DE2303238A1 - Verfahren zur herstellung hochtitriger diagnostischer und therapeutischer seren, sowie zur unspezifischen steigerung des antikoerpertiters zwecks erhoehung des impfschutzes in der human- und veterinaermedizin - Google Patents
Verfahren zur herstellung hochtitriger diagnostischer und therapeutischer seren, sowie zur unspezifischen steigerung des antikoerpertiters zwecks erhoehung des impfschutzes in der human- und veterinaermedizinInfo
- Publication number
- DE2303238A1 DE2303238A1 DE19732303238 DE2303238A DE2303238A1 DE 2303238 A1 DE2303238 A1 DE 2303238A1 DE 19732303238 DE19732303238 DE 19732303238 DE 2303238 A DE2303238 A DE 2303238A DE 2303238 A1 DE2303238 A1 DE 2303238A1
- Authority
- DE
- Germany
- Prior art keywords
- day
- therapeutic
- diagnostic
- increase
- veterinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 7
- 230000001225 therapeutic effect Effects 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 4
- 230000008569 process Effects 0.000 title claims description 3
- 229960005486 vaccine Drugs 0.000 title 1
- 206010070834 Sensitisation Diseases 0.000 claims description 9
- 230000008313 sensitization Effects 0.000 claims description 9
- 210000002966 serum Anatomy 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 4
- 238000001727 in vivo Methods 0.000 claims description 4
- 150000004694 iodide salts Chemical class 0.000 claims description 2
- 150000007530 organic bases Chemical class 0.000 claims description 2
- 238000005868 electrolysis reaction Methods 0.000 claims 2
- 230000035943 smell Effects 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 23
- 238000002474 experimental method Methods 0.000 description 17
- 241001465754 Metazoa Species 0.000 description 14
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 12
- VGTPCRGMBIAPIM-UHFFFAOYSA-M sodium thiocyanate Chemical compound [Na+].[S-]C#N VGTPCRGMBIAPIM-UHFFFAOYSA-M 0.000 description 8
- 239000002671 adjuvant Substances 0.000 description 7
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- 230000037396 body weight Effects 0.000 description 6
- 241000283073 Equus caballus Species 0.000 description 5
- 239000000427 antigen Substances 0.000 description 5
- 102000036639 antigens Human genes 0.000 description 5
- 108091007433 antigens Proteins 0.000 description 5
- 230000005012 migration Effects 0.000 description 4
- 238000013508 migration Methods 0.000 description 4
- 235000009518 sodium iodide Nutrition 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 231100000433 cytotoxic Toxicity 0.000 description 3
- 230000001472 cytotoxic effect Effects 0.000 description 3
- 230000035931 haemagglutination Effects 0.000 description 3
- -1 rhodanide ions Chemical class 0.000 description 3
- 241000700198 Cavia Species 0.000 description 2
- 230000024932 T cell mediated immunity Effects 0.000 description 2
- 238000012754 cardiac puncture Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 241000283069 Equus przewalskii Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910000464 lead oxide Inorganic materials 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- YEXPOXQUZXUXJW-UHFFFAOYSA-N oxolead Chemical compound [Pb]=O YEXPOXQUZXUXJW-UHFFFAOYSA-N 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- KIWUVOGUEXMXSV-UHFFFAOYSA-N rhodanine Chemical compound O=C1CSC(=S)N1 KIWUVOGUEXMXSV-UHFFFAOYSA-N 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000004071 soot Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 150000003567 thiocyanates Chemical class 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DD16107872A DD101815A1 (enrdf_load_stackoverflow) | 1972-02-17 | 1972-02-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2303238A1 true DE2303238A1 (de) | 1973-08-23 |
Family
ID=5485441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19732303238 Pending DE2303238A1 (de) | 1972-02-17 | 1973-01-24 | Verfahren zur herstellung hochtitriger diagnostischer und therapeutischer seren, sowie zur unspezifischen steigerung des antikoerpertiters zwecks erhoehung des impfschutzes in der human- und veterinaermedizin |
Country Status (4)
| Country | Link |
|---|---|
| DD (1) | DD101815A1 (enrdf_load_stackoverflow) |
| DE (1) | DE2303238A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2181732A1 (enrdf_load_stackoverflow) |
| SU (1) | SU580863A1 (enrdf_load_stackoverflow) |
-
1972
- 1972-02-17 DD DD16107872A patent/DD101815A1/xx unknown
-
1973
- 1973-01-24 DE DE19732303238 patent/DE2303238A1/de active Pending
- 1973-02-14 FR FR7305224A patent/FR2181732A1/fr active Granted
- 1973-02-15 SU SU7301882648A patent/SU580863A1/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| SU580863A1 (ru) | 1977-11-25 |
| FR2181732A1 (en) | 1973-12-07 |
| FR2181732B1 (enrdf_load_stackoverflow) | 1978-07-28 |
| DD101815A1 (enrdf_load_stackoverflow) | 1973-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| OHW | Rejection |