DE2438851C2 - N↑2↑-Dansyl-L-argininderivate, ihre Salze mit Säuren, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel - Google Patents

N↑2↑-Dansyl-L-argininderivate, ihre Salze mit Säuren, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Info

Publication number
DE2438851C2
DE2438851C2 DE2438851A DE2438851A DE2438851C2 DE 2438851 C2 DE2438851 C2 DE 2438851C2 DE 2438851 A DE2438851 A DE 2438851A DE 2438851 A DE2438851 A DE 2438851A DE 2438851 C2 DE2438851 C2 DE 2438851C2
Authority
DE
Germany
Prior art keywords
dansyl
radical
carbon atoms
arginine
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2438851A
Other languages
German (de)
English (en)
Other versions
DE2438851A1 (de
Inventor
Ryoji Tokio/Tokyo Kikumoto
Kazuo Tokio/Tokyo Ohkubo
Shosuke Kobe Hyogo Okamoto
Yoshikuni Yokohama Kanagawa Tamao
Shniji Tonomura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP9069973A external-priority patent/JPS5521742B2/ja
Priority claimed from JP11603573A external-priority patent/JPS5521743B2/ja
Priority claimed from JP11729273A external-priority patent/JPS5521744B2/ja
Priority claimed from JP13750173A external-priority patent/JPS5521745B2/ja
Priority claimed from JP3114174A external-priority patent/JPS5542073B2/ja
Priority claimed from JP3326074A external-priority patent/JPS5521746B2/ja
Priority claimed from JP6157374A external-priority patent/JPS5542074B2/ja
Application filed by Mitsubishi Chemical Industries Ltd filed Critical Mitsubishi Chemical Industries Ltd
Publication of DE2438851A1 publication Critical patent/DE2438851A1/de
Application granted granted Critical
Publication of DE2438851C2 publication Critical patent/DE2438851C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/08—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
DE2438851A 1973-08-13 1974-08-13 N↑2↑-Dansyl-L-argininderivate, ihre Salze mit Säuren, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel Expired DE2438851C2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP9069973A JPS5521742B2 (OSRAM) 1973-08-13 1973-08-13
JP11603573A JPS5521743B2 (OSRAM) 1973-10-16 1973-10-16
JP11729273A JPS5521744B2 (OSRAM) 1973-10-18 1973-10-18
JP13750173A JPS5521745B2 (OSRAM) 1973-12-10 1973-12-10
JP3114174A JPS5542073B2 (OSRAM) 1974-03-19 1974-03-19
JP3326074A JPS5521746B2 (OSRAM) 1974-03-25 1974-03-25
JP6157374A JPS5542074B2 (OSRAM) 1974-05-31 1974-05-31

Publications (2)

Publication Number Publication Date
DE2438851A1 DE2438851A1 (de) 1975-02-27
DE2438851C2 true DE2438851C2 (de) 1987-03-19

Family

ID=27564271

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2438851A Expired DE2438851C2 (de) 1973-08-13 1974-08-13 N↑2↑-Dansyl-L-argininderivate, ihre Salze mit Säuren, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Country Status (9)

Country Link
US (1) US4670420A (OSRAM)
CA (1) CA1029026A (OSRAM)
CH (4) CH612929A5 (OSRAM)
DE (1) DE2438851C2 (OSRAM)
DK (1) DK140431B (OSRAM)
FR (1) FR2240720B1 (OSRAM)
GB (1) GB1475346A (OSRAM)
NL (1) NL165652C (OSRAM)
NO (1) NO140344C (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7512637A (nl) * 1974-11-08 1976-05-11 Mitsubishi Chem Ind Werkwijze ter bereiding van een geneesmiddel, het aldus gevormde geneesmiddel en werkwijze voor de bereiding van actieve component.
CA1102316A (en) * 1975-12-09 1981-06-02 Shosuke Okamoto N su2 xx-arylsulfonyl-l-argininamides and the pharmaceutically acceptable salts thereof
FR2378004B2 (fr) * 1975-12-09 1985-09-13 Mitsubishi Chem Ind Derives de l'argininamide, leur preparation et leurs utilisations therapeutiques
EP0190852A3 (en) * 1985-01-31 1988-11-02 Ajinomoto Co., Inc. Dipeptide derivatives and antihypertensive drugs containing them
GB9504350D0 (en) * 1995-03-04 1995-04-26 Sod Conseils Rech Applic Arginine derivatives
KR20040007565A (ko) * 2001-05-15 2004-01-24 다이쇼 세이야꾸 가부시끼가이샤 아르기닌 유도체

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE420919B (sv) * 1973-08-13 1981-11-09 Mitsubishi Chem Ind Forfarande for framstellning av n?722-dansyl-l-argininderivat och farmaceutiskt godtagbara syradditionssalter derav
US4069329A (en) * 1974-11-08 1978-01-17 Mitsubishi Chemical Industries Limited N2 -Naphthalenesulfonyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof
US4072743A (en) * 1974-11-08 1978-02-07 Mitsubishi Chemical Industries Limited N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US4069317A (en) * 1974-11-08 1978-01-17 Mitsubishi Chemical Industries Ltd. N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
US4072744A (en) * 1974-11-08 1978-02-07 Mitsubishi Chemical Industries Limited N2 -naphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICHTS-ERMITTELT

Also Published As

Publication number Publication date
CH612929A5 (OSRAM) 1979-08-31
NO742886L (OSRAM) 1975-03-10
DK429474A (OSRAM) 1975-04-21
CH613946A5 (OSRAM) 1979-10-31
NO140344C (no) 1979-08-15
NL7410647A (nl) 1975-02-17
NO140344B (no) 1979-05-07
GB1475346A (en) 1977-06-01
CH613945A5 (OSRAM) 1979-10-31
FR2240720B1 (OSRAM) 1978-07-21
CA1029026A (en) 1978-04-04
NL165652C (nl) 1981-05-15
CH612928A5 (OSRAM) 1979-08-31
DK140431B (da) 1979-08-27
US4670420A (en) 1987-06-02
NL165652B (nl) 1980-12-15
DK140431C (OSRAM) 1980-01-28
FR2240720A1 (OSRAM) 1975-03-14
DE2438851A1 (de) 1975-02-27

Similar Documents

Publication Publication Date Title
US3978045A (en) N2 -dansyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof
JPH06239822A (ja) 新規なｎ−ベンゾイルアミノ酸誘導体、これらの化合物を含有する医薬組成物およびこれらの化合物を製造する方法
DE2824064A1 (de) Phthalazin-derivate, ihre herstellung und solche derivate enthaltende arzneimittel
CH645625A5 (de) Benzoesaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel.
DE3444046C2 (OSRAM)
DE3125471C2 (de) Piperazinderivate, Verfahren zu ihrer Herstellung und Arzneimittel, die diese Verbindungen enthalten
DE2613420C2 (de) Benzamidderivate, Verfahren zu ihrer Herstellung und Arzneimittel mit diesen Verbindungen als Wirkstoff
US4227006A (en) N2 -Dansyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof
EP0018360B1 (de) N-(5-Methoxybentofuran-2-ylcarbonyl)-N'-benzylpiperazin und Verfahren zu dessen Herstellung
US4297357A (en) N-Phenethylacetamide compounds and process for preparation thereof
EP0065295A1 (de) Substituierte Tryptaminderivate von Thienyloxypropanolaminen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate auf Basis dieser Verbindungen sowie ihre Verwendung
DE2438851A1 (de) N hoch 2-dansyl-l-argininderivate, ihre salze mit saeuren, verfahren zu ihrer herstellung und arzneimittel
Thyrum et al. p-Amino-N-[2-(substituted amino) ethyl] benzamides. Potential antifibrillatory drugs
DE1620295C3 (de) Isochinolo eckige Klammer auf 2,1-d eckige Klammer zu benzo eckige Klammer auf 1,4 eckige Klammer zu diazepin-6-one
DE3642497A1 (de) Substituierte aminopropionsaeureamide, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte
DE2643384A1 (de) Neue 5,6-dihydropyrimidin-4(3h)-onderivate, verfahren zu ihrer herstellung und ihre verwendung als wirkstoff in pharmazeutischen praeparaten
DE2528194C2 (de) Benzhydryloxyäthylamin-Derivate, deren Salze, Verfahren zur Herstellung derselben und solche enthaltende Arzneimittel
DE2012667C3 (de) 3- (4-substituierte-1-Piperazinyl)-carbonylmethyl-2-benzothiazolinone und ihre Säureadditionssalze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharamazeutische Präparate
US3927001A (en) D-glucaro-1,5-lactam derivatives
DE69310186T2 (de) 1,2-dihydro-2-oxo-3-aminochinoxalin derivate, ihre verwendung als heilmittel
US4113877A (en) Substituted 2-aminomethylphenyl sulfamates
DE2635548C2 (de) N↑2↑-substituierte L-Argininester und -amide, deren Herstellung und Verwendung
DE2029991C3 (de) 2-Hydroxy-5-aminobenzamide, Verfahren zu ihrer Herstellung und Arzneimittel, die diese Verbindungen enthalten
DE2559928C2 (de) N-Aroyl-L-phenylalanyl-L-tyrosine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2722399A1 (de) Anti-inflammatorisches mittel, verfahren zu seiner herstellung und daraus hergestellte arzneimittel

Legal Events

Date Code Title Description
D2 Grant after examination
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MITSUBISHI KASEI CORP., TOKIO/TOKYO, JP OKAMOTO, S