DE2336751A1 - Neue zusammensetzungen fuer die lokalisation von tiefliegenden gefaessthromben mit radioaktivem spuerstoff - Google Patents
Neue zusammensetzungen fuer die lokalisation von tiefliegenden gefaessthromben mit radioaktivem spuerstoffInfo
- Publication number
- DE2336751A1 DE2336751A1 DE19732336751 DE2336751A DE2336751A1 DE 2336751 A1 DE2336751 A1 DE 2336751A1 DE 19732336751 DE19732336751 DE 19732336751 DE 2336751 A DE2336751 A DE 2336751A DE 2336751 A1 DE2336751 A1 DE 2336751A1
- Authority
- DE
- Germany
- Prior art keywords
- kiu
- streptokinase
- urokinase
- labeled
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims description 11
- 230000002285 radioactive effect Effects 0.000 title description 6
- 230000004807 localization Effects 0.000 title description 5
- 231100001261 hazardous Toxicity 0.000 title 1
- 108010023197 Streptokinase Proteins 0.000 claims description 17
- 229960005202 streptokinase Drugs 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 14
- 229960005356 urokinase Drugs 0.000 claims description 14
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims description 12
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 claims description 12
- 108090000790 Enzymes Proteins 0.000 claims description 10
- 102000004190 Enzymes Human genes 0.000 claims description 10
- 229910021626 Tin(II) chloride Inorganic materials 0.000 claims description 10
- 229940088598 enzyme Drugs 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 10
- 235000011150 stannous chloride Nutrition 0.000 claims description 10
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 claims description 10
- 208000005189 Embolism Diseases 0.000 claims description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
- 230000002792 vascular Effects 0.000 claims description 8
- 208000007536 Thrombosis Diseases 0.000 claims description 6
- 238000005349 anion exchange Methods 0.000 claims description 4
- 239000000872 buffer Substances 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 3
- 230000005855 radiation Effects 0.000 claims description 3
- 239000003146 anticoagulant agent Substances 0.000 claims description 2
- 230000002537 thrombolytic effect Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003929 acidic solution Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102000008100 Human Serum Albumin Human genes 0.000 description 3
- 108091006905 Human Serum Albumin Proteins 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000700 radioactive tracer Substances 0.000 description 3
- CVNKFOIOZXAFBO-UHFFFAOYSA-J tin(4+);tetrahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[Sn+4] CVNKFOIOZXAFBO-UHFFFAOYSA-J 0.000 description 3
- 102000008946 Fibrinogen Human genes 0.000 description 2
- 108010049003 Fibrinogen Proteins 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000006172 buffering agent Substances 0.000 description 2
- 229940012952 fibrinogen Drugs 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical group [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 2
- QHGNHLZPVBIIPX-UHFFFAOYSA-N tin(ii) oxide Chemical compound [Sn]=O QHGNHLZPVBIIPX-UHFFFAOYSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003113 alkalizing effect Effects 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000007982 barbital buffer Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000009206 nuclear medicine Methods 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 229910052713 technetium Inorganic materials 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00282100A US3812245A (en) | 1972-08-21 | 1972-08-21 | Novel compositions for radiotracer localization of deep vein thrombi |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2336751A1 true DE2336751A1 (de) | 1974-02-28 |
Family
ID=23080113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19732336751 Pending DE2336751A1 (de) | 1972-08-21 | 1973-07-19 | Neue zusammensetzungen fuer die lokalisation von tiefliegenden gefaessthromben mit radioaktivem spuerstoff |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3812245A (enrdf_load_html_response) |
| JP (1) | JPS5346915B2 (enrdf_load_html_response) |
| BE (1) | BE802052A (enrdf_load_html_response) |
| DE (1) | DE2336751A1 (enrdf_load_html_response) |
| FR (1) | FR2196788B1 (enrdf_load_html_response) |
| GB (1) | GB1432878A (enrdf_load_html_response) |
| NL (1) | NL7309907A (enrdf_load_html_response) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2199731A1 (de) | 2008-12-18 | 2010-06-23 | Rheinmetall Waffe Munition ARGES GmbH | Haftladung |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4416865A (en) * | 1973-02-20 | 1983-11-22 | Research Corporation | Radiopharmaceuticals for localization of thromboembolic disease |
| US3927193A (en) * | 1973-05-18 | 1975-12-16 | Hoffmann La Roche | Localization of tumors by radiolabelled antibodies |
| US4036945A (en) * | 1976-05-03 | 1977-07-19 | The Massachusetts General Hospital | Composition and method for determining the size and location of myocardial infarcts |
| JPS54165220U (enrdf_load_html_response) * | 1978-05-12 | 1979-11-20 | ||
| US4224303A (en) * | 1978-07-21 | 1980-09-23 | A. C. Smith | Signalling particles for introduction into blood flowing through a vessel of interest |
| US4293537A (en) * | 1978-09-05 | 1981-10-06 | Wong Dennis W | Novel chemical method of labeling proteins with 99m Tc-Technetium at physiological condition |
| JPS5597349A (en) * | 1978-12-28 | 1980-07-24 | Showa Seitai Mfg | Bag with pleat |
| JPS5598747U (enrdf_load_html_response) * | 1978-12-28 | 1980-07-09 | ||
| SE418570B (sv) * | 1979-10-17 | 1981-06-15 | Mattsson Soeren | Apparat for bestemning av leget av ett omrade i menniskokroppen med upptag av en med ett radioaktivt emne merkt forening med hjelp av en detektoranordning |
| WO1981001417A1 (en) * | 1979-11-13 | 1981-05-28 | S Husain | Isolation of plasminogen activators useful as therapeutic and diagnostic agents |
| USRE32271E (en) * | 1979-11-13 | 1986-10-28 | Isolation of plasminogen activators useful as therapeutic and diagnostic agents | |
| US4385046A (en) * | 1980-12-15 | 1983-05-24 | Minnesota Mining And Manufacturing Company | Diagnostic radio-labeled polysaccharide derivatives |
-
1972
- 1972-08-21 US US00282100A patent/US3812245A/en not_active Expired - Lifetime
-
1973
- 1973-06-06 FR FR7320558A patent/FR2196788B1/fr not_active Expired
- 1973-07-06 BE BE6044231A patent/BE802052A/xx unknown
- 1973-07-12 GB GB3338073A patent/GB1432878A/en not_active Expired
- 1973-07-17 NL NL7309907A patent/NL7309907A/xx unknown
- 1973-07-19 DE DE19732336751 patent/DE2336751A1/de active Pending
- 1973-08-15 JP JP9164173A patent/JPS5346915B2/ja not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2199731A1 (de) | 2008-12-18 | 2010-06-23 | Rheinmetall Waffe Munition ARGES GmbH | Haftladung |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5346915B2 (enrdf_load_html_response) | 1978-12-16 |
| US3812245A (en) | 1974-05-21 |
| NL7309907A (enrdf_load_html_response) | 1974-02-25 |
| GB1432878A (en) | 1976-04-22 |
| FR2196788A1 (enrdf_load_html_response) | 1974-03-22 |
| BE802052A (fr) | 1973-11-05 |
| FR2196788B1 (enrdf_load_html_response) | 1978-07-28 |
| JPS4965890A (enrdf_load_html_response) | 1974-06-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69230912T2 (de) | Radioaktiv-markiertes metall-bindendes protein zur behandlung von arthritis | |
| DE3528979C2 (enrdf_load_html_response) | ||
| DE3783242T2 (de) | Aminogruppen enthaltende hochmolekulare verbindungen und deren verwendung. | |
| DE69932183T2 (de) | ANWENDUNG VON ZIELGERICHTETEM RADIUM 223 FüR PALLIATIVE UND THERAPEUTISCHE BEHANDLUNG VON KNOCHENKREBS | |
| DE69110554T2 (de) | Radiopharmazeutische Zusammensetzungen, Verabreichungsmethode und Verfahren zur Herstellung derselben. | |
| DE2336751A1 (de) | Neue zusammensetzungen fuer die lokalisation von tiefliegenden gefaessthromben mit radioaktivem spuerstoff | |
| DE2814038B2 (de) | Mit einem Radionuklid für radioaktive Tests markierbares Material | |
| DE69033953T2 (de) | Kolloidale radiomarkierte zusammensetzungen, deren anwendung und verfahren zu deren herstellung | |
| CH649924A5 (de) | Reduktionsmaterial zur reduktion von technetium unter bildung eines technetiummarkierten liganden. | |
| DE2538388A1 (de) | Verfahren zur herstellung eines stabilen, nicht-radioaktiven traegermaterials und seine verwendung zur herstellung von tc-99m-markierten diagnosemitteln | |
| DE3320560C2 (enrdf_load_html_response) | ||
| DE2235681A1 (de) | Macroaggregate aus albumin, technetium99m und zinn(ii)-ionen, verfahren zu ihrer herstellung und ihre verwendung als radioindikatoren bei der untersuchung von organen | |
| DE69630727T2 (de) | Radioaktiven Chitosankomplex und deren Anwendung in Strahlungstherapie | |
| DE2124752A1 (de) | Verfahren zur Herstellung eines diagnostischen Präparats auf Basis von Makroaggregaten von mit 99mTc markiertem Serumeiweiß | |
| DE2534985C2 (enrdf_load_html_response) | ||
| DE194851T1 (de) | Therapie der menschlichen tumore. | |
| DE2947500A1 (de) | Radiojodierte (omega) -phenylfettsaeuren, ihre herstellung und praeparate zur szintigraphischen untersuchung desherzmuskels und der leber | |
| DE2710728C2 (de) | Reagens für die radiologische Abtastung von Organen, Verfahren zu seiner Herstellung und seine Verwendung | |
| DE69129463T2 (de) | Verwendung von substanzen in partikelform | |
| EP0141100B1 (de) | N-(4-Aminobenzoyl)-aminodicarbonsäuren zur Stabilisierung von Technetium-99m-Präparaten, stabilisierte Injektionspräparate und Verfahren zu ihrer Herstellung | |
| Anghileri et al. | New colloidal chromic radiophosphate (P32) for local irradiation of the central nervous system | |
| DE69317343T2 (de) | Verwendung eines direkten Inhibitors von Thrombin zur Herstellung eines Arzneimittels mit thrombolytischer Aktivität | |
| DE69428554T2 (de) | Mittel zum Vermeiden des Verklebens von Thallium 201 zu einer Container | |
| DE2020348B2 (de) | Träger für ein szintigraphisches Präparat und dessen Verwendung | |
| DE1932231A1 (de) | Diagnostisches und therapeutisches Praeparat auf der Basis eines chelatgebundenen Radio-Nuclids |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHA | Expiration of time for request for examination |