DE2454106A1 - Verfahren zur herstellung eines loeslichen salzes der acetylsalicylsaeure - Google Patents
Verfahren zur herstellung eines loeslichen salzes der acetylsalicylsaeureInfo
- Publication number
- DE2454106A1 DE2454106A1 DE19742454106 DE2454106A DE2454106A1 DE 2454106 A1 DE2454106 A1 DE 2454106A1 DE 19742454106 DE19742454106 DE 19742454106 DE 2454106 A DE2454106 A DE 2454106A DE 2454106 A1 DE2454106 A1 DE 2454106A1
- Authority
- DE
- Germany
- Prior art keywords
- arginine
- preparation
- acetylsalicylic acid
- soluble salt
- salicylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 title claims description 12
- 229960001138 acetylsalicylic acid Drugs 0.000 title claims description 12
- 150000003839 salts Chemical class 0.000 title claims description 9
- 238000000034 method Methods 0.000 title claims description 8
- 238000002360 preparation method Methods 0.000 title claims description 3
- 229930064664 L-arginine Natural products 0.000 claims description 11
- 235000014852 L-arginine Nutrition 0.000 claims description 11
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims description 8
- 239000004475 Arginine Substances 0.000 claims description 4
- 235000001014 amino acid Nutrition 0.000 claims description 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 4
- 235000009697 arginine Nutrition 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 2
- UQJRAOCVSMOMNW-UHFFFAOYSA-N acetyl 2-hydroxybenzoate Chemical compound CC(=O)OC(=O)C1=CC=CC=C1O UQJRAOCVSMOMNW-UHFFFAOYSA-N 0.000 claims 2
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 239000002798 polar solvent Substances 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 15
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000002904 solvent Substances 0.000 description 4
- -1 L-arginine amino acid Chemical class 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 230000001195 anabolic effect Effects 0.000 description 1
- 239000003435 antirheumatic agent Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000012454 non-polar solvent Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000007738 vacuum evaporation Methods 0.000 description 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES423794A ES423794A1 (es) | 1974-03-01 | 1974-03-01 | Procediemiento de obtencion de una nueva sal soluble de acido acetilsalicilico. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2454106A1 true DE2454106A1 (de) | 1975-09-04 |
Family
ID=8466099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19742454106 Withdrawn DE2454106A1 (de) | 1974-03-01 | 1974-11-14 | Verfahren zur herstellung eines loeslichen salzes der acetylsalicylsaeure |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS50117912A (enrdf_load_stackoverflow) |
| CH (1) | CH589034A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2454106A1 (enrdf_load_stackoverflow) |
| ES (1) | ES423794A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2262529A1 (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101486644B (zh) * | 2009-02-24 | 2012-07-25 | 合肥工业大学 | 阿司匹林精氨酸盐的制备方法 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1237115B (it) * | 1989-10-24 | 1993-05-18 | Sali della furosemide, procedimento per la loro preparazione e composizionni farmaceutiche che li contengono | |
| GB9200114D0 (en) * | 1992-01-04 | 1992-02-26 | Scras | Dual inhibitors of no synthase and cyclooxygenase |
-
1974
- 1974-03-01 ES ES423794A patent/ES423794A1/es not_active Expired
- 1974-11-14 DE DE19742454106 patent/DE2454106A1/de not_active Withdrawn
- 1974-11-27 CH CH1570474A patent/CH589034A5/xx not_active IP Right Cessation
- 1974-11-28 FR FR7438969A patent/FR2262529A1/fr active Granted
- 1974-12-16 JP JP49144339A patent/JPS50117912A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101486644B (zh) * | 2009-02-24 | 2012-07-25 | 合肥工业大学 | 阿司匹林精氨酸盐的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2262529B1 (enrdf_load_stackoverflow) | 1978-11-24 |
| JPS50117912A (enrdf_load_stackoverflow) | 1975-09-16 |
| CH589034A5 (enrdf_load_stackoverflow) | 1977-06-30 |
| ES423794A1 (es) | 1976-05-01 |
| FR2262529A1 (en) | 1975-09-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8141 | Disposal/no request for examination |