DE25722T1 - Monoklonaler antikoerper gegen menschliche zytotoxische und suppressor-t-zellen und verfahren zu dessen herstellung. - Google Patents
Monoklonaler antikoerper gegen menschliche zytotoxische und suppressor-t-zellen und verfahren zu dessen herstellung.Info
- Publication number
- DE25722T1 DE25722T1 DE198080303272T DE80303272T DE25722T1 DE 25722 T1 DE25722 T1 DE 25722T1 DE 198080303272 T DE198080303272 T DE 198080303272T DE 80303272 T DE80303272 T DE 80303272T DE 25722 T1 DE25722 T1 DE 25722T1
- Authority
- DE
- Germany
- Prior art keywords
- cells
- monoclonal antibody
- antibody according
- hybridoma
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title claims 17
- 231100000433 cytotoxic Toxicity 0.000 title claims 8
- 230000001472 cytotoxic effect Effects 0.000 title claims 8
- 238000004519 manufacturing process Methods 0.000 title claims 5
- 238000000034 method Methods 0.000 title claims 4
- 210000004027 cell Anatomy 0.000 claims 11
- 210000004408 hybridoma Anatomy 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 9
- 241000699666 Mus <mouse, genus> Species 0.000 claims 8
- 241000699670 Mus sp. Species 0.000 claims 6
- 210000004989 spleen cell Anatomy 0.000 claims 6
- 230000004927 fusion Effects 0.000 claims 5
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 4
- 201000000050 myeloid neoplasm Diseases 0.000 claims 4
- 230000002093 peripheral effect Effects 0.000 claims 4
- 239000006228 supernatant Substances 0.000 claims 4
- 238000010367 cloning Methods 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 206010025538 Malignant ascites Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 210000000952 spleen Anatomy 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 208000008190 Agammaglobulinemia Diseases 0.000 claims 1
- 206010003445 Ascites Diseases 0.000 claims 1
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 1
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 206010020983 Hypogammaglobulinaemia Diseases 0.000 claims 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000003306 harvesting Methods 0.000 claims 1
- 244000309465 heifer Species 0.000 claims 1
- 201000006747 infectious mononucleosis Diseases 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 229940126619 mouse monoclonal antibody Drugs 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 210000004287 null lymphocyte Anatomy 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/948—Microorganisms using viruses or cell lines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
- Y10S530/809—Fused cells, e.g. hybridoma
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7664279A | 1979-09-18 | 1979-09-18 | |
| US06/082,515 US4364932A (en) | 1979-09-18 | 1979-10-09 | Monoclonal antibody to human cytotoxic and suppressor T cells and methods of preparing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE25722T1 true DE25722T1 (de) | 1984-07-19 |
Family
ID=26758322
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE198080303272T Pending DE25722T1 (de) | 1979-09-18 | 1980-09-17 | Monoklonaler antikoerper gegen menschliche zytotoxische und suppressor-t-zellen und verfahren zu dessen herstellung. |
| DE8080303272T Expired DE3070669D1 (en) | 1979-09-18 | 1980-09-17 | Monoclonal antibody to human cytotoxic and suppressor t cells, and method of preparing it |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8080303272T Expired DE3070669D1 (en) | 1979-09-18 | 1980-09-17 | Monoclonal antibody to human cytotoxic and suppressor t cells, and method of preparing it |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4364932A (enExample) |
| EP (1) | EP0025722B2 (enExample) |
| AU (1) | AU537806B2 (enExample) |
| CA (1) | CA1170593A (enExample) |
| DE (2) | DE25722T1 (enExample) |
| DK (1) | DK154566C (enExample) |
| ES (1) | ES8200559A1 (enExample) |
| FI (1) | FI75364C (enExample) |
| GR (1) | GR70286B (enExample) |
| HK (1) | HK23986A (enExample) |
| IE (1) | IE50534B1 (enExample) |
| IL (1) | IL61063A (enExample) |
| MY (1) | MY8600515A (enExample) |
| NO (1) | NO159884C (enExample) |
| NZ (1) | NZ194982A (enExample) |
| PH (1) | PH16567A (enExample) |
| PT (1) | PT71814B (enExample) |
| SG (1) | SG6386G (enExample) |
| YU (1) | YU44411B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4803262A (en) * | 1979-10-09 | 1989-02-07 | Ortho Pharmaceutical Corporation | Hybrid cell line for producing monoclonal antibody to human cytotoxic and suppressor T cells, antibody, and methods |
| US4637983A (en) * | 1979-10-09 | 1987-01-20 | Ortho Pharmaceutical Corporation | Hybrid cell line for producing monoclonal antibody to human cytotoxic and suppressor T cells, antibody, and methods |
| USRE32011E (en) * | 1981-12-14 | 1985-10-22 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
| US4511662A (en) * | 1982-06-18 | 1985-04-16 | Bio-Rad Laboratories, Inc. | Simultaneous assay for T and B lymphocyte populations and subpopulations |
| US4443427A (en) * | 1982-06-21 | 1984-04-17 | Sidney Farber Cancer Institute, Inc. | Monoclonal antibody |
| US4524025A (en) * | 1982-06-30 | 1985-06-18 | E. I. Du Pont De Nemours And Company | Hybridoma cell lines and monoclonal antibodies to theophylline |
| US4579827A (en) * | 1983-03-11 | 1986-04-01 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibodies to human gastrointestinal cancers and hybridoma method of production of the monoclonal antibodies |
| US4677056A (en) * | 1983-08-18 | 1987-06-30 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibody subsetting human helper and killer T-cells and method |
| US5130144B1 (en) * | 1984-02-06 | 1995-08-15 | Univ Johns Hopkins | Human stem cells and monoclonal antibodies |
| US4965204A (en) * | 1984-02-06 | 1990-10-23 | The Johns Hopkins University | Human stem cells and monoclonal antibodies |
| FR2560212B1 (fr) * | 1984-02-24 | 1989-12-29 | Unicet | Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps |
| US4649106A (en) * | 1984-06-01 | 1987-03-10 | Dana-Farber Cancer Institute, Inc. | Distinguishing subsets of human cells |
| JPS6179164A (ja) * | 1984-09-26 | 1986-04-22 | Amano Pharmaceut Co Ltd | 抗原抗体反応の短縮方法 |
| US5431897A (en) * | 1985-04-19 | 1995-07-11 | Sloan-Kettering Institute For Cancer Research | Method of imaging colorectal carcinoma lesion and composition for use therein |
| EP0302894B1 (en) * | 1986-04-28 | 1992-11-19 | Endotronics Inc. | Method of culturing leukocytes |
| US4970299A (en) * | 1986-07-03 | 1990-11-13 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibodies selective for prostate cancer |
| US5085985A (en) * | 1987-11-12 | 1992-02-04 | Becton Dickinson & Co. | Monoclonal antibodies and their use in a method for monitoring subsets of activated T cells |
| US5601819A (en) * | 1988-08-11 | 1997-02-11 | The General Hospital Corporation | Bispecific antibodies for selective immune regulation and for selective immune cell binding |
| EP1030865A2 (en) * | 1997-11-13 | 2000-08-30 | Schering Corporation | Th2 CELL DEPLETION; COMPOSITIONS; METHODS |
| CA2310805A1 (en) | 1997-11-24 | 1999-06-03 | Johnson T. Wong | Methods for treatment of hiv or other infections using a t cell or viral activator and anti-retroviral combination therapy |
| US7653260B2 (en) | 2004-06-17 | 2010-01-26 | Carl Zeis MicroImaging GmbH | System and method of registering field of view |
| US8582924B2 (en) | 2004-06-30 | 2013-11-12 | Carl Zeiss Microimaging Gmbh | Data structure of an image storage and retrieval system |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4196265A (en) * | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
| US4172124A (en) * | 1978-04-28 | 1979-10-23 | The Wistar Institute | Method of producing tumor antibodies |
| US4284412A (en) * | 1979-07-13 | 1981-08-18 | Ortho Diagnostics, Inc. | Method and apparatus for automated identification and enumeration of specified blood cell subclasses |
-
1979
- 1979-10-09 US US06/082,515 patent/US4364932A/en not_active Expired - Lifetime
-
1980
- 1980-09-11 GR GR62868A patent/GR70286B/el unknown
- 1980-09-17 AU AU62476/80A patent/AU537806B2/en not_active Expired
- 1980-09-17 IE IE1944/80A patent/IE50534B1/en not_active IP Right Cessation
- 1980-09-17 DK DK394880A patent/DK154566C/da not_active IP Right Cessation
- 1980-09-17 CA CA000360432A patent/CA1170593A/en not_active Expired
- 1980-09-17 DE DE198080303272T patent/DE25722T1/de active Pending
- 1980-09-17 NO NO802751A patent/NO159884C/no unknown
- 1980-09-17 EP EP80303272A patent/EP0025722B2/en not_active Expired - Lifetime
- 1980-09-17 FI FI802917A patent/FI75364C/fi not_active IP Right Cessation
- 1980-09-17 DE DE8080303272T patent/DE3070669D1/de not_active Expired
- 1980-09-17 NZ NZ194982A patent/NZ194982A/xx unknown
- 1980-09-17 IL IL61063A patent/IL61063A/xx not_active IP Right Cessation
- 1980-09-18 ES ES495165A patent/ES8200559A1/es not_active Expired
- 1980-09-18 YU YU2392/80A patent/YU44411B/xx unknown
- 1980-09-18 PH PH24603A patent/PH16567A/en unknown
- 1980-09-18 PT PT71814A patent/PT71814B/pt not_active IP Right Cessation
-
1986
- 1986-01-21 SG SG63/86A patent/SG6386G/en unknown
- 1986-04-03 HK HK239/86A patent/HK23986A/en not_active IP Right Cessation
- 1986-12-30 MY MY515/86A patent/MY8600515A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ194982A (en) | 1983-02-15 |
| YU44411B (en) | 1990-08-31 |
| NO802751L (no) | 1981-03-19 |
| ES495165A0 (es) | 1981-11-16 |
| GR70286B (enExample) | 1982-09-03 |
| NO159884B (no) | 1988-11-07 |
| PT71814B (en) | 1982-03-26 |
| IL61063A (en) | 1984-04-30 |
| EP0025722A3 (en) | 1981-11-04 |
| SG6386G (en) | 1986-11-21 |
| IL61063A0 (en) | 1980-11-30 |
| EP0025722A2 (en) | 1981-03-25 |
| FI75364C (fi) | 1988-06-09 |
| AU6247680A (en) | 1981-04-09 |
| PT71814A (en) | 1980-10-01 |
| NO159884C (no) | 1989-02-15 |
| US4364932A (en) | 1982-12-21 |
| PH16567A (en) | 1983-11-18 |
| CA1170593A (en) | 1984-07-10 |
| YU239280A (en) | 1984-04-30 |
| DK154566C (da) | 1989-04-17 |
| DE3070669D1 (en) | 1985-06-27 |
| AU537806B2 (en) | 1984-07-12 |
| FI75364B (fi) | 1988-02-29 |
| FI802917A7 (fi) | 1981-03-19 |
| EP0025722B1 (en) | 1985-05-22 |
| EP0025722B2 (en) | 1999-04-14 |
| ES8200559A1 (es) | 1981-11-16 |
| DK394880A (da) | 1981-03-19 |
| IE50534B1 (en) | 1986-05-14 |
| DK154566B (da) | 1988-11-28 |
| MY8600515A (en) | 1986-12-31 |
| HK23986A (en) | 1986-04-11 |
| IE801944L (en) | 1981-03-18 |
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