DE2412137A1 - Praeparat zur verwendung bei blutuntersuchungsverfahren - Google Patents
Praeparat zur verwendung bei blutuntersuchungsverfahrenInfo
- Publication number
- DE2412137A1 DE2412137A1 DE2412137A DE2412137A DE2412137A1 DE 2412137 A1 DE2412137 A1 DE 2412137A1 DE 2412137 A DE2412137 A DE 2412137A DE 2412137 A DE2412137 A DE 2412137A DE 2412137 A1 DE2412137 A1 DE 2412137A1
- Authority
- DE
- Germany
- Prior art keywords
- physiological saline
- modified
- saline solution
- gelatin
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000002360 preparation method Methods 0.000 title claims description 5
- 238000000034 method Methods 0.000 title description 11
- 238000009534 blood test Methods 0.000 title description 3
- 239000002504 physiological saline solution Substances 0.000 claims description 27
- 229920000159 gelatin Polymers 0.000 claims description 24
- 235000019322 gelatine Nutrition 0.000 claims description 24
- 108010010803 Gelatin Proteins 0.000 claims description 23
- 239000008273 gelatin Substances 0.000 claims description 23
- 235000011852 gelatine desserts Nutrition 0.000 claims description 23
- 210000004369 blood Anatomy 0.000 claims description 9
- 239000008280 blood Substances 0.000 claims description 9
- 238000012360 testing method Methods 0.000 claims description 8
- 238000012956 testing procedure Methods 0.000 claims description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 33
- 210000004027 cell Anatomy 0.000 description 22
- 239000011521 glass Substances 0.000 description 15
- 239000000725 suspension Substances 0.000 description 12
- 239000000243 solution Substances 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 9
- 239000011780 sodium chloride Substances 0.000 description 8
- 239000011550 stock solution Substances 0.000 description 8
- 230000004520 agglutination Effects 0.000 description 7
- 210000003743 erythrocyte Anatomy 0.000 description 7
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 6
- 229960005091 chloramphenicol Drugs 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 229940053050 neomycin sulfate Drugs 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 4
- 206010001497 Agitation Diseases 0.000 description 3
- 206010018910 Haemolysis Diseases 0.000 description 3
- 238000013019 agitation Methods 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000008588 hemolysis Effects 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 244000309466 calf Species 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108700024394 Exon Proteins 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004523 agglutinating effect Effects 0.000 description 1
- 230000000922 anti-bactericidal effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000010961 commercial manufacture process Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 231100000989 no adverse effect Toxicity 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000013014 purified material Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Inorganic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/343,973 US3970427A (en) | 1973-03-22 | 1973-03-22 | Process for reducing sticking of blood cells to glass in blood testing procedures |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2412137A1 true DE2412137A1 (de) | 1974-10-03 |
Family
ID=23348475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2412137A Withdrawn DE2412137A1 (de) | 1973-03-22 | 1974-03-13 | Praeparat zur verwendung bei blutuntersuchungsverfahren |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3970427A (enExample) |
| JP (1) | JPS5029735A (enExample) |
| BE (1) | BE812714A (enExample) |
| CA (1) | CA1033663A (enExample) |
| CH (1) | CH586554A5 (enExample) |
| DE (1) | DE2412137A1 (enExample) |
| ES (1) | ES424506A1 (enExample) |
| FR (1) | FR2222655B1 (enExample) |
| GB (1) | GB1421308A (enExample) |
| IT (1) | IT1005603B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH588700A5 (enExample) * | 1975-02-28 | 1977-06-15 | Hoffmann La Roche | |
| JPS5642142A (en) * | 1979-08-31 | 1981-04-20 | Amano Pharmaceut Co Ltd | Removing method for nonspecific reaction inhibiting action in immunity measuring method |
| US4259207A (en) * | 1979-09-19 | 1981-03-31 | American Hospital Supply Corporation | Suspending medium for immunologic reactions |
| DE19735460A1 (de) | 1997-08-16 | 1999-02-18 | Rolf Prof Dr Med Zander | Spül- oder Lagerungsflüssigkeit für Blutzellen |
| WO2015034178A1 (ko) * | 2013-09-09 | 2015-03-12 | 국립암센터 | 파라핀블록 제조용 혈중 세포 응집제 및 이를 이용한 파라핀블록 제조방법 |
| KR101643403B1 (ko) | 2013-09-09 | 2016-07-28 | 국립암센터 | 파라핀블록 제조용 혈중 세포 응집제 및 이를 이용한 파라핀블록 제조방법 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE962635C (de) * | 1954-08-01 | 1957-04-25 | Biotest Serum Institut Gmbh | Verfahren zur Herstellung von Blutkoerperchen-Konserven |
| US3677710A (en) * | 1969-06-02 | 1972-07-18 | Nathan M Hirsch | Apparatus for washing blood cells |
-
1973
- 1973-03-22 US US05/343,973 patent/US3970427A/en not_active Expired - Lifetime
-
1974
- 1974-03-11 CA CA194,549A patent/CA1033663A/en not_active Expired
- 1974-03-11 GB GB1075274A patent/GB1421308A/en not_active Expired
- 1974-03-13 DE DE2412137A patent/DE2412137A1/de not_active Withdrawn
- 1974-03-16 JP JP49030516A patent/JPS5029735A/ja active Pending
- 1974-03-20 CH CH385374A patent/CH586554A5/xx not_active IP Right Cessation
- 1974-03-20 IT IT749374A patent/IT1005603B/it active
- 1974-03-21 ES ES424506A patent/ES424506A1/es not_active Expired
- 1974-03-21 FR FR7409733A patent/FR2222655B1/fr not_active Expired
- 1974-03-22 BE BE142354A patent/BE812714A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IT1005603B (it) | 1976-09-30 |
| CH586554A5 (enExample) | 1977-04-15 |
| JPS5029735A (enExample) | 1975-03-25 |
| ES424506A1 (es) | 1977-01-01 |
| BE812714A (fr) | 1974-07-15 |
| CA1033663A (en) | 1978-06-27 |
| US3970427A (en) | 1976-07-20 |
| GB1421308A (en) | 1976-01-14 |
| FR2222655B1 (enExample) | 1979-03-16 |
| FR2222655A1 (enExample) | 1974-10-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| 8125 | Change of the main classification |
Ipc: G01N 33/54 |
|
| 8136 | Disposal/non-payment of the fee for publication/grant |