DE2359864A1 - Neue imidazo eckige klammer auf 2,1-b eckige klammer zu thiazolderivate, ihre herstellung und die zusammensetzungen, die sie enthalten - Google Patents

Neue imidazo eckige klammer auf 2,1-b eckige klammer zu thiazolderivate, ihre herstellung und die zusammensetzungen, die sie enthalten

Info

Publication number
DE2359864A1
DE2359864A1 DE2359864A DE2359864A DE2359864A1 DE 2359864 A1 DE2359864 A1 DE 2359864A1 DE 2359864 A DE2359864 A DE 2359864A DE 2359864 A DE2359864 A DE 2359864A DE 2359864 A1 DE2359864 A1 DE 2359864A1
Authority
DE
Germany
Prior art keywords
hydroxy
ethylenediamine
oxirane
solution
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE2359864A
Other languages
German (de)
English (en)
Inventor
Francois Debarre
Claude Jeanmart
Pierre Edouard Simon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7242580A external-priority patent/FR2207708A1/fr
Priority claimed from FR7335158A external-priority patent/FR2245348A1/fr
Application filed by Rhone Poulenc SA filed Critical Rhone Poulenc SA
Publication of DE2359864A1 publication Critical patent/DE2359864A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE2359864A 1972-11-30 1973-11-30 Neue imidazo eckige klammer auf 2,1-b eckige klammer zu thiazolderivate, ihre herstellung und die zusammensetzungen, die sie enthalten Pending DE2359864A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7242580A FR2207708A1 (en) 1972-11-30 1972-11-30 2-Aryl-2,3,5,6-tetrahydroimidazo(2,1-b)thiazoles - with antidepressant, psychoenergising and anorectic activity
FR7335158A FR2245348A1 (en) 1973-10-02 1973-10-02 2-Aryl-2,3,5,6-tetrahydroimidazo(2,1-b)thiazoles - with antidepressant, psychoenergising and anorectic activity

Publications (1)

Publication Number Publication Date
DE2359864A1 true DE2359864A1 (de) 1974-06-06

Family

ID=26217429

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2359864A Pending DE2359864A1 (de) 1972-11-30 1973-11-30 Neue imidazo eckige klammer auf 2,1-b eckige klammer zu thiazolderivate, ihre herstellung und die zusammensetzungen, die sie enthalten

Country Status (20)

Country Link
US (1) US4005212A (US07582779-20090901-C00044.png)
JP (1) JPS5314077B2 (US07582779-20090901-C00044.png)
AR (1) AR203186A1 (US07582779-20090901-C00044.png)
AT (1) AT329554B (US07582779-20090901-C00044.png)
BE (1) BE808008A (US07582779-20090901-C00044.png)
CA (1) CA1002955A (US07582779-20090901-C00044.png)
CH (1) CH579577A5 (US07582779-20090901-C00044.png)
DD (1) DD107697A5 (US07582779-20090901-C00044.png)
DE (1) DE2359864A1 (US07582779-20090901-C00044.png)
DK (1) DK136823B (US07582779-20090901-C00044.png)
ES (1) ES421011A1 (US07582779-20090901-C00044.png)
GB (1) GB1404708A (US07582779-20090901-C00044.png)
HU (1) HU167368B (US07582779-20090901-C00044.png)
IE (1) IE38552B1 (US07582779-20090901-C00044.png)
IL (1) IL43723A (US07582779-20090901-C00044.png)
LU (1) LU68887A1 (US07582779-20090901-C00044.png)
NL (1) NL7316016A (US07582779-20090901-C00044.png)
OA (1) OA04567A (US07582779-20090901-C00044.png)
SE (1) SE399894B (US07582779-20090901-C00044.png)
SU (1) SU518133A3 (US07582779-20090901-C00044.png)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2829821A1 (de) * 1977-07-06 1979-02-01 Dso Pharmachim R,s-eckige klammer auf 2-(2-hydroxyaethylamin)-1-phenyl eckige klammer zu -aethylamin-derivate und verfahren zu ihrer herstellung
US4370482A (en) 1978-02-15 1983-01-25 American Cyanamid Co. Synthesis of tetramisole, levamisole and their derivatives
EP0103830A2 (de) * 1982-09-22 1984-03-28 Bayer Ag Wachstumsfördernde Phenylethylamin-Derivate
US4620009A (en) * 1980-03-17 1986-10-28 Cyanamid Agricultural De Puerto Rico, Inc. Synthesis of intermediates for tetramisole, levamisole and their derivatives

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA827736B (en) * 1981-11-25 1983-08-31 Pfizer Bicyclic imidazole and imidazolines as ectoparasiticides and anthelmintics
US5516647A (en) * 1993-11-05 1996-05-14 Abbott Laboratories Compounds useful as alkaline phosphatase inhibitors and therapeutic agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU409983B2 (en) * 1965-07-19 1970-12-31 Imperial Chemical Industries Of Australia New Zealand Limited Process for the manufacture of thia zolidines and thiazolidines produced thereby

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2829821A1 (de) * 1977-07-06 1979-02-01 Dso Pharmachim R,s-eckige klammer auf 2-(2-hydroxyaethylamin)-1-phenyl eckige klammer zu -aethylamin-derivate und verfahren zu ihrer herstellung
US4370482A (en) 1978-02-15 1983-01-25 American Cyanamid Co. Synthesis of tetramisole, levamisole and their derivatives
US4620009A (en) * 1980-03-17 1986-10-28 Cyanamid Agricultural De Puerto Rico, Inc. Synthesis of intermediates for tetramisole, levamisole and their derivatives
EP0103830A2 (de) * 1982-09-22 1984-03-28 Bayer Ag Wachstumsfördernde Phenylethylamin-Derivate
EP0103830A3 (de) * 1982-09-22 1985-07-31 Bayer Ag Wachstumsfördernde Phenylethylamin-Derivate

Also Published As

Publication number Publication date
LU68887A1 (US07582779-20090901-C00044.png) 1974-07-05
DD107697A5 (US07582779-20090901-C00044.png) 1974-08-12
OA04567A (fr) 1980-05-31
NL7316016A (US07582779-20090901-C00044.png) 1974-06-04
SU518133A3 (ru) 1976-06-15
JPS5314077B2 (US07582779-20090901-C00044.png) 1978-05-15
US4005212A (en) 1977-01-25
GB1404708A (en) 1975-09-03
BE808008A (fr) 1974-05-29
DK136823B (da) 1977-11-28
IL43723A (en) 1976-07-30
AU6300973A (en) 1975-05-29
IE38552L (en) 1974-05-30
AT329554B (de) 1976-05-25
AR203186A1 (es) 1975-08-22
DK136823C (US07582779-20090901-C00044.png) 1978-05-08
SE399894B (sv) 1978-03-06
IE38552B1 (en) 1978-04-12
CH579577A5 (US07582779-20090901-C00044.png) 1976-09-15
ATA1005173A (de) 1975-08-15
ES421011A1 (es) 1976-06-16
IL43723A0 (en) 1974-03-14
CA1002955A (fr) 1977-01-04
HU167368B (US07582779-20090901-C00044.png) 1975-09-27
JPS4993390A (US07582779-20090901-C00044.png) 1974-09-05

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