04-22 |
| FR2329677B1 (da) | 1980-06-06 |
| IE44542L (en) | 1977-04-30 |
| CA1078766A (en) | 1980-06-03 |
| DE2646677A1 (de) | 1977-05-05 |
| AU512447B2 (en) | 1980-10-09 |
| AU1919076A (en) | 1978-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8128 | New person/name/address of the agent |
Representative=s name: KOHLER, M., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 80 |
|
| 8125 | Change of the main classification |
Ipc: C12P 19/00 |
|
| 8128 | New person/name/address of the agent |
Representative=s name: GLAESER, J., DIPL.-ING., 2000 HAMBURG KRESSIN, H., |
|
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |